Article
Dermatology
Vitoria Tonini Porto Ferreira, Gustavo Carlos Silva, Airton Abrahao Martin, Patricia Maria Berardo Goncalves Maia Campos
Summary: This study aimed to evaluate the effects of topical dexpanthenol on the components and physiological parameters of the stratum corneum (SC), and found that its application can increase the fluidity of skin lipids and proteins, maintain proper physiological conditions, and prevent excessive water loss.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Instruments & Instrumentation
Soo Chin Yeoh, Choon Fu Goh
Summary: Salicylates have a long history in pain relief, with salicylic acid and methyl salicylate being widely used for keratolytic and anti-inflammatory actions. This review discusses strategies to enhance skin permeation of these compounds, highlighting the formulations targeting different skin indications and discussing pharmacokinetics and metabolisms of these salicylates. Future perspectives in topical delivery strategies are also discussed for translational considerations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pathology
Eda Yildizhan, Burak Veli Ulger, Murat Akkus, Dilara Akinci, Omer Basol
Summary: This study aimed to compare the efficacy of topical Dexpanthenol and Sucralfate in an experimental wound model in rats, and evaluate their effects on EGF levels. The results showed that both Dexpanthenol and Sucralfate groups were better than the control group in terms of promoting wound healing, but there was no statistically significant difference between these two groups.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Review
Immunology
Audrey Gueniche, Muriel Liboutet, Stephanie Cheilian, Dominique Fagot, Franck Juchaux, Lionel Breton
Summary: Probiotics are defined as live microorganisms that provide health benefits to the host when administered in adequate amounts. Some non-replicative bacterial preparations may retain similar activity to live forms. Vitreoscilla filiformis extract has shown similar biological activity to probiotics and can help improve skin barrier function.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Instruments & Instrumentation
Maria Alice Maciel Tabosa, Magdalena Hoppel, Annette L. Bunge, Richard H. Guy, M. Begona Delgado-Charro
Summary: The study shows that drug clearance from the difficult-to-access compartment in the skin can be inferred from systemic pharmacokinetic data, and is closely related to key physical chemical properties of the drug. A multiple regression analysis was used to determine this relationship and demonstrated that the model predictions correlated well with in vitro skin experiments.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Wang Hee Lee, Jun Gi Rho, Yeyoung Yang, Seulbi Lee, Sohui Kweon, Hyung-Mo Kim, Juhwan Yoon, Hongseo Choi, Eunyoung Lee, Su Ha Kim, Sohee You, Yujin Song, Young Soo Oh, Hwan Kim, Hwa Seung Han, Ji Hye Han, Myeongwoo Jung, Young Hwan Park, Yang Seon Choi, Sukyoung Han, Junho Lee, Sangdun Choi, Jung-Woong Kim, Jae Hyung Park, Eun Kyung Lee, Woo Keun Song, Eunha Kim, Wook Kim
Summary: Hyaluronic acid nanoparticles (HA-NPs) have been identified as a potential topical nanomedicine for effectively and safely treating psoriasis by suppressing immune responses and restoring skin barrier function without causing overt toxicity.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Chemistry, Medicinal
Gebhard Thoma, Rudolf O. Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J. Rudewicz, Hans-Guenter Zerwes
Summary: The JAK kinases JAK1, JAK2, JAK3, and TYK2 play key roles in cytokine signaling and are linked to many immune system-related diseases. Topical administration of JAK inhibitors has been considered to limit their action locally. CEE321, a clinical candidate disclosed here, is a potent pan JAK inhibitor with inhibitory effects on specific biomarkers related to atopic dermatitis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Hope T. Sounouvou, Anna Lechanteur, Geraldine Piel, Brigitte Evrard
Summary: Silicones, particularly polydimethylsiloxane, have been extensively used in the pharmaceutical industry, especially in topical applications. They provide undeniable textural and sensory benefits and contribute to the physicochemical properties, stability, and biopharmaceutical behavior of formulations. However, their synthetic nature and non-biodegradability raise concerns about their environmental impact. This paper explores the challenges in preparing silicone-based drugs and discusses the in vivo behavior of these polymers, as well as the toxicological and environmental risks associated with their application.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biophysics
Marco Fornasier, Francesca Dessi, Rosa Pireddu, Chiara Sinico, Emiliano Carretti, Sergio Murgia
Summary: The encapsulation of natural antioxidants into lipid vesicular gels made by monoolein and sodium taurocholate was studied for topical application. Bile salts were found to affect the phase behavior of monoolein and form suitable drug carriers. Oscillating rheological studies showed that ferulic acid has a structuring effect on the lipid matrix. In vitro experiments on pig skin demonstrated that caffeic acid is mostly retained in the gel while ferulic acid is released to a higher degree.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Infectious Diseases
Matthew Dallo, Kavina Patel, Adelaide A. Hebert
Summary: Topical antibiotics are effective in managing various indications in dermatology, such as acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists need to be familiar with the different types of topical antibiotics, their indications, mechanisms of action, adverse events, and spectra of activity. Antibiotic resistance should also be taken into consideration when prescribing these medications.
Review
Dermatology
R. Oakley, B. W. M. Arents, S. Lawton, S. Danby, C. Surber
Summary: This review emphasizes the therapeutic significance of topical corticosteroid (TCS) vehicles, highlighting their impact on TCS bioavailability. It stresses the importance of research methods and standardization in determining TCS product bioavailability. Additionally, it discusses the need to understand which resources offer information for selecting the best TCS products and why products should be prescribed by brand or manufacturer.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Mingyue Cui, Christian Wiraja, Sharon Wan Ting Chew, Chenjie Xu
Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Mar Calzado-Delgado, M. Olga Guerrero-Perez, King Lun Yeung
Summary: The article describes two drug delivery systems for topical administration of vitamin C. The electrospun PVA nanofiber carrier releases vitamin C in bursts, while the PVA nanofiber-molecular capsule delivers vitamin C at a constant rate. Both systems protect vitamin C and provide increased heat stability.
Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)