Article
Chemistry, Multidisciplinary
Tzu-Sen Yang, May-Show Chen, Cheng-Jyun Huang, Chin-Yi Chen, Agnese Brangule, Aleksej Zarkov, Aivaras Kareiva, Chung-Kwei Lin, Jen-Chang Yang
Summary: 》In this study, the modification of Bi2O3 radiopacifier by doping hafnium ions via the sol-gel process was investigated, which showed improved radiopacity, diametral tensile strength, and in vitro cell viability. The addition of hafnium at a specific ratio and calcination temperature produced a novel bismuth/hafnium composite powder suitable as an alternative radiopacifier for root canal filling materials.
APPLIED SCIENCES-BASEL
(2021)
Article
Biotechnology & Applied Microbiology
Amjad Abu Hasna, Ana Luisa Theodoro, Larissa Marques Pereira, Lucas de Paula Ramos, Tiago Moreira Bastos Campos, Maisour Ala Rachi, Talal Al-Nahalwi, Luciane Dias de Oliveira, Claudio Antonio Talge Carvalho
Summary: This study evaluates the antimicrobial, genotoxic, and morphological effects of five mineral oxides and two mineral trioxide aggregates. The results show that 5MO, MTA, and MTA HP have effective antimicrobial action against certain bacteria. Additionally, 5MO and MTA have no genotoxic effects on macrophage and osteoblast cells.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Marcos Coelho Santiago, Ana Livia Gomes-Cornelio, Laudimar Alves de Oliveira, Mario Tanomaru-Filho, Loise Pedrosa Salles
Summary: Calcium silicate-based cements vary in their biological properties due to differences in components like radiopacifiers and calcium sulfate. In this study, six cements were compared in terms of their effects on human osteoblastic cells, revealing variations in cell viability, migration, and differentiation potential. The findings suggest that certain cements may have specific advantages for promoting osteogenesis in reparative and regenerative contexts.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Chung-Min Kang, Saemi Seong, Je Seon Song, Yooseok Shin
Summary: The use of hydraulic silicate cements for vital pulp therapy promotes tissue healing and mineralized tissue formation. The study found that different HSCs had similar outcomes in long-term partial pulpotomy of permanent teeth, with no significant clinical influencing factors.
Article
Dentistry, Oral Surgery & Medicine
Manoela Domingues Martins, Fernanda Hack Coelho, Maria Stella Moreira, Marcia Martins Marques, Emily Ferreira Salles Pilar, Renato Miotto Palo, Felipe Martins Silveira, Patricia Maria Poli Kopper
Summary: This study aimed to evaluate the cytotoxicity, biocompatibility, and osteoinductive profile of MTA Flow in comparison with MTA Angelus. The results showed that MTA Flow exhibited non-cytotoxic behavior, better biocompatibility, and the ability to stimulate tissue mineralization. The immunoexpression of bone matrix proteins in the MTA Flow group was similar to or higher than that observed in the MTA Angelus and control groups.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Biology
Maurizio Bossu, Patrizia Mancini, Erika Bruni, Daniela Uccelletti, Adele Preziosi, Marco Rulli, Michela Relucenti, Orlando Donfrancesco, Flavia Iaculli, Gianni Di Giorgio, Roberto Matassa, Alessandro Salucci, Antonella Polimeni
Summary: This study compared the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine, with ProRoot MTA showing better cell vitality and antibiofilm effect. Both cements demonstrated stable and successful outcomes in vitro experiments and in vivo treatments, indicating predictable and successful results in endodontic therapy.
Article
Dentistry, Oral Surgery & Medicine
Poliana Amanda Oliveira Silva, Stella Maris de Freitas Lima, Danilo Cesar Mota Martins, Ingrid Aquino Amorim, Cristiano Lacorte, Jeesser Alves de Almeida, Octavio Luiz Franco, Taia Maria Berto Rezende
Summary: The study evaluated the in vitro effects of MTA Repair HP, showing that undiluted MTA Repair HP reduced biofilm on teeth, was not cytotoxic to dental pulp cells, and promoted cell migration and proliferation.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Materials Science, Biomaterials
Dongjing Xu, Jiawei Liu, Honglian Dai, Jinyong Zhang, Wen Hou, Xiaopei Wu, Yanan Zhao
Summary: The development of root canal sealers with good antibacterial and physicochemical properties is essential for treating refractory root canal infection. In this study, a novel premixed root canal sealer containing TMP, KH2PO4, MgO, ZrO2, and a bioactive oil phase was developed and evaluated for its properties and effectiveness. MgO improved the anti-biofilm ability while ZrO2 enhanced the radiopacity of the sealer. Additionally, the sealer showed easy-to-use design, good sealing ability, and biocompatibility, making it a promising option for root canal infection treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Carlos Roberto Emerenciano Bueno, Francine Benetti, Marina Tolomei Sandoval Cury, Ana Maria Veiga Vasques, Leopoldo Cosme-Silva, India Olinta de Azevedo Queiroz, Ana Claudia Rodrigues da Silva, Rogerio de Castilho Jacinto, Luciano Tavares Angelo Cintra, Eloi Dezan-Junior
Summary: The purpose of this study was to evaluate the biocompatibility, biomineralization, collagen maturation, and antibacterial activity of endodontic sealers containing calcium hydroxide. The results showed that all sealers exhibited satisfactory biocompatibility and antimicrobial activity against planktonic bacteria. Sealer 26 induced more biomineralization and collagen maturation compared to other sealers. The findings suggest that these resinous endodontic sealers could be effective in clinical applications.
Article
Multidisciplinary Sciences
Ashraf Abou ElReash, Mohamed Grawish, Walied Abdo, Amr M. Abdelghany, Luo Junsi, Xie Xiaoli, Hamdi Hamama
Summary: This study compared the bone tissue reaction of three materials and found that calcium silicate-based cement induced more bone formation compared to an ion-releasing resin modified glass-ionomer cement. However, the bio-inductive properties of the three materials were similar. This suggests that bioactive resin composite can be used as a retrograde filling material.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sinem Birant, Muazzez Gokalp, Yazgul Duran, Mine Koruyucu, Tunc Akkoc, Figen Seymen
Summary: This study evaluated the biocompatibility and cytotoxic effects of NeoMTA Plus, ProRootMTA, and Biodentine on human dental pulp stem cells. Results showed that all materials extracts did not have cytotoxic effects and did not induce apoptosis in the hDPSCs. Although Biodentine exhibited higher cell viability rates, there were no statistically significant differences between the material groups.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ivona Bago, Ruzica Lucic, Ana Budimir, Valentina Rajic, Merima Balic, Ivica Anic
Summary: In this in vitro study, the apical sealing ability of total fill bioceramic root repair material (BC-RRM) and mineral trioxide aggregate (MTA) was compared using two different retrograde preparation techniques: ultrasonic or Er,Cr:YSGG laser. The results showed that BC-RRM and MTA filled in ultrasonic preparations had similar sealing abilities, while BC-RRM showed more leakage when used in retro cavities prepared with the Er,Cr:YSGG laser.
BIOENGINEERING-BASEL
(2022)
Article
Materials Science, Multidisciplinary
Seyedeh Zahra Karrari, Hossein Afarideh, Hamid Kermanshah, Giuliana Aquilanti, Davoud Agha Aligol, Zahra Shahidi, Simone Pollastri, Danilo Oliveira de Souza
Summary: This in vitro study examined the effects of OrthoMTA, a commercially available dental bioactive cement, on demineralized dentine using complementary analysis techniques. The study found that OrthoMTA can effectively recover the calcium species of the original tooth, demonstrating its potential for use in both direct pulp capping and remineralization of affected dentin in IPC procedures.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Physical
Ines Raquel Pereira, Catarina Carvalho, Siri Paulo, Jose Pedro Martinho, Ana Sofia Coelho, Anabela Baptista Paula, Carlos Miguel Marto, Eunice Carrilho, Maria Filomena Botelho, Ana Margarida Abrantes, Manuel Marques Ferreira
Summary: This study evaluated and compared the sealing ability of two calcium silicate-based sealers through nuclear medicine, showing that White ProRoot MTA had a significantly better sealing ability than TotalFill BC RRM Fast Set Putty.
Article
Multidisciplinary Sciences
J. Camilleri, C. Wang, S. Kandhari, J. Heran, R. M. Shelton
Summary: Regulatory testing and standard test methods for hydraulic cements used in dentistry and root-end filling materials are lacking. This study aimed to establish a simple and reproducible method for testing the solubility of hydraulic materials used in root-end filling in dentistry. Different methods were used to determine solubility, and the results varied depending on the method used. The proposed new method showed advantages over the ISO standard in terms of simplicity and better mimicking of the clinical environment.
SCIENTIFIC REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Juan J. Segura-Egea, Daniel Cabanillas-Balsera, Jenifer Martin-Gonzalez, Luciano T. A. Cintra
Summary: Systemic conditions such as smoking habits and diabetes may influence the repair of periapical tissues after root canal treatment, leading to incomplete healing.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Francine Benetti, Luciana Louzada Ferreira, Alexandre Henrique Dos Reis-Prado, Flavio Duarte Faria, Edilson Ervolino, Fabio Luiz Camargo Vellela Berbert, Renato de Toledo Leonardo, Joao Dias, Joao Eduardo Gomes-Filho, Luciano Tavares Angelo Cintra
Summary: This study evaluated the biocompatibility and immunoinflammatory response of Sealepox and Sealepox-RP and compared them with PRMTA. The results showed that Sealepox and Sealepox-RP exhibited similar immunoinflammatory response regarding IL-6, TNF-alpha, and CD5 compared to PRMTA.
Article
Dentistry, Oral Surgery & Medicine
Maria Clara Bertolini Botelho, Luciano Tavares Angelo Cintra, Cristiane Cantiga da Silva, Giseli Mitsuy Kayahara, Rosani Belzunces Pereira, Mylena Fernanda Oliveira Santos, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Sandra Helena Penha Oliveira, Daniel Galera Bernabe
Summary: This study evaluated the influence of early life stress on the severity of apical periodontitis in Wistar rats. The results showed that early life stress exacerbates the inflammatory process and increases periapical bone resorption.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alexandre Henrique dos Reis-Prado, Sabrina de Castro Oliveira, Juliana Goto, Gerluza Aparecida Borges Silva, Luciano Tavares Angelo Cintra, Ricardo Alves de Mesquita, Raphael Escorsim Szawka, Antonio Paulino Ribeiro-Sobrinho, Francine Benetti
Summary: EDTA irrigation was found to improve the formation of newly formed intracanal connective tissue after REP in immature rat molars. However, EDTA did not have an influence on cementum-like tissue formation, apical closure, inflammatory infiltrate, and maturation of collagen fibers.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bianca Elvira Belardi, Maria Sara de Lima Coutinho Mattera, Thais Veronica Saori Tsosura, Rodrigo Martins Dos Santos, Cristiane Cantiga-Silva, Luciano Tavares Angelo Cintra, Fernando Yamamoto Chiba, Lara Teschi Bravo, Nubia Ramos Carvalho, Ana Carolina Nascimento Carnevali, Renan Akira Fujii de Oliveira, Edilson Ervolino, Doris Hissako Matsushita
Summary: Maternal periodontal disease and apical periodontitis are associated with insulin resistance, alterations in insulin signaling, and inflammatory pathways in the gastrocnemius muscle of adult offspring, leading to worsened health.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rodrigo Martins dos Santos, Bianca Elvira Belardi, Thais Veronica Saori Tsosura, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Nathalia Evelyn Silva Machado, Cristiane Cantiga-Silva, Nubia Ramos Carvalho, Lara Teschi Bravo, Ana Carla Thalez Ywabuchi Nobumoto, Sandra Helena Penha Oliveira, Luciano Tavares Angelo Cintra, Doris Hissako Matsushita
Summary: This study evaluated the effects of melatonin (MEL) on the expression of TLR4, MyD88, TRIF, IRF-3, NF-kappa B, IL-1 beta and LPS, as well as the lipid profile in rats with apical periodontitis (AP) fed on a high-fat diet (HFD). MEL treatment reduced IRF-3 protein expression in the gastrocnemius muscle (GM) and IL-1 beta plasma concentration in the APMEL and HFDMEL groups. LPS plasma concentration decreased only in the HFDMEL group. Additionally, LDL decreased and HDL increased in the HFDMEL and HFDAPMEL groups. Treatment with MEL exhibited anti-inflammatory and anti-hyperlipidemic effects.
