Review
Nutrition & Dietetics
Luca Dalle Carbonare, Monica Mottes, Maria Teresa Valenti
Summary: Osteonecrosis of the jaw is a severe clinical condition characterized by exposed bone that does not heal over time. Diagnosis is primarily clinical with imaging feedback playing a confirmatory role. Medication-related osteonecrosis of the jaw, particularly induced by bisphosphonates, has been widely discussed, but the exact mechanism remains debatable.
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Article
Medicine, General & Internal
Gianluca Colapinto, Funda Goker, Riccardo Nocini, Massimo Albanese, Pier Francesco Nocini, Salvatore Sembronio, Francesca Argenta, Massimo Robiony, Massimo Del Fabbro
Summary: The aim of this randomized study was to evaluate the effect of pentoxifylline and tocopherol in patients that had developed MRONJ after tooth extractions. The study showed that patients who received pharmacological treatment had better mucosal healing after 1 month and clinical and radiographic healing of the bone lesion after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
A. Cerrato, G. Zanette, M. Boccuto, A. Angelini, M. Valente, C. Bacci
Summary: In 2014, the AAOMS changed the term from BRONJ to MRONJ due to the increasing number of osteonecrosis cases associated with different antiresorptive and antiangiogenic therapies. Actinomyces infection is commonly encountered in MRONJ cases, presenting a wide spectrum of clinical manifestations.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Pharmacology & Pharmacy
M. Dioguardi, M. DI Cosola, C. Copelli, S. Cantore, C. Quarta, G. Nitsch, D. Sovereto, F. Spirito, G. A. Caloro, A. P. Cazzolla, R. Aiuto, E. Cascardi, A. greco Lucchina, L. LO Muzio, A. Ballini, F. Mastrangelo
Summary: Bisphosphonates, commonly used anti-resorptive medications, inhibit osteoclast activity by disrupting the macrophage colony-stimulating factor pathway. Oral surgery in patients undergoing bisphosphonate therapy carries a high risk of developing osteonecrosis of the jaws.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Maria Helde Frankling, Caritha Klasson, Linda Bjoerkhem-Bergman
Summary: The purpose of this study was to explore the levels of 25-hydroxyvitamin D (25-OHD) in patients with palliative cancer care. The results showed that supplementation with vitamin D led to a significant increase in 25-OHD levels, regardless of season, age, tumor type, or colectomy.
Article
Chemistry, Multidisciplinary
Salvatore D'Amato, Antonio Troiano, Giorgio Lo Giudice, Davide De Cicco, Mario Rusciano, Gianpaolo Tartaro, Giuseppe Colella
Summary: Surgical resection showed higher complete healing cases and statistically significant difference in recurrence rate compared to debridement. Debridement is an unfavorable prognostic factor when compared to surgical resection, with a 4.9 times higher risk of recurrence. Quality of life mean values improved significantly in the surgical resection group and slightly in the debridement group.
APPLIED SCIENCES-BASEL
(2021)
Review
Medicine, General & Internal
Hemil Dario Rosales, Henry Garcia Guevara, Stefania Requejo, Maria Dianella Jensen, Julio Acero, Sergio Olate
Summary: This study analyzed medication-related osteonecrosis of the jaw (MRONJ) in children and young patients, and its relation with oral surgery. The study found a low presence of MRONJ in children and young patients treated with antiresorptive drugs. Data collection was weak, and details of therapy were not clear in most of the included articles.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Kun-Jung Hsu, Szu-Yu Hsiao, Ping-Ho Chen, Han-Sheng Chen, Chun-Ming Chen
Summary: The study investigated maxillary MRONJ in elderly patients through a meta-analysis, revealing specific characteristics such as female-to-male ratio, average age, and clinical efficacy of surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Oliver Ristow, Thomas Rueckschloss, Julius Moratin, Michael Mueller, Reinald Kuehle, Horn Dominik, Maximilian Pilz, Veronika Shavlokhova, Sven Otto, Jurgen Hoffmann, Christian Freudlsperger
Summary: The study showed that the sub-periosteal prepared mucoperiosteal flap had a significantly higher success rate than the epi-periosteal prepared mucosa flap for patients undergoing antiresorptive treatment. Additionally, the high number of necrotic biopsies highlighted the importance of alveoplasty as a preventive measure.
Article
Endocrinology & Metabolism
Takahiro Kunihara, Hidetoshi Tohmori, Manabu Tsukamoto, Masashi Kobayashi, Toshiya Okumura, Hidefumi Teramoto, Takahiko Hamasaki, Takuma Yamasaki, Tsuyoshi Nakagawa, Nobukazu Okimoto, Saeko Fujiwara
Summary: We investigated the incidence and trend of osteonecrosis of the jaw caused by antiresorptive agent dose in Kure city, Japan over a 5-year period. The results showed that the incidence of osteonecrosis of the jaw was 24 times higher among osteoporosis patients with low-dose agents and 421 times higher among cancer patients with high-dose agents compared to the general population without agents.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Oncology
Christian Bacci, Alessia Cerrato, Elisa Bardhi, Anna Chiara Frigo, Selma Ahcene Djaballah, Stefano Sivolella
Summary: This study assessed the efficacy of different preventive dental visits and treatments in reducing the risk of medication-related osteonecrosis of the jaws (MRONJ). The results indicated that compliance with specialist recommendations can reduce the risk of MRONJ for patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Ann-Kristin Struckmeier, Falk Wehrhan, Raimund Preidl, Melanie Mike, Tina Moench, Lea Eilers, Jutta Ries, Leah Trumet, Rainer Lutz, Carol Geppert, Marco Kesting, Manuel Weber
Summary: The aim of this study was to compare macrophage populations in the craniofacial and extracranial skeleton and investigate the changes induced by Zol application and surgical interventions. The results showed that there were significantly more macrophages and a heightened pro-inflammatory environment in the jaw bones compared to the tibia. Tooth extraction increased the number of macrophages and worsened the inflammatory environment in the jaw bones, which was amplified by Zol application. The study suggests that targeting macrophages could be an attractive strategy to prevent MRONJ.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
N. Heim, A. Faron, J. Fuchs, M. Martini, R. H. Reich, K. Loeffler
Article
Dentistry, Oral Surgery & Medicine
Nils Heim, Anton Faron, Valentin Wiedemeyer, Rudolf Reich, Markus Martini
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Markus Martini, Andreas Roehrig, Rudolf Hermann Reich, Martina Messing-Juenger
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Markus Martini, Anne Klausing, Martina Messing-Juenger, Guido Luechters
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Markus Martini, Valentin Wiedemeyer, Nils Heim, Martina Messing-Juenger, Sabine Linsen
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Markus Martini, Anne Klausing, Nils Heim, Hans-Peter Fischer, Alexandra Sommer, Rudolf Hermann Reich
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Markus Martini, Anne Klausing, Guido Luechters, Nils Heim, Martina Messing-Juenger
HEAD & FACE MEDICINE
(2018)
Article
Dentistry, Oral Surgery & Medicine
Nils Heim, Moritz Berger, Valentin Wiedemeyer, Rudolf Reich, Markus Martini
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Nils Heim, Benedict Juergensen, Franz-Josef Kramer, Valentin Wiedemeyer
Summary: This study categorized the microbial flora and antibiotic susceptibility in patients with head and neck infections of odontogenic origin. It found high levels of antibiotic resistance, particularly against clindamycin, emphasizing the importance of immediate surgical treatment as the basis of abscess treatment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Computer Science, Theory & Methods
Nikolai Spuck, Matthias Schmid, Nils Heim, Ute Klarmann-Schulz, Achim Hoerauf, Moritz Berger
Summary: Discrete hazard models are widely used for analyzing discrete or grouped versions of continuous event times. To address the issue of non-linear effects and interactions between explanatory variables, we propose a novel class of models that utilizes recursive partitioning techniques. In a simulation study and real-world applications, the proposed models show competitive predictive performance and the ability to detect informative variables.
STATISTICS AND COMPUTING
(2023)
Article
Surgery
Nils Heim, Felix B. Warwas, Lamia Singer, Franz-Josef Kramer, Christoph Bourauel, Werner Gotz
Summary: Eagle syndrome is a rare disease caused by abnormal elongated styloid process or ossified stylohyoid ligament, presenting with a variety of symptoms. Micro-CT scanning revealed different shapes and ultrastructures between the two types, as well as different symptomatology.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
