Journal
JOURNAL OF INFECTION
Volume 74, Issue -, Pages S108-S113Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/S0163-4453(17)30200-1
Keywords
Candidiasis; Premature neonate; Low birth weight infants; Risk factors; Biomarkers
Categories
Funding
- MRC
- University of Aberdeen (MRC Centre for Medical Mycology)
- Wellcome Trust Strategic Award - Medical Mycology Fungal Immunology
- MRC [MR/N006364/1] Funding Source: UKRI
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Fungal infections largely caused by Candida species are responsible for a significant disease burden in neonates and invasive candidiasis in hospitalised neonates has high associated morbidity and mortality. Early initiation of antifungal treatment improves outcome but the recognition and diagnosis of systemic fungal infection in this population is difficult due to the non-specific clinical presentation and the high false negative rate of cultures. There is a need for a practical, sensitive and rapid diagnostic test to enhance identification and early treatment. Serum detection of (1,3)-beta-d-glucan and Candida PCR are promising candidates but at present limited data exists for their use in the neonatal intensive care setting. Until such investigations are validated, early initiation of antifungal treatment on the basis of risk factor profile and clinical features remains the safest practical approach. (C) 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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