Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Endocrinology & Metabolism
Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Alexander Jakobsen, Bolette Hartmann, Eva Winning Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe S. orensen Torekov, Birgitte Holst
Summary: This study examined the impact of diet-induced weight loss on levels of the anorexigenic hormone neurotensin (NT) in mice and humans, and whether these levels predict body weight change. The results showed that diet-induced weight loss reduced NT levels in both mice and humans, and regulated hunger-related gene expression in mice. Additionally, individuals who continued to lose weight after weight loss had higher peak NT secretion compared to those who regained weight.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Environmental Sciences
Thomas P. van der Meer, Chris H. L. Thio, Martijn van Faassen, Andre P. van Beek, Harold Snieder, Frank N. R. van Berkum, Ido P. Kema, Konstantinos C. Makris, Bruce H. R. Wolffenbuttel, Jana V. van Vliet-Ostaptchouk
Summary: The study investigated the impact of a dietary intervention on exposure to endocrine disrupting chemicals (EDCs) and their mobilization in urine. Results showed a reduction in most phthalates in obese participants after a weight reduction intervention, with no increase in urinary EDC excretions associated with reduction in adipose tissue. Higher baseline exposure to certain EDCs was linked to reduced weight loss, indicating obesogenic properties.
ENVIRONMENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Jinhua Xue, Yuanyuan Lu, Toujun Zou, Wei Shi, Shuang Wang, Xu Cheng, Juan Wan, Yun Chen, Min Wang, Qingzheng Wang, Xia Yang, Mingxing Ding, Zhili Qi, Yi Ding, Manli Hu, Xin Zhang, Hongliang Li, Yufeng Hu
Summary: Obesity is a common health burden in companion pets, and dietary management and exercise are effective options for weight loss. This study aimed to develop a weight-loss diet rich in protein and fiber, supplemented with astaxanthin, and evaluate its effects on metabolic homeostasis in an obese beagle model.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Katarzyna Ilowiecka, Pawel Glibowski, Michal Skrzypek, Wojciech Styk
Summary: The study suggests that post-therapeutic support after weight loss can increase the chances of long-term weight maintenance in obesity treatment, and may be influenced by certain genotypes.
Article
Endocrinology & Metabolism
Megan Rodgers, Alexandra L. Migdal, Tahereh Ghorbani Rodriguez, Zsu-Zsu Chen, Anjali K. Nath, Robert E. Gerszten, Natasha Kasid, Elena Toschi, Juliet Tripaldi, Brent Heineman, Minh Phan, Long Ngo, Eleftheria Maratos-Flier, Jody Dushay
Summary: In this study, long-term weight loss with exenatide treatment was similar to that achieved with a hypocaloric diet in a population of early high responders. Weight loss at 3 months of treatment predicted super responder status in both treatment groups, with individual variability observed in weight loss outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Isabella Gastaldo, Rosa Casas, Violeta Moize
Summary: This narrative review summarizes the existing research on the clinical impact of a Mediterranean diet before and after bariatric surgery, focusing on its effects on weight loss and improvement in comorbidities. Although the current knowledge is limited, the findings suggest that adopting a Mediterranean diet before and after bariatric surgery is of significant value.
Article
Nutrition & Dietetics
Hanan Abbas, Simone Perna, Afzal Shah, Clara Gasparri, Mariangela Rondanelli
Summary: This study evaluated the efficacy and safety of a hypocaloric diet under hospitalization in obese patients. The results showed that the diet led to weight reduction and improvements in blood biochemistry parameters, while not affecting muscle mass, liver, and thyroid profiles. Lower insulin levels and higher serum calcium and potassium levels were predictors of weight loss.
Article
Nutrition & Dietetics
Mari Naatanen, Anna Karlund, Santtu Mikkonen, Anton Klavus, Otto Savolainen, Marko Lehtonen, Leila Karhunen, Kati Hanhineva, Marjukka Kolehmainen
Summary: This study investigated the effect of two isocaloric 24-week weight maintenance diets on metabolism and identified metabolite features associated with successful weight loss maintenance. It was found that the dietary fiber, protein, and fat content of the diet influenced amino acid and lipid metabolism, and increased abundance of certain phospholipids and free fatty acids was associated with better weight loss maintenance.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Orly Ben-Yacov, Anastasia Godneva, Michal Rein, Smadar Shilo, Dmitry Kolobkov, Netta Koren, Noa Cohen Dolev, Tamara Travinsky Shmul, Bat Chen Wolf, Noa Kosower, Keren Sagiv, Maya Lotan-Pompan, Niv Zmora, Adina Weinberger, Eran Elinav, Eran Segal
Summary: In this clinical trial comparing PPT diet and MED diet in prediabetes patients, the PPT diet was found to significantly improve glycemic control by reducing the daily time with glucose levels >140 mg/dL (7.8 mmol/L) and HbA(1c) levels compared to the MED diet. These results could have implications for dietary advice in clinical practice.
Article
Food Science & Technology
Stanislava Ivanova, Cedric Delattre, Diana Karcheva-Bahchevanska, Niko Benbasat, Vanya Nalbantova, Kalin Ivanov
Summary: Obesity rates have increased significantly since the 1970s, leading to various health risks. Plant-based diets are considered to be an effective strategy for weight control, due to their benefits on gut health and metabolic functions.
