The Role of Shed PrPcin the Neuropathogenesis of HIV Infection

Total Prion Protein Levels in the Cerebrospinal Fluid are Reduced in Patients with Various Neurological Disorders

(2017) Felix Meyne et al.   JOURNAL OF ALZHEIMERS DISEASE

TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis

(2016) Josiane Lilian dos Santos Schiavinato et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase

(2015) Hong Qiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dopamine Increases CD14+CD16+ Monocyte Migration and Adhesion in the Context of Substance Abuse and HIV Neuropathogenesis

(2015) Jacqueline S. Coley et al.   PLoS One

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells

(2013) Hua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China

(2013) Lin Yuan et al.   JOURNAL OF NEUROVIROLOGY

The Soluble Form of the Cellular Prion Protein Enhances Phagocytic Activity and Cytokine Production by Human Monocytes Via Activation of ERK and NF-κB

(2013) Jae-Won Jeon et al.   Immune Network

Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity

(2012) Krzysztof Nieznanski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

(2012) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of the Notch-Hey1 Axis Blocks Embryonal Rhabdomyosarcoma Tumorigenesis

(2011) B. C. Belyea et al.   CLINICAL CANCER RESEARCH

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals

(2011) Scott L. Letendre et al.   JOURNAL OF NEUROVIROLOGY

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation

(2010) Toni K. Roberts et al.   AMERICAN JOURNAL OF PATHOLOGY

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Improved Synthesis of ADAM10 Inhibitor GI254023X

(2010) Nicole Hoettecke et al.   Neurodegenerative Diseases

Prion protein and Alzheimer disease

(2010) Katherine A.B. Kellett et al.   Prion

Reduction of PrPC in human cerebrospinal fluid after spinal cord injury

(2010) Anna Carnini et al.   Prion

Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers

(2009) Haakon B. Nygaard et al.   ARCHIVES OF NEUROLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Novel TACE inhibitors in drug discovery: a review of patented compounds

(2009) Prashant R Murumkar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein

(2009) David R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS Inflammation and Macrophage/Microglial Biology Associated with HIV-1 Infection

(2009) Anjana Yadav et al.   Journal of Neuroimmune Pharmacology

Measurement of soluble inflammatory mediators in cerebrospinal fluid of human immunodeficiency virus–positive patients at distinct stages of infection by solid-phase protein array

(2009) Thorsten Nolting et al.   JOURNAL OF NEUROVIROLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Regulation of Embryonic Cell Adhesion by the Prion Protein

(2009) Edward Málaga-Trillo et al.   PLOS BIOLOGY

ADAM10-Mediated E-Cadherin Release Is Regulated by Proinflammatory Cytokines and Modulates Keratinocyte Cohesion in Eczematous Dermatitis

(2008) Thorsten Maretzky et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Three-dimensional domain architecture of the ADAM family proteinases

(2008) Soichi Takeda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY