Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Mi-Hyang Jung, So-Young Lee, Jong-Chan Youn, Woo-Baek Chung, Sang-Hyun Ihm, Dongwoo Kang, Dae-Sung Kyoung, Hae Ok Jung, Kiyuk Chang, Ho-Joong Youn, Hokyou Lee, Danbee Kang, Juhee Cho, Hidehiro Kaneko, Hyeon Chang Kim
Summary: This study aimed to explore the association between adherence to antihypertensive medication and clinical outcomes in adult patients with cancer. Nonadherence to antihypertensive medication was found to be common in cancer patients and was associated with higher overall mortality and cardiovascular mortality, as well as an increased risk of cardiovascular events. Thus, improving adherence to antihypertensive medication is crucial in cancer patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Syed Karam Mustafa Gardezi, William W. Aitken, Mohammad Hashim Jilani, Jerzy Wilinski
Summary: Medication non-adherence is a significant healthcare barrier, particularly in asymptomatic diseases like hypertension. Poor adherence to blood pressure (BP) medications is associated with increased cardiovascular (CV) deaths. Even a small increase in adherence rate could lead to a substantial decrease in preventable CV deaths.
Review
Peripheral Vascular Disease
Ruixing Zhang, Hongtao Yin, Mengdi Yang, Xianqiong Lei, Donghu Zhen, Zheng Zhang
Summary: Hypertension and osteoporosis are common comorbidities in the elderly. The effects of antihypertensive drugs on bone metabolism are controversial, with different drugs having different effects. Some drugs may improve bone density by stimulating osteoblast differentiation and reducing osteoclast generation, while others may not have a significant relationship with bone density or strength, and may even increase fracture risk.
Article
Medicine, General & Internal
Shu-Yuan Zhang, Li-Yuan Tao, Yun-Yun Yang, Tao Kong, Cun-Jin Wu, Yang Wang, Jing-Zhou Chen, Lei Song, Yi-Bo Wang, Ru-Tai Hui, Wei-Li Zhang
Summary: This study compared the long-term antihypertensive efficacy, cost-effectiveness, and cardiovascular outcomes of generic drugs versus brand-name drugs. The results showed no significant differences in blood pressure lowering efficacy and cardiovascular outcomes between the two types of drugs. However, brand-name drugs may have a slight advantage in certain populations in terms of blood pressure control.
CHINESE MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
L. E. J. Peeters, M. H. W. Kappers, E. Boersma, E. K. Massey, L. van Dijk, T. van Gelder, B. C. P. Koch, J. Versmissen
Summary: This study aims to reduce the prevalence of resistant hypertension by monitoring drug concentrations and providing personalized feedback. It will be the first trial focusing specifically on patients with resistant hypertension and combining drug concentration monitoring with comprehensive feedback to improve adherence.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Review
Cardiac & Cardiovascular Systems
Francesco Ferrara, Andrea Zovi, Eduardo Nava, Roberto Langella, Antonio Vitiello
Summary: Cardiovascular diseases are becoming a leading cause of death and hospitalization in the Western world. Various classes of antihypertensive drugs, such as ACE inhibitors, sartans, calcium antagonists, beta blockers, and diuretics, differ in mechanism, efficacy, tolerability, and cost. This analysis examines the prescribing trends of antihypertensive drugs in an Italian healthcare company, highlighting aspects of pharmacoeconomics, pharmacoutili-zation, and pharmacological differences.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Health Care Sciences & Services
Gary Chun-Yun Kang
Summary: This study aimed to determine the efficacy of technology-based interventions in improving adherence to antihypertensive medications. The results showed that several interventions significantly improved adherence and had a positive impact on blood pressure control. However, randomized controlled trials on technological interventions in this area are still limited.
