Article
Biochemistry & Molecular Biology
Annapoorna Mohandas, Jayakumar Rangasamy
Summary: This study developed an injectable nanocurcumin and arginine incorporated chitosan hydrogel to prevent hypoxia induced endothelial damage. The hydrogel showed significant antioxidant activity and biodegradation in vitro, with better release of curcumin and arginine at acidic pH. The hydrogel effectively reduced the effect of hypoxia induced endothelial dysfunction in cultured endothelial cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Thuan Thai, Fei Zhong, Lei Dang, Enoch Chan, Jacqueline Ku, Ernst Malle, Carolyn L. Geczy, John F. Keaney, Shane R. Thomas
Summary: The study demonstrates that transcytosed MPO in endothelial cells activates eNOS by promoting phospholipase C-dependent calcium signaling and altering eNOS phosphorylation status. This activation occurs despite reduced cellular uptake of the eNOS substrate L-arginine. These findings suggest a compensatory signaling response in endothelial cells to maintain eNOS activity and NO production in the presence of MPO-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ting Li, Zhiyong Liu, Jinglei Hu, Lin Chen, Tiantian Chen, Qianqian Tang, Bixia Yu, Bo Zhao, Chun Mao, Mimi Wan
Summary: A zwitterion-based artificial chemotactic nanomotor is proposed for precise targeting in vivo, utilizing high levels of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) as chemoattractants. The chemotactic behavior of the nanomotors is evaluated through static models, dynamic models, in vivo models, and mesoscale hydrodynamics simulations. This chemotactic delivery strategy has the potential to improve delivery efficiency and be applicable to various inflammatory diseases.
ADVANCED MATERIALS
(2022)
Article
Food Science & Technology
Joseph Festa, Aamir Hussain, Amon Hackney, Unmesh Desai, Tarsem S. Sahota, Harprit Singh, Mariasole Da Boit
Summary: Endothelial dysfunction (ED), secondary to reduced nitric oxide (NO) production and oxidative stress, is an early marker of atherosclerosis. Elderberry extract (EB) with high anthocyanin content has vascular protective effects and can prevent monocyte adhesion and inflammatory response. EB upregulates key markers of endothelial function and ameliorates ED, suggesting its potential use in preventing atherosclerosis progression.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Changzhen Sun, Ji Lu, Jun Wang, Ping Hao, Chunhong Li, Lu Qi, Lin Yang, Bin He, Zhirong Zhong, Na Hao
Summary: A novel redox-sensitive drug delivery system with aggregation-induced emission property was developed for simultaneous cellular imaging and intelligent drug delivery and release, showing effective inhibition of tumor growth in mice. This innovative polymeric micelle opens up new possibilities for multifunctional drug delivery systems.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kyung Ha Ku, Michelle K. Dubinsky, Aravin N. Sukumar, Noeline Subramaniam, Manon Y. M. Feasson, Ranju Nair, Eileen Tran, Brent M. Steer, Britta J. Knight, Philip A. Marsden
Summary: The study reveals that the SSRE and KLF elements in the eNOS promoter play critical roles in endothelial cells, providing new mechanistic insights into the transcription of the eNOS gene under chronic shear stress in vivo.
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wenji Hu, Yating Sun, Yuhuan Li, Jing Xie, Robert J. Lee, Fengying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, Youxin Li, Lesheng Teng
Summary: The newly synthesized amphiphilic polymers can self-assemble into micellar nanoparticles with favorable hydrolysis kinetics, biocompatibility, and long circulation time. These materials not only exhibit better inflammation-targeting effects, but also do not induce an acidic microenvironment during degradation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Xiaowan Han, Tong Li, Tieshan Wang, Baofu Wang, Yang Li, Lei Wang, Ziwen Lu, Aiming Wu, Lisong Liu, Guozhong Pan, Mingjing Zhao
Summary: This study evaluated the correlation between different microparticle phenotypes and plaque burden, and investigated the role of microparticles in atherosclerosis. The results showed that CD11a(+) LMP and CD11a(+)/CD45(+) LMP may be potential biomarkers for predicting carotid atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abhishesh Kumar Vikas, Abhishesh Kumar Mehata, Matte Kasi Viswanadh, Ankit Kumar Malik, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu
Summary: This research developed redox-sensitive dual-receptor-targeted nanoparticles loaded with cabazitaxel, showing significantly improved cellular uptake and anticancer activity against A549 lung cancer cells.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Review
Pharmacology & Pharmacy
Seyedmehdi Hossaini Nasr, Xuefei Huang
Summary: Nanomedicine is a powerful tool that can target atherosclerotic plaques, and the advances in designing nanoparticles with therapeutic effects on these plaques have been summarized to stimulate further development and future translation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Aastha Gupta, Ankita Dhiman, Ankur Sood, Ravi Bharadwaj, Neal Silverman, Garima Agrawal
Summary: In this study, disulfide crosslinked dextran/eudragit S-100 nanoparticles (DEEU NPs) were developed for colorectal cancer treatment. These redox environment sensitive DEEU NPs showed high encapsulation efficiency for the doxorubicin (DOX) model drug and exhibited significant release in the reducing environment. The DOX-DEEU NPs demonstrated enhanced cytotoxicity for cancer cells and the in vivo biodistribution results indicated their potential as a promising platform for colorectal cancer treatment.
Meeting Abstract
Chemistry, Multidisciplinary
Jee Young Chung, Hyun Lin Lee, Qurrat Ul Ain, Yoon Sung Song, Yong-Hee Kim
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Chemistry, Multidisciplinary
Qurrat Ul Ain, Jee Young Chung, Yong-Hee Kim
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Chemistry, Medicinal
Qurrat Ul Ain, Jong Hwan Lee, Young Sun Woo, Yong-Hee Kim
ARCHIVES OF PHARMACAL RESEARCH
(2016)
Article
Chemistry, Multidisciplinary
Yoonsung Song, Ye-Ram Kim, So Mi Kim, Qurrat Ul Ain, Kiseok Jang, Chul-Su Yang, Yong-Hee Kim
JOURNAL OF CONTROLLED RELEASE
(2016)
Review
Chemistry, Multidisciplinary
Seok-Beom Yong, Yoonsung Song, Hyung Jin Kim, Qurrat Ul Ain, Yong-Hee Kim
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Medicine, Research & Experimental
Jee Young Chung, Qurrat Ul Ain, Hyun Lin Lee, So-Mi Kim, Yong-Hee Kim
MOLECULAR PHARMACEUTICS
(2017)
Article
Polymer Science
Qurrat Ul Ain, Young Sun Woo, Jee Young Chung, Yong-Hee Kim
MACROMOLECULAR RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Jee Young Chung, Qurrat Ul Ain, Yoonsung Song, Seok-Beom Yong, Yong-Hee Kim
Review
Biotechnology & Applied Microbiology
Qurrat Ul Ain, Estefania V. R. Campos, Ariel Huynh, Dominik Witzigmann, Sarah Hedtrich
Summary: Gene therapies are powerful in treating diseases, but face challenges in skin disorders due to the unique barrier properties of human skin that limit the efficient delivery of nucleic acid payloads. Delivery strategies are identified as the major obstacle in fully utilizing the potential of gene therapies for various human diseases, not just skin disorders.
TRENDS IN BIOTECHNOLOGY
(2021)
Editorial Material
Nanoscience & Nanotechnology
Partho Protim Adhikary, Qurrat Ul Ain, Andreas Christian Hocke, Sarah Hedtrich
Summary: Scientists globally face challenges in finding appropriate animal models for studying SARS-CoV-2 infections due to interspecies-related differences, but human-based models like micro-engineered multi-organs-on-chip may provide a solution.
NATURE REVIEWS MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)