SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B

Six3 dosage mediates the pathogenesis of holoprosencephaly

(2016) Xin Geng et al.   DEVELOPMENT

The expression profile and clinic significance of the SIX family in non-small cell lung cancer

(2016) Qian Liu et al.   Journal of Hematology & Oncology

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

(2016) Zeyou Wang et al.   Journal of Hematology & Oncology

Expression profile of SIX family members correlates with clinic-pathological features and prognosis of breast cancer

(2016) Han-Xiao Xu et al.   MEDICINE

Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

(2016) Feimeng Zheng et al.   Nature Communications

The DACH/EYA/SIX gene network and its role in tumor initiation and progression

(2015) Yu Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B

(2015) Si Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2014) R. Stupp et al.   ANNALS OF ONCOLOGY

Aurora-A Inhibition Offers a Novel Therapy Effective against Intracranial Glioblastoma

(2014) J. R. Van Brocklyn et al.   CANCER RESEARCH

Radiotherapy Followed by Aurora Kinase Inhibition Targets Tumor-Propagating Cells in Human Glioblastoma

(2014) N. Li et al.   MOLECULAR CANCER THERAPEUTICS

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

(2014) Sigrid B. Thoresen et al.   NATURE CELL BIOLOGY

The aurora kinases in cell cycle and leukemia

(2014) B Goldenson et al.   ONCOGENE

Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued

(2013) David Reboutier et al.   JOURNAL OF CELL BIOLOGY

Aurora Kinase Inhibition As an Anticancer Strategy

(2013) John F. Hilton et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas

(2013) Jonathan W. Friedberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

(2013) M Marxer et al.   ONCOGENE

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

(2013) A B D'Assoro et al.   ONCOGENE

Down-Regulation of SIX3 is Associated with Clinical Outcome in Lung Adenocarcinoma

(2013) Min-Li Mo et al.   PLoS One

Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly

(2013) W. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling

(2012) Dung-Fang Lee et al.   Cell Stem Cell

Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling

(2012) D. Carlin et al.   DEVELOPMENT

Chromosomal instability and cancer: a complex relationship with therapeutic potential

(2012) Samuel F. Bakhoum et al.   JOURNAL OF CLINICAL INVESTIGATION

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Aurora B kinase phosphorylates and instigates degradation of p53

(2012) C. P. Gully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells

(2011) Minfeng Shu et al.   Molecular Cancer

MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

(2011) Zuping Zhang et al.   Molecular Cancer

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

(2010) J. den Hollander et al.   BLOOD

Metastasis-Associated Protein 1 and Its Short Form Variant Stimulates Wnt1 Transcription through Promoting Its Derepression from Six3 Corepressor

(2010) R. Kumar et al.   CANCER RESEARCH

Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells

(2010) Leroy W. Wheeler et al.   CELL CYCLE

Cell Fate Determination Factor Dachshund Reprograms Breast Cancer Stem Cell Function

(2010) Kongming Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

(2010) A. A. Dar et al.   MOLECULAR CANCER THERAPEUTICS

Clinical Experience with Aurora Kinase Inhibitors: A Review

(2009) D. S. Boss et al.   ONCOLOGIST

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation

(2008) R. D. Coletta et al.   CANCER RESEARCH

p21 and p27: roles in carcinogenesis and drug resistance

(2008) Abde M. Abukhdeir et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein

(2008) Yongsu Jeong et al.   NATURE GENETICS