Journal
DEVELOPMENTAL CELL
Volume 34, Issue 3, Pages 310-322Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2015.06.019
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Funding
- Wellcome Trust
- BBSRC [BB/C508050/1]
- MRC [G0500916]
- NIH [R01GM094424-04]
- Finnish Academy grant [WBS 1250271]
- MRC [G0500916] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C508050/1] Funding Source: researchfish
- Cancer Research UK [17064] Funding Source: researchfish
- Medical Research Council [G0500916] Funding Source: researchfish
- The Francis Crick Institute [10176, 10182, 10175, 10436] Funding Source: researchfish
- Wellcome Trust [102853/B/13/Z] Funding Source: researchfish
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How tissues acquire their characteristic shape is a fundamental unresolved question in biology. While genes have been characterized that control local mechanical forces to elongate epithelial tissues, genes controlling global forces in epithelia have yet to be identified. Here, we describe a genetic pathway that shapes appendages in Drosophila by defining the pattern of global tensile forces in the tissue. In the appendages, shape arises from tension generated by cell constriction and localized anchorage of the epithelium to the cuticle via the apical extracellular-matrix protein Dumpy (Dp). Altering Dp expression in the developing wing results in predictable changes in wing shape that can be simulated by a computational model that incorporates only tissue contraction and localized anchorage. Three other wing shape genes, narrow, tapered, and lanceolate, encode components of a pathway that modulates Dp distribution in the wing to refine the global force pattern and thus wing shape.
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