Journal
JOURNAL OF CYSTIC FIBROSIS
Volume 16, Issue 6, Pages 702-708Publisher
ELSEVIER
DOI: 10.1016/j.jcf.2017.03.004
Keywords
Cystic fibrosis; Prognostic factors; Registry data; Logistic model; Prognostic score
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Funding
- Vaincre La Mucoviscidose Association
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Background: Therapeutic progress in patients with cystic fibrosis (CF) has resulted in improved prognosis over the past decades. We aim to reevaluate prognostic factors of CF and provide a prognostic score to predict the risk of death or lung transplantation (LT) within a 3-year period in adult patients. Methods: We developed a logistic model using data from the French CF Registry and combined the coefficients into a prognostic score. The discriminative abilities of the model and the prognostic score were assessed by c-statistic. The prognostic score was validated using a 10-fold cross validation. Results: The risk of death or LT within 3 years was related to eight characteristics. The development and the validation provided excellent results for the prognostic score; the c-statistic was 0.91 and 0.90 respectively. Conclusion: The score developed to predict 3-year death or LT in adults with CF might be useful for clinicians to identify patients requiring specialized evaluation for LT. (C) 2017 The Authors. Published by Elsevier B.V.
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