30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor and NaCl transport mechanisms in the renal distal nephron

Hypokalemia and Pendrin Induction by AldosteroneNovelty and Significance

(2017) Ning Xu et al.   HYPERTENSION

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4

(2017) Maria Castañeda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases

(2016) Juliette Hadchouel et al.   Annual Review of Physiology

Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3

(2016) Kenichi Ishizawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular K+rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−-dependent and independent mechanisms

(2016) David Penton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Double Knockout of the Na+-Driven Cl−/HCO3−Exchanger and Na+/Cl−Cotransporter Induces Hypokalemia and Volume Depletion

(2016) Anne Sinning et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

(2016) Andrew S. Terker et al.   KIDNEY INTERNATIONAL

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

(2015) Andrew S. Terker et al.   Cell Metabolism

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action

(2015) Ankita Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension

(2015) R. A. Lazelle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport

(2015) A. S. Terker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel  -Subunit

(2015) R. Perrier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of the epithelial Na+channel by the mTORC2/SGK1 pathway

(2015) Florian Lang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

(2015) Dao-Hong Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development

(2015) Sheerazed Boulkroun et al.   Frontiers in Endocrinology

Collecting Duct Principal Cell Transport Processes and Their Regulation

(2014) D. Pearce et al.   Clinical Journal of the American Society of Nephrology

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride

(2014) S. Bazua-Valenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association of Urinary Sodium and Potassium Excretion with Blood Pressure

(2014) Andrew Mente et al.   NEW ENGLAND JOURNAL OF MEDICINE

Urinary serine proteases and activation of ENaC in kidney—implications for physiological renal salt handling and hypertensive disorders with albuminuria

(2014) Per Svenningsen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation

(2014) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Mineralocorticoid Receptor Phosphorylation Regulates Ligand Binding and Renal Response to Volume Depletion and Hyperkalemia

(2013) Shigeru Shibata et al.   Cell Metabolism

Angiotensin Retains Sodium by Dephosphorylating Mineralocorticoid Receptors in Renal Intercalated Cells

(2013) John W. Funder   Cell Metabolism

Renal β-intercalated cells maintain body fluid and electrolyte balance

(2013) Victor Gueutin et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

(2013) Caroline Ronzaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium Transport Is Modulated by p38 Kinase-Dependent Cross-Talk between ENaC and Na,K-ATPase in Collecting Duct Principal Cells

(2013) Y.-B. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overexpression of Pendrin in Intercalated Cells Produces Chloride-Sensitive Hypertension

(2013) T. Jacques et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice

(2013) Mads V. Sorensen et al.   KIDNEY INTERNATIONAL

Regulation of Two Renal Chloride Transporters, AE1 and Pendrin, by Electrolytes and Aldosterone

(2013) Nilufar Mohebbi et al.   PLoS One

Renal intercalated cells are rather energized by a proton than a sodium pump

(2013) R. Chambrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Renal Potassium Secretion: Molecular Mechanisms

(2013) Paul A. Welling   SEMINARS IN NEPHROLOGY

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

Claudins and the Kidney

(2012) Jianghui Hou et al.   Annual Review of Physiology

Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron

(2012) Nils van der Lubbe et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Differential ubiquitylation of the mineralocorticoid receptor is regulated by phosphorylation

(2012) Nourdine Faresse et al.   FASEB JOURNAL

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure

(2012) M. Soleimani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profound hypokalemia and hypochloremic metabolic alkalosis during thiazide therapy in a child with Pendred syndrome

(2011) I. Pela et al.   CLINICAL NEPHROLOGY

Life-threatening metabolic alkalosis in Pendred syndrome

(2011) Narayanan Kandasamy et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

An unfortunate case of Pendred syndrome

(2011) A Sanei-Moghaddam et al.   JOURNAL OF LARYNGOLOGY AND OTOLOGY

Aldosterone Requires Vasopressin V1a Receptors on Intercalated Cells to Mediate Acid-Base Homeostasis

(2011) Y. Izumi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

(2011) Ewout J Hoorn et al.   NATURE MEDICINE

Mineralocorticoid Receptor Mutations Differentially Affect Individual Gene Expression Profiles in Pseudohypoaldosteronism Type 1

(2010) Fábio L. Fernandes-Rosa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

(2010) Françoise Leviel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclin-Dependent Kinase 5 Modulates the Transcriptional Activity of the Mineralocorticoid Receptor and Regulates Expression of Brain-Derived Neurotrophic Factor

(2010) Tomoshige Kino et al.   MOLECULAR ENDOCRINOLOGY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

(2009) P. San-Cristobal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel

(2008) P. Svenningsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY