A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

(2017) Alon Oyler-Yaniv et al.   IMMUNITY

ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes

(2016) Steven A. Bryce et al.   JOURNAL OF IMMUNOLOGY

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

(2016) Erica Russo et al.   Cell Reports

Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells

(2015) M. Jafarnejad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo

(2014) M. R. Britschgi et al.   JOURNAL OF IMMUNOLOGY

Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing

(2014) F. Lin et al.   JOURNAL OF IMMUNOLOGY

Arrestin 3 Mediates Endocytosis of CCR7 following Ligation of CCL19 but Not CCL21

(2014) M. A. Byers et al.   JOURNAL OF IMMUNOLOGY

Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation duringMycobacterium tuberculosisInfection

(2014) Nicholas A. Cilfone et al.   JOURNAL OF IMMUNOLOGY

Involvement of Histamine in Endothelium-Dependent Relaxation of Mesenteric Lymphatic Vessels

(2014) Irina Tsoy Nizamutdinova et al.   MICROCIRCULATION

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

(2014) Sophie E. Acton et al.   NATURE

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

Antigen-Pulsed CpG-ODN-Activated Dendritic Cells Induce Host-Protective Immune Response by Regulating the T Regulatory Cell Functioning in Leishmania donovani-Infected Mice: Critical Role of CXCL10

(2014) Saikat Majumder et al.   Frontiers in Immunology

Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K

(2013) Chinh Tran-To Su et al.   BMC BIOINFORMATICS

Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes

(2013) Yana Wang et al.   Integrative Biology

Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

(2013) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

On-Lattice Simulation of T Cell Motility, Chemotaxis, and Trafficking in the Lymph Node Paracortex

(2012) Gib Bogle et al.   PLoS One

Optical projection tomography reveals dynamics of HEV growth after immunization with protein plus CFA and features shared with HEVs in acute autoinflammatory lymphadenopathy

(2012) Varsha Kumar et al.   Frontiers in Immunology

Nitric oxide formation by lymphatic bulb and valves is a major regulatory component of lymphatic pumping

(2011) H. Glenn Bohlen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Development of a mathematical model to describe the transport of monocyte chemoattractant protein-1 through a three-dimensional collagen matrix

(2011) Krisada Leemasawatdigul et al.   CARDIOVASCULAR PATHOLOGY

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells

(2011) Meike Wendland et al.   IMMUNITY

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration

(2011) Asolina Braun et al.   NATURE IMMUNOLOGY

Reaction-Diffusion Modelling of Interferon Distribution in Secondary Lymphoid Organs

(2011) G. Bocharov et al.   Mathematical Modelling of Natural Phenomena

Reproducible Isolation of Lymph Node Stromal Cells Reveals Site-Dependent Differences in Fibroblastic Reticular Cells

(2011) Anne L. Fletcher et al.   Frontiers in Immunology

CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19

(2010) Mirjam R. Britschgi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Dendritic Cells Distinguish Individual Chemokine Signals through CCR7 and CXCR4

(2010) B. G. Ricart et al.   JOURNAL OF IMMUNOLOGY

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo

(2009) H. Glenn Bohlen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY