Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries

Mice Homozygous for a Deletion in the Glaucoma Susceptibility Locus INK4 Show Increased Vulnerability of Retinal Ganglion Cells to Elevated Intraocular Pressure

(2016) Shan Gao et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage

(2016) Mariya Hristova et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

(2015) Jonathan G. Crowston et al.   EXPERIMENTAL EYE RESEARCH

Electrophysiological assessment of retinal ganglion cell function

(2015) Vittorio Porciatti   EXPERIMENTAL EYE RESEARCH

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival

(2015) Jaclynn Levine et al.   GLIA

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death

(2015) Shreyasi Choudhury et al.   Molecular Neurodegeneration

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

(2015) Miho Shiratori-Hayashi et al.   NATURE MEDICINE

Assessment of inner retina dysfunction and progressive ganglion cell loss in a mouse model of glaucoma

(2014) María J. Pérez de Lara et al.   EXPERIMENTAL EYE RESEARCH

Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats

(2014) Mei-Na Wu et al.   HIPPOCAMPUS

Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis

(2014) K. Drogemuller et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

(2014) Mansin Wong et al.   MOLECULAR NEUROBIOLOGY

Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

(2014) James P. O'Callaghan et al.   PLoS One

Reversible reactivity by optic nerve astrocytes

(2013) Daniel Sun et al.   GLIA

Differential Progression of Structural and Functional Alterations in Distinct Retinal Ganglion Cell Types in a Mouse Model of Glaucoma

(2013) L. Della Santina et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

A micromechanical procedure for viscoelastic characterization of the axons and ECM of the brainstem

(2013) Samad Javid et al.   Journal of the Mechanical Behavior of Biomedical Materials

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension

(2013) Shaodan Zhang et al.   PLoS One

The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve

(2013) Juan Qu et al.   PLoS One

Relationship between the Magnitude of Intraocular Pressure during an Episode of Acute Elevation and Retinal Damage Four Weeks later in Rats

(2013) Bang V. Bui et al.   PLoS One

Stat3 Inhibition Attenuates Mechanical Allodynia through Transcriptional Regulation of Chemokine Expression in Spinal Astrocytes

(2013) Xiaodong Liu et al.   PLoS One

STAT3-Mediated astrogliosis protects myelin development in neonatal brain injury

(2012) Hiroko Nobuta et al.   ANNALS OF NEUROLOGY

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

(2012) Robert W. Nickells et al.   Annual Review of Neuroscience

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers

(2012) XIAOCHUN WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

(2011) Glyn Chidlow et al.   ACTA NEUROPATHOLOGICA

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)

(2011) Lyle W. Ostrow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Global estimates of visual impairment: 2010

(2011) Donatella Pascolini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

(2011) F. Haroon et al.   JOURNAL OF IMMUNOLOGY

Critical role of calpain in axonal damage-induced retinal ganglion cell death

(2011) Morin Ryu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mild Stretch-Induced Injury Increases Susceptibility to Interleukin-1β-Induced Release of Matrix Metalloproteinase-9 from Astrocytes

(2011) Hantamalala Ralay Ranaivo et al.   JOURNAL OF NEUROTRAUMA

Glaucoma

(2011) Harry A Quigley   LANCET

High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes

(2011) J. Wang et al.   NEUROSCIENCE

Structural Remodeling of Astrocytes in the Injured CNS

(2011) Daniel Sun et al.   NEUROSCIENTIST

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Structural Remodeling of Fibrous Astrocytes after Axonal Injury

(2010) D. Sun et al.   JOURNAL OF NEUROSCIENCE

Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons

(2010) R. D. Fields et al.   Science Signaling

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse

(2009) Daniel Sun et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Selective inner retinal dysfunction precedes ganglion cell loss in a mouse glaucoma model

(2008) D J Holcombe et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Mouse models of retinal ganglion cell death and glaucoma

(2008) Stuart J. McKinnon et al.   EXPERIMENTAL EYE RESEARCH

Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes

(2008) Nicola Hamilton et al.   GLIA

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

(2008) I. Soto et al.   JOURNAL OF NEUROSCIENCE

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

(2008) B. P. Buckingham et al.   JOURNAL OF NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE