Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice

Neurons exhibitLyz2promoter activity in vivo: Implications for using LysM-Cre mice in myeloid cell research

(2016) Johannes Orthgiess et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

(2015) Sharad K. Sharma et al.   JOURNAL OF IMMUNOLOGY

Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema

(2015) Bing-Hua Su et al.   JOURNAL OF PATHOLOGY

Matrix metalloproteinases in destructive lung disease

(2015) A. McGarry Houghton   MATRIX BIOLOGY

Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis

(2014) Bo Tao et al.   JOURNAL OF IMMUNOLOGY

Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry

(2013) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

(2013) T. Ishii et al.   EUROPEAN RESPIRATORY JOURNAL

Decreased serum transforming growth factor-β1 concentration with aging is associated with the severity of emphysema in chronic obstructive pulmonary disease

(2013) Koichiro Kamio et al.   Geriatrics & Gerontology International

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

(2012) Xue Zhang et al.   FASEB JOURNAL

Pathogenesis of chronic obstructive pulmonary disease

(2012) Rubin M. Tuder et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

(2011) H. H. Zhu et al.   BLOOD

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

(2011) Michael Seimetz et al.   CELL

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

(2011) R. E. Vandenbroucke et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of Shp2-Mediated Mitogen-Activated Protein Kinase Signaling in Muller Glial Cells Results in Retinal Degeneration

(2011) Z. Cai et al.   MOLECULAR AND CELLULAR BIOLOGY

IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

(2011) Kong Chen et al.   PLoS One

Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD

(2011) I. Haq et al.   THORAX

Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia

(2010) J. Bies et al.   BLOOD

Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy

(2010) Hongqiang Cheng et al.   CIRCULATION RESEARCH

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases

(2009) Vincent Lagente et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MMP12,Lung Function, and COPD in High-Risk Populations

(2009) Gary M. Hunninghake et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Molecular pathogenesis of emphysema

(2008) Laimute Taraseviciene-Stewart et al.   JOURNAL OF CLINICAL INVESTIGATION