Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer

(2017) Wei Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relationship of Aurora-A kinase and EGFR inhibition in non-small cell lung cancer (NSCLC) cell lines.

(2017) J. Zhang et al.   JOURNAL OF CLINICAL ONCOLOGY

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

(2016) Zhendong Song et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

(2016) Hengmiao Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827

(2015) JIA CHEN et al.   ONCOLOGY REPORTS

Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck

(2015) Alexander Hoellein et al.   Oncotarget

Design and synthesis of novel pyrimido[4,5- b ]azepine derivatives as HER2/EGFR dual inhibitors

(2013) Youichi Kawakita et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

(2013) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aurora kinases in head and neck cancer

(2013) Ranee Mehra et al.   LANCET ONCOLOGY

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation

(2012) Aleem Gangjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

(2012) Jean-Yves Le Brazidec et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors

(2011) Aleem Gangjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ADP-Glo: A Bioluminescent and Homogeneous ADP Monitoring Assay for Kinases

(2010) Hicham Zegzouti et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

(2010) Aleem Gangjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies

(2010) I. Astsaturov et al.   Science Signaling

RNAi-mediated knockdown of AURKB and EGFR shows enhanced therapeutic efficacy in prostate tumor regression

(2009) M K Addepalli et al.   GENE THERAPY