Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Article
Clinical Neurology
Xiaotian Shen, Bixi Gao, Zilan Wang, Yanbo Yang, Zhouqing Chen, Lelin Yu, Zhong Wang
Summary: Aerobic exercise has a positive impact on the recovery of adolescents with mild traumatic brain injury, reducing symptom scores and recovery time, but does not significantly help with neurocognitive function recovery.
WORLD NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Shaun J. Markovic, Melinda Fitzgerald, Jeremiah J. Peiffer, Brendan R. Scott, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Belinda M. Brown
Summary: Older adults are at increased risk of mild traumatic brain injury (mTBI) and slower recovery, with lifestyle factors playing a role in post-mTBI neurocognitive outcomes. Further research is needed to better understand the therapeutic utility of lifestyle-based modifications in improving neurocognitive functioning following mTBI in older adults.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Sport Sciences
Stanley Herring, W. Ben Kibler, Margot Putukian, Gary S. Solomon, Lori Boyajian-O'Neill, Katherine L. Dec, R. Robert Franks, Peter A. Indelicato, Cynthia R. LaBella, John J. Leddy, Jason Matuszak, E. Barry McDonough, Francis O'Connor, Karen Michelle Sutton
Summary: This document is part of a series of annual consensus documents written for practicing team physicians, aiming to provide optimal medical care for athletes with sports-related concussion. It outlines selected medical issues important to team physicians responsible for athletes with SRC and was developed by the Team Physician Consensus Conference (TPCC), an alliance of six major professional associations.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Rehabilitation
Helene Audrit, Miriam H. Beauchamp, Simon Tinawi, Maude Lague-Beauvais, Elaine de Guise
Summary: This article discusses the development of a novel intervention for patients with persistent post-concussive symptoms (PCSs) in the post-acute phase after mild traumatic brain injury (mTBI). The intervention, based on a biopsychosocial approach, targets factors perpetuating PCSs and provides practical tools for managing symptoms. Each session focuses on a specific category of PCS, aiming to reinforce individual objectives and promote a return to activities.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Rehabilitation
Eunkyung Kim, Han Gil Seo, Hyun Haeng Lee, Seung Hak Lee, Seung Hong Choi, Roh-Eul Yoo, Won-Sang Cho, Seo Jung Yun, Min-Gu Kang, Byung-Mo Oh
Summary: The study aimed to investigate changes in regional brain volume after mild traumatic brain injury and their relationship with cognitive deficits. The results showed that individuals with mild traumatic brain injury had reduced brainstem volume and this reduction was significantly associated with cognitive function, especially performance on tests like executive card sorting, forward digit span, and verbal learning.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Sean C. Rose, Deborah A. Levine, Junxin Shi, Krista Wheeler, Taylour Aungst, Rachel M. Stanley, Miriam H. Beauchamp
Summary: This study examined the incidence and healthcare utilization of mild traumatic brain injury (mTBI) in young children presenting to U.S. emergency departments. The findings showed that early childhood mTBI is prevalent and results in a significant financial burden. There is wide variation in diagnostic coding and treatment strategies among emergency departments, highlighting the need for further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Behavioral Sciences
Fanny Degeilh, Tilmann von Soest, Lia Ferschmann, Joanne C. Beer, Malo Gaubert, Inga K. Koerte, Christian K. Tamnes
Summary: Childhood mTBI is associated with an increased risk of developing social problems, possibly due to changes in the structural development of the social brain. This study used data from the ABCD Study to examine the development of social problems and cortical thickness in social brain regions following childhood mTBI. The findings showed different developmental trajectories in social problems between children with and without mTBI, with the mTBI group showing higher levels of social problems. Both groups showed similar decreases in social brain cortical thickness.
Review
Psychiatry
Kathryn A. Ritchie, Beth S. Slomine
Summary: Mild traumatic brain injury (mTBI) is a significant public health concern for children. While most children recover within 1 month after mTBI, 10-30% experience lingering neuropsychiatric or neuropsychological symptoms. Factors associated with prolonged recovery include preinjury mental health concerns, female sex, and family characteristics. Early management includes reassurance and brief rest, while specialized evaluation and multimodal therapies are recommended for symptoms lasting more than 4 weeks.
CURRENT OPINION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Yulan Zhang, Zhihai Huang, Honglin Xia, Jing Xiong, Xu Ma, Chengyi Liu
Summary: Traumatic brain injury (TBI) is a significant public health issue worldwide, and while guidelines typically recommend rest post-TBI, recent evidence suggests that exercise may enhance functional outcomes. Exercise has shown promise in improving cognitive recovery, mood disorders, and post-concussion syndrome in TBI patients, though challenges remain in clinical application and understanding the underlying mechanisms of exercise's benefits.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Sport Sciences
Camille Larson-Dupuis, Edith Leveille, Martine Desjardins, Marianne Jodoin, Marie-Eve Bourassa, Helene Bergeron, Christelle Beaulieu, Julie Carrier, Veronique Pepin, Louis De Beaumont
Summary: This study examined the long-term cognitive effects of a single mild traumatic brain injury (mTBI) on late adulthood patients and evaluated the cognitive effects of an aerobic exercise program for these patients. Results showed significant improvements in fitness for the participants in the aerobic group, but no significant between-group differences in neuropsychological measures postintervention. Future directions in optimizing mTBI intervention were discussed based on the findings.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2021)