Article
Biochemistry & Molecular Biology
Hari Naga Prasada Reddy Chittireddy, J. V. Shanmukha Kumar, Anuradha Bhimireddy, Mohammed Rafi Shaik, Althaf Hussain Shaik, Abdulrahman Alwarthan, Baji Shaik
Summary: Cross contamination of beta-lactams in pharmaceutical products is a high risk for patients. A highly sensitive UHPLC-MS/MS method was developed for the detection of trace contamination of Cephapirin and Ceftiofur. This method is important for monitoring cross contamination in facility surfaces and determining acceptable limits for regulatory purposes.
Article
Veterinary Sciences
Edgar Alfonseca-Silva, Juan Carlos Cruz-Villa, Lilia Gutierrez, Hector Sumano
Summary: The study assessed the bacteriological and clinical cure-efficacies of sequentially intramammary administration of enro-C followed by ceftiofur HCl in treating recurrent subclinical mastitis in Holstein/Friesian cows. Results showed that outstanding clinical and bacteriological cure rates were achieved in cows affected by RScM with this approach.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Anri Timonen, Marju Sammul, Suvi Taponen, Tanel Kaart, Kerli Motus, Piret Kalmus
Summary: This study investigated the usage of antimicrobial drugs in cows with clinical mastitis in large dairy herds in Estonia. The findings revealed that different treatment methods and drugs could impact the outcome of the treatment, and further research is needed to understand the factors that influence veterinarians' choices.
Review
Veterinary Sciences
Pamela L. Ruegg
Summary: Treatment of clinical mastitis with antimicrobials is common in adult dairy cows, but few studies have assessed clinical outcomes. Somatic cell count is an important indicator, while differences among approved therapies are minimal.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
T. Tomazi, M. Sumnicht, A. C. C. H. Tomazi, J. C. C. Silva, L. Bringhenti, L. M. Duarte, M. M. M. Silva, M. X. Rodrigues, R. C. Bicalho
Summary: The study evaluated the effect of different intramammary antibiotic interventions on cure rates of clinical mastitis caused by gram-positive bacteria. It found that ceftiofur hydrochloride treatment had better clinical cure rates compared to amoxicillin treatment. Quarters in the negative control group had higher cfu counts compared to antibiotic-treated groups post-enrollment.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Infectious Diseases
Stefan Borchardt, Wolfgang Heuwieser
Summary: The study compared immediate intramammary antimicrobial treatment of mild and moderate clinical mastitis with a selective treatment protocol based on on-farm culture results. The results showed that implementing a pathogen-based treatment protocol for these cases can effectively reduce antimicrobial use without negative effects on cow health.
Article
Infectious Diseases
Franziska Preine, Demetrio Herrera, Christian Scherpenzeel, Piret Kalmus, Finola McCoy, Sebastian Smulski, Paivi Rajala-Schultz, Anne Schmenger, Paolo Moroni, Volker Kromker
Summary: This study compares the therapeutic approaches for mastitis treatment in lactation in different European countries. Veterinarians make the treatment decisions and farm personnel are responsible for treatment administration. Penicillin is increasingly becoming the first-choice drug for mastitis treatment. The use of critically important antimicrobials is limited in some countries. Monitoring systems for antibiotic use are being introduced in more countries. The exchange of different views can help European countries move towards a common high standard of antimicrobial stewardship in veterinary medicine.
Article
Infectious Diseases
Sofie Rutjens, Nick Vereecke, Ward De Spiegelaere, Siska Croubels, Mathias Devreese
Summary: Optimizing antimicrobial treatment during bacterial infections in livestock requires a deep understanding of the impact of such treatment on the pathogen and commensal microbiota. This study investigated the excretion of ceftiofur and cefquinome in the gut and feces of pigs after intramuscular administration. The findings provide valuable information on the gut excretion of these antimicrobials.
Review
Agriculture, Dairy & Animal Science
Ellen de Jong, Kayley D. McCubbin, David Speksnijder, Simon Dufour, John R. Middleton, Pamela L. Ruegg, Theo J. G. M. Lam, David F. Kelton, Scott McDougall, Sandra M. Godden, Alfonso Lago, Paeivi J. Rajala-Schultz, Karin Orsel, Sarne De Vliegher, Volker Kromker, Diego B. Nobrega, John P. Kastelic, Herman W. Barkema
Summary: The treatment of clinical mastitis (CM) and the use of antimicrobials for dry cow therapy account for a large amount of antimicrobial use (AMU) on dairy farms. However, recent advancements have allowed for the exclusion of nonsevere CM cases that are likely to be cured without antimicrobials, as well as cases with a low bacteriological cure rate. These advancements include the availability of rapid diagnostic tests and improved udder health management practices. This review provides an evidence-based protocol for selective CM treatment decisions, which can aid in reducing AMU, improving udder health, and benefiting farm economics.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Infectious Diseases
Jensine Wilm, Line Svennesen, Esben Ostergaard Eriksen, Tariq Halasa, Volker Kromker
Summary: The study investigated the treatment approach of Danish veterinarians towards clinical mastitis, finding that it generally involves systemic and intramammary antibiotic administration along with supportive nonsteroidal anti-inflammatory drugs. Challenges were identified in targeting treatment towards pathogens due to delays in current analysis practices, leading veterinarians to start treatment immediately rather than waiting for test results. Recommendations for improvement include encouraging rapid pathogen determination methods to target treatments effectively and potentially reducing combined antibiotic administration in specific cases.
Article
Microbiology
Isabel Krebs, Yanchao Zhang, Nicole Wente, Stefanie Leimbach, Volker Kromker
Summary: This study investigated factors associated with the severity of clinical mastitis (CM). The most common pathogens isolated were Escherichia coli and Streptococcus spp. High pathogen shedding, low previous somatic cell count (SCC), high outside temperature, and high humidity were associated with severe mastitis.
Article
Agriculture, Dairy & Animal Science
Ashok Boora, Sarita Yadav, Parvina Devi, Kunwar Pal Singh, Pawanjit Singh Cheema, Vijay Muley, Virender Sehrawat, Ketan Dhamanaskar, Inderjeet Singh
Summary: The study aimed to evaluate the efficacy of Ceftiofur hydrochloride intramammary formulation in treating lactation clinical mastitis, and found that the treatment group showed better results in terms of bacteriological, clinical, and pathogen cure compared to the control group.
Article
Agriculture, Dairy & Animal Science
Joaquin Barca, Ynte H. Schukken, Ana Meikle, Pablo Chilibroste, Mette Bouman, H. Hogeveen
Summary: This randomized controlled trial examined the effects of pegbovigrastim (PEG) treatment on the partial net return of grazing dairy cows. The study found that PEG treatment increased the partial net return and resulted in an economic benefit of $210 ± $100 per cow per year. It also reduced the cost of treatment for clinical mastitis and numerically reduced the cost of culling.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Microbiology
Frederik Fredebeul-Krein, Anne Schmenger, Nicole Wente, Yanchao Zhang, Volker Kroemker
Summary: Severe mastitis can cause significant damage to the general condition of cows, even leading to sepsis and death. This study identified coliform bacteria and increasing pathogen shedding as factors associated with the severity of mastitis. Additionally, lactation stages and previous diseases prior to mastitis were found to be related to the progression of severe mastitis in cows. Understanding these risk factors can serve as a basis for further research on the exact influence they have on mastitis severity.
Article
Agriculture, Multidisciplinary
Rodrigo Garcia Motta, Lorrayne de Souza Araujo Martins, Antonio Campanha Martinez, Rogerio Giuffrida, Marcio Garcia Ribeiro
Summary: This study investigated the efficacy of intramammary ceftiofur in the treatment of staphylococcal subclinical mastitis in primiparous cows. The results showed that early lactation treatment with intramammary ceftiofur resulted in a microbiological cure rate of 73.3%. The study also found that cloxacillin, penicillin, and tetracycline had poor antimicrobial activity against staphylococci.
SEMINA-CIENCIAS AGRARIAS
(2022)