Article
Biochemical Research Methods
Vanessa Soares Lara, Rafaela Alves da Silva, Tatiane Ponteado Ferrari, Carlos Ferreira dos Santos, Sandra Helena Penha de Oliveira
Summary: This study evaluated the antimicrobial action of losartan against C. albicans biofilms. The results showed that losartan inhibited the growth of C. albicans biofilms and had no significant toxicity on human cells. This indicates that losartan can be repurposed to interfere with the metabolism and development of Candida biofilms.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ana Claudia Rodrigues da Silva, Ana Maria Veiga Vasques, Carlos Roberto Emerenciano Bueno, Edilson Ervolino, Luciano Tavares Angelo Cintra, Claudia Cristina Biguetti, Mariza Akemi Matsumoto, Eloi Dezan-Junior
Summary: This study evaluated the effects of cigarette smoke inhalation on apical periodontitis in rats. The results showed that cigarette smoke worsened the condition and led to a pro-inflammatory immune response.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Danila de Oliveira, Fernando I. Souza, Mariana T. Caixeta, Cristiane Duque, Sandra H. P. Oliveira, Eduardo P. Rocha
Summary: This study evaluated the impact of ultrathin ceramic laminate veneers placed subgingivally without a finish line on the periodontium. Results showed that the restored teeth had similar periodontal behavior compared to before restoration, indicating that ultrathin ceramic laminate veneers do not contribute to plaque accumulation or changes in oral microbiota.
INTERNATIONAL JOURNAL OF PROSTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Claudia Azucena Palafox- Sanchez, Alvaro Cruz, Diana Celeste Salazar-Camarena, Luis Gerardo Gascon, Luciano Tavares Angelo Cintra, Jose Francisco Munoz-Vale, Samuel Garcia-Arelano, Carlos Estrela, Paula Annahi Menchaca-Tapia
Summary: This study investigated the changes in systemic cytokine levels in patients with acute apical abscesses (AAA), and found that patients with AAA had increased serum levels of TNF-a, IL-6, and IL-10. Antibiotic treatment was associated with a decrease in IL-6 and IL-10 levels, while TNF-a levels decreased after antibiotic and endodontic treatment.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marjorie de Oliveira Gallinari, Ester Alves Ferreira Bordini, Vitor de Toledo Stuani, Fernanda Balestrero Cassiano, Camila Correa da Silva Braga de Melo, Juliano Milanezi de Almeida, Luciano Tavares Angelo Cintra, Carlos Alberto De Souza Costa, Diana Gabriela Soares
Summary: This study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide (CH-Ca) and functionalized with bioactive doses of simvastatin (SV) for bone tissue regeneration. The results showed that the CH-Ca-SV scaffold exhibited the most intense bio-stimulating effect, leading to increased deposition of mineralized matrix.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Camila de Sousa Caneschi, Francine Benetti, Luiz Carlos Alves de Oliveira, Jadson Claudio Belchior, Raquel Conceicao Ferreira, Allyson Nogueira Moreira, Luis Fernando dos Santos Alves Morgan
Summary: The objective of this study was to develop a new bleaching agent with minimum concentration of hydrogen peroxide (HP), without adverse effects, and with bleaching effectiveness. The bleaching efficacy and cytotoxicity of a new niobium-based bleaching gel were evaluated and compared to already available HP-based gels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Daniel Cabanillas-Balsera, Victoria Areal-Quecuty, Cristiane Cantiga-Silva, C. B. M. de Cardoso, Luciano Tavares Angelo Cintra, Jenifer Martin-Gonzalez, Juan J. Segura-Egea
Summary: There is no association between the prevalence of AP and hypertension, but hypertensive patients have significantly increased odds of losing root-filled teeth. Given the high prevalence of hypertension, it is very common to perform root canal treatments on hypertensive patients. It is imperative to communicate this heightened risk to patients and recommend periodic monitoring of oral health and hypertension, paying special attention to this subset of patients.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)