Synthesis and characterisation of celastrol derivatives as potential anticancer agents

Optimization and biological evaluation of celastrol derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties

(2016) Fen Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis

(2016) Thomas Divya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation

(2016) Christina Mernøe Jensen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antitumor activity of new octapeptide analogs of somatostatin containing unnatural amino acids

(2015) Svetlana Ts. Staykova et al.   AMINO ACIDS

Design and synthesis of celastrol derivatives as anticancer agents

(2015) Wen-Jian Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives

(2015) René Csuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice

(2015) Zhenyu Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway

(2015) XIAOLONG YU et al.   ONCOLOGY REPORTS

Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine

(2015) Qi-Wei Jiang et al.   Oncotarget

Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents

(2014) Yulian Voynikov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-fatigue effects of porcine placenta and its amino acids in a behavioral test on mice

(2014) Phil-Dong Moon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Identification of Potent Caspase-3 Inhibitors for Treatment of Multi- Neurodegenerative Diseases Using Pharmacophore Modeling and Docking Approaches

(2014) Khurshid Ahmad et al.   CNS & Neurological Disorders-Drug Targets

Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism

(2014) Chaoyun Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHAin vitroandin vivo

(2014) Lin Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2

(2014) Longhe Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation

(2014) Xing-Xing Fan et al.   MOLECULES

Design, Synthesis and Biological Evaluation of C(6)-Modified Celastrol Derivatives as Potential Antitumor Agents

(2014) Kaiyong Tang et al.   MOLECULES

Synthesis and biological activity of mycophenolic acid-amino acid derivatives

(2013) Dorota Iwaszkiewicz-Grzes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets

(2012) Lada Klaić et al.   ACS Chemical Biology

Antimicrobial peptides containing unnatural amino acid exhibit potent bactericidal activity against ESKAPE pathogens

(2012) R.P. Hicks et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Schizandrin Protects Primary Rat Cortical Cell Cultures from Glutamate-Induced Apoptosis by Inhibiting Activation of the MAPK Family and the Mitochondria Dependent Pathway

(2012) Meng-Shiou Lee et al.   MOLECULES

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

(2010) Daniel Paris et al.   Journal of Neuroinflammation