Article
Cardiac & Cardiovascular Systems
Jiqing Li, Zhentang Zhang, Shucheng Si, Bojie Wang, Fuzhong Xue
Summary: Antihypertensive adherence was found to be more strongly associated with the risk of CVD, with low-adherence patients having higher BP burden and fluctuation range than high-adherence patients. Patients with high adherence experienced a 28% greater reduction in BP burden compared to those with low adherence.
Review
Cardiac & Cardiovascular Systems
Jyoti R. Sharma, Phiwayinkosi V. Dludla, Girish Dwivedi, Rabia Johnson
Summary: Poor adherence to prescribed antihypertensive therapy is a significant problem in sub-Saharan Africa, leading to high prevalence of uncontrolled hypertension. Reliable methods for assessing medication adherence are limited, hindering effective strategies for improvement. This review explores various methods and proposes hair-based therapeutic drug monitoring as a promising approach.
Article
Medical Laboratory Technology
Stine Rognstad, Camilla L. Soraas, Ola U. Bergland, Aud Hoieggen, Magnus Strommen, Arne Helland, Mimi S. Opdal
Summary: This study established serum reference ranges for 24 frequently used antihypertensive drugs based on prescription data and literature review. The results suggest that combining serum drug concentration measurements, blood pressure measurements, and other clinical data may help identify nonadherent patients and tailor individualized antihypertensive treatment in line with the concept of personalized medicine.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Biochemistry & Molecular Biology
Lea Wagmann, Aline C. Vollmer, Lucas Lauder, Felix Mahfoud, Markus R. Meyer
Summary: The study aimed to monitor adherence to antihypertensive medication by developing a quantification procedure for drug concentrations in blood plasma. Results showed that plasma concentration interpretation is more complex than urine screening but can effectively assess adherence. Further data is needed to determine if plasma quantification is superior in assessing adherence to antihypertensive medication.
Article
Pharmacology & Pharmacy
Valeria Avataneo, Elvira Fanelli, Amedeo De Nicolo, Franco Rabbia, Alice Palermiti, Marco Pappaccogli, Jessica Cusato, Francesco Giuseppe De Rosa, Antonio D'Avolio, Franco Veglio
Summary: Saliva may serve as a feasible biological sample for non-invasive therapeutic drug monitoring, with prompt availability and potential accessibility even in out-of-clinic settings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, Maria Jesus Lallana, Javier Armesto, Maria Jose Rabanaque
Summary: This study analyzed patterns of antihypertensive drug use among new users in a Southern European population, identifying factors that influence persistence. The results showed that overall persistence with antihypertensive therapy was poor and influenced by sex, age, and type of therapy. Fixed combinations were found to be effective for initial therapy, especially for patients at higher risk of discontinuation.
Article
Cardiac & Cardiovascular Systems
Hasan Obeid, Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Pierre Boutouyrie, Rosa Maria Bruno, Hakim Khettab, Remi Goupil, Mohsen Agharazii
Summary: The study validates the feasibility and reliability of radial-digital PWV as a measure of regional stiffness of small conduit arteries and investigates its response to changes in hydrostatic pressure. The results demonstrate that this method can be used for assessing the stiffness of small arteries and allows for a comprehensive evaluation of arterial stiffness gradient from larger to smaller arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alexandre Persu, Piotr Dobrowolski, Heather L. Gornik, Jeffrey W. Olin, David Adlam, Michel Azizi, Pierre Boutouyrie, Rosa Maria Bruno, Marion Boulanger, Jean-Baptiste Demoulin, Santhi K. Ganesh, Tomasz J. Guzik, Magdalena Januszewicz, Jason C. Kovacic, Mariusz Kruk, Peter de Leeuw, Bart L. Loeys, Marco Pappaccogli, Melanie H. A. M. Perik, Emmanuel Touze, Patricia Van der Niepen, Daan J. L. Van Twist, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz
Summary: Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that predominantly affects women. Its exact cause is still poorly understood, but it is likely to involve a combination of genetic and environmental factors, leading to arterial fibrosis, cellular hyperplasia, and distortion of the arterial wall architecture. FMD can affect various arteries throughout the body, not just the renal and cerebrovascular arteries.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Benjamin Kably, Eliane M. Billaud, Audrey Derobertmasure, Anne Blanchard, Pierre Boutouyrie, Michel Azizi
Summary: Urinary measurement of AcSDKP can serve as a reliable method for assessing adherence to ACEI treatment, showing good consistency and correlation with ACEI metabolite concentrations.
JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Editorial Material
Peripheral Vascular Disease
Pierre Boutouyrie, Rachel E. Climie, Rosa-Maria Bruno
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Article
Physiology
Silvia Seoni, Simeon Beeckman, Yanlu Li, Soren Aasmul, Umberto Morbiducci, Roel Baets, Pierre Boutouyrie, Filippo Molinari, Nilesh Madhu, Patrick Segers
Summary: The study demonstrated the use of template matching and matrix profile for assessing signal quality and developing automated classifiers, showing the potential for future real-time implementation. Both methods were able to generate quality metrics on par with expert assessment, indicating their suitability for automated grading of LDV signal quality.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Pierre Boutouyrie
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, General & Internal
Junior Justin, Antoine Fayol, Rosa-Maria Bruno, Hakim Khettab, Pierre Boutouyrie
Summary: High blood pressure is the leading cause of death worldwide, with approximately 1.5 billion people suffering from hypertension in 2010. The guidelines for hypertension management by Canadian, American, International, and European organizations provide the basic principles, but they differ in the definition, measurement, and treatment of blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Pierre Boutouyrie, Antoine Fayol, Catherine Fortier, Hakim Khettab, Catalin Cristian, Umit Gencer, David Fouassier, Elie Mousseaux, Audrey Derobertmasure, Carole Leguy, Rosa-Maria Bruno
Summary: This study investigates the cardiovascular consequences of long-term microgravity on large arteries. The results show that changes in arterial properties differ according to the arterial territory and structure type. Furthermore, head-down bed rest (HDBR) leads to an increase in arterial stiffness, which does not completely recover after HDBR. These findings highlight the importance of considering the long-term cardiovascular effects of microgravity.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Salma Adham, Anne Legrand, Rosa-Maria Bruno, Clarisse Billon, Violaine Dalens, Pierre Boutouyrie, Jean-Michael Mazzella, Sonia Gueguen, Michael Frank, Tristan Mirault, Xavier Jeunemaitre
Summary: Most vEDS patients have arterial lesions, primarily in medium-size arteries (MSA). DN variants are associated with a higher prevalence of arterial lesions, especially in supra-aortic trunks, while HI variants are more likely to have both arterial and aortic lesions. Patients with DN variants have a higher frequency of MSA lesions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Aboubakari Nambiema, Quentin Lisan, Julien Vaucher, Marie-Cecile Perier, Pierre Boutouyrie, Nicolas Danchin, Frederique Thomas, Catherine Guibout, Geoffroy Solelhac, Raphael Heinzer, Xavier Jouven, Pedro Marques-Vidal, Jean-Philippe Empana
Summary: The study found that higher healthy sleep scores and improvement over time were associated with a lower risk of coronary heart disease and stroke in the community.
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Peripheral Vascular Disease
Pierre Paradis, Nada Mahjoub, Ku-Geng Huo, Olga Berillo, Chantal Richer, Julio C. Fraulob-Aquino, Marie Briet, Pierre Boutouyrie, Mark L. Lipman, Daniel Sinnett, Ernesto L. Schiffrin
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Peripheral Vascular Disease
Pierre Paradis, Olga Berillo, Ku-Geng Huo, Julio C. Fraulob-Aquino, Chantal Richer, Marie Briet, Pierre Boutouyrie, Mark L. Lipman, Daniel Sinnett, Ernesto L. Schiffrin
JOURNAL OF HYPERTENSION
(2021)
