Virus-Specific CD8+T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression

Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector

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Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity

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Antigen-specific T cell therapies for cancer: Figure 1.

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Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios

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Cytomegalovirus induces apoptosis in acute leukemia cells as a virus-versus-leukemia function

(2015) Michael Koldehoff et al.   LEUKEMIA & LYMPHOMA

Prognostic Significance of Programmed Cell Death 1 (PD-1) or PD-1 Ligand 1 (PD-L1) Expression in Epithelial-Originated Cancer

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Adoptive cell transfer as personalized immunotherapy for human cancer

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Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells

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Cancer vaccines: Trafficking of tumor-specific T cells to tumor after therapeutic vaccination

(2014) Yared Hailemichael et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

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STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells

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Resolving the titer of murine cytomegalovirus by plaque assay using the M2-10B4 cell line and a low viscosity overlay

(2014) Katherine A Zurbach et al.   Virology Journal

Systemic Hematogenous Maintenance of Memory Inflation by MCMV Infection

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Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme

(2014) Andrea Schuessler et al.   Frontiers in Oncology

Competition between T cells maintains clonal dominance during memory inflation induced by MCMV

(2013) Holly Turula et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Changes in Functional but Not Structural Avidity during Differentiation of CD8+ Effector Cells In Vivo after Virus Infection

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The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

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Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

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Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

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T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Sustained CD8+ T Cell Memory Inflation after Infection with a Single-Cycle Cytomegalovirus

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(2010) John S. Yi et al.   IMMUNOLOGY

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

(2010) Kirsten M.L. Hertoghs et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

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Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

(2009) C. M. Snyder et al.   JOURNAL OF IMMUNOLOGY

Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion

(2009) S. D. Blackburn et al.   JOURNAL OF VIROLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY

Concurrent Generation of Effector and Central Memory CD8 T Cells during Vaccinia Virus Infection

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