Article
Nanoscience & Nanotechnology
Felix Sauvage, Van Phuc Nguyen, Yanxiu Li, Aranit Harizaj, J. Sebag, Dimitri Roels, Viktor Van Havere, Karen Peynshaert, Ranhua Xiong, Juan C. Fraire, Marie-Jose Tassignon, Katrien Remaut, Yannis M. Paulus, Kevin Braeckmans, Stefaan C. De Smedt
Summary: This paper introduces a new method for treating eye floaters, involving the generation of vapour nanobubbles by exposing gold nanoparticles or indocyanine green to low-energy laser pulses to disrupt collagen aggregates in the eyes. This approach may provide a safe and efficient treatment for millions of patients suffering from debilitating vitreous opacities and opens up the possibility of highly safe use of pulsed lasers in the posterior segment of the eye.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Rebecca L. Hershman, Yamin Li, Feihe Ma, Qioabing Xu, James A. Van Deventer
Summary: Due to a lack of tools to interfere with undruggable targets, many intracellular signaling events are still poorly understood. Antibodies have the potential to elucidate intracellular mechanisms by disrupting cell signaling cascades. However, their size and chemical composition hinder their ability to naturally cross the cell membrane. This study describes a strategy using cationic lipid nanoparticles to deliver recombinant antibodies for selective disruption of intracellular signaling.
Article
Chemistry, Multidisciplinary
Yasunori Tabayashi, Shota Sakaki, Naoto Koshizaki, Yuji Yamauchi, Yoshie Ishikawa
Summary: Pulsed laser melting in liquid (PLML) is a technique used to produce submicrometer spherical particles (SMPs). By monitoring transmittance measurements of monodisperse Au SMP colloidal solutions on a transient time scale, the temporal dependence of the thickness of thermally induced nanobubbles (TINBs) and the pressure within the bubble can be studied. These TINBs play a crucial role in promoting the formation of large particles via particle merging during laser heating in the PLML process.
Article
Chemistry, Physical
Kentaro Suehara, Ryosuke Takai, Yoshie Ishikawa, Naoto Koshizaki, Kazunobu Omura, Harunori Nagata, Yuji Yamauchi
Summary: Pulsed Laser Melting in Liquid (PLML) is a technique used to fabricate submicrometer spherical particles (SMPs) by transiently heating raw particles above the melting point in liquid and inducing thermally induced bubbles. The reduction of metal-oxide nanoparticles in ethanol during PLML process is mediated by molecules decomposed from ethanol, such as ethylene, resulting in a decrease in Gibbs free energies of oxide reduction reactions.
Article
Chemistry, Multidisciplinary
Hieu T. M. Nguyen, Nitesh Katta, Jessica A. Widman, Eri Takematsu, Xu Feng, Susana A. Torres-Hurtado, Tania Betancourt, Aaron B. Baker, Laura J. Suggs, Thomas E. Milner, James W. Tunnell
Summary: This study found that using gold nanorods and laser irradiation can induce cancer cell death, increase the expression of damage-associated molecular patterns, and promote the activation of dendritic cells.
Review
Biochemistry & Molecular Biology
Tianyu Ma, Xianghan Chen, Ming Wang
Summary: Messenger RNA (mRNA) holds great potential for disease prevention and treatment, as well as genome editing. However, its instability, immunogenicity, and poor cell membrane permeability limit its therapeutic use. Lipid nanoparticles (LNPs) have emerged as a promising vehicle for mRNA delivery, especially for developing mRNA-based vaccines against COVID-19. This review summarizes recent advances in designing ionizable lipids and formulating LNPs for intracellular and tissue-targeted mRNA delivery, and discusses the progress of LNPs in achieving spatiotemporally controlled CRISPR/Cas9 genome editing via intracellular mRNA delivery. The future of LNP-based mRNA delivery for CRISPR/Cas9 genome editing and genetic disorder treatment is also discussed.
Article
Chemistry, Multidisciplinary
Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-Gonzalez, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Felix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sanchez
Summary: Nanomotors, powered by enzymes and triggered by laser irradiation, can improve drug delivery efficiency and overcome biological barriers. These nanomotors can collectively displace and disrupt protein fibers in a blocked microchannel. This active motion and mechanical disruption provide a clear advantage for improving therapy.
Article
Chemistry, Analytical
Pallavi Gupta, Srabani Kar, Ashish Kumar, Fan-Gang Tseng, Shantanu Pradhan, Pallab Sinha Mahapatra, Tuhin Subhra Santra
Summary: Optoporation-based delivery technique using nano-spiked core-shell gold-coated polystyrene nanoparticles (ns-AuNPs) enables high-throughput intracellular delivery of model cargo within 3D cancer spheroids, demonstrating potential translational benefits for anti-cancer therapeutics to tumors by achieving high delivery efficiency with minimal cellular damage.
Article
Chemistry, Multidisciplinary
Peng Liu, Xiangli Ru, Yi Chang, Nana Ma, Ge Li, Huifeng Chen, Xueqing Ren, Zhengyu Bai, Xiaoming Ma, Lin Yang
Summary: A highly selective heterogeneous living cell catalytic system (LCCS) with intracellular Pd nanodots has been constructed. The LCCS demonstrates selective catalytic hydrogenation for acrylamides under mild conditions, with self-reproducible, reusable and recyclable performance. The size-selectivity is closely related to the inherent gating effect of the cell membrane.
Article
Chemistry, Multidisciplinary
Joseph Hardie, Jessa Marie Makabenta, Aarohi Gupta, Rui Huang, Roberto Cao-Milan, Ritabrita Goswami, Xianzhi Zhang, Parvati Abdulpurkar, Michelle E. Farkas, Vincent M. Rotello
Summary: Intracellular bacterial infections are difficult to treat. However, a new strategy using bioorthogonal nanozymes shows promising results. By targeting the delivery of nanozymes to macrophages and converting pro-antibiotics into active species, this approach effectively kills pathogenic bacteria within cells.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Physical
Debajyoti Bhaduri, Tina Ghara, Pavel Penchev, Soumitra Paul, Catalin Pruncu, Stefan Dimov, David Morgan
Summary: A novel LP strategy was proposed to improve the re-melting of aluminium alloys by introducing a thermally insulating ceramic baseplate, resulting in significant reductions in surface roughness and residual stresses. The study highlights the importance of controlling heat dissipation in laser polishing of thermally conductive materials to achieve desired surface integrity properties.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Luke Bhan, Cody L. Covington, Kalman Varga
Summary: This study proposes a laser-driven quantum electron ratchet nanodevice, which uses bubble-shaped nanodiode structures to induce plasma oscillation in the vertical direction and funnel electrons towards a sharp tip for net electron transport in the horizontal direction.
Article
Engineering, Electrical & Electronic
Safa A. Abdulrahman, Muslim F. Jawad, Raid A. Ismail
Summary: In this study, a nanostructured cerium oxide thin film was prepared by using pulsed laser deposition as an antireflection coating for silicon solar cells. The experimental results showed that the grain size of the film increased and the carrier concentration decreased with the increase of laser pulses. The maximum power conversion efficiency and fill factor of the silicon solar cell were significantly improved after the deposition with an appropriate number of laser pulses.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Xuelin Wang, Xuedong Li, Minghui Duan, Shaobo Shan, Xiyu Zhu, Yi Chai, Hongzhang Wang, Xuyang Sun, Lei Sheng, Guangchao Qing, Wei Rao, Liang Hu, Junge Chen, Jing Liu
Summary: By utilizing the shape transformability of Ga particles, researchers have developed a new strategy for intracellular therapy that can effectively kill cancer cells. This strategy uses a physical mechanical approach to enable Ga particles to escape from endosomes and disrupt the endosomal membrane, resulting in efficient cancer cell killing. Experimental results demonstrate that this strategy significantly inhibits tumor growth and prolongs survival time.
Article
Materials Science, Biomaterials
Zongjun Liu, Peng Wan, Mingxin Yang, Fang Han, Tianran Wang, You Wang, Yu Li
Summary: This study developed a targeting-enhanced tumor-selective cancer therapy by preparing nanoparticles that can deliver drugs selectively into cancer tissue, achieving remarkable antitumor performance with negligible toxic side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Gaelle Houthaeve, Gerardo Garcia-Diaz Barriga, Stephan Stremersch, Herlinde De Keersmaecker, Juan Fraire, Jo Vandesompele, Pieter Mestdagh, Stefaan De Smedt, Kevin Braeckmans, Winnok H. De Vos
Summary: The study investigates the effects of VNB photoporation on cell homeostasis, finding that A-type lamins are upregulated after photoporation and contribute to the recovery of the nucleus. Selective depletion of A-type lamins reduces cell viability, while stimulation of LMNA transcription increases the survival rate of successfully transfected cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elke De Schutter, Jana Ramon, Benjamin Pfeuty, Caroline De Tender, Stephan Stremersch, Koen Raemdonck, Ken Op de Beeck, Wim Declercq, Franck B. Riquet, Kevin Braeckmans, Peter Vandenabeele
Summary: This study investigates the membrane permeabilizing features of Gasdermin E (GSDME) and its role in regulating secondary necrosis. The results show that GSDME accelerates cell lysis and affects the influx of fluorescently labeled dextrans, while the efflux is independent of GSDME expression. Furthermore, the passage of dextrans is dependent on their molecular weight.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Environmental
Qingli Qu, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans, Stefaan C. De Smedt, Ranhua Xiong, Chaobo Huang
Summary: Core-shell multicompartmental microparticles resembling eukaryotic cells have been created using an oil-free gas-shearing fabrication method. The resulting mangosteen-like particles have segregated compartments, making them suitable for controlling enzymatic cascade reactions. This approach shows potential for applications like developing artificial pancreatic beta cells for insulin release.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Heyang Zhang, Jeroen Bussmann, Florian H. Huhnke, Joke Devoldere, An-Katrien Minnaert, Wim Jiskoot, Friedhelm Serwane, Joachim Spatz, Magnus Roding, Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut
Summary: The study shows that packaging different mRNA encoding into the same lipoplexes is crucial for efficient delivery into individual cells. On the other hand, mixtures of lipoplexes containing only one type of mRNA tend to result in large variations in uptake and expression levels among individual cells.
Review
Nanoscience & Nanotechnology
Gaelle Houthaeve, Stefaan C. De Smedt, Kevin Braeckmans, Winnok H. De Vos
Summary: Delivery of nanomaterials into cells by disrupting the plasma membrane (PM) can have various effects on cell viability and physiology, including permanent phenotypic alterations. Understanding this cellular response is crucial for optimizing nano-delivery conditions.
Review
Chemistry, Multidisciplinary
Jie Li, Bogdan V. Parakhonskiy, Andre G. Skirtach
Summary: The article provides an overview of the fabrication methods and applications of polyelectrolyte multilayer capsules, highlighting the current trends and expanding range of applications.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pathology
Cedric Peleman, Winnok H. De Vos, Isabel Pintelon, Ann Driessen, Annelies Van Eyck, Christophe Van Steenkiste, Luisa Vonghia, Joris De Man, Benedicte Y. De Winter, Tom Vanden Berghe, Sven M. Francque, Wilhelmus J. Kwanten
Summary: A new image analysis method was used to quantify the differences between liver lobule zones in NAFLD. The results showed that this method accurately measured the distribution of hypoxia markers in the steatotic liver and overcame the impact of steatosis on pathologists' interpretation.
Article
Cell Biology
Louis Van der Meeren, Joost Verduijn, Dmitri V. Krysko, Andre G. Skirtach
Summary: The investigation of regulated cell death (RCD) has gained increasing importance in recent years. A microfluidics-based technique called shear flow deformability cytometry (sDC) is used to distinguish dying cells from viable cells based on their mechanical properties. Analysis of the deformation and morphological characteristics of cells indicates significant differences in RCD-induced cells compared to control cells. These results highlight the importance of mechanical properties during RCD and the significance of label-free techniques like sDC for the detection and sorting of live and dead cells.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Ilia Goemaere, Deep Punj, Aranit Harizaj, Jessica Woolston, Sofie Thys, Karen Sterck, Stefaan C. De Smedt, Winnok H. De Vos, Kevin Braeckmans
Summary: Photoporation is a gentle and efficient method for transfecting cells, and response surface methodology (RSM) proves to be a valuable approach for optimizing the photoporation procedure. By varying PDNP size, concentration, and laser fluence, the RSM designs successfully identified an optimal delivery yield and revealed a strong dependence on PDNP size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Louis van der Meeren, Iuliia Efimova, Robin Demuynck, Bogdan Parakhonskiy, Dmitri V. Krysko, Andre G. Skirtach
Summary: The clearance of dead cells is important for tissue homeostasis and immune responses, but the impact of the mechanobiological properties of dead cells on efferocytosis is not well understood. This study found that cancer cells undergoing ferroptosis have reduced Young's modulus. A nano-coating was developed to modulate their Young's modulus. The coating increased the Young's modulus of the dead cells and enhanced their efferocytosis by macrophages. This research highlights the crucial role of mechanobiology in regulating efferocytosis and its potential for therapeutic strategies and drug delivery systems.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Christophe Hermans, Celine Merlin, Ho Wa Lau, Elly Marcq, Marlies Verschuuren, Winnok H. De Vos, Filip Lardon, Evelien L. J. Smits, Christophe Deben
Summary: The study aims to enhance the efficacy of auranofin (AF) as a cancer treatment by combining it with the PARP inhibitor olaparib (referred to as 'aurola'). High concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein. The combination strategy of oxidative stress induction with PARP inhibition could be a promising treatment for mutant p53 cancers.
Article
Biochemistry & Molecular Biology
Claudia F. Lossio, Vinicius J. S. Osterne, Vanir R. Pinto-Junior, Simin Chen, Messias V. Oliveira, Joost Verduijn, Isabel Verbeke, Sonia Serna, Niels C. Reichardt, Andre Skirtach, Benildo S. Cavada, Els J. M. Van Damme, Kyria S. Nascimento
Summary: This study investigated the structural properties and anticancer potential of a mannose-specific lectin from Canavalia villosa seeds. The lectin showed specific binding activity to carbohydrates and inhibited cancer cell proliferation by activating autophagic and apoptotic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Lenny Van Daele, Babs van de Voorde, Robin Colenbier, Lobke De Vos, Laurens Parmentier, Louis Van der Meeren, Andre Skirtach, Ruslan I. Dmitriev, Peter Dubruel, Sandra Van Vlierberghe
Summary: Cardiovascular diseases are the leading cause of death worldwide. Poly(alkylene terephthalate)s (PATs) with longer alkyl chain lengths show potential for improving compliance in vascular graft materials. This study investigated the effects of polymer molar mass and alkyl chain length on the surface properties of spin-coated PAT films, as well as endothelial cell adhesion and proliferation. The results showed that higher molar mass and longer alkyl chain lengths increased surface roughness, while no significant trend was observed for wettability. All investigated PATs were non-cytotoxic and supported endothelial cell adhesion and growth, with some PATs even promoting angiogenic maturation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Sonali Mohanty, Simona Premcheska, Joost Verduijn, Hannes Rijckaert, Andre G. G. Skirtach, Kristof Van Hecke, Anna M. M. Kaczmarek
Summary: This work demonstrates the potential of using hollow spheres as novel vehicles for dual-mode thermometry and pH-dependent drug release in the biomedical field. By exploiting the upconversion luminescence properties of hollow Y2O3 and Y2O2SO4 materials, optical temperature sensors were successfully developed and utilized for monitoring the drug release of doxorubicin. These findings highlight the feasibility of using this type of vehicle for simultaneous thermometry and drug delivery applications.
Review
Chemistry, Multidisciplinary
Lin Cao, Yanqi Huang, Bogdan Parakhonskiy, Andre G. Skirtach
Summary: Nanoarchitectonics allows the design and construction of structures at the nanoscale, but the assembled structures may not always follow the projected design. This research discusses the fabrication of structures from molecules, polymers, nanoparticles, and nanosheets to polymer brushes, layer-by-layer assembly structures, and hydrogels through self-assembly processes, without the requirement for perfect order.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
