Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Carola Heneweer, Tuula Penate Medina, Robert Tower, Holger Kalthoff, Richard Kolesnick, Steven Larson, Oula Penate Medina
Summary: The study demonstrates that the release ability of sphingomyelin liposomes in liposomal delivery is affected by treatment with sphingomyelinase enzyme, which can make the liposomes leakier and sensitive to cellular stress. Under radiation-induced stress, the targeting ability of liposomes is enhanced, with a higher concentration of released fluorescent markers found at cancer sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Biophysics
Kaichun Li, Dong Zhou, Hengqing Cui, Guoyan Mo, Yu Liu, Kaikai Zheng, Zheng Zhou, Jian Li, Ping Dai, Jing Sun, Yuhong Zhang, Jie Gao
Summary: This study developed nanoparticles for cancer treatment that can gradually release drugs in the tumor environment, achieving deep tumor penetration and efficient tumor cell therapy. The nanoparticles have good stability and biocompatibility, making them a promising and practical approach for anticancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Yulin Li, Liudi Wang, Guoqiang Zhong, Guoying Wang, Yanzhao Zhu, Jian Li, Lan Xiao, Yanhui Chu, Yan Wu, Kaichun Li, Jie Gao
Summary: In this study, gelatin/laponite/doxorubicin (GLD) nanoparticles were developed to address the limitations of nanoparticles in cancer treatment, including low drug loading, poor colloidal stability, insufficient tumor penetration, and uncontrolled drug release. The GLD nanoparticles showed high drug encapsulation efficacy and strong colloidal stability. In the tumor environment, the gelatin component of GLD was broken down by matrix metallopeptidase-2 (MMP-2) to release smaller laponite nanoparticles for effective tumor cell endocytosis. This sequential drug delivery, triggered by the tumor microenvironment, led to improved anticancer effectiveness and strong in vivo biocompatibility. The study offers a useful method for anticancer therapy.
Article
Cell Biology
Meng Liang, Na Li, Fei Liu, Nan Zeng, Changyuan Yu, Shuo Li
Summary: This study presents a DNA nanoprism triggered by APE1 for drug delivery and precise drug release in tumor cells. The nanoprism successfully served as a controlled drug delivery carrier, selectively releasing drugs in response to APE1 activity in cancer cells. This finding provides a new strategy for precision medicine by exploiting the overexpression of APE1 in cancer cells.
Article
Nanoscience & Nanotechnology
Kevin N. Baumann, Tim Schroeder, Prashanth S. Ciryam, Diana Morzy, Philip Tinnefeld, Tuomas P. J. Knowles, Silvia Hernandez-Ainsa
Summary: This study presents a method to achieve triggered drug release by forming a DNA mesh on large unilamellar liposomes. The programmability and adaptability of DNA nanoarchitectures in combination with liposomes prove to have great potential in drug delivery. The results demonstrate that the triggered-release mechanism can enhance the cytotoxicity of the loaded drug, suggesting its promising application in targeted drug delivery.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Kevin N. Baumann, Tim Schroeder, Prashanth S. Ciryam, Diana Morzy, Philip Tinnefeld, Tuomas P. J. Knowles, Silvia Hernandez-Ainsa
Summary: In this study, a method was presented to form biocompatible hybrid carriers by combining DNA nanoarchitectures with liposomes, which can meet the requirements for drug release. The release of dye from the carriers was increased after triggering.
ACS APPLIED BIO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Richard Browning, Nia Thomas, Laura K. Marsh, Louise R. Tear, Joshua Owen, Eleanor Stride, Nicola J. Farrer
Summary: Active loading of the Pt-IV prodrug iproplatin into liposomes using a calcium acetate gradient resulted in a 3-fold enhancement in drug concentration compared to passive loading strategies. Ultrasound-triggered release of iproplatin from microbubble-liposome construct offers greater control over drug delivery, leading to increased platinum concentration in breast cancer cells.
Article
Medicine, Research & Experimental
Junjie Ren, Jing Zhou, Han Liu, Xiaodan Jiao, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The study introduces a new therapeutic strategy of inducing redox dyshomeostasis by inhibiting glutaminolysis and accumulating ROS, which triggers immunogenic cell death to suppress tumor cell proliferation. Utilizing custom-made nanoparticles with ultrasound-activated therapy can effectively disrupt redox homeostasis within tumor cells.
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Olivier Feron, Christiani A. Amorim
Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao
Summary: A new microfluidic nanoprecipitation approach has been developed for making polymer NPs with tunable drug loading up to 50%. The synthesized NPs remain very stable under acidic conditions but release the drug in a sustained manner at neutral pH.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jie Zhou, Qiao Yu, Juan Song, Shan Li, Xiang-Ling Li, Bin K. Kang, Hong-Yuan Chen, Jing-Juan Xu
Summary: In this study, a photothermally triggered nanoplatform (Au@MSN-Cu/PEG/DSF) was constructed to achieve synergistic therapy and overcome the challenges in cancer treatment. The platform released DSF to chelate with Cu2+ and generate highly cytotoxic CuET, inducing cell apoptosis. The Cu+ species formed further promoted toxic mitochondrial protein aggregation, leading to cell cuproptosis. With the combination of photothermal therapy, Au@MSN-Cu/PEG/DSF effectively killed tumor cells and inhibited tumor growth.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Natasha Bidesi, Vladimir Shalgunov, Umberto Maria Battisti, Lars Hvass, Jesper Tranekjaer Jorgensen, Christian B. M. Poulie, Andreas I. Jensen, Andreas Kjaer, Matthias M. Herth
Summary: Pretargeting imaging has gained attention for its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine derivative has been synthesized and developed into an iodine-125 analog. Radiolabeling with N-chlorosuccinimide or chloramine-T in MeCN or MeOH resulted in a radiochemical conversion of >80%. Deