Article
Pharmacology & Pharmacy
Apoorva Panda, Abhishek Shettar, Purnendu Kumar Sharma, Michael A. Repka, S. Narasimha Murthy
Summary: Micro needles are explored for dermal delivery of macromolecules such as enzymes like lysozyme, with different polymers showing varying release rates and stability effects on the trapped enzyme. Structure strength, release profiles, and stability assessments were conducted to evaluate the potential of using polymeric micro needles for dermal applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Alejandro B. Rodriguez-Navarro, Christian Grenier, Antonio G. Checa, Concepcion Jimenez-Lopez, Purificacion Sanchez-Sanchez, Diego Bertone, Nelson A. Lagos
Summary: This study provides a detailed analysis of the micro-nano-structure of giant barnacle shells and the interaction between the organic matrix and the mineral component. It reveals that incorporating organic matter into the mineral influences the morphology and orientation of calcite crystals, inducing isotropic straining of the calcite crystal lattice. Insoluble organic matrices primarily consist of chitin-rich membranes that promote the nucleation of calcite crystals, while soluble organic matter composed of proteins and polysaccharides affects calcium carbonate precipitation, leading to the formation of calcite with modified morphology.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Crystallography
Petya P. Elenska, Ivaylo L. Dimitrov
Summary: The study explores lysozyme crystallization under various conditions and suggests that lower supersaturation solutions may produce denser crystal populations. Higher supersaturation can still lead to earlier nucleation, and rapid decrease in solution temperature may impact pre-crystallization protein-protein interactions, affecting the formation of clusters that act as active centers for nucleation. The findings indicate a strong influence of sharp temperature variation on lysozyme crystal nucleation in systems with relatively low final supersaturation.
Article
Chemistry, Multidisciplinary
Zemin Zhang, Florian Vogelbacher, Jianbo De, Yang Wang, Qing Liao, Yang Tian, Yanlin Song, Mingzhu Li
Summary: Solution-processed, surface-patterned perovskite single-crystal microdisk lasers with high crystal quality and improved emission directionality were successfully synthesized using spin-coating and nanoimprinting techniques. These lasers have a low lasing threshold and high quality factor, making them promising for advanced nanophotonic designs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Zakariae Amghouz, Rafael Mendoza-Merono, Alaa Adawy
Summary: This paper reports the crystallization of single α-TiP crystals through prolonged hydrothermal treatment of a metallic titanium alloy in a highly concentrated phosphoric acid solution. The crystalline structure of the obtained crystals was analyzed and their properties were investigated. The results showed that the α-TiP crystals have a monoclinic structure and exhibit higher thermal stability.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Pathum Chandika, Pipuni Tennakoon, Tae-Hee Kim, Se-Chang Kim, Jae-Young Je, Jae-Il Kim, Bonggi Lee, BoMi Ryu, Hyun Wook Kang, Hyun-Woo Kim, Young-Mog Kim, Chang Su Kim, Il-Whan Choi, Won Sun Park, Myunggi Yi, Won-Kyo Jung
Summary: Coagulation is a defense mechanism that prevents bleeding, but excessive clot formation can lead to serious diseases. The use of anticoagulants like heparin is limited, so there is interest in studying natural anticoagulants from marine sources.
Article
Engineering, Chemical
Siyu Pu, Kunn Hadinoto
Summary: The development of a segmented slug flow crystallizer (SFC) design improved the reproducibility of crystal size distribution by limiting the formation of small crystals and large agglomerates, resulting in the production of lysozyme crystals with well-preserved bioactivity.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Chemistry, Physical
Xiaobing Ding, Yukai Zhang, Fang Sheng, Yanqing Li, Lili Zhi, Xiaobing Cao, Xian Cui, Daming Zhuang, Jinquan Wei
Summary: The study successfully prepared high-quality all-inorganic perovskite films from all aqueous solutions, achieving a higher efficiency for perovskite solar cells. This method is simple and environmentally friendly, providing a solution to eliminate solvent toxicity from organic solvents in the fabrication process.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Multidisciplinary Sciences
Syou Maki, Masayuki Hagiwara
Summary: We have developed a new type of compact magnetic force booster that can levitate protein crystals in a solution without contact. By controlling the magnetic field, we were able to control the growth of crystals from the initial nucleation stage. The shape of the booster was designed to ensure stability against external forces and resulted in spherical condensation and shell-shaped crystals. This technique has great potential for innovation in protein crystal engineering.
SCIENTIFIC REPORTS
(2022)
Article
Crystallography
M. Longo, R. J. Heigl, T. E. Schrader
Summary: The isothermal crystallization kinetics of hen-egg-white Lysozyme was investigated through a time-resolved neutron diffraction experiment, observing the temporal evolution of Bragg peaks and analyzing small angle neutron scattering curves. A correlated behavior between Lysozyme concentration decrease and crystallization fraction increase was observed, with parameters compatible with previous studies. The use of constant neutron flux highlighted the strength of neutrons in studying biological samples without radiation damage.
JOURNAL OF CRYSTAL GROWTH
(2021)
Article
Chemistry, Multidisciplinary
Moo Sun Hong, Amos E. Lu, Jaehan Bae, Jong Min Lee, Richard D. Braatz
Summary: This article describes a droplet-based evaporative system for evaluating protein crystallization conditions and kinetics, demonstrating successful prediction of crystallization kinetics through accurate control of temperature and humidity, fast and accurate image analysis, and estimation based on experimental data. The estimated kinetics are suitable for the model-based design and control of protein crystallization processes.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Multidisciplinary Sciences
Xiaofang Jia, Jingwen Song, Wenyan Lv, Jonathan P. Hill, Jun Nakanishi, Katsuhiko Ariga
Summary: This study reports how human mesenchymal stem cells rapidly adapt to dynamic microenvironment through lipid raft microdomains in the plasma membrane that drive neurogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Denise Maria Figueiredo Araujo, Iranildo Jose da Cruz Filho, Tiago Santos, Daniel Tarciso Martins Pereira, Diego Santa Clara Marques, Alice da Conceicao Alves de Lima, Thiago Mendonca de Aquino, George Jackson de Moraes Rocha, Maria do Carmo Alves de Lima, Fatima Nogueira
Summary: In this study, alkaline lignins extracted from Buchenavia viridiflora, a tree species from the Amazon rainforest, were investigated for their different biological activities. The lignins showed antioxidant, anti-inflammatory, anti-tumor, and antiparasitic activities, with low cytotoxicity. These findings suggest the potential pharmaceutical and biomedical applications of the lignins studied.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
K. Vasanth Kumar, Kiran A. Ramisetty, K. Renuka Devi, Gamidi Rama Krishna, Claire Heffernan, Andrew A. Stewart, Jian Guo, Srinivas Gadipelli, Dan J. L. Brett, Evangelos P. Favvas, Ake C. Rasmuson
Summary: Crystallization experiments on highly supercooled solutions produced highly pure and crystalline mesocrystals of curcumin, exhibiting a crystallographic hierarchy. The formation of spherulites is attributed to the high degree of supercooling and particle-mediated crystallization is proposed as an efficient method for organic compound purification.
Article
Chemistry, Multidisciplinary
Siyu Chen, Lin Zhu, Bingwen Zhang, Shu-Na Yun, Jinyi Wang, Mao-Sen Yuan
Summary: Two pyridine-substituted fluorenone compounds with extraordinary crystal-growth capacity were discovered, which can directly and quickly form single crystals under antisolvent-assistance conditions; the results indicate that multiple intermolecular hydrogen-bonding sites and planar aromatic structure dominate the mass transfer during crystal growth.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Physical
Johannes Hoffmann, James Flannigan, Andrew Cashmore, Maria L. Briuglia, Rene R. E. Steendam, Charline J. J. Gerard, Mark D. Haw, Jan Sefcik, Joop H. ter Horst
Summary: Controlling particle formation in industrial crystallization processes is still a challenge. Secondary nucleation is identified as the dominant nucleation mechanism, and enantioselective secondary nucleation can be used to control the chirality of the product, making antisolvent crystallization a viable crystallization-enhanced deracemization technique.
FARADAY DISCUSSIONS
(2022)
Article
Chemistry, Physical
Ruel Cedeno, Romain Grossier, Mehdi Lagaize, David Nerini, Nadine Candoni, Adrian Flood, Stephane Veesler
Summary: This study presents a novel approach for measuring and analyzing induction times in arrays of microdroplets. By controlling relative humidity, interference between microdroplets can be eliminated. Statistical analysis shows that the dimensionless induction times obtained from different datasets obey the same distribution, confirming the effect of confinement. The experimental method and data-treatment procedure presented in this study offer promising routes in the study of nucleation kinetics.
FARADAY DISCUSSIONS
(2022)
Article
Medicine, Research & Experimental
Jean A. Boutin
M S-MEDECINE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alicia Schirer, Anne Rouch, Estelle Marcheteau, Johann Stojko, Sophie Landron, Elodie Jeantet, Benjamin Fould, Gilles Ferry, Jean A. Boutin
Summary: The study provides a detailed method for labeling target proteins in cells using mutant ligase, revealing challenges such as difficulty in evaluating the click chemistry step in living cells and suggesting the preferred use of the Halo-Tag technique for clearer protein imaging in cellular context.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Charline J. J. Gerard, Maria L. Briuglia, Nazer Rajoub, Teresa F. Mastropietro, Wenqian Chen, Jerry Y. Y. Heng, Gianluca Di Profio, Joop H. ter Horst
Summary: A method to determine protein template crystallization behavior has been presented and validated through experiments. The use of silica particles has been shown to enhance crystallization and nucleation rate, highlighting the importance of template particle characteristics in promoting protein crystallization.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stephane Veesler
Summary: The presence of concentration and temperature gradients in saline microdroplets evaporating in air makes them unsuitable for nucleation studies. However, immersing the droplet in oil and reducing the volume can address this issue. In this study, a model for evaporation dynamics of microdroplets in a thin layer of oil was presented. The model takes into account the diffusion distance, solute concentration, and diffusive interaction between neighboring droplets. Experimental data showed that neglecting diffusive interactions can lead to inaccurate droplet concentration measurement in nucleation experiments.
Article
Biochemistry & Molecular Biology
Jean A. Boutin, Stephane Bedut, Magali Jullian, Mathieu Galibert, Lukasz Frankiewicz, Philippe Gloanec, Gilles Ferry, Karine Puget, Jerome Leprince
Summary: PMCAs are a family of transmembrane proteins responsible for calcium homeostasis and possibly linked to certain diseases. Through studying the functionality of PMCAs, a series of new peptide inhibitors with IC50 in the low mu M range have been discovered.
Article
Biochemistry & Molecular Biology
Celine Legros, Anne Rojas, Clemence Dupre, Chantal Brasseur, Isabelle Riest-Fery, Olivier Muller, Jean-Claude Ortuno, Olivier Nosjean, Sophie-Penelope Guenin, Gilles Ferry, Jean A. Boutin
Summary: D3/D2 sub-specificity is a complex problem to solve due to the lack of easy structural biology of G-protein coupled receptors. This study used directed mutagenesis and basic binding experiments to explore a rational approach for the discovery of highly specific D3 ligands over D2 ligands. Stable expression of receptors in HEK cells was used to construct mutants and chimeras of D2 and D3 receptors, and their binding characteristics were analyzed using standard binding conditions. The study demonstrated the feasibility and potential of the approach.
Article
Biotechnology & Applied Microbiology
Sophie Maria, Laurent Bonneau, Benjamin Fould, Gilles Ferry, Jean Albert Boutin, Charlotte Cabanne, Xavier Santarelli, Gilles Joucla
Summary: In this study, three culture methods were compared to determine the perfusion process parameters for a CHO cell line producing a monoclonal antibody. The push-to-low (PTL) and perfusion-without-bleeding (PWB) methods resulted in lower CSPRmin estimations, suggesting a three-step approach to determine the perfusion parameters.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stephane Veesler
Summary: In this study, we present the first stochastic treatment of NaCl-water nucleation kinetics using a recently developed microfluidic system and evaporation model. Our experimental results show an excellent agreement between the measured interfacial energies, extracted from a modified Poisson distribution of nucleation time, and theoretical predictions. Additionally, our analysis of nucleation parameters in microdroplets of different sizes reveals an interesting interplay between kinetic confinement and shifting of nucleation mechanisms. Overall, our findings emphasize the importance of treating nucleation stochastically rather than deterministically to bridge the gap between theory and experiment.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Review
Biochemistry & Molecular Biology
J. A. Boutin, D. J. Kennaway, R. Jockers
Summary: Since its discovery in 1958, melatonin has been a topic of great interest for scientists. Recently, the focus has shifted from studying its natural role in regulating biological time to exploring its potential roles in various clinical conditions. While there is extensive literature supporting the positive effects of high doses of melatonin, there are also limitations and flaws in the experimental evidence. This review aims to provide a critical analysis of the existing literature and encourage further reflection and research on the true capabilities of melatonin.
Article
Crystallography
Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoit Robert, Nadine Candoni, Stephane Veesler
Summary: This paper presents a newly developed modular microfluidic platform for crystallisation studies without use of surfactants. By dissolving a powder, the set-up generates saturated solutions that can be used for solubility measurements or distributed in microdroplets. The cooling rate influences both nucleation and polymorphism results, reflecting the competition between thermodynamics and kinetics.
