Article
Medicine, General & Internal
Francesca De Vito, Evelina Suraci, Raffaella Marasco, Francesco Luzza, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino
Summary: Increased levels of duodenal GLUT-5 are associated with NAFLD and liver fibrosis. Inhibition of intestinal GLUT-5-mediated fructose uptake may be a strategy for preventing and treating NAFLD.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Arturo Jimenez-Chavez, Russell Morales-Rubio, Eliu Sanchez-Gasca, Monica Rivera-Rosas, Marisela Uribe-Ramirez, Omar Amador-Munoz, Y. Margarita Martinez-Dominguez, Irma Rosas-Perez, Elizabeth H. Choy, David A. Herman, Michael T. Kleinman, Andrea De Vizcaya-Ruiz
Summary: Insulin resistance and metabolic disorders can be induced by exposure to fine particulate matter (PM2.5) and high fructose sweeteners and fat rich diets. In this study, concomitant exposure to PM2.5 and a fructose rich diet led to leptin release, systemic hyperinsulinemia, Insulin/AKT dysregulation, histological damage, and increased HOMA-IR. These findings suggest that the combination of ubiquitous environmental pollutant PM2.5 and metabolic disease risk factor FRD can contribute to the global pandemic of metabolic disorders.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Elena Fauste, Maria Panadero, Cristina Donis, Paola Otero, Carlos Bocos
Summary: Research indicates that maternal fructose intake can have negative effects on pregnancy outcomes in offspring, including increased fat accumulation and decreased insulin sensitivity. Fructose intake also impacts fetal lipid metabolism and hormone levels.
Article
Food Science & Technology
Rebeca Berdun, Mariona Jove, Joaquim Sol, Weijing Cai, John C. He, Reyna Rodriguez-Mortera, Meritxell Martin-Gari, Reinald Pamplona, Jaime Uribarri, Manuel Portero-Otin
Summary: This study found that a low-AGE diet significantly alters circulating metabolomes and lipidomes, including sphingolipid, ether-lipid, and glycerophospholipid metabolism. This dietary approach can reproduce some plasma characteristics of healthy aging.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Plant Sciences
Prarambh S. R. Dwivedi, V. P. Rasal, Rajashekar S. Chavan, Pukar Khanal, Vishakha Parab Gaonkar
Summary: The fruit pulp of Feronia elephantum can reverse insulin resistance by increasing glucose uptake and decreasing gluconeogenesis, potentially through the regulation of multiple proteins via multiple bioactives.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Chemical
Yunjie Liao, Nathan A. Davies, I. David L. Bogle
Summary: This study investigates the impact of fructose on the liver system and validates the findings through in vivo experiments. The results suggest that targeting three intervention points simultaneously can effectively reduce lipid production under insulin resistance conditions. This demonstrates the potential of system models in understanding the liver system's response to fructose variation and identifying potential drug targets.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Nutrition & Dietetics
Arianna Mazzoli, Cristina Gatto, Raffaella Crescenzo, Luisa Cigliano, Susanna Iossa
Summary: The study found that unhealthy diets during adolescence can lead to prolonged dysregulation of liver metabolic activity, persisting even after dietary improvements have been made.
