Article
Biochemistry & Molecular Biology
Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Summary: This study investigates the detectability of in utero fetal cardiac mitochondrial programming in early-stage IUGR pregnancy using a nonhuman primate model. The results show that early fetal responses to IUGR can be detected and that in utero cardiac mitochondrial adaptations are already present at this early stage. These adaptations affect the expression of oxidative phosphorylation subunits and may play a role in offspring's mitochondrial dysfunction and increased predisposition to cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jennifer L. Wayland, Jessica R. Doll, Matthew J. Lawson, Traci E. Stankiewicz, Jarren R. Oates, Keisuke Sawada, Michelle S. M. A. Damen, Pablo C. Alarcon, David B. Haslam, Andrew T. Trout, Emily A. Defranco, Corie M. Klepper, Jessica G. Woo, Maria E. Moreno-Fernandez, Marialena Mouzaki, Senad Divanovic
Summary: Maternal obesity has negative impacts on offspring health, including decreased neonatal survival, increased risk of obesity, and accelerated susceptibility to metabolic diseases. Severe maternal obesity alters the offspring microbiome and creates a proinflammatory gestational environment, leading to inflammatory changes in utero and adulthood. The findings from this study are consistent with human cohort studies.
Article
Endocrinology & Metabolism
Brianna F. Moore, Katherine A. Sauder, Allison L. B. Shapiro, Tessa Crume, Gregory L. Kinney, Dana Dabelea
Summary: The study assessed the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life. The results suggest that fetal exposure to cannabis may be associated with increased adiposity and fasting glucose in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biology
Liang Liu, Yinxian Wen, Qubo Ni, Liaobin Chen, Hui Wang
Summary: Prenatal ethanol exposure can lead to fetal developmental damage and increased susceptibility to chronic diseases in adults. Ethanol affects fetal development through direct and indirect effects mediated by glucocorticoids. It alters epigenetic modifications and programming of neuroendocrine axes. Differences in ethanol metabolic enzymes and sensitivity to glucocorticoids may contribute to severity and sex differences. Offspring exposed to ethanol during pregnancy show catch-up growth with abundant nutrition after birth but are more likely to develop diseases in adverse environments.
BIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Shu Tang, Chun-Yi Ho, Chien-Ning Hsu, You-Lin Tain
Summary: Melatonin, a hormone released by the pineal gland at night, has various functions and plays a crucial role in kidney health and disease. As the prevalence of chronic kidney disease continues to rise, it is important to find a strategy to not only treat but also prevent it. This review examines the effect of melatonin on kidney development, its clinical uses in early life, preventive applications in animal models, and considerations for melatonin supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Camille Gosseaume, Thierry Fournier, Isabelle Jeru, Marie-Leone Vignaud, Isabelle Missotte, Francoise Archambeaud, Xavier Debussche, Celine Droumaguet, Bruno Feve, Sophie Grillot, Bruno Guerci, Sylvie Hieronimus, Yves Horsmans, Estelle Nobecourt, Catherine Pienkowski, Christine Poitou, Jean-Paul Thissen, Olivier Lascols, Severine Degrelle, Vassilis Tsatsaris, Corinne Vigouroux, Camille Vatier
Summary: This study evaluates the role of the adipogenic PPARG-encoded PPAR gamma nuclear receptor in metabolism, reproduction, and perinatal features in patients with PPARG-related lipodystrophy. The results show that most patients suffer from metabolic complications such as diabetes, partial lipodystrophy, hypertriglyceridemia, liver steatosis, and hypertension, as well as reproductive issues such as acute pancreatitis and polycystic ovary syndrome. Moreover, the presence of PPARG variants in affected foetuses could impair prenatal growth and parturition.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Manal B. M. Hemida, Kristiina A. Vuori, Nona C. Borgstrom, Robin Moore, Sarah Rosendahl, Johanna Anturaniemi, Alessandra Estrela-Lima, Anna Hielm-Bjoerkman
Summary: This study investigates the association between early life variables and otitis in dogs later in life. The results suggest that diet, specifically a non-processed meat-based diet, can decrease the risk of otitis, while an ultra-processed carbohydrate-based diet increases the risk. Other factors, such as exposure to sunlight and the type of flooring during puppyhood, also impact the risk of otitis development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yu Qi Lee, Eugenie R. Lumbers, Tracy L. Schumacher, Clare E. Collins, Kym M. Rae, Kirsty G. Pringle
Summary: Suboptimal nutrition during pregnancy is recognized as a significant modifiable factor in the development of chronic diseases in offspring. The study found that dietary intake of pregnant Indigenous Australian women did not meet national guidelines and that maternal nutrition during pregnancy can impact fetal growth but not fetal kidney growth. Urgent strategies are needed to support and optimize nutrient intake in Indigenous pregnant women.
