Article
Dentistry, Oral Surgery & Medicine
Alexander Wick, Philipp Bankosegger, Sven Otto, Bettina Hohlweg-Majert, Timm Steiner, Florian Probst, Oliver Ristow, Christoph Pautke
Summary: This study identified several risk factors significantly increasing the onset of MRONJ in patients treated with DNO, including chemotherapy/hormonal therapy, DNO dosage, breast cancer, corticosteroid intake, hypertension, diabetes mellitus, periodontal disease, apical ostitis, and denture use. Switching medications did not affect the development of MRONJ.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Oncology
Raiza Querrer, Nathalia Ferrare, Nilce Melo, Cristine Miron Stefani, Paula Elaine Diniz dos Reis, Carla Ruffeil Moreira Mesquita, Gabriel Alvares Borges, Andre Ferreira Leite, Paulo Tadeu Figueiredo
Summary: Bisphosphonate-related ONJ and denosumab-related ONJ exhibit differences in imaging characteristics, with the former showing bone sequestra increase, cortical bone lysis, and bone density increase, while the latter showing larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Geriatrics & Gerontology
Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Andrei Gresita, Stephen Hamlet, Robert Love, Michael Hadjiargyrou, Chien-Ling Huang, Iulian Nusem, Rodica Ileana Miroiu, Aurel Popa-Wagner, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) refers to the non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with certain medications. Studies have been conducted to explore MRONJ's classification, clinical features, and pathophysiology, as well as its management and new trends in treatment. Conservative therapy may not be effective for severe cases of MRONJ, but new methods that promote local angiogenesis and vascularization show promise in limited trials.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Nutrition & Dietetics
Luca Dalle Carbonare, Monica Mottes, Maria Teresa Valenti
Summary: Osteonecrosis of the jaw is a severe clinical condition characterized by exposed bone that does not heal over time. Diagnosis is primarily clinical with imaging feedback playing a confirmatory role. Medication-related osteonecrosis of the jaw, particularly induced by bisphosphonates, has been widely discussed, but the exact mechanism remains debatable.
Article
Endocrinology & Metabolism
Worakanya Buranaphatthana, Apichai Yavirach, Elizabeth M. Leaf, Marta Scatena, Hai Zhang, Jonathan Y. An, Cecilia M. Giachelli
Summary: Research has shown that in a tooth extraction-triggered MRONJ model, the use of engineered osteoclasts can prevent specific pathological features of MRONJ.
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Joao Andre Correia, Jose Ricardo Ferreira, Miguel Amaral Nunes, Antonio Capelo, Miguel de Araujo Nobre, Francisco Salvado
Summary: VSP and CAD/CAM-customized materials facilitated complete resection of necrotic bone and rigid fixation in MRONJ patients, leading to simplified approach with shorter operative times, reduced morbidity, and predictable results.
APPLIED SCIENCES-BASEL
(2021)
Review
Medicine, General & Internal
Sven Otto, Suad Aljohani, Riham Fliefel, Sara Ecke, Oliver Ristow, Egon Burian, Matthias Troeltzsch, Christoph Pautke, Michael Ehrenfeld
Summary: MRONJ, a well-known side effect of antiresorptive and antiangiogenic drugs, is believed to have a strong association with local infection in its pathogenesis.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, General & Internal
Funda Goker, Emma Grecchi, Massimo Del Fabbro, Salvatore Longoni, Luigi Vito Stefanelli, Francesco Grecchi
Summary: The oral rehabilitation of MRONJ patients is challenging. This case study describes the successful use of zygomatic implants as an alternative for a patient with a large maxillary defect. After three years of follow-up, the patient showed healing and healthy tissues around the implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Medicine, General & Internal
Hemil Dario Rosales, Henry Garcia Guevara, Stefania Requejo, Maria Dianella Jensen, Julio Acero, Sergio Olate
Summary: This study analyzed medication-related osteonecrosis of the jaw (MRONJ) in children and young patients, and its relation with oral surgery. The study found a low presence of MRONJ in children and young patients treated with antiresorptive drugs. Data collection was weak, and details of therapy were not clear in most of the included articles.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cristiana Palmela Pereira, Ana Rodrigues, Adriana Santos, Francisco Salvado, Rui Santos, Roberto Cameriere
Summary: This study aimed to estimate cut-off points for Portuguese legal ages using the I-3M method and comparing them with other methods. The results showed that Demirjian's method and Cameriere's method yielded similar results, with Nolla and Moorrees methods showing higher sensitivity or specificity in certain age groups. However, Cameriere's method was deemed more stable and suitable for use in the Portuguese population.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
David Faustino Angelo, Yadong Wang, Pedro Morouco, Florencio Monje, Lisete Monico, Raul Gonzalez-Garcia, Carla Moura, Nuno Alves, David Sanz, Jin Gao, Rita Sousa, Lia Neto, Pedro Faisca, Francisco Salvado, Monica Lopez Pena, Maria Permuy, Fernando Munnoz
Summary: In this study, new 3D tailored TMJ disc implants were developed, with PGS+PCL disc demonstrating safety and the ability to prevent condyle degenerative changes. In contrast, PCL and PCL+PEGDA discs presented a higher risk of degenerative changes due to material fragmentation.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Joao Andre Correia, Jose Ricardo Ferreira, Miguel Amaral Nunes, Antonio Capelo, Miguel de Araujo Nobre, Francisco Salvado
Summary: VSP and CAD/CAM-customized materials facilitated complete resection of necrotic bone and rigid fixation in MRONJ patients, leading to simplified approach with shorter operative times, reduced morbidity, and predictable results.
APPLIED SCIENCES-BASEL
(2021)
Meeting Abstract
Rheumatology
V. C. Romao, M. J. Sousa Bandeira, M. Silverio-Antonio, R. Simao, J. Pinto, A. I. Goncalves, M. J. Goncalves, A. L. Martins, P. Jose, G. Coutinho, L. Morena Bueno Silva, M. Brito Lanca, R. Esteves Marques, C. Macieira, N. Khmelinskii, W. Rodrigues, F. Salvado, J. E. Fonseca
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cristiana Palmela Pereira, Carla Belo, Joana Sardinha, Rui Santos, Francisco Salvado, Roberto Cameriere
Summary: This study aims to validate the European regression formula in the Portuguese population and compare its accuracy with Demirjian's method for age estimation. The results indicate that the European regression formula is more accurate in the Portuguese population, but both methods perform well in classifying the age of 12 years.
ACTA STOMATOLOGICA CROATICA
(2022)
Article
Medicine, General & Internal
Miguel de Araujo Nobre, Francisco Salvado, Joao Andre Correia, Maria Cristina Faria Teixeira, Francisco Azevedo Coutinho
Summary: This retrospective study aimed to investigate the outcome of full-arch rehabilitations supported by implants in grafted bone. The results showed a dental implant cumulative success rate of 88.1% at 14 years and a patient survival rate of 76.8%. The incidence of biological and mechanical complications were 36% and 86.1% respectively. Overall, this treatment alternative is valid despite the rate of implant failures and complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Medicine, General & Internal
J. A. Correia, A. Loio, I. A. Furtado, A. Capelo, C. Caldas, N. Santos, F. Salvado
ANNALS OF MEDICINE
(2021)
Meeting Abstract
Medicine, General & Internal
J. R. Ferreira, M. A. Nunes, F. Salvado
ANNALS OF MEDICINE
(2021)
Meeting Abstract
Medicine, General & Internal
T. Nunes, A. Amaral, A. Mariz de Almeida, F. Salvado
ANNALS OF MEDICINE
(2021)
Meeting Abstract
Oncology
Jose Cunha Coutinho, Filipa Contente, Goncalo Cunha Coutinho, Beatriz Mota, Leonor Cruz, Teresa Coelho, Claudia Andrade, Cecilia Caldas, Adelina Aguiar, Paulo Palmela, Francisco Salvado
Meeting Abstract
Oncology
Leonor Cruz, Jose Coutinho, Goncalo Coutinho, Beatriz Mota, Teresa Coelho, Filipa Contente, Claudia Andrade, Paulo Palmela, Cecilia Caldas, Rita Simao, Francisco Salvado
Meeting Abstract
Oncology
Leonor Cruz, Ana Teresa Coelho, Jose Coutinho, Filipa Contente, Beatriz Mota, Goncalo Coutinho, Claudia Andrade, Claudia Mata, Sofia Pinto, Paulo Palmela, Nuno Santos, Cecilia Caldas, Francisco Salvado
Meeting Abstract
Oncology
B. Mota, C. Andrade, L. Cruz, A. T. Coelho, J. Coutinho, G. Coutinho, F. Contente, M. Nunes, S. Fontes, F. Salvado
Article
Dentistry, Oral Surgery & Medicine
Diana Augusto, Cristiana Palmela Pereira, Ana Rodrigues, Roberto Cameriere, Francisco Salvado, Rui Santos
Summary: The study aimed to provide reliable information on dental age assessment for age estimation in 12-14 legal ages using I-2M and I-3M, comparing their accuracy in different age groups. Results showed that both methods are reliable for the legal age thresholds of 12 and 14 years.
ACTA STOMATOLOGICA CROATICA
(2021)