JOURNAL OF CRYSTAL GROWTH
(2023)
Article
Clinical Neurology
Maeva Vallucci, Jean A. Boutin, Elzbieta Janda, Florence Blandel, Ruth Musgrove, Donato Di Monte, Gilles Ferry, Patrick P. Michel, Etienne C. Hirsch
Summary: Evidence suggests that NQO2 is expressed in dopaminergic neurons and its inhibitor, S29434, has a role in reducing toxicity induced by MPTP, but does not show robust protective activity in a mouse model of MPTP-induced neurodegeneration.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biochemical Research Methods
Nazer Rajoub, Charline J. J. Gerard, Elvira Pantuso, Enrica Fontananova, Rocco Caliandro, Benny D. Belviso, Efrem Curcio, Fiore P. Nicoletta, James Pullen, Wenqian Chen, Jerry Y. Y. Heng, Sean Ruane, John Liddell, Natalie Alvey, Joop H. ter Horst, Gianluca Di Profio
Summary: This study investigates the use of template-assisted membrane crystallization for purifying monoclonal antibodies, replacing the protein A affinity stage in traditional chromatography-based purification. By using crystallization with templates attached to a membrane, protein purification can be achieved in a more cost-effective and environmentally sustainable manner.
Article
Chemistry, Multidisciplinary
Ruel Cedeno, Romain Grossier, Nadine Candoni, Stephane Veesler
Summary: This study presents a rapid microfluidic technique for measuring the aqueous solubility of metastable phases. By analyzing the dissolution behavior of crystals in contact with supersaturated microdroplets, and with the help of nucleation time measurement technique and calculation of interfacial energies, the interfacial energies of both the metastable and stable phases were accessed. Classical Nucleation Theory was used to model the competition of polymorphs, and the results were in good agreement with observations and experimental reports.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Crystallography
Jianzheng Hu, Long Yan, Ning Zhou, Yao Chen, Xiaoni Yang, Lianqiao Yang, Shiping Guo
Summary: The effect and mechanism of carrier gas velocity, V/III ratio, and carrier gas velocity match on the growth rate of AlN were investigated in this study. The results showed that the growth rate of AlN initially increased with hydrogen flow rate, reached saturation, and then decreased monotonically. The turning point value depended on the equipment and process. By increasing the MO VM, the growth rate of AlN could be improved, but the uniformity deteriorated due to turbulence and loss of uniform boundary layer. High quality AlN films were successfully grown on nano-patterned sapphire substrates with improved crystalline quality and atomic smooth surfaces.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Tingting Ma, Yang Li, Kangning Sun, Qinglin Cheng, Sen Li
Summary: This study investigates the melting process and nucleation behavior of sodium crystals using molecular dynamics simulation. The results show good agreement between simulated and experimental values for the melting temperature, density, and radial distribution function of sodium. The diffusion coefficient of liquid sodium increases linearly with temperature, and the homogeneous nucleation rate of melting in superheated sodium crystal exponentially increases with temperature. The findings provide theoretical support for applications involving heat and mass transfer in sodium-related systems.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Hisato Nishii, Shintarou Iida, Akira Yamasaki, Takumi Ikenoue, Masao Miyake, Toshiya Doi, Tetsuji Hirato
Summary: Epitaxial V2O3 films were fabricated on sapphire substrates using mist chemical vapor deposition (mist CVD) method, eliminating the need for high vacuum conditions. The films can be grown on sapphire substrates even under atmospheric pressure, with the optimal growth temperature at 823 K. The films grown at 823 K exhibit a metal-insulator transition at approximately 155 K. The film on C-plane sapphire exhibits a lower transition temperature compared to those on R- and A-plane sapphire substrates.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Jani Jesenovec, Kevin Zawilski, Peter Alison, Stephan J. Meschter, Sambit K. Saha, Andrew J. Sepelak, Peter G. Schunemann
Summary: In this study, NiSb needles were successfully formed in InSb by manipulating the growth rate and adding NiSb. These needle structures in InSb can be used to tune the magnetoresistance of devices. Additionally, undoped InSb crystals demonstrated good infrared transmission at low growth rates.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
D. Joseph Daniel, P. Karuppasamy, H. J. Kim
Summary: The 2-amino 4-methyl pyridinium oxalate (2A4MPO) compound was synthesized and its crystal structure, functional groups, thermal stability, electrical properties, and third-order nonlinear optical properties were studied. The results demonstrate that the synthesized crystal has good structural integrity, thermal stability, and potential for third-order nonlinear optical applications.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
C. W. Lan
Summary: The past two decades have witnessed a significant transformation in solar silicon crystal growth, especially in the competition between multi-crystalline silicon (Multi-Si) and mono-crystalline silicon (Mono-Si). The demand for this crucial material has exponentially surged, with silicon solar panels capturing over 95% of the global PV market share. The advancements in crystal growth technology during this period have set historical benchmarks, with the market share shifting from high-performance multi-crystalline silicon (HPM-Si) to CZ silicon.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Peiyao Hao, Lili Zheng, Hui Zhang
Summary: A novel design of argon gas tube for removing impurities during silicon ingot growth was developed, and numerical simulations showed that it can effectively extract SiO.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Geetika Sahu, Chanchal Chakraborty, Subhadeep Roy, Souri Banerjee
Summary: This article discusses the novel fractal nature of hydrothermally synthesized MoS2 QDs. By adjusting the reaction time, the study found that the average size of QDs increases and then decreases with longer reaction times. STEM images indicate that shorter reaction times lead to sheet formation, while extended reaction times cause sheets to fragment into QDs.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Pengjian Lu, Wei Huang, Junjun Wang, Haitao Yang, Shiyue Guo, Bin Li, Ting Wang, Chitengfei Zhang, Rong Tu, Song Zhang
Summary: A systematic study on the tetramethylsilane-hydorgen (TMS-H-2) system for the deposition of pure single-crystal SiC by high-temperature chemical vapor deposition (HTCVD) method is conducted. The study investigates the effect of temperature, pressure, and H-2:TMS ratio on the deposition conditions and provides a theoretical basis and guidance for improving the quality and cost of industrial production of single-crystal SiC.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Xinyu Jiang, Liangliang Liu, Yanqing Liu, Yan Wang, Zhaoping Hou
Summary: Investigation on the preparation of anisometric templated textured high entropy or multi-element doped ferroelectric ceramics was conducted using A-site disordered niobate microcrystals. The effects of process parameters on the morphology and chemical composition were studied, and the photocatalytic properties of the microcrystals were evaluated.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Mobashsara Tabassum, Md. Ashraful Alam, Sabrina Mostofa, Raton Kumar Bishwas, Debasish Sarkar, Shirin Akter Jahan
Summary: In this study, high crystallinity copper nanoparticles were synthesized by altering the reaction medium at low temperatures. The results show that changing the reaction medium can reduce the surface energy of precursors and promote the formation of highly crystalline copper nanoparticles.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Ivan Bodnar, Vitaly V. Khoroshko, Veronika A. Yashchuk, Valery F. Gremenok, Mohsin Kazi, Mayeen U. Khandaker, Tatiana I. Zubar, Daria I. Tishkevich, Alex Trukhanov, Sergei Trukhanov
Summary: This work presents the production of single crystals of Cu2ZnGeSe4, a semiconducting quaternary compound, using a gas chemical method with iodine as a transporter. The phase state, crystal structure, and lattice constants of the synthesized samples were refined and determined. The band gap of Cu2ZnGeSe4 was calculated using transmission spectrum and it was found that the band gap increases by 12% with decreasing temperature in the range of 20-300 K.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Timur Malin, Igor Osinnykh, Vladimir Mansurov, Dmitriy Protasov, Sergey Ponomarev, Denis Milakhin, Konstantin Zhuravlev
Summary: The effect of growth temperature on the buffer leakage currents of GaN-on-Si layers was investigated. It was found that higher growth temperature results in lower leakage currents. The defects in GaN layers grown at different temperatures were studied using photoluminescence technique, and a correlation between leakage currents, structural perfection, and donor concentration in GaN-on-Si layers was established. It was also observed that reduced growth temperature leads to the formation of inversion domains.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Thi-Hoai-Thu Nguyen, Jyh-Chen Chen
Summary: The effect of heater power control on heat, flow, and oxygen transport for CCz crystal growth was studied. Shorter upper side heater design could improve crystal quality and growth, but with higher power consumption.
JOURNAL OF CRYSTAL GROWTH
(2024)
Article
Crystallography
Peter Rudolph
Summary: This article presents an overview of selected contributions to the development of crystal growth technology by the Laudise Prize awardee 2023. It discusses various aspects such as shaped crystal growth, the correlation between melt structure and crystal quality, control of intrinsic defects and inclusions, prevention of dislocation cell patterns, and melt growth experiments under a travelling magnetic field.
JOURNAL OF CRYSTAL GROWTH
(2024)