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Brittany B. Rice, Sara Y. Ngo Tenlep, Obadah Tolaymat, Attaas T. Alvi, Fallon R. Slone, Claire L. Crosby, Stevi S. Howard, Cecile L. Hermanns, Nishimwe P. Montessorie, Hollie I. Swanson, Kevin J. Pearson
Summary: This study investigated the effects of PCB exposure on glucose tolerance and body composition in offspring expressing or lacking Nrf2, finding that PCB exposure during nursing led to reduced body weight and impaired glucose disposal. The study also revealed that the presence or absence of Nrf2 did not significantly impact the metabolic responses of offspring to in utero PCB exposure. Future research will focus on understanding the influence of maternal Nrf2 genotypic differences on offspring metabolic responses.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Cynthia Barrera, Valeska Castillo, Rodrigo Valenzuela, Carina A. Valenzuela, Diego F. Garcia-Diaz, Miguel Llanos
Summary: This study aimed to determine the effects of a nutritional intervention during pregnancy and lactation on metabolic alterations of obese female progenitors' offspring and on the involvement of the endocannabinoid system (ECS). The results showed that the intervention normalized some hormonal parameters and hepatic mRNA levels of ECS components, improving the condition of the obese offspring.
Article
Biochemistry & Molecular Biology
Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yuji Hattori, Itsuki Kageyama, Atsushi Teshigawara, Yuki Nouchi, Hiroaki Ishikawa, Ryosuke Fujii, Yoshiji Ohta, Koji Suzuki, Yohei Shimono, Koji Ohashi, Shuji Hashimoto
Summary: Excessive maternal fructose intake may lead to abnormal liver function in offspring, increasing the risk of developing metabolic disorders. This abnormal hepatic programming induced by an imbalanced maternal nutritional environment is likely to be maintained throughout life and contribute to metabolic disorders.
Article
Agriculture, Dairy & Animal Science
Jessica G. Syring, Matthew S. Crouse, Tammi L. Neville, Alison K. Ward, Carl R. Dahlen, Lawrence P. Reynolds, Pawel P. Borowicz, Kyle J. McLean, Bryan W. Neville, Joel S. Caton
Summary: This study investigated the correlation between concentrations of B-12 and folate in maternal serum, allantoic fluid, and amniotic fluid, and concentrations of methionine-folate cycle intermediates in fetal fluids, as well as fetal hepatic gene expression. The study found that restricted maternal nutrition resulted in increased B-12 and folate concentrations in allantoic fluid, as well as altered gene expression in fetal liver. These findings contribute to our understanding of the effects of restricted maternal nutrition on fetal programming and can help in the development of strategic supplementation plans for beef cattle.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Cell Biology
Terisha Ghazi, Pragalathan Naidoo, Rajen N. Naidoo, Anil A. Chuturgoon
Summary: The concept of Developmental Origins of Health and Disease (DOHaD) suggests that in utero exposures can have long-term effects on health. The placenta plays a crucial role in fetal programming and can be impacted by maternal exposure to air pollution and heavy metals, leading to changes in DNA methylation patterns. These changes in placental DNA methylation have been associated with adverse birth outcomes and potential health issues in later life, highlighting the importance of environmental policies to reduce air pollution.
Article
Immunology
Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, Evon Batey Lee, Micah O. Mazurek, Aaron McLaughlin, Eric A. Macklin, Erin McDonnell, Daniel J. Davis, Anthony M. Belenchia, Catherine H. Gillespie, Catherine A. Peterson, Margaret L. Bauman, Kara Gross Margolis, Jeremy Veenstra-VanderWeele, David Q. Beversdorf
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Article
Nutrition & Dietetics
Anthony M. Belenchia, Karen L. Jones, Matthew Will, David Q. Beversdorf, Victoria Vieira-Potter, Cheryl S. Rosenfeld, Catherine A. Peterson
EUROPEAN JOURNAL OF NUTRITION
(2018)
Article
Nutrition & Dietetics
Anthony M. Belenchia, Aneesh K. Tosh, Laura S. Hillman, Catherine A. Peterson
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2013)
Review
Endocrinology & Metabolism
Catherine A. Peterson, Aneesh K. Tosh, Anthony M. Belenchia
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Hematology
Neekun Sharma, Rishabh Dev, Anthony M. Belenchia, Annayya R. Aroor, Adam Whaley-Connell, Lakshmi Pulakat, Chetan P. Hans
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Cell Biology
Anthony M. Belenchia, Madhavi P. Gavini, Ryan G. Toedebusch, Vincent G. DeMarco, Lakshmi Pulakat
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Review
Endocrinology & Metabolism
Folami Y. Ideraabdullah, Anthony M. Belenchia, Cheryl S. Rosenfeld, Seth W. Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D. Levinlo, Catherine A. Peterson
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Cell Biology
Neekun Sharma, Anthony M. Belenchia, Ryan Toedebusch, Lakshmi Pulakat, Chetan P. Hans
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Madhavi P. Gavini, Abuzar Mahmood, Anthony M. Belenchia, Paige Beauparlant, Senthil A. Kumar, Sivakumar Ardhanari, Vincent G. DeMarco, Lakshmi Pulakat
Summary: NP-6A4, a new AT2R peptide agonist, shows promising results in protecting the heart from chronic inflammation induced by untreated obesity. It enhances AT2R expression and suppresses inflammatory cytokines, potentially serving as an ideal adjuvant drug to protect against myocardial damage.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Carolyn A. Robinson, Hsin-Yeh Hsieh, Shu-Yu Hsu, Yang Wang, Braxton T. Salcedo, Anthony Belenchia, Jessica Klutts, Sally Zemmer, Melissa Reynolds, Elizabeth Semkiw, Trevor Foley, XiuFeng Wan, Chris G. Wieberg, Jeff Wenzel, Chung-Ho Lin, Marc C. Johnson
Summary: The genetic material of SARS-CoV-2 has been detected in raw wastewater around the world during the COVID-19 pandemic, showing high detectability in feces and household wastewater both before and after a positive qPCR test. However, the study found that pasteurization of raw wastewater did not reduce the SARS-CoV-2 signal if RNA was extracted immediately after, with a decrease in signal observed when extraction was delayed. Surprisingly, the recovery of SARS-CoV-2 signal after concentration was consistently higher than that of a control virus, indicating potential differences in the nature of the genetic material detected in wastewater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Shu-Yu Hsu, Mohamed B. Bayati, Chenhui Li, Hsin-Yeh Hsieh, Anthony Belenchia, Jessica Klutts, Sally A. Zemmer, Melissa Reynolds, Elizabeth Semkiw, Hwei-Yiing Johnson, Trevor Foley, Chris G. Wieberg, Jeff Wenzel, Marc C. Johnson, Chung-Ho Lin
Summary: Wastewater-based epidemiology is a cost-effective method for tracking COVID-19. This study validated the utility of five population biomarkers for normalizing SARS-CoV-2 loads in wastewater and evaluated their effectiveness in assessing real-time population contributions. The results showed that PARA is the most reliable population biomarker and improves the correlation between SARS-CoV-2 load per capita and case numbers.
Article
Engineering, Environmental
Mohamed Bayati, Hsin-Yeh Hsieh, Shu-Yu Hsu, Chenhui Li, Elizabeth Rogers, Anthony Belenchia, Sally A. Zemmer, Todd Blanc, Cindy LePage, Jessica Klutts, Melissa Reynolds, Elizabeth Semkiw, Hwei-Yiing Johnson, Trevor Foley, Chris G. Wieberg, Jeff Wenzel, Terri Lyddon, Mary LePique, Clayton Rushford, Braxton Salcedo, Kara Young, Madalyn Graham, Reinier Suarez, Anarose Ford, Zhentian Lei, Lloyd Sumner, Brian P. Mooney, Xing Wei, C. Michael Greenlief, Marc C. Johnson, Chung-Ho Lin
Summary: Recent SARS-CoV-2 wastewater-based epidemiology surveillance has found a positive correlation between the number of COVID-19 patients in a sewershed and the level of viral genetic material in the wastewater. However, the variability in viral load among treatment facilities receiving industrial wastewater has made clinical prediction challenging. This study developed a systematic ranking process and metabolomic analysis to identify wastewater treatment facilities exhibiting SARS-CoV-2 suppression, as well as the chemicals suppressing the signals. It was found that certain bioactive compounds in wastewater can significantly reduce the stability of SARS-CoV-2 genetic marker signals.
Article
Cell Biology
Anthony M. Belenchia, Asma Boukhalfa, Vincent G. DeMarco, Alexander Mehm, Abuzar Mahmood, Pei Liu, Yinian Tang, Madhavi P. Gavini, Brian Mooney, Howard H. Chen, Lakshmi Pulakat
Summary: In this study, it was found that the new AT2R agonist NP-6A4 could attenuate heart disease and cardiac damage, increase AT2R expression, activate an 8-protein autophagy network, and improve autophagy marker expression. The protective effects of NP-6A4 were confirmed to act through AT2R. Therefore, NP-6A4 may be an effective drug for treating heart disease induced by obesity and pre-diabetes, especially in young obese women.
Article
Veterinary Sciences
Anthony M. Belenchia, Sarah A. Johnson, Alyssa C. Kieschnick, Cheryl S. Rosenfeld, Catherine A. Peterson
COMPARATIVE MEDICINE
(2017)