Article
Rehabilitation
Noah D. Silverberg, Grant L. Iverson, Alison Cogan, Kristen Dams-O-Connor, Richard Delmonico, Min Jeong P. Graf, Mary Alexis Iaccarino, Maria Kajankova, Joshua Kamins, Karen L. McCulloch, Gary McKinney, Drew Nagele, William J. Panenka, Amanda R. Rabinowitz, Nick Reed, Jennifer Wethe, Victoria Whitehair, Vicki Anderson, David B. Arciniegas, Mark T. Bayley, Jeffery J. Bazarian, Kathleen R. Bell, Steven P. Broglio, David Cifu, Gavin A. Davis, Jiri Dvorak, Ruben J. Echemendia, Gerard A. Gioia, Christopher C. Giza, Sidney R. Hinds II, Douglas I. Katz, Brad G. Kurowski, John J. Leddy, Natalie Le Sage, Angela Lumba-Brown, Andrew I. R. Maas, Geoffrey T. Manley, Michael McCrea, David K. Menon, Jennie Ponsford, Margot Putukian, Stacy J. Suskauer, Joukje van der Naalt, William C. Walker, Keith Owen Yeates, Ross Zafonte, Nathan D. Zasler, Roger Zemek
Summary: This study aims to develop new diagnostic criteria for mild traumatic brain injury (TBI) that are appropriate for use across the lifespan and in sports, civilian trauma, and military settings. Through a rapid evidence review and Delphi method, a 90.7% agreement on the diagnostic criteria was reached, which will improve the quality and consistency of mild TBI research and clinical care.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: Studies on the long-term symptoms and disability after mild traumatic brain injury (mTBI) have produced mixed results. This systematic review and meta-analysis aimed to determine the prevalence of self-reported post-concussion symptoms (PCS) and disability following mTBI. The findings suggest that approximately one in three adults with mTBI experience at least mild severity PCS 3-6 months after the injury, but controlling for attrition bias, the true prevalence may be one in six. Well-designed studies with representative samples and high retention rates are needed to further investigate this issue.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: This systematic review and meta-analysis found that nearly one in three adults with mild traumatic brain injury experience mild severity post-concussion symptoms 3-6 months later. However, controlling for attrition bias, the true prevalence may be one in six. This highlights the need for studies with representative samples and high retention rates.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Neurosciences
Molly Cairncross, Hiresh Gindwani, Anna Rita Egbert, Ivan J. Torres, James S. Hutchison, Kristen Dams O'Connor, William J. Panenka, Jeffrey R. Brubacher, Louise Meddings, Lexynn Kwan, Keith O. Yeates, Robin Green, Noah D. Silverberg
Summary: This study evaluated the effectiveness of using the Brief Test of Adult Cognition by Telephone (BTACT) to distinguish between adults with mild traumatic brain injury (mTBI) and trauma controls without head or neck injuries. The results showed that the BTACT had poor accuracy in differentiating between the two groups and did not significantly differ in terms of overall scores. Therefore, the BTACT may lack sensitivity to subacute cognitive impairment caused by mTBI.
Article
Medicine, General & Internal
Benedikte a. Madsen, Silje C. R. Fure, Nada Andelic, Daniel Loke, Marianne Lovstad, Cecilie Roe, Emilie Isager Howe
Summary: Approximately 30% of individuals with mild traumatic brain injury (mTBI) experience persistent post-concussion symptoms (PPCS). Personality traits such as neuroticism, openness to experience, and conscientiousness are associated with more severe PPCS and lower return to work (RTW) in patients with mild-to-moderate TBI. However, after controlling for PPCS, personality traits are no longer significantly associated with RTW.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Todd J. Schwedt
Summary: Post-traumatic headache is a common and persistent symptom following mild traumatic brain injury, with onset typically within 7 days post-injury. Pathophysiological mechanisms of post-traumatic headache involve structural, functional, metabolic, and neuroinflammatory factors. Effective therapy options are currently lacking, with future research priorities including optimizing diagnostic criteria and understanding pathophysiology.
Article
Medicine, General & Internal
Etienne Gaudette, Seth A. Seabury, Nancy Temkin, Jason Barber, Anthony M. DiGiorgio, Amy J. Markowitz, Geoffrey T. Manley
Summary: This study assessed the employment and economic outcomes for working-age adults with mild traumatic brain injury (mTBI) in the 12 months after injury. It also explored the association between returning to work and employer assistance.
Article
Critical Care Medicine
Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Antti Korvenoja, Kaisa Maki, Taina Nybo, Rahul Raj, Susanna Melkas
Summary: This prospective cohort study found that patients with traumatic microbleeds (TMBs) in mild traumatic brain injury (mTBI) did not experience more post-concussion symptoms or worse overall recovery compared to patients without TMBs. TMBs do not seem to be a significant prognostic factor of return to work (RTW) in mTBI patients.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Antti Korvenoja, Kaisa Maki, Taina Nybo, Rahul Raj, Susanna Melkas
Summary: The study investigated the association between traumatic intracranial lesions detected by CT and MRI and return to work (RTW) as well as post-concussion symptoms in patients with complicated mild traumatic brain injury (MTBI). The results suggest that positive primary CT and multiple types of lesions in MRI were most clearly associated with delayed RTW.
ACTA NEUROCHIRURGICA
(2022)
Article
Medicine, General & Internal
Valeska Hofmann, Christian Deininger, Stefan Doebele, Christian Konrads, Florian Wichlas
Summary: The number of fall-related hospitalizations among older adults has been on the rise in recent decades. One common reason for this is mild traumatic brain injury (mTBI) in older individuals taking anticoagulant medication. Research found that geriatric patients under anticoagulant medication do not necessarily require a second cCT scan if the initial scan shows no signs of intracranial bleeding and the patient is asymptomatic.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Debbie Y. Madhok, Robert M. Rodriguez, Jason Barber, Nancy R. Temkin, Amy J. Markowitz, Natalie Kreitzer, Geoffrey T. Manley
Summary: This study found that most patients with mild TBI, with a GCS score of 15 and a negative head CT scan, did not fully recover at 2 weeks and 6 months after the injury. Emergency department clinicians should recommend 2-week follow-up visits to identify patients with incomplete recovery and facilitate rehabilitation.
Article
Clinical Neurology
Amaal J. Starling, Melissa M. Cortez, Nicholas R. Jarvis, Nan Zhang, Frank Porreca, Catherine D. Chong, Todd J. Schwedt
Summary: This study characterized cutaneous heat and light-induced pain thresholds in people with post-traumatic headache (PTH) compared with healthy controls (HCs). The results showed that participants with PTH had higher photophobia symptom severity score and lower light-induced pain thresholds. Exposure to a bright light stressor reduced heat pain thresholds in participants with PTH immediately post stressor, but not in HCs. The study provides evidence for multimodal sensory dysfunction in people with PTH.
Article
Clinical Neurology
William C. Walker, Sarah W. Clark, Kaleb Eppich, Elisabeth A. Wilde, Aaron M. Martin, Chelsea M. Allen, Melissa M. Cortez, Mary Jo Pugh, Samuel R. Walton, Kimbra Kenney
Summary: This study analyzed the relationship between lifetime history of mild traumatic brain injury (mTBI) and other factors with headache prevalence and impact among combat-exposed current and former service members. The results showed that regardless of the remoteness of mTBI, participants with positive mTBI history had higher headache prevalence and impact. Blast-related mTBI posed the highest risk and was uniquely associated with elevated headache burden. Other demographic and potentially modifiable risk factors were also identified.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Christina Devoto, Rany Vorn, Sara Mithani, Timothy B. Meier, Chen Lai, Steven P. Broglio, Thomas Mcallister, Christopher C. Giza, Daniel Huber, Jaroslaw Harezlak, Kenneth L. Cameron, Gerald Mcginty, Jonathan Jackson, Kevin Guskiewicz, Jason P. Mihalik, Alison Brooks, Stefan Duma, Steven Rowson, Lindsay D. Nelson, Paul Pasquina, Christine Turtzo, Lawrence Latour, Michael A. Mccrea, Jessica M. Gill, CARE Consortium Investigators
Summary: This study aimed to investigate plasma phosphorylated tau (p-tau181) protein in mild traumatic brain injury (mTBI) patients and concussed athletes. The study found that plasma p-tau181 concentrations were significantly elevated within 48 hours of injury in both groups, with the highest levels observed in patients with neuroimaging evidence of injury. These findings suggest that plasma p-tau181 concentrations may be related to brain injury and could potentially serve as an early diagnostic biomarker for mTBI/concussions.
FRONTIERS IN NEUROLOGY
(2023)