Review
Health Care Sciences & Services
Olivia Patsalos, Johanna Keeler, Ulrike Schmidt, Brenda W. J. H. Penninx, Allan H. Young, Hubertus Himmerich
Summary: This systematic review found that calorie-restricted diets can reduce depressive symptoms in obese patients, with effect sizes ranging from approximately 0.2 to 0.6. However, the effects of dietary supplements on depression were less clear.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyo Bin Lee, Ah Young Lee, Yumi Jang, Young Hye Kwon
Summary: This study investigated the distinctive effects of soy protein components on adiposity and circulating miRNA profiles in obese mice. The results showed that soy isoflavones are the main contributor to the health-beneficial effects of soy protein in diet-induced obesity. The dysregulation of circulating miRNAs coincided with obesity.
Article
Peripheral Vascular Disease
Minghao Kou, Xiang Li, Xiaojian Shao, Elin Grundberg, Xuan Wang, Hao Ma, Yoriko Heianza, J. Alfredo Martinez, George A. Bray, Frank M. Sacks, Lu Qi
Summary: DNAm may play a critical role in connecting prenatal adverse events and cardiometabolic disorders, including hypertension in later life. The study found that regional DNAm at LINC00319 was associated with weight loss and blood pressure reduction, suggesting that DNAm could be a metabolic memory bridging early and later life.
Article
Nutrition & Dietetics
Giovanna Flore, Antonio Preti, Mauro Giovanni Carta, Andrea Deledda, Michele Fosci, Antonio Egidio Nardi, Andrea Loviselli, Fernanda Velluzzi
Summary: Only 25% of patients succeed in maintaining the result of weight loss for a long time after a low-calorie diet. This systematic review and meta-analysis find that intensive intervention during the maintenance phase may contribute to greater preservation of weight loss achieved during the previous slimming phase, although the difference from the control group is not statistically significant.
Article
Engineering, Biomedical
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi, Hyungil Jung
Article
Chemistry, Applied
Suyong Kim, Jeongwon Lee, F. Lahiji Shayan, Seohyun Kim, Inyoung Huh, Yonghao Ma, Huisuk Yang, Geonwoo Kang, Hyungil Jung
CARBOHYDRATE POLYMERS
(2018)
Article
Pharmacology & Pharmacy
Inyoung Huh, Suyong Kim, Huisuk Yang, Mingyu Jang, Geonwoo Kang, Hyungil Jung
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Shayan Fakhraei Lahiji, Yoojung Jang, Yonghao Ma, Manita Dangol, Huisuk Yang, Mingyu Jang, Hyungil Jung
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Engineering, Biomedical
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F. Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Chemistry, Applied
G. Kang, T. N. T. Tu, S. Kim, H. Yang, M. Jang, D. Jo, J. Ryu, J. Baek, H. Jung
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2018)
Article
Dermatology
Huisuk Yang, Suyong Kim, Mingyu Jang, Hyeonjun Kim, Seunghee Lee, Youseong Kim, Younghyon Andrew Eom, Geonwoo Kang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Ye Eun Lee, Jaesuk Koh, Hyungil Jung
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Dermatology
Geonwoo Kang, Suyong Kim, Huisuk Yang, Mingyu Jang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Go Woon Choi, Hyungil Jung
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Pharmacology & Pharmacy
Seunghee Lee, Shayan Fakhraei Lahiji, Jeesu Jang, Mingyu Jang, Hyungil Jung
Article
Chemistry, Applied
M. Jang, S. Baek, G. Kang, H. Yang, S. Kim, H. Jung
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2020)
Article
Engineering, Biomedical
Mingyu Jang, Bo Mi Kang, Huisuk Yang, Jungyoon Ohn, Ohsang Kwon, Hyungil Jung
Summary: Dissolving microneedles (DMN) with therapeutic molecules have been developed to enhance transdermal drug delivery efficiency, particularly for treating skin inflammatory diseases like atopic dermatitis (AD). High-dose TA-DMN is presented as a potential candidate for the treatment of skin inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jungyoon Ohn, Mingyu Jang, Bo Mi Kang, Huisuk Yang, Jin Tae Hong, Kyu Han Kim, Ohsang Kwon, Hyungil Jung
Summary: The newly designed candle flame-shaped TA-loaded dissolving microneedles can effectively treat chronic inflammatory skin diseases, reduce patient pain, and are favored by dermatologists.
Article
Pharmacology & Pharmacy
Jeeho Sim, SeongDae Gong, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Jaesung Park, Youngchan Kim, Hyunkyu Lee, Hyunji Jung, Youseong Kim, Chansol Jeon, Hyeri Ahn, Minkyung Kim, Jaibyung Choi, Ho Lee, Hyungil Jung
Summary: This study used a dissolvable micro-channeling system (DMCS) to enhance the delivery of serum through micro-channels embedded with dissolving microneedles (DMNs). The results showed that this combinatorial serum application method significantly improved the transdermal delivery of active compounds and had better skincare efficacy compared to only using serum application.
Article
Pharmacology & Pharmacy
Huisuk Yang, Geonwoo Kang, Mingyu Jang, Daniel Junmin Um, Jiwoo Shin, Hyeonjun Kim, Jintae Hong, Hyunji Jung, Hyemyoung Ahn, Seongdae Gong, Chisong Lee, Ui-Won Jung, Hyungil Jung
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)