Article
Pharmacology & Pharmacy
Juanjuan Cheng, Lieqiang Xu, Qiuxia Yu, Guoshu Lin, Xingdong Ma, Mengyao Li, Fengkun Guan, Yuhong Liu, Xiaoqi Huang, Jianhui Xie, Jiannan Chen, Ziren Su, Yucui Li
Summary: This study found that metformin has significant pharmacological effects on fructose-induced insulin resistance, improving insulin resistance features and reducing pancreatic damage. In addition, metformin can suppress the inflammatory response and enhance antioxidant capacity. The activation of AMPK by metformin is proposed to occur through regulating the expression of AMPD1 and ADSS to increase AMP levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Juanjuan Cheng, Xingdong Ma, Guangtao Yan, Qiuxia Yu, Zhen Huang, Guoshu Lin, Mengyao Li, Fengkun Guan, Ziren Su, Fang Yan, Yuhong Liu, Qingfeng Xie
Summary: This study aimed to examine the protective effect of berberine against fructose-induced insulin resistance in rats and L6 cells and its potential activation mechanism on AMPK. The results showed that berberine effectively reversed body weight gain, dyslipidemia, and insulin intolerance. Moreover, berberine alleviated inflammation, enhanced antioxidant capacity, and promoted glucose uptake. The beneficial effect was associated with the upregulation of Nrf2 and AKT/GLUT4 pathways, regulated by AMPK, and berberine activated AMPK by increasing AMP levels and the AMP/ATP ratio while suppressing AMPD1 and promoting ADSL expression.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Sanja Kovacevic, Jelena Brkljacic, Danijela Vojnovic Milutinovic, Ljupka Gligorovska, Biljana Bursac, Ivana Elakovic, Ana Djordjevic
Summary: The study found that feeding fructose led to proliferation of small adipocytes capable of storing fats and enhanced inflammation in female rats, potentially contributing to the development of insulin resistance. In contrast, fructose had no effect on plasma uric acid and VAT inflammation in male rats, but showed less prominent alterations in VAT insulin signaling.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Catherine C. Cohen, Kelvin W. Li, Adina L. Alazraki, Carine Beysen, Carissa A. Carrier, Rebecca L. Cleeton, Mohamad Dandan, Janet Figueroa, Jack Knight-Scott, Cynthia J. Knott, Kimberly P. Newton, Edna M. Nyangau, Claude B. Sirlin, Patricia A. Ugalde-Nicalo, Jean A. Welsh, Marc K. Hellerstein, Jeffrey B. Schwimmer, Miriam B. Vos
Summary: Dietary sugar restriction in adolescents with NAFLD can reduce hepatic de novo lipogenesis (DNL) and fasting insulin levels, as well as decrease hepatic fat and ALT. These results support the hypothesis that hepatic DNL is a critical metabolic abnormality linking dietary sugar and NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Nutrition & Dietetics
Aline Fernandes-da-Silva, Carolline Santos Miranda, Daiana Araujo Santana-Oliveira, Brenda Oliveira-Cordeiro, Camilla Rangel-Azevedo, Flavia Maria Silva-Veiga, Fabiane Ferreira Martins, Vanessa Souza-Mello
Summary: Obesity challenges lipid and carbohydrate metabolism, leading to glucolipotoxicity and ER dysfunction, triggering ER stress and metabolic abnormalities. Dietary interventions can alleviate ER stress induced by excessive fat or sugar intake, impacting adipose tissue, liver, and pancreas function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Morgan Welch, Cassandra Secunda, Nabin Ghimire, Isabel Martinez, Amber Mathus, Urja Patel, Sarayu Bhogoju, Mashael Al-Mutairi, Kisuk Min, Ahmed Lawan
Summary: Obesity is a global epidemic that affects the development of metabolic diseases such as fatty liver disease. Membrane lipids play important roles in lipid homeostasis and are implicated in the pathogenesis of fatty liver disease. Recent studies using genetic and pharmacological mouse models have provided insights into the role of lipid species in various mechanisms/pathways related to fatty liver disease.
Article
Nutrition & Dietetics
Wiktor Bzdega, Piotr Franciszek Kurzyna, Ewa Harasim-Symbor, Adam Holownia, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Summary: CBG treatment may modulate sphingolipid metabolism, protecting the liver against the development of metabolic disorders.
Article
Immunology
Mandana Khalili, Wendy C. King, David E. Kleiner, Raymond T. Chung, Atul K. Bhan, Marc G. Ghany, Mark S. Sulkowski, Mauricio Lisker-Melman, Mamta K. Jain, Harry L. A. Janssen, Amanda S. Hinerman, Arun J. Sanyal, Richard K. Sterling
Summary: In most hepatitis B virus/HIV-coinfected patients, fatty liver disease status did not significantly change over a period of 3-4 years. Patients with unfavorable lipid and lipoprotein profiles at baseline may have an increased risk of cardiovascular disease.
CLINICAL INFECTIOUS DISEASES
(2022)