Article
Environmental Sciences
Ping-Chi Hsu, Zheng-Kuan Li, Ching-Shu Lai, Li-Ho Tseng, Chia-Wei Lee, Fu-Jen Cheng, Chao-Yu Chang, Jenq-Renn Chen
Summary: The study revealed that BDE-209, an endocrine disrupting chemical, can impact male reproductive function from F1 to F3 generations, leading to changes in DNA methylation levels and alterations in sperm function.
Article
Biochemistry & Molecular Biology
Ping-Chi Hsu, Jia-Ying Jhong, Li-Ping Huang, Kuo-Hsin Lee, Hsin-Pao Chen, Yue-Leon Guo
Summary: Prenatal exposure to DEHP can lead to transgenerational adverse effects on the male reproductive system, affecting AGD, AGI, sperm count, and DNA methylation status. Moreover, DEHP exposure also alters the methylation levels of various genes, contributing to the observed phenotypic changes across generations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sanaz Keyhan, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, David L. Corcoran, Adelheid Soubry, Catherine Hoyo, Susan K. Murphy
Summary: Male obesity is associated with altered sperm DNA methylation profiles that appear to affect reprogramming fidelity in a subset of sperm, suggestive of an influence on the spermatogonia. Further work is required to determine the potential heritability of these DNA methylation alterations. If heritable, these changes have the potential to impede normal development.
CLINICAL EPIGENETICS
(2021)
Article
Genetics & Heredity
Rose Schrott, Jennifer L. Modliszewski, Andrew B. Hawkey, Carole Grenier, Zade Holloway, Janequia Evans, Erica Pippen, David L. Corcoran, Edward D. Levin, Susan K. Murphy
Summary: This study provides a comprehensive characterization of the effects of cannabis exposure on the sperm methylome in rats. The results show that paternal preconception exposure to cannabis can lead to detectable changes in offspring DNA methylation, which are functionally related to changes in gene expression and cardiomegaly.
EPIGENETICS & CHROMATIN
(2022)
Article
Obstetrics & Gynecology
Weijian Zhu, Lei Jiang, Yan Li, Junhui Sun, Chunchun Lin, Xuefeng Huang, Wuhua Ni
Summary: This study identified a cluster of comethylated patterns associated with sperm DNA fragmentation (SDF) and found that BRCA1 may be the hub gene involved in sperm DNA damage.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Weijian Zhu, Lei Jiang, Chengshuang Pan, Junhui Sun, Xuefeng Huang, Wuhua Ni
Summary: The study evaluated DNA methylation patterns in sperm from men with differential levels of sperm DNA fragmentation index (DFI). The results showed that high DFI in male sperm was associated with significantly altered methylation in specific CpG fragments corresponding to nine genes. This suggests that sperm DNA damage may influence DNA methylation patterns in human sperm.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Xiaoguo Zheng, Zhenhua Li, Guishuan Wang, Hanshu Wang, Yuchuan Zhou, Xinzhi Zhao, C. Yan Cheng, Yunbo Qiao, Fei Sun
Summary: Research has shown that paternal exposure to long-term psychological stress can impact offspring through epigenetic alterations in sperm, specifically Differential DNA Methylation Regions (DMRs) related to stress response genes. These DMRs are inherited inter- and transgenerationally, passing paternal disorders epigenetically to offspring and evading embryonic reprogramming. Stress-induced dysregulation of sperm small non-coding RNAs may play a role in the occurrence of DMRs and paternal inheritance of disorders.
Article
Biochemistry & Molecular Biology
Gurbet Karahan, Josee Martel, Sophia Rahimi, Mena Farag, Fernando Matias, Amanda J. Macfarlane, Donovan Chan, Jacquetta Trasler
Summary: This study assessed the impact of paternal genetic and lifestyle factors on assisted reproductive technology (ART) outcomes. The findings suggest that paternal factors can potentially aggravate morphological and epigenetic defects in embryos conceived through ART.
HUMAN MOLECULAR GENETICS
(2023)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Article
Biology
Diljeet Gill, Aled Parry, Fatima Santos, Hanneke Okkenhaug, Christopher D. Todd, Irene Hernando-Herraez, Thomas M. Stubbs, Ines Milagre, Wolf Reik
Summary: Ageing is a gradual decline in organismal fitness that is associated with reduced cellular function and altered gene expression. Recent research has shown that the epigenome can be rejuvenated during somatic cell reprogramming, suggesting that full reprogramming may not be necessary to reverse ageing. In this study, the researchers developed a method called maturation phase transient reprogramming (MPTR), which selectively expresses reprogramming factors until a rejuvenation point and then withdraws them. They found that this method rejuvenated multiple cellular attributes, including the transcriptome and epigenome, to a larger extent than previous protocols. Overall, this work demonstrates the possibility of separating rejuvenation from complete pluripotency reprogramming and may facilitate the discovery of anti-ageing genes and therapies.
Article
Biology
Clare J. Venney, Kyle W. Wellband, Eric Normandeau, Carolyne Houle, Dany Garant, Celine Audet, Louis Bernatchez
Summary: This study investigates the effects of parental and offspring temperatures on DNA methylation in brook charr. The results show that parental maturation temperature has a significant impact on offspring methylation, while offspring rearing temperature has a minimal effect. The intergenerational inheritance of DNA methylation could facilitate adaptation to a warming environment.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Fisheries
Yu Cheng, Swapnil Gorakh Waghmare, Songpei Zhang, Pavlina Vechtova, Fabian Schumacher, Burkhard Kleuser, Azin Mohagheghi Samarin, Azadeh Mohagheghi Samarin, Zuzana Linhartova, Abhipsha Dey, Mariola Dietrich, Jan Sterba, Sayyed Mohammad Hadi Alavi, Catherine Labbe, Otomar Linhart
Summary: Short-term storage of sperm affects the motility but not the epigenetics of common carp spermatozoa. The use of an extender for sperm storage is reliable in fertilization and embryo production. Further research is needed to understand the larval growth and performance of these fish.
Article
Environmental Sciences
Na Zhao, Lei Jia, Lu Chen, Jieyan Lin, Zhongdian Dong, Bo Zhang
Summary: Proper DNA methylation in sperm is crucial for the normal development of fertilized embryos. Abnormal sperm DNA methylation is associated with male fertility impairment, offspring quality decline, and disease susceptibility. This study characterized the DNA methylation profiles of pseudomale and male tongue sole sperm and identified differential methylation regions associated with sex. It provides valuable insights into the coordination between different epigenetic mechanisms in sex determination.
FRONTIERS IN MARINE SCIENCE
(2022)
Review
Cell Biology
John Charles Rotondo, Carmen Lanzillotti, Chiara Mazziotta, Mauro Tognon, Fernanda Martini
Summary: Research has shown a correlation between sperm DNA methylation and male infertility, with various genes displaying differential methylation patterns in impaired spermatogenesis and reproductive dysfunction. Specifically, DNA methylation defects in MEST and H19 within imprinted genes, as well as MTHFR within non-imprinted genes, have been linked to male infertility. Further studies are needed to better understand the mechanisms affecting methylation in sperm and its impact on male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Plant Sciences
Taiko Kim To, Yuichiro Nishizawa, Soichi Inagaki, Yoshiaki Tarutani, Sayaka Tominaga, Atsushi Toyoda, Asao Fujiyama, Frederic Berger, Tetsuji Kakutani
Summary: The paper has published a correction notice, see details in the link provided.
