Article
Chemistry, Physical
Wojciech Eliasz, Beata Czarnecka, Anna Surdacka
Summary: The study aimed to assess the weight of apically extruded debris during root canal preparation using instruments with different movement kinematics. The results showed that engine-driven root canal preparation with various instruments led to similar levels of apical extrusion of debris.
Article
Dentistry, Oral Surgery & Medicine
Chi Wai Chan, Virginia Rosy Romeo, Angeline Lee, Chengfei Zhang, Prasanna Neelakantan, Eugenio Pedulla
Summary: This laboratory study compared the accumulated hard tissue debris (AHTD) and shaping performance of three different root canal instrumentation systems using micro-CT analysis. The results showed no significant differences in AHTD percentage and unprepared canal surface area among the three groups. However, the GF group had significantly less volume and surface area increase compared to the RB group, and the GF and OC groups had significantly less transportation at 3 mm from the apex compared to the RB group. The OC group required less time for instrumentation compared to the RB and GF groups.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
HyeWon Kim, Su-Jin Jeon, Min-Seock Seo
Summary: TruNatomy demonstrated better shaping ability in simulated S-shaped canals compared to ProTaper GOLD and WaveOne GOLD, maintaining the original apical canal curvature more effectively. TruNatomy removed less resin than the other groups in all sections and had the shortest shaping time.
Article
Dentistry, Oral Surgery & Medicine
Ramon Miguens-Vila, Benjamin Martin-Biedma, Gustavo De-Deus, Felipe G. Belladonna, Alejandro Pena-Lopez, Pablo Castelo-Baz
Summary: This study evaluated the influence of different root canal instrumentation systems on dentinal microcrack generation in curved root canals using microCT analysis. Results showed the presence of dentinal microcracks, which were all pre-existing and not generated after root canal preparation with the tested systems.
JOURNAL OF ENDODONTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Dongsheng Yu, Li Guo, Jing Gao, Jie Liu, Deqin Yang
Summary: Curved root canals pose challenges in cleaning, shaping, and filling. Postoperative complications are caused by apical extrusion of debris and root canal transportation. This study aims to comprehensively evaluate the differences in these factors among different NiTi files.
Article
Dentistry, Oral Surgery & Medicine
Emina Kabil, Marko Katic, Ivica Anic, Ivona Bago
Summary: The study concluded that all tested techniques had similar transportation and centering abilities in the apical part of the canal, but reciprocating instruments resulted in more canal transportation and less centered preparations overall, as well as in the middle and coronal parts of the canal.
JOURNAL OF ENDODONTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Elif Kalyoncuoglu, Canguurol Keskin, Ali Keles, Kubra Bozsoy, Rawan Alqawasmi
Summary: This study aimed to evaluate the efficacy of examinations by endoscope of root canals to determine residual root canal filling materials. The endoscope detected residual root canal filling material as efficiently as periapical radiography.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Heba Abdelkafy, Alaa M. Eldehna, Nada A. Salem
Summary: This study compared canal transportation and centring ability in primary root canals using ProTaper Next, AF baby, and Kidzo Elephant files. The results showed no significant difference in canal transportation and centring ability in the buccolingual direction among the tested files. However, in the mesiodistal direction at the cervical root canal level, ProTaper Next showed a higher transportation liability.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gabiana Rodrigues Freitas, Thais Marchand Ribeiro, Fabiana Soares Grecca Vilella, Tiago Andre Fontoura de Melo
Summary: This study evaluated the influence of endodontic cavity access into molars on the chemomechanical preparation of curved root canals. The results showed that there was no significant difference in the transport and centralization of endodontic instruments between conventional and minimally invasive access types. Therefore, the type of cavity access did not affect the preparation of curved root canals with 0.25 and 0.04 taper instruments.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, General & Internal
Sasti Gayatri, Sebeena Mathew, Karthick Kumaravadivel, Boopathi Thangavel, Deepa N. Thangaraj, Athira Shaji
Summary: The aim of this study was to compare the amount of debris produced during the removal of root canal obturating material using different files in extracted teeth with simulated apical root resorption. The results showed that all file systems were associated with significantly more debris extrusion in the teeth with simulated apical root resorption compared to those without it. Among the control and experimental groups, the ProTaper Universal retreatment file was associated with the least amount of apically extruded debris, followed by the Reciproc Blue file and the HyFlex Remover file.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Wojciech Eliasz, Beata Czarnecka, Anna Surdacka
Summary: The study aimed to compare the incidence of cracks within radicular dentin after instrumentation with different kinematics tools. Partial cracks were observed in all study groups, with no significant differences among experimental groups, indicating that instrumentation with PTN, WOG, and TF may result in dentinal cracks formation.
Review
Dentistry, Oral Surgery & Medicine
Yuhong Liang, Lin Yue
Summary: This review introduces the terms and concepts of engine-driven nickel-titanium (NiTi) endodontic files, as well as the improvements and advancements in different generations of these instruments. Continuous advancements have resulted in better shaping efficiency and resistance in NiTi systems. In clinical practice, the appropriate system should be chosen based on root canal anatomy, instrument characteristics, and operator experience.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Chemistry, Physical
Keiichiro Maki, Arata Ebihara, Hayate Unno, Satoshi Omori, Taro Nakatsukasa, Shunsuke Kimura, Takashi Okiji
Summary: This study examined how downward loads affect the torque/force and shaping outcome of ProTaper NEXT rotary instrumentation. The results showed that increasing the downward load improved the canal centering ability, reduced the instrumentation time, and increased the upward force.
Article
Dentistry, Oral Surgery & Medicine
Chen Chen, Wenxin Zhang, Yuhong Liang
Summary: This study compared apical root defects during canal instrumentation with two NiTi rotary systems using OCT scans, and found less root defects in the HCM group.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Aylin Islam, Gurkan Unsal, Alaa Almashharawi
Summary: The study evaluated the performance of RaceEvo, R-Motion, ProTaper Gold (PTG) systems in curved primary root canals using CBCT, with the PTG group showing significantly higher values in terms of canal transportation and volumetric dentin removal compared to other groups.
APPLIED SCIENCES-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Michele Correale, Olga Lamacchia, Michele Ciccarelli, Giuseppe Dattilo, Lucia Tricarico, Natale Daniele Brunetti
Summary: Alterations in endothelial function, inflammatory activation, and nitric oxide-cGMP pathway play a role in the pathophysiology of heart failure. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have emerged as potential treatments for heart failure, but their protective mechanisms are not fully understood.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Rodolfo Citro, Costantina Prota, Donatella Ferraioli, Giuseppe Iuliano, Michele Bellino, Ilaria Radano, Angelo Silverio, Serena Migliarino, Maria Vincenza Polito, Artemisia Ruggiero, Rosa Napoletano, Vincenzo Bellizzi, Michele Ciccarelli, Gennaro Galasso, Carmine Vecchione
Summary: In a metropolitan area not previously investigated, the prevalence of Anderson-Fabry disease (FD) was found to be high (10%) among patients with left ventricular hypertrophy of unknown origin.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Carmine Izzo, Valeria Visco, Jessica Gambardella, Germano Junior Ferruzzi, Antonella Rispoli, Maria Rosaria Rusciano, Anna Laura Toni, Nicola Virtuoso, Albino Carrizzo, Paola Di Pietro, Guido Iaccarino, Carmine Vecchione, Michele Ciccarelli
Summary: The COVID-19 pandemic caused by SARS-CoV-2 is a global challenge, with cardiovascular involvement being a crucial complication. This report discusses the role of microRNAs in cardiovascular complications associated with COVID-19, highlighting their potential as biomarkers and predictors of cardiac and vascular damage.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mario Cristiano, Giuseppe Iuliano, Antonella Rispoli, Lucia Soriente, Michele Ciccarelli, Gennaro Galasso, Carmine Vecchione, Rodolfo Citro
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Review
Biochemistry & Molecular Biology
Paola Di Pietro, Carmine Izzo, Angela Carmelita Abate, Paola Iesu, Maria Rosaria Rusciano, Eleonora Venturini, Valeria Visco, Eduardo Sommella, Michele Ciccarelli, Albino Carrizzo, Carmine Vecchione
Summary: Cardiovascular diseases (CVDs) are the leading cause of death and illness worldwide, accounting for 47% of deaths in Europe. Bioactive sphingolipids, including ceramides and sphingosine-1-phosphate (S1P), have been identified as drivers of CVDs. Monitoring sphingolipid levels could provide insights into the progression and severity of cardiovascular diseases and may be a potential target for therapeutic intervention.
Article
Cardiac & Cardiovascular Systems
Giulia Elena Mandoli, Maria Concetta Pastore, Alberto Giannoni, Giovanni Benfari, Frank Lloyd Dini, Gianmarco Rosa, Nicola Riccardo Pugliese, Claudia Taddei, Michele Correale, Natale Daniele Brunetti, Pietro Mazzeo, Erberto Carluccio, Anna Mengoni, Andrea Igoren Guaricci, Laura Piscitelli, Rodolfo Citro, Michele Ciccarelli, Giuseppina Novo, Egle Corrado, Annalisa Pasquini, Valentina Loria, Giuseppe De Carli, Anna Degiovanni, Giuseppe Patti, Ciro Santoro, Luca Moderato, Mariantonietta Cicoira, Marco Canepa, Alessandro Malagoli, Michele Emdin, Matteo Cameli
Summary: Echocardiographic predictors, such as left atrial strain and global longitudinal strain, can help predict left ventricular reverse remodelling and clinical response in patients with heart failure and reduced ejection fraction (HFrEF) who are treated with Sacubitril/valsartan.
Review
Medicine, General & Internal
Angelo Silverio, Francesco Paolo Cancro, Luca Esposito, Michele Bellino, Debora D'Elia, Monica Verdoia, Maria Giovanna Vassallo, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso, Giuseppe De Luca
Summary: The control of cardiovascular risk factors, promotion of a healthy lifestyle, and antithrombotic therapy are important for secondary prevention after acute coronary syndrome (ACS). Identification of novel risk factors and targets is essential to optimize preventive strategies for patients who have recurrent ischemic events despite optimal control of traditional risk factors and pharmacological therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Mengozzi, Nicola Riccardo Pugliese, Giovambattista Desideri, Stefano Masi, Fabio Angeli, Carlo Maria Barbagallo, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Raffaella Dell'Oro, Lanfranco D'Elia, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Maria Masulli, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Roberto Pontremoli, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Elisa Russo, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Claudio Borghi, Agostino Virdis
Summary: High serum uric acid (SUA) levels have been found to predict all-cause mortality (ACM) and cardiovascular mortality (CVM) in cardiometabolic patients without established cardiovascular disease, regardless of triglyceride (TG) levels. The study included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort, and the findings were confirmed by exploratory and sensitivity analyses. This suggests that SUA plays a substantial role in predicting cardiovascular risk in both normotriglyceridemia and hypertriglyceridemia.
Article
Biology
Alfonso Campanile, Valeria Visco, Stefania De Carlo, Germano Junior Ferruzzi, Costantino Mancusi, Carmine Izzo, Felice Mongiello, Paola Di Pietro, Nicola Virtuoso, Amelia Ravera, Domenico Bonadies, Carmine Vecchione, Michele Ciccarelli
Summary: This study compares the effects of Sac/Val and standard medical therapy on prognostically significant CPET parameters in HFrEF patients. After a median follow-up of 16 months, no significant differences were observed in peak VO2 and other CPET measures between Sac/Val and standard therapy.
Review
Cardiac & Cardiovascular Systems
Valeria Visco, Carmine Izzo, Costantino Mancusi, Antonella Rispoli, Michele Tedeschi, Nicola Virtuoso, Angelo Giano, Renato Gioia, Americo Melfi, Bianca Serio, Maria Rosaria Rusciano, Paola Di Pietro, Alessia Bramanti, Gennaro Galasso, Gianni D'Angelo, Albino Carrizzo, Carmine Vecchione, Michele Ciccarelli
Summary: Arterial hypertension is a growing concern with the increasing aging population, and the potential of artificial intelligence in its prevention and treatment is well recognized. This article reviews the benefits of AI in managing hypertension, including personalized medicine and tailored treatment. However, the limitations and technical issues, such as biases and data privacy, should also be considered.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Medicine, General & Internal
Gianluigi Cuomo, Francesca Paola Iannone, Anna Di Lorenzo, Crescenzo Testa, Michele Ciccarelli, Elio Venturini, Arturo Cesaro, Mario Pacileo, Ercole Tagliamonte, Antonello D'Andrea, Carmine Vecchione, Carlo Vigorito, Francesco Giallauria
Summary: Although some cancer treatments are known to cause cardiotoxicity, cardiologists and oncologists have promoted the development of cardio-oncology to prevent cardiovascular disease in cancer patients. Cardio-oncology rehabilitation aims to improve symptoms, quality of life, cardiorespiratory fitness, and survival through risk factor correction, drug therapies, and exercise programs. Global longitudinal strain (GLS) has recently gained interest as an imaging modality for evaluating cardiac function in cancer patients undergoing rehabilitation programs.
CLINICS AND PRACTICE
(2023)
Review
Cardiac & Cardiovascular Systems
Michele Ciccarelli, Ines Falcao Pires, Johann Bauersachs, Luc Bertrand, Christophe Beauloye, Dana Dawson, Nazha Hamdani, Denise Hilfiker-Kleiner, Linda W. van Laake, Frank Lezoualc'h, Wolfgang A. Linke, Ida G. Lunde, Peter P. Rainer, Antonella Rispoli, Valeria Visco, Albino Carrizzo, Matteo Dal Ferro, Davide Stolfo, Jolanda van der Velden, Serena Zacchigna, Stephane Heymans, Thomas Thum, Carlo Gabriele Tocchetti
Summary: This scientific statement highlights the challenges in acute heart failure (AHF) treatment and emphasizes the need for research models and understanding of its mechanisms. It also discusses potential molecular targets for new therapeutic perspectives.
CARDIOVASCULAR RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Ciaglia, F. Montella, V. Lopardo, R. M. Esposito, F. Guarracino, G. Spinetti, A. A. Maciag, M. Ciccarelli, C. Vitale, S. G. Pellegrino, B. Polverino, C. Izzo, C. Vecchione, A. A. Puca
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Esposito, F. P. Cancro, A. Silverio, M. Di Maio, M. Bellino, S. Romei, M. Tedeschi, M. Ciccarelli, C. Vecchione, G. Galasso
EUROPEAN HEART JOURNAL
(2022)
