Journal
JOURNAL OF ENDODONTICS
Volume 43, Issue 9, Pages S1-S6Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.joen.2017.06.002
Keywords
Cell signaling; clinical translation; dentin; inflammation; pulp; regeneration; regenerative endodontics; stem cells
Categories
Funding
- Septodont
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Pulp regeneration and its clinical translation into regenerative endodontic procedures are receiving increasing research attention, leading to significant growth of the published scientific and clinical literature within these areas. Development of research strategies, which consider patient-, clinician-, and scientist-based outcomes, will allow greater focus on key research questions driving more rapid clinical translation. Three key areas of focus for these research questions should include cells, signaling, and infection/inflammation. A translational pathway is envisaged in which clinical approaches are increasingly refined to provide regenerative endodontic protocols that are based on a robust understanding of the physiological processes and events responsible for the normal secretion, structure, and biological behavior of pulpal tissue.
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