The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation

12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

(2015) Tobias Rothe et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

(2015) Iftach Shaked et al.   NATURE IMMUNOLOGY

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

NR4A nuclear receptors are orphans but not lonesome

(2014) Kondababu Kurakula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Guard of Delinquency? A Role of Microglia in Inflammatory Neurodegenerative Diseases of the CNS

(2014) Weijiang Wu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

Potential Drugs Targeting Microglia: Current Knowledge and Future Prospects

(2013) Parakalan Rangarajan et al.   CNS & Neurological Disorders-Drug Targets

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Inflammation: a role for NR4A orphan nuclear receptors?

(2011) Jason P. McMorrow et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

The molecular basis of neurodegeneration in multiple sclerosis

(2011) Hans Lassmann et al.   FEBS LETTERS

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance

(2010) Wendy Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mouse models for multiple sclerosis: Historical facts and future implications

(2010) Andrew L. Croxford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Radical changes in multiple sclerosis pathogenesis

(2010) Jack van Horssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology