Article
Biodiversity Conservation
Wenyan He, Lihua You, Min Chen, Youcai Tuo, Ning Liao, Hongwei Wang, Jia Li
Summary: Water hypoxia in lakes and reservoirs is increasing globally due to global warming. The interpretation of the Mn/Fe ratio for reconstructing historical redox conditions may be problematic because factors other than redox processes can affect the accumulation of Fe and Mn. In this study, the Fe and Mn contents and bacterial diversity in the sediment of a monomictic reservoir were examined to determine the deposition time frame and sedimentary rate. It was found that the Mn/Fe ratio alone is not sufficient for interpreting the historic oxygenation regimes of reservoirs, and factors such as runoff sediment input, hydrodynamic characteristics, and bacterial distributions should be considered.
ECOLOGICAL INDICATORS
(2023)
Article
Engineering, Civil
Guillaume Lorette, David Viennet, David Labat, Nicolas Massei, Matthieu Fournier, Mathieu Sebilo, Pierre Crancon
Summary: This study aims to understand the hydrodynamical and geochemical variations at the outflow of karst systems, using a multi-proxy approach to trace water origins, evaluate mixing phenomena, and consider contributions from both autogenic and allogenic recharge sources. The research conducted in the Ouysse karst system in western France showcases how water-mixing processes in binary karst systems can be studied and analyzed using global water chemistry, hydrograph and chemograph analysis, and source-mixing calculation during a flood event. The information obtained can be valuable for forecasting and management actions related to water resource management.
JOURNAL OF HYDROLOGY
(2021)
Article
Geosciences, Multidisciplinary
Jing Liu, Qingze Chen, Yixuan Yang, Hongyan Wei, Minwang Laipan, Runliang Zhu, Hongping He, Michael F. Hochella
Summary: The chemistry of Fe and Mn in natural geochemical systems are closely coupled, and the coupled redox reactions between Fe and Mn play important roles in environmental system dynamics. The crystallization and transformation of FeOx and MnOx are bilaterally affected by the coupled redox between Fe and Mn. The coupled redox cycling of Fe and Mn exerts more complex and significant influences on biogeochemical processes compared to individual Fe or Mn.
EARTH-SCIENCE REVIEWS
(2022)
Article
Geosciences, Multidisciplinary
Helga Madrigal-Solis, Pablo Jimenez-Gavilan, Inaki Vadillo-Perez, Alicia Fonseca-Sanchez, Hazel Calderon-Sanchez, Luis Quesada-Hernandez, Alicia Gomez-Cruz
Summary: The volcanic Barva and Colima multiaquifer system plays a crucial role in the drinking water supply for approximately 30% of the population in Costa Rica. This research aimed to develop a model to distinguish groundwaters based on the primary aquifer and flow path, evaluate interaquifer connections, and assess the hydrochemical processes governing water quality. The study found resilience to seasonal chemical variation in deeper aquifers, identified groundwater mixing processes, and highlighted weathering as the primary process affecting groundwater quality.
HYDROGEOLOGY JOURNAL
(2022)
Article
Geochemistry & Geophysics
Zhiming Xu, Chengquan Wu, Zhengwei Zhang, Jinhong Xu, Xiyao Li, Ziru Jin
Summary: Large-scale manganese carbonate deposits were formed in South China during the interglacial of the Sturtian and Marinoan periods, hosted in the black rock series at the basal Datangpo Formation of the Cryogenian period. The Fe content in ores ranges from 1.15 to 7.18 wt.%, with an average of 2.80 wt.%, and the Mn/Fe ratio is 8.9, indicating complete separation of Mn and Fe during the formation of manganese ores.
Article
Environmental Sciences
Meng Zhao, Yonghai Jiang, Yongfeng Jia, Xinying Lian, Fan Feng, Changjian Shang, Yongge Zang, Beidou Xi
Summary: High geogenic Mn groundwater is harmful to human health, especially children's IQ. The release of Mn from aquifer sediments is the primary cause, but the role of anthropogenic activities is unclear. A study on a historical petrochemical waste storage site revealed elevated Mn and other pollutants in the groundwater, caused by in-situ generation and anthropogenic pollution. The mobilization of Mn was mainly attributed to the reductive dissolution of Mn oxides. This study highlights the secondary geogenic pollution risk in groundwater due to anthropogenic perturbation and the importance of studying the enhanced release of Mn.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Daniel Abiriga, Live S. Vestgarden, Harald Klempe
Summary: The study analyzed redox conditions in groundwater contaminated by leachate from Revdalen Landfill over a 24-year period, finding elevated levels of certain parameters exceeding Norwegian drinking water norms while others showed strong attenuation along the groundwater flow path. Oxygen, nitrate, and sulphate increased farther out in the plume, and the redox conditions shifted as the landfill ecosystem transitioned from reducing to aerobic conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Gustavo Covatti, Thi Ngoc Anh Hoang, Thomas Grischek
Summary: Geogenic arsenic contamination of groundwater, especially in Asia, poses a health threat to millions of people worldwide. A study conducted in Hanoi, Vietnam, analyzed the water quality of Riverbank filtration (RBF) wells and riverbed sediment, revealing high concentrations of arsenic in both. The presence of muddy riverbeds was found to significantly contribute to the release of arsenic, suggesting the importance of river mud deposition and morphology on arsenic contamination in aquifers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Paula Cristina Neuburger de Oliveira, Gustavo Barbosa Athayde, Otavio Augusto Boni Licht, Didier Gastmans, Bianca do Amaral, Diego Alberto Tavares, Lucas Henrique Garcia, Camila de Vasconcelos Mueller Athayde
Summary: This research evaluates the hydrochemistry of a fractured volcanic aquifer at Paraná 3 Basin in southern Brazil. The study describes the distinctive characteristics of the geological units and analyzes the hydrogeochemical processes. The research also focuses on the flow depth contribution and the anthropic influences on groundwater chemistry.
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2023)
Article
Environmental Sciences
Mukseet Mahmood, Shunsuke Taki, Satoshi Nakai, Takehiko Gotoh, Wataru Nishijima, Akira Umehara, Tomo Aoyagi, Yuya Sato, Tomoyuki Hori, Yoko Katayama, Reka Hajdu-Rahkama, Jaakko A. Puhakka
Summary: In the Seto Inland Sea, Japan, chemical oxygen demand has increased while dissolved oxygen concentrations in bottom water have also increased. This study found that changes in redox conditions led to an increase in organic carbon in sediment, with sulfur-oxidizing bacteria potentially playing a role. Experiments showed that autotrophic bacteria stimulation, especially sulfur-oxidizing bacteria, increased sedimentary organic carbon and dissolved organic carbon in overlying water.
MARINE POLLUTION BULLETIN
(2021)
Article
Materials Science, Multidisciplinary
Junlie Yao, Zihou Li, Zhouhua Li, Xiaoxia Wu, Chunshu Pan, Jie Xing, Aoran Zhang, Bo Jiang, Fang Yang, Aiguo Wu
Summary: A novel ultrasmall iron-manganese nanomedicine was designed to disrupt the metabolic and redox homeostasis of breast cancer and bone metastases sites by using ATP, hydrogen peroxide, and NADPH reactivities. Additionally, this nanomedicine provided dual-mode T1/T2 magnetic resonance imaging for tumor detection.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Duo Xiang, Changdong Gu, Haoran Xu, Gang Xiao
Summary: Research successfully synthesized bixbyite-type (Mn0.8Fe0.2)(2)O-3 and extruded it into honeycomb units, which maintained 85% of initial capacity after 100 redox cycles. A self-assembled core-shell MnFe2O4@Mn2.7Fe0.3O4 structure was found during the reduction step, transforming into a homogeneous solid solution of (Mn0.8Fe0.2)(2)O-3 during oxidation step. Through density functional theory calculations, it was revealed that the lower formation energy of oxygen vacancies in the shell contributes to the improvement of oxygen diffusion rate.
Article
Chemistry, Multidisciplinary
Cherie L. DeVore, Lucia Rodriguez-Freire, Noelani Villa, Maedeh Soleimanifar, Jorge Gonzalez-Estrella, Abdul Mehdi S. Ali, Juan Lezama-Pacheco, Carlyle Ducheneaux, Jose M. Cerrato
Summary: We conducted an integrated study combining aqueous chemistry, spectroscopy, and microbiology techniques to investigate the release of arsenic, iron, and manganese from contaminated sediments under different aerobic and anaerobic conditions. Our results showed that the highest concentrations of these metals were released under anaerobic conditions with the addition of an exogenous electron donor. XANES analyses confirmed the reduction of arsenic under anaerobic conditions. Additionally, the release of these metals after a reaction with phosphate was significantly lower compared to experiments amended with glucose.
ACS EARTH AND SPACE CHEMISTRY
(2022)
Article
Materials Science, Ceramics
S. Rossano, V. Khomenko, A. Bedidi, C. Muller, C. Loisel, J. Ferrand, L. Sarrasin, A. Bertin
Summary: Manganese, used as a colourizer in the glass industry, has been studied in its role as a decolourizer in medieval-like glasses. The addition of manganese affects the concentration of Fe(2+) and Fe3+ in the glass composition, leading to uncoloured glasses at certain melting temperatures.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Engineering, Environmental
Feng Pan, Yu Cai, Zhanrong Guo, Yuyao Fu, Xindi Wu, Huatai Liu, Xinhong Wang
Summary: Estuarine sediments play a crucial role in the transport and mobility of molybdenum (Mo) from rivers to the ocean. The geochemistry of manganese (Mn) in estuarine sediments is key in the mobility of dissolved Mo, with oxic intertidal sediments acting as Mo sinks and anoxic subtidal sediments functioning as Mo sources. Redox conditions and physicochemical processes are important factors controlling Mo mobility in estuarine sediments.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Oncology
Veronica Davalos, Manel Esteller
Summary: Cancer development is caused by changes in the structure and function of the genome. Epigenetic alterations regulate gene expression programs that promote tumorigenesis and can be used as useful tools in clinical decision making. Unlike genetic changes, epigenetic modifications can be reversed, making them an attractive target for drug development.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Oncology
Iris van der Strate, Fatemeh Kazemzadeh, Iris D. Nagtegaal, Debbie Robbrecht, Agnes van de Wouw, Catarina S. Padilla, Saskia Duijts, Manel Esteller, F. Anthony Greco, Nicholas Pavlidis, Amir Qaseem, Petur Snaebjornsson, Sophie Veldhuijzen van Zanten, Caroline Loef
Summary: The study proposes a multi-layer classification for the diagnostic workup of CUP using the Delphi method. The recommended initial diagnostic includes history and physical examination, full blood count, serum marker analysis, biopsy of accessible lesion, CT scan, and immunohistochemical testing. Consensus was also reached on the need for an ideal diagnostic lead time for CUP patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paolo Petazzi, Olga Caridad Jorge-Torres, Antonio Gomez, Iolanda Scognamiglio, Jordi Serra-Musach, Angelika Merkel, Daniela Grases, Clara Xiol, Mar O'Callaghan, Judith Armstrong, Manel Esteller, Sonia Guil
Summary: Rett syndrome is a severe neurodevelopmental disease caused by mutations in the MeCP2 gene, which affects synaptic plasticity and neuronal activity. The MeCP2 protein is critical for the proper expression of immediate-early genes (IEGs) involved in activity-dependent responses, and abnormal expression of IEGs is found in MeCP2-deficient neurons and in RTT patients. These findings highlight the importance of IEGs in synaptic development and the regulatory role of MeCP2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jiajin Chen, Yunjie Song, Yi Li, Yongyue Wei, Sipeng Shen, Yang Zhao, Dongfang You, Li Su, Maria Moksnes Bjaanaes, Anna Karlsson, Maria Planck, Johan Staaf, Aslaug Helland, Manel Esteller, Hongbing Shen, David C. C. Christiani, Ruyang Zhang, Feng Chen
Summary: This study identified significant gene-gene interactions associated with non-small-cell lung cancer survival through a three-step analytic strategy. Two interactions were found at both the epigenetic and transcriptional levels, providing potential clues for precision treatment of NSCLC.
MOLECULAR ONCOLOGY
(2023)
Review
Genetics & Heredity
Ines Orsolic, Arnaud Carrier, Manel Esteller
Summary: Cancer was once believed to be solely genetic, but now it is known that dysregulated genetic and epigenetic mechanisms work together in cancer development. Recently, the epitranscriptome, which refers to chemical modifications of RNA molecules, has been found to play a role in regulating RNA function. Specific enzymes responsible for these modifications, known as RMPs, are being investigated for their potential as therapeutic targets or diagnostic markers in cancer. The study of epitranscriptomics has revealed the critical role of RNA modifications in cellular pathways and their potential importance in cancer treatment.
TRENDS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
David Ortega-Alarcon, Rafael Claveria-Gimeno, Sonia Vega, Olga C. Jorge-Torres, Manel Esteller, Olga Abian, Adrian Velazquez-Campoy
Summary: Hydroxymethylated cytosine (5hmC) is a stable DNA epigenetic mark that interacts with MeCP2 in a distinct mode with a specific thermodynamic signature. Mutations associated with Rett syndrome alter the interaction between MeCP2 and dsDNA in a cytosine modification-specific manner, which may be correlated with disease onset time and clinical severity score.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Miriam Gene, Miriam Cuatrecasas, Irene Amat, Jesus Alberto Veiga, Maria Jesus Fernandez Acenero, Victoria Fuste Chimisana, Jordi Tarragona, Ismael Jurado, Rebeca Fernandez-Victoria, Carolina Martinez Ciarpaglini, Cristina Alenda Gonzalez, Carlos Zac, Pilar Ortega de la Obra, Maria Teresa Fernandez-Figueras, Manel Esteller, Eva Musulen
Summary: Colitis-associated colorectal carcinoma (CAC) in inflammatory bowel disease (IBD) is caused by p53 alterations and follows a chronic inflammation-dysplasia-cancer carcinogenesis pathway. Gastric metaplasia (GM) is described as the initial event of serrated colorectal cancer (CRC) in the colon mucosa under chronic stress. This study analyzed p53 alterations and microsatellite instability (MSI) to characterize CAC and investigate its relationship with GM. Results showed that p53 mutation pattern was present in more than half of the CAC cases, with stable (MSS) tumors being the most common and MUC5AC negative. Only six unstable (MSI-H) tumors had wild-type p53 pattern (p=0.010) and were MUC5AC positive (p=0.005). MUC5AC staining was more frequently observed in intestinal mucosa with inflammation or chronic changes than in CAC, particularly in those with wild-type p53 pattern and MSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jose Alfredo Flores Ronces, Edith R. Salcedo Sanchez, Manuel Martinez Morales, Juan Manuel Esquivel Martinez, Oscar Talavera Mendoza, Maria Vicenta Esteller Alberich
Summary: The Taxco mining district in Mexico is internationally known for its production of silver, jewelry, and precious metal handicrafts. Improper disposal of waste from human activities has been causing contamination of the springwater, which is used for drinking and domestic purposes by the residents, thus posing a health threat. A study was conducted using a multi-tracer approach to analyze the springwater samples, including hydrochemical data, trace elements, and isotopes d(2)H, d(18)O, H-3, and Sr-87/Sr-86 ratios. The results showed the origin and age of the springwater, as well as the water-rock interactions and flow paths, highlighting the potential of using Sr-87/Sr-86 ratios as a fingerprint for further studies.
Editorial Material
Oncology
Maxime Janin, Manel Esteller
Summary: Mutations in splicing factors are commonly found in CLL, but other mechanisms such as METTL3 overexpression can also lead to abnormal splicing. METTL3 deposits epitranscriptomic marks in spliceosome transcripts, causing aberrant splicing, but also vulnerability to METTL3 inhibitors.
BLOOD CANCER DISCOVERY
(2023)
Letter
Oncology
Carlos A. Garcia-Prieto, Veronica Davalos, Manel Esteller
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Lucia Salz, Alexander Seitz, Daniel Schaefer, Julia Franzen, Tatjana Holzer, Carlos A. Garcia-Prieto, Iris Buerger, Olaf Hardt, Manel Esteller, Wolfgang Wagner
Summary: CAR T cell expansion during culture leads to DNA hypermethylation, which downregulates the expression of genes relevant to T cell function. This hypermethylation signature can predict cell culture time and is associated with reduced long-term survival and therapeutic outcome in CAR T cell products.
Article
Environmental Sciences
Julio Cesar Garcia-Colin, Carlos Diaz-Delgado, Humberto Salinas Tapia, Carlos Roberto Fonseca Ortiz, Maria Vicenta Esteller Alberich, Khalidou M. Ba, Daury Garcia Pulido
Summary: This work proposes the use of green infrastructure to manage percolated water in urban agricultural areas. Hydro-informatics tools are developed to estimate the water requirement for crops and the capacity for water reuse. The results confirm the applicability of these methods and show the potential for collecting water and preventing pollution.
Article
Geochemistry & Geophysics
Heriberto Morales-deAvila, Melida Gutierrez, Claudia Patricia Colmenero-Chacon, Hugo Enrique Junez-Ferreira, Maria Vicenta Esteller-Alberich
Summary: Central Mexico is known for high concentrations of arsenic and fluoride in groundwater, but concentrations vary within the region. The study divided the area into four sections based on lithology and climate, and found that these factors significantly affect the groundwater quality.
Article
Water Resources
Claudia Patricia Colmenero-Chacon, Heriberto Morales-deAvila, Melida Gutierrez, Maria Vicenta Esteller-Alberich, Maria Teresa Alarcon-Herrera
Summary: Groundwater salinization poses a significant threat to water supply in coastal and arid areas, including Central Mexico. Human activities, dissolution of rocks, and evaporation are major contributors to groundwater salinity. Temporal trends were observed in only a few wells, primarily in nitrate concentrations.
Article
Biochemistry & Molecular Biology
Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausio
Summary: This study used a neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out to investigate the changes in linker histones during neural cell differentiation. The results showed that MeCP2 played a crucial role in dendrite and axon development and exhibited extensive co-localization with linker histones. Additionally, the size of the nucleus decreased during differentiation, but the MeCP2 knock out cells showed a significant increase in nucleus size after differentiation.
Article
Geochemistry & Geophysics
Om Prakash Kumar, Amiya S. Naik, P. Gopinathan, T. Subramani, Vishvajeet Singh, Prakash K. Singh, Uma K. Shukla, Arun Prabhu
Summary: This study characterizes lignite samples from Kapurdi, Giral, and Sonari mines in Rajasthan's Barmer Basin using petrographic and geochemical techniques. The results provide insights into the geochemical properties, hydrocarbon potential, depositional environment, and paleo-climatic conditions of these lignite deposits. The study finds high volatile matter and sulfur concentrations in the Barmer lignite deposits, as well as indications of a wet environment during organic material decomposition. The findings have implications for understanding the coalification profile and hydrocarbon source rock potential in the region.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2024)
Review
Geochemistry & Geophysics
Ashkan Jahandari, Behnam Abbasnejad
Summary: The assessment of heavy metal concentrations in agricultural soil is important for crop safety and quality, as well as potential risks to human health. This review analyzed published data on seven heavy metals in Iranian farmland soils and found that nickel and cadmium exceeded permissible levels. Arsenic showed significant contamination in multiple provinces, while lead and cadmium were highly contaminated in Fars province. Overall, the contamination levels of heavy metals in Iranian agricultural soils were relatively low.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2024)
Article
Geochemistry & Geophysics
Imran Ud Din, Said Muhammad, Shah Faisal, Inayat ur Rehman, Wajid Ali
Summary: The presence of heavy metal contamination in coal mines and surrounding environments in the Hangu and Kurram districts poses potential risks to the environment and human health.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2024)
Article
Geochemistry & Geophysics
Douglas Almeida Silveira, Paola Ferreira Barbosa, Cassiano Costa e Castro, Guilherme Ferreira da Silva, Joseneusa Brilhante Rodrigues
Summary: This study analyzed apatite grains from the Angico dos Dias Carbonatite Complex region in Brazil using an electron probe microanalyzer. The results showed that the apatite grains had characteristics of metacarbonatitic lithotypes and some had undergone substitution processes. Statistical analysis helped identify the sources of the apatite grains and confirmed the presence of carbonatitic bodies in the area.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2024)
