PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8+T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

PD-1/PD-L1 blockade in cancer treatment: perspectives and issues

(2016) Junzo Hamanishi et al.   International Journal of Clinical Oncology

Tumor immune profiling predicts response to anti–PD-1 therapy in human melanoma

(2016) Adil I. Daud et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

PD-L1 expression in human cancers and its association with clinical outcomes

(2016) Jinming Yu et al.   OncoTargets and Therapy

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

(2016) Matthias Hoffmann et al.   PLoS Pathogens

Discovering protective CD8 T cell epitopes—no single immunologic property predicts it!

(2015) Pavlo Gilchuk et al.   CURRENT OPINION IN IMMUNOLOGY

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

(2015) Kim C. Ohaegbulam et al.   TRENDS IN MOLECULAR MEDICINE

CD8+ T Cells Targeting a Single Immunodominant Epitope are Sufficient for Elimination of Established SV40 T Antigen-Induced Brain Tumors

(2014) A. M. Tatum et al.   JOURNAL OF IMMUNOLOGY

Terminal Deoxynucleotidyl Transferase Establishes and Broadens Antiviral CD8+ T Cell Immunodominance Hierarchies

(2014) S. M. M. Haeryfar et al.   JOURNAL OF IMMUNOLOGY

Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance

(2014) M. F. Kotturi et al.   JOURNAL OF IMMUNOLOGY

Suppression of Immunodominant Antitumor and Antiviral CD8+ T Cell Responses by Indoleamine 2,3-Dioxygenase

(2014) Mateusz Rytelewski et al.   PLoS One

Mixed Proteasomes Function To Increase Viral Peptide Diversity and Broaden Antiviral CD8+ T Cell Responses

(2013) D. Zanker et al.   JOURNAL OF IMMUNOLOGY

Immunodomination during Peripheral Vaccinia Virus Infection

(2013) Leon C. W. Lin et al.   PLoS Pathogens

CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

(2013) Masanori Isogawa et al.   PLoS Pathogens

Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study

(2012) H. Sihto et al.   CLINICAL CANCER RESEARCH

Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen

(2012) Bianca P Gomez et al.   Cell and Bioscience

Differential Regulation of Simultaneous Antitumor and Alloreactive CD8+ T-Cell Responses in the Same Host by Rapamycin

(2011) S. Maleki Vareki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Nondominant CD8 T Cells Are Active Players in the Vaccine-Induced Antitumor Immune Response

(2011) Jennifer N. Uram et al.   JOURNAL OF IMMUNOLOGY

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

(2010) R. Houben et al.   JOURNAL OF VIROLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene

(2008) A. Kassem et al.   CANCER RESEARCH

Altered Immunodominance Hierarchies of Influenza A Virus-Specific H-2b-Restricted CD8+T Cells in the Absence of Terminal Deoxynucleotidyl Transferase

(2008) Matilde Leon-Ponte et al.   IMMUNOLOGICAL INVESTIGATIONS