Article
Cell & Tissue Engineering
M. Hofstee, M. Riool, F. Gieling, V Stenger, C. Constant, D. Nehrbass, S. Zeiter, R. G. Richards, S. A. J. Zaat, T. F. Moriarty
Summary: The study revealed that in mice, fracture-related infection (FRI) leads to osteolysis, the formation of staphylococcal abscess communities (SACs), and an immunosuppressive environment. Mice inoculated with S. aureus showed abnormal bone healing and severe osteolysis.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Oliver Goldmann, Eva Medina
Summary: Our study found that myeloid-derived suppressor cells (MDSC) inhibit CD4+ T cell responses by interfering with their metabolic activity during Staphylococcus aureus infection. MDSC are highly glycolytic and excrete a large amount of lactate, altering the intracellular and extracellular lactate concentration gradient, preventing removal of lactate by CD4+ T cells, leading to the accumulation of endogenous lactate, inhibiting cellular bioenergetics, and stopping glycolysis. Reestablishment of MDSC metabolic activity may improve CD4+ T cell functionality during chronic S. aureus infection.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Marloes Hofstee, Anja Heider, Sonja Haeckel, Caroline Constant, Martijn Riool, R. Geoff Richards, T. Fintan Moriarty, Sebastian A. J. Zaat
Summary: The study found that SACs can trigger MDSC expansion and identified potential mediators as an additional strategy for treating chronic S. aureus infections.
Review
Biochemistry & Molecular Biology
Jingshan Cai, Yudan Cui, Jun Yang, Shengjun Wang
Summary: MDSCs play a crucial role in tumor immunity, closely linked to tumor EMT and possessing unique functions in an immunosuppressive environment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Immunology
Jie Shen, Mengyu Zhang, Ke Zhang, Yahan Qin, Meifang Liu, Shujuan Liang, Daquan Chen, Meiyu Peng
Summary: This study found that Angelica polysaccharide (APS) promoted the proliferation, differentiation, and immunosuppressive function of myeloid-derived suppressor cells (MDSC) through the STAT1 and STAT3 signaling pathways. In vivo, APS increased the proportion of MDSC in mice, suggesting that its clinical application should consider the possible side effects of increasing MDSC quantity and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Oliver Dietrich, Alexander Heinz, Oliver Goldmann, Robert Geffers, Andreas Beineke, Karsten Hiller, Antoine-Emmanuel Saliba, Eva Medina
Summary: This study used single-cell RNA sequencing and functional metabolic profiling to investigate the generation and maintenance factors of MDSCs in chronic Staphylococcus aureus infection. The research found that MDSCs not only originate in bone marrow, but also at extramedullary sites in infected mice, and that MDSCs require high glycolytic activity and glucose consumption rates to remain in an immature state.
JOURNAL OF INNATE IMMUNITY
(2022)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Maria Iglesias-Escudero, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Pena, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos Lopez-Hoyos
Summary: Lung transplantation is a primary treatment for end-stage lung diseases, but long-term survival is limited. The study explores the dysregulation of immune mechanisms and the role of myeloid-derived suppressor cells (MDSCs) in promoting graft tolerance. The results suggest that increased frequencies of Mo-MDSCs after acute cellular rejection may be associated with the development of chronic lung allograft dysfunction (CLAD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Carlos Lamsfus Calle, Rolf Fendel, Anurag Singh, Thomas L. Richie, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmuller
Summary: Malaria can lead to severe complications and chronic infections, causing conditions like anemia and immunologic hyporesponsiveness. The study on controlled human malaria infection revealed that malaria-induced immunosuppression, with circulating PMN-MDSC serving as an early indicator of infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Vaishali Bhardwaj, Stephen M. M. Ansell
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells composed of pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections. They exhibit distinct characteristics and exert strong immunosuppressive effects on T-cells and other immune cells, making them a major obstacle to cancer immunotherapies. However, the clinical outcomes of targeting MDSCs in hematological malignancies, particularly B-cell malignancies, still require further exploration. This review provides a comprehensive summary of the complex biology and immunosuppressive pathways of MDSCs, with a focus on their role in modulating T-cell function in hematological malignancies, and discusses the challenges, therapeutic strategies, and clinical relevance of targeting MDSCs in these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Maria Luisa Sanchez-Leon, Carlos Jimenez-Cortegana, Gabriel Cabrera, Elba Monica Vermeulen, Luis de la Cruz-Merino, Victor Sanchez-Margalet
Summary: Dendritic cells (DCs) play a diminished role in various malignancies due to immunosuppressive conditions in the tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs) accumulate in the TME and inhibit DC functions, maturation, and development. DC-based vaccines have been developed to improve antitumor immunity, and their effectiveness in murine models and cancer patients, alone or in combination with other treatments, has been explored.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ying He, Sze Wan Hung, Bo Liang, Ruizhe Zhang, Yating Gao, Ching Yan Chu, Tao Zhang, Hui Xu, Jacqueline Pui Wah Chung, Chi Chiu Wang
Summary: The study demonstrated that Sunitinib inhibited endometriotic lesions by promoting the maturation of MDSCs and inhibiting immunosuppressive functions, showing potential therapeutic effects for treating endometriosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xueyan Li, Xue Deng, Xiaoqi Luo, Jiahui Zhong, Hui Wu, Siru Chen, Jiayi Chen, Xuhui Huang, Changjun Wang
Summary: Alcohol consumption can inhibit the growth of liver cancer by regulating the immunosuppressive microenvironment, specifically through the downregulation of myeloid-derived suppressor cells (MDSCs) and the increase of CD4+ and CD8+ T cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)