Article
Cardiac & Cardiovascular Systems
Anusha Seneviratne, Luke Cave, Gareth Hyde, Soren Kragh Moestrup, David Carling, Justin C. Mason, Dorian O. Haskard, Joseph James Boyle
Summary: Metformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, resulting in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jie Liu, Dezhao Li, Yaoshan Dun, Hui Li, Jeffrey W. Ripley-Gonzalez, Jie Zhang, Ling Qiu, Baiyang You, Suixin Liu
Summary: The study found that Rhodiola can reduce lipid accumulation in the liver of NAFLD by facilitating the MIF pathway and the downstream lipophagy and lipid metabolism.
Review
Medicine, Research & Experimental
Yinxing Cui, Junhua Chen, Zhao Zhang, Houyin Shi, Weichao Sun, Qian Yi
Summary: AMPK plays a key role in regulating metabolism and inflammation in macrophages, and has significant impacts on immune-related diseases, infectious diseases, and immunotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ljupka Gligorovska, Ana Teofilovic, Danijela Vojnovic Milutinovic, Nenad Miladinovic, Sanja Kovacevic, Natasa Velickovic, Ana Djordjevic
Summary: Dietary fructose can disturb hepatic lipid metabolism leading to lipid accumulation and steatosis, with Mif deficiency exacerbating these effects by enhancing inflammation and activating the GR signaling pathway.
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Biochemistry & Molecular Biology
Juan Li, Hanxiang Zhan, Yidan Ren, Maoxiao Feng, Qin Wang, Qinlian Jiao, Yuli Wang, Xiaoyan Liu, Shujun Zhang, Lutao Du, Yunshan Wang, Chuanxin Wang
Summary: This study found that SIRT4 activates the phosphorylation of p53 protein and promotes autophagy in PDAC by suppressing glutamine metabolism, thereby inhibiting tumor growth and progression.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Summary: This study revealed the role of MIF and TGF-β1 in post-traumatic joint contracture, showing that MIF can enhance TGF-β1 production in fibroblasts through MAPK signaling, leading to fibroblast function changes and joint capsule fibrosis. Further investigation into this mechanism may lead to potential therapeutic targets for PTJC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Zhang, T. Xu, Q. Xu, Q. Dong, Y. Luo, L. Gao, Y. Pan
Summary: This study revealed significant increases in levels of MCP-1 and MIF in periodontitis patients, along with enhanced secretion of MIF in gingival epithelial tissue. Limited evidence suggested a correlation between MIF and periodontal conditions, with Porphyromonas gingivalis potentially contributing to periodontitis development and progression through MIF.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Critical Care Medicine
Tianlong Li, Jiahao Zhang, Minghui Long, Xiaofang Jiang, Cheng Yang, Fengqin Wang, Lianjiu Su, Zhiyong Peng
Summary: This study found that serum MIF level might serve as a biomarker for predicting the occurrence, development, and outcomes of septic AKI.
Review
Nutrition & Dietetics
Fatiha Brahmi, Anne Vejux, Imen Ghzaiel, Mohamed Ksila, Amira Zarrouk, Taoufik Ghrairi, Soukena Essadek, Stephane Mandard, Valerio Leoni, Giuseppe Poli, Dominique Vervandier-Fasseur, Omar Kharoubi, Adil El Midaoui, Atanas G. Atanasov, Smail Meziane, Norbert Latruffe, Boubker Nasser, Balkiss Bouhaouala-Zahar, Olfa Masmoudi-Kouki, Khodir Madani, Lila Boulekbache-Makhlouf, Gerard Lizard
Summary: COVID-19, caused by SARS-CoV-2, has had a significant impact on the world, making it crucial to find effective solutions. Research has shown that plant extracts have promising inhibiting effects on the coronavirus. Understanding the influence of diet on COVID-19 patients is also important. This review summarizes the influence of medicinal plant extracts on COVID-19, explores the possibilities of plant treatment/co-treatment and dietary interventions, discusses the impact of nutrient deficiencies on coronavirus susceptibility and complications, and covers major food groups that are effective against COVID-19 pathogenesis.
