Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor d-1-methyl-tryptophan

Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma

(2016) A. Viardot et al.   BLOOD

Mesenchymal stem cells deliver and release conditionally replicative adenovirus depending on hepatic differentiation to eliminate hepatocellular carcinoma cells specifically

(2016) Xiangfei Yuan et al.   CANCER LETTERS

Indoleamine 2,3-dioxygenase mediates inhibition of virus-specific CD8+ T cell proliferation by human mesenchymal stromal cells

(2016) Jian Hong et al.   CYTOTHERAPY

Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells

(2016) P Shou et al.   ONCOGENE

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

Blinatumomab for the treatment of acute lymphoblastic leukemia

(2015) Jason B. Kaplan et al.   INVESTIGATIONAL NEW DRUGS

Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells

(2015) Dongmei Fan et al.   Journal of Hematology & Oncology

AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells

(2015) Dongmei Fan et al.   Journal of Hematology & Oncology

A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+tumor cells

(2015) Uwe Reusch et al.   mAbs

Suppression of orthotopically implanted hepatocarcinoma in mice by umbilical cord-derived mesenchymal stem cells with sTRAIL gene expression driven by AFP promoter

(2014) Cihui Yan et al.   BIOMATERIALS

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment

(2014) W. Ling et al.   CANCER RESEARCH

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice

(2014) W. Jing et al.   MOLECULAR CANCER THERAPEUTICS

Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications

(2013) Dae-Won Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells

(2013) Andreia Ribeiro et al.   Stem Cell Research & Therapy

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Human Umbilical Cord Mesenchymal Stem Cells as Vehicles of CD20-Specific TRAIL Fusion Protein Delivery: A Double-Target Therapy against Non-Hodgkin’s Lymphoma

(2012) Cihui Yan et al.   MOLECULAR PHARMACEUTICS

How mesenchymal stem cells interact with tissue immune responses

(2012) Yufang Shi et al.   TRENDS IN IMMUNOLOGY

Disulfide-stabilized diabody antiCD19/antiCD3 exceeds its parental antibody in tumor-targeting activity

(2012) Li Wei et al.   CELLULAR ONCOLOGY

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

Single-colour flow cytometric assay to determine NK cell-mediated cytotoxicity and viability against non-adherent human tumor cells

(2011) Ajit Thakur et al.   BIOTECHNOLOGY LETTERS

Immunosuppressive Properties of Mesenchymal Stem Cells

(2011) Mohamed Abumaree et al.   Stem Cell Reviews and Reports

Matrine Induces Cell Anergy in Human Jurkat T Cells through Modulation of Mitogen-Activated Protein Kinases and Nuclear Factor of Activated T-Cells Signaling with Concomitant Up-Regulation of Anergy-Associated Genes Expression

(2010) Ting Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting of XIAP Combined with Systemic Mesenchymal Stem Cell-Mediated Delivery of sTRAIL Ligand Inhibits Metastatic Growth of Pancreatic Carcinoma Cells

(2010) Andrea Mohr et al.   STEM CELLS

Bispecific T-Cell Engaging Antibodies for Cancer Therapy

(2009) P. A. Baeuerle et al.   CANCER RESEARCH

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma

(2008) S. M. Kim et al.   CANCER RESEARCH