Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon Chih, Aun Yeong Chong, Vladimir Dzavik, Derek Y. Y. So, Natasha Aleksova, George A. Wells, Jordan Bernick, Christopher B. Overgaard, Ellamae Stadnick, Lisa M. Mielniczuk, Rob S. B. Beanlands, Heather J. Ross
Summary: This study aimed to determine predictors of early coronary artery disease (CAD) after heart transplantation. Heart transplant recipients were evaluated for one year for coronary anatomic-physiologic changes and the related predictors. The study found that fibrotic plaque on optical coherence tomography and index of microcirculatory resistance could predict CAD progression early posttransplant.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Editorial Material
Cardiac & Cardiovascular Systems
Rabea Asleh, Sudhir S. Kushwaha
Summary: Cardiac allograft vasculopathy (CAV) is a leading cause of late mortality after heart transplantation. Despite advancements in therapy, CAV progression remains a devastating complication, highlighting the need for better understanding, early diagnosis, and treatment methods to improve outcomes.
JACC-HEART FAILURE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Roest, Ricardo P. J. Budde, Jasper J. Brugts, Jan von der Thusen, Theo van Walsum, Yannick J. H. J. Taverne, Felix Zijlstra, Daniel Bos, Olivier C. Manintveld
Summary: This study found that the volume of epicardial fat (EFV) is associated with the development of cardiac allograft vasculopathy (CAV) in heart transplant patients, and the recipient sex has a greater influence on EFV than the donor sex.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Madeleine Orban, Sarah Ulrich, Dominic Dischl, Patrick von Samson-Himmelstjerna, Rene Schramm, Katharina Tippmann, Ralph Hein-Rothweiler, Anna Strueven, Anja Lehner, Daniel Braun, Joerg Hausleiter, Andre Jakob, Marcus Fischer, Christian Hagl, Nikolaus Haas, Steffen Massberg, Julinda Mehilli, Dalla Pozza Robert
Summary: This study compared the development of intimal hyperplasia in pediatric and adult heart transplant patients using optical coherence tomography (OCT), showing a higher I/M ratio in children and higher absolute intima thickness in adults. Age and time seem to have an impact on the prevalence of intimal hyperplasia in intracoronary imaging.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Spartalis, Eleftherios Spartalis, Gerasimos Siasos
Summary: Cardiac allograft vasculopathy (CAV) is a significant risk factor for the long-term survival of heart transplant recipients, and its etiology and identification remain challenging. Early diagnosis and prevention are crucial, and advancements in diagnostic techniques have provided prognostic tools and biomarkers, while pharmaceutical advancements have improved the progression of the disease.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sharon Chih, Christiane C. Wiefels, Rob S. B. Beanlands
Summary: Heart transplantation is an effective therapy for end-stage heart disease, but Cardiac allograft vasculopathy (CAV) is a common and life-threatening complication post-transplantation. Cardiac PET shows high diagnostic accuracy for CAV and helps in patient risk stratification.
SEMINARS IN NUCLEAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jung-Min Ahn, Frederik M. Zimmermann, Lars Gullestad, Oskar Angeras, Kristjan Karason, Kristoffer Russell, Ketil Lunde, Kozo Okada, Helen Luikart, Kiran K. Khush, Yasuhiro Honda, Nico H. J. Pijls, Sang Eun Lee, Jae-Joong Kim, Seung-Jung Park, Ole-Geir Solberg, William F. Fearon
Summary: The study validated that the index of microcirculatory resistance (IMR) measured early after heart transplantation is associated with subsequent acute rejection at 1 year and clinical events at 10 years. Patients with higher IMR are more likely to experience rejection and major adverse cardiac events, suggesting that early IMR measurement can identify high-risk patients and guide personalized posttransplantation management.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rabea Asleh, Alexandros Briasoulis, Byron Smith, Camden Lopez, Hilmi Alnsasra, Naveen L. Pereira, Brooks S. Edwards, Alfredo L. Clavell, John M. Stulak, Chaim Locker, Walter K. Kremers, Richard C. Daly, Amir Lerman, Sudhir S. Kushwaha
Summary: Study suggests that early use of aspirin after heart transplantation may delay CAV progression, reduce mortality, and decrease the risk of CAV-related graft dysfunction. However, it does not seem to affect the overall rate of CAV-associated events.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Stefan Roest, Olivier C. Manintveld, Marit A. E. Kolff, Ferdi Akca, Jesse F. Veenis, Alina A. Constantinescu, Jasper J. Brugts, Ozcan Birim, Lennie M. van Osch-Gevers, Tamas Szili-Torok, Kadir Caliskan
Summary: The need for permanent pacemakers after heart transplantation is increasing, and donor age, ischemic time, and pre-transplant amiodarone use are risk factors for early pacemaker implantation. Donor age and cardiac allograft vasculopathy (CAV) are risk factors for late pacemaker implantation. Late pacemaker implantation has a negative impact on survival, possibly indicating underlying progressive cardiac disease.
Article
Medicine, Research & Experimental
Jan Novak, Tana Machackova, Jan Krejci, Julie Bienertova-Vasku, Ondrej Slaby
Summary: Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation is one of the last options for patients with terminal refractory heart failure. The prognosis of patients after heart transplantation is influenced by rejection and allograft vasculopathy, with monitoring requiring invasive and uncomfortable procedures. MiRNAs play a potential role in the pathophysiology of rejection and may be used in clinical practice for diagnosis and prediction of rejection occurrence.
Article
Cardiac & Cardiovascular Systems
Nina Fluschnik, Bastiaan Geelhoed, Peter Moritz Becher, Benedikt Schrage, Fabian J. Brunner, Dorit Knappe, Alexander M. Bernhardt, Stefan Blankenberg, Jon Kobashigawa, Hermann Reichenspurner, Renate B. Schnabel, Christina Magnussen
Summary: This study analyzed data from 40,647 heart transplant recipients and found that male sex, African American and Asian ethnicity, ischemic cardiomyopathy, overweight, and smoking are recipient risk factors associated with CAV, while older age, male sex, smoking, diabetes, and arterial hypertension are donor-related risk factors for CAV. Classical cardiovascular risk factors played a relatively minor role in the 5-year attributable risk for CAV.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Peter J. Kennel, Alexandre Yahi, Yoshifumi Naka, Donna M. Mancini, Charles C. Marboe, Klaas Max, Kemal Akat, Thomas Tuschl, Elena-Rodica M. Vasilescu, Emmanuel Zorn, Nicholas P. Tatonetti, Paul Christian Schulze
Summary: This study utilized next-generation small RNA sequencing to analyze circulating miRNAs as potential biomarkers for detecting and predicting allograft rejection after heart transplantation. It found three specific miRNAs with significantly increased levels in patients with cardiac rejection and identified potential predictors for acute cellular rejection (ACR) and antibody-mediated rejection (AMR), with hsa-miR-486-5p being strongly associated with acute rejection episodes. Monitoring allograft rejection using circulating miRNAs may offer an alternative to invasive endomyocardial biopsy.
Review
Cardiac & Cardiovascular Systems
Juan M. Ortega-Legaspi, Paco E. Bravo
Summary: This review provides an overview of the complex pathophysiology, detection, and treatment of cardiac allograft vasculopathy (CAV) beyond the first year post heart transplantation. Understanding CAV is crucial for improving long-term outcomes in heart transplant patients.
Article
Critical Care Medicine
Henrik Vase, Steffen Christensen, Aage Christiansen, Christian Juhl Therkelsen, Evald Hoj Christiansen, Hans Eiskjaer, Steen Hvidtfeldt Poulsena
Article
Immunology
Laerke Marie Nelson, Arne Kristian Andreassen, Bert Andersson, Einar Gude, Hans Eiskjaer, Goran Radegran, Goran Dellgren, Lars Gullestad, Finn Gustafsson
Article
Cardiac & Cardiovascular Systems
Thomas Gilljam, Kristina H. Haugaa, Henrik K. Jensen, Anneli Svensson, Henning Bundgaard, Jim Hansen, Goran Dellgren, Finn Gustafsson, Hans Eiskjaer, Arne K. Andreassen, Johan Sjogren, Thor Edvardsen, Anders G. Holst, Jesper Hastrup Svendsen, Pyotr G. Platonov
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Adelina Yafasova, Jawad H. Butt, Marie B. Elming, Jens C. Nielsen, Jens Haarbo, Lars Videbaek, Line L. Olesen, Flemming H. Steffensen, Niels E. Bruun, Hans Eiskjaer, Axel Brandes, Anna M. Thogersen, Kenneth Egstrup, Finn Gustafsson, Christian Hassager, Jesper H. Svendsen, Dan E. Hofsten, Christian Torp-Pedersen, Steen Pehrson, Jens J. Thune, Lars Kober
Summary: The Danish study found that ICD implantation did not provide an overall survival benefit in patients with nonischemic systolic heart failure. However, in patients aged 70 and younger, ICD implantation was associated with a lower incidence of all-cause mortality, cardiovascular death, and sudden cardiovascular death.
Article
Cardiac & Cardiovascular Systems
Emil Dariush Lichscheidt, Nichlas Riise Jespersen, Bent Roni Ranghoj Nielsen, Katrine Berg, Jacob Seefeldt, Jens Randel Nyengaard, Hans Erik Botker, Hans Eiskjor
Summary: The study found impaired myocardial mitochondrial respiration in HTx patients with CAV, which is associated with reduced myocardial contractile function and abnormal cristae morphology. These results suggest that mitochondrial targeted treatment should be evaluated in patients with CAV in future clinical studies.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Rikke E. Mols, Istvan Bakos, Bo Christensen, Erzsebet Horvath-Puho, Brian B. Logstrup, Hans Eiskjaer
Summary: This study assessed the impact of multimorbidity and socioeconomic factors on health care service utilization in heart transplant recipients, finding that recipients with multiple chronic conditions utilized services more and socioeconomic status also had an influence on service utilization.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Immunology
Frederik F. Dalsgaard, Niels Moeslund, Zhang L. Zhang, Michael Pedersen, Erisela Qerama, Sandor Beniczky, Pia Ryhammer, Lars B. Ilkjaer, Michiel Erasmus, Hans Eiskjaer
Summary: Clamping the arch vessels during NRP can halt brain function, while reperfusion during NRP can restore brain activity.
Article
Immunology
Niels Moeslund, Zhang Long Zhang, Lars Bo Ilkjaer, Pia Ryhammer, Christine Cramer, Johan Palmfeldt, Michael Pedersen, Michiel Elardus Erasmus, Steven Tsui, Hans Eiskjaer
Summary: This study investigated the effects of high oxygenation (HOX) and low oxygenation (LOX) on donor heart function. The results showed that the HOX group had improved right ventricular function, while the left ventricular function remained stable at baseline levels. Hemodynamic function was similar between the two groups. The LOX group exhibited more myocardial damage and poorer contractile performance.
Article
Engineering, Biomedical
Zhang Long Zhang, Niels Moeslund, Michiel Andy Hu, Roland Hoffmann, Leonie Harmina Venema, Caroline Van De Wauwer, Wim Timens, Toshihiro Okamoto, Erik Alfons Maria Verschuuren, Henri Gerrit Derk Leuvenink, Hans Eiskjaer, Michiel Elardus Erasmus
Summary: Sheep lungs acquired from an abattoir can be perfused ex vivo under similar conditions as lab animal lungs, with similar results in terms of oxygenation and ATP restoration. Furthermore, costs can be significantly reduced by using this abattoir model. By increasing accessibility and lowering costs for lung perfusion experiments, more results can be achieved in the field of lung diseases.
Article
Immunology
Niels Moeslund, Zhang Long Zhang, Frederik Flyvholm Dalsgaard, Sif Bay Glenting, Lars Bo Ilkjaer, Pia Ryhammer, Johan Palmfeldt, Michael Pedersen, Michiel Erasmus, Hans Eiskjaer
Summary: The hemodynamic effects of aortic arch vessel (AAV) clamping during normothermic regional perfusion (NRP) were investigated in a porcine model. The results showed that significantly less norepinephrine (NE) was used in the clamp group compared with the nonclamp group to maintain mean arterial pressure > 60 mm Hg. There were no differences in blood pressure or cardiac function between the two groups. This study suggests that AAV clamping during NRP in donation after circulatory death does not negatively affect cardiac function or inflammation.
Article
Cardiac & Cardiovascular Systems
Niels Moeslund, Imran A. Ertugrul, Michiel A. Hu, Frederik Flyvholm Dalsgaard, Lars Bo Ilkjaer, Pia Ryhammer, Michael Pedersen, Michiel E. Erasmus, Hans Eiskjaer
Summary: In this study, a novel oxygenated hypothermic machine perfusion (HMP) system was compared to static cold storage (SCS) in heart transplantation (HTX). The results showed that hearts preserved with HMP exhibited increased biventricular contractility post-HTX and required less dobutamine for maintaining cardiac output. Additionally, HMP groups had lower levels of myocardial damage. Therefore, DCD HTX can be successfully performed using DPP followed by preservation with HMP.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Jawad H. Butt, Adelina Yafasova, Seiko N. Doi, Jens C. Nielsen, Jens Haarbo, Hans Eiskjaer, Axel Brandes, Anna M. Thogersen, Finn Gustafsson, Christian Hassager, Jesper H. Svendsen, Dan E. Hofsten, Lars Videbaek, Christian Torp-Pedersen, Steen Pehrson, Jens Jakob Thune, Lars Kober
Letter
Cardiac & Cardiovascular Systems
Seiko Nakajima Doi, Jens Jakob Thune, Jens Cosedis Nielsen, Jens Haarbo, Lars Videbaek, Rasmus Rorth, Soren Lund Kristensen, Niels Eske Bruun, Finn Gustafsson, Hans Eiskjaer, Christian Hassager, Jesper Hastrup Svendsen, Dan Eik Hofsten, Christian Torp-Pedersen, Steen Pehrson, Lars Kober, Jawad Haider Butt
CIRCULATION-HEART FAILURE
(2023)
Article
Surgery
Tor Skibsted Clemmensen, Pernille Koefoed-Nielsen, Lis-Ann Jensen, Steen Hvitfeldt Poulsen, Niels Ramsing Holm, Brian Bridal Logstrup, Evald Hoj Christiansen, Jouke Dijkstra, Kamilla Pernille Bjerre Valen, Hans Eiskjaer
CLINICAL TRANSPLANTATION
(2017)