Article
Biochemistry & Molecular Biology
Caroline Barau, Shirin Leick, Claudio Caccia, Lolita Portal, Valerio Leoni, Philippe Le Corvoisier, Didier Morin, Bijan Ghaleh, Sandrine Pons
Summary: Exercise can provide cardioprotection against myocardial infarction by restoring pro-survival pathways and increasing resistance of mitochondrial permeability transition pore. Oxysterols, specifically 7 beta-hydroxycholesterol, play a role in the inactivation of these pathways. Regular exercise enhances the RISK pathway and decreases 7 beta-hydroxycholesterol concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Serena Di Cosimo, Eliana La Rocca, Silva Ljevar, Maria Carmen De Santis, Marta Bini, Vera Cappelletti, Marta Valenti, Paolo Baili, Filippo G. de Braud, Secondo Folli, Gianfranco Scaperrotta, Chiara Volpi, Andrea Vingiani, Claudio Vernieri, Paolo Verderio, Rosalba Miceli, Giancarlo Pruneri
Summary: This study found that HER2-low breast cancer patients have poor treatment response after neoadjuvant chemotherapy, and those without complete response have a dismal prognosis, especially when the primary tumor is hormone receptor-negative.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Genetics & Heredity
Lorenzo Ferrando, Andrea Vingiani, Anna Garuti, Claudio Vernieri, Antonino Belfiore, Luca Agnelli, Gianpaolo Dagrada, Diana Ivanoiu, Giuseppina Bonizzi, Elisabetta Munzone, Luana Lippolis, Martina Dameri, Francesco Ravera, Marco Colleoni, Giuseppe Viale, Luca Magnani, Alberto J. Ballestrero, Gabriele J. Zoppoli, Giancarlo J. Pruneri
Summary: Breast cancer is the most common cancer in women and is often treated with endocrine therapy. However, many patients develop resistance to this therapy, leading to tumor recurrence. In this study, researchers analyzed the molecular characteristics of hormone receptor positive breast cancer patients and identified potential mechanisms of endocrine resistance, including amplification of the ESR1 gene and mutations in MAP3K. Patients with MAP3K mutations had a worse prognosis.
Editorial Material
Oncology
Giancarlo Pruneri, Daniele Lorenzini, Mauro G. Mastropasqua, Giuseppe Perrone, Antonio Rizzo, Donatella Santini, Chiara C. Volpi, Saverio Cinieri, Alberto Zambelli, Anna Sapino, Isabella Castellano
Summary: Multigenic tests are crucial for selecting adjuvant therapy in ER+/HER2- breast cancer. The workload generated by these tests is often underestimated, affecting timely therapy initiation. This article discusses the evolving role of pathology laboratories in using multigenic tests and proposes a reflex testing model to optimize turnaround time and therapy intervention.
Article
Radiology, Nuclear Medicine & Medical Imaging
Margarita Kirienko, Giovanni Centonze, Giovanna Sabella, Mauro Sollai, Martina Sollini, Xiaoli Lan, Haojun Chen, Luigi Terracciano, Ettore Seregni, Massimo Milione
Summary: This study discovered the expression of FAP in alpha cells of the Langerhans islets in the pancreas, which has implications for the use of radioligands.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Marco D'Agostino, Marco Di Cecco, Carla Marani, Maurizio Giovanni Vigili, Sara Sileno, Chiara Costanza Volpi, Annunziata Gloghini, Daniele Avitabile, Alessandra Magenta, Siavash Rahimi
Summary: This study investigated the relationship between immunohistochemical expression of nucleophosmin (NPM) and high-risk human papillomavirus (HR-HPV) mRNA in ten patients with p16-positive oropharyngeal squamous cell carcinoma (OPSCC). The findings showed a positive correlation between NPM expression and HR-HPV mRNA, suggesting that NPM and HPV testing could be used as predictive markers for tumor progression and therapeutic decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lorenzo Castagnoli, Simona Corso, Alma Franceschini, Alessandra Raimondi, Sara Erika Bellomo, Matteo Dugo, Federica Morano, Michele Prisciandaro, Silvia Brich, Antonino Belfiore, Andrea Vingiani, Maria Di Bartolomeo, Giancarlo Pruneri, Elda Tagliabue, Silvia Giordano, Filippo Pietrantonio, Serenella M. Pupa
Summary: In this study, cotargeting HER2 and FASN was found to enhance the efficacy of anti-HER2 therapy, providing a new opportunity for treating trastuzumab-resistant HER2+ gastric cancer.
Article
Infectious Diseases
Jari Intra, Davide Carcione, Roberta Maria Sala, Claudia Siracusa, Paolo Brambilla, Valerio Leoni
Summary: A retrospective analysis of antimicrobial data from Enterobacter spp. strains isolated over 20 years (2000-2019) revealed a significant decrease in the use of aminoglycosides and fluoroquinolones, but no significant changes in other antimicrobial agents. There was, however, a significant increase in resistance to fosfomycin, possibly due to uncontrolled and improper usage.
Article
Oncology
Francesca Ligorio, Riccardo Lobefaro, Giovanni Fuca, Leonardo Provenzano, Lucrezia Zanenga, Vincenzo Nasca, Caterina Sposetti, Giulia Salvadori, Angela Ficchi, Andrea Franza, Antonia Martinetti, Elisa Sottotetti, Barbara Formisano, Catherine Depretto, Gianfranco Scaperrotta, Antonino Belfiore, Andrea Vingiani, Cristina Ferraris, Giancarlo Pruneri, Filippo de Braud, Claudio Vernieri
Summary: Severe calorie restriction in the form of cyclic fasting or fasting-mimicking diets enhances the antitumor activity of cytotoxic chemotherapy in mouse models of triple-negative breast cancer. Clinical evidence suggests that cyclic fasting-mimicking diets may have a positive impact on the outcomes of advanced triple-negative breast cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Laura Sala, Chiara Maura Ciniselli, Fabio Bozzi, Valeria Summo, Chiara Bonini, Silvia Brich, Alessia Bertolotti, Trupia Desire Viola, Chiara Costanza Volpi, Sara Pizzamiglio, Biagio Paolini, Antonella Aiello, Giovanni Apolone, Paolo Verderio, Umberto Cortinovis
Summary: The periprosthetic capsule formation in implant-based breast reconstruction is a result of inflammatory events, leading to fibrous tissue deposition. The study found a Treg-controlled inflammation in the periprosthetic effusions and capsules.
Article
Multidisciplinary Sciences
Arianna Bresci, Jeong Hee Kim, Silvia Ghislanzoni, Francesco Manetti, Lintong Wu, Federico Vernuccio, Chiara Ceconello, Salvatore Sorrentino, Ishan Barman, Italia Bongarzone, Giulio Cerullo, Renzo Vanna, Dario Polli
Summary: Screening for anticancer therapy in vitro can lead to the identification of additional treatments and improve clinical outcomes. This study demonstrates the potential of all-optical, label-free, and quantitative microscopy techniques in early detection of therapy-induced senescent cells in tumor cells, providing a rapid and accurate method for research in anticancer treatment.
Article
Biochemistry & Molecular Biology
Shigeki Kusamura, Adele Busico, Elena Conca, Iolanda Capone, Luca Agnelli, Daniele Lorenzini, Silvia Brich, Marta Angelini, Chiara Costanza Volpi, Desire Viola Trupia, Vincenzo Lagano, Tommaso Torelli, Annunziata Gloghini, Dario Baratti, Marcello Guaglio, Massimo Milione, Marcello Deraco, Federica Perrone
Summary: This study aimed to explore the mechanisms by which KRAS and GNAS mutations contribute to immune evasion in PMP, as well as to identify potential therapeutic and prognostic targets. The study found immunosuppressive factors such as GM-CSF, A2AR, and PD-L1 in PMP, which were unrelated to GNAS and KRAS status.
Article
Chemistry, Analytical
Silvia Ghislanzoni, Jeon Woong Kang, Arianna Bresci, Andrea Masella, Koseki J. Kobayashi-Kirschvink, Dario Polli, Italia Bongarzone, Peter T. C. So
Summary: This study used optical diffraction tomography and Raman spectroscopy to analyze the structure of vacuoles in cancer cells and detect chemical species within them. The researchers found that the vacuoles contained diluted cell-derived macromolecules and could be distinguished from the surrounding medium and cells using their Raman fingerprint. This noninvasive approach is valuable for studying complex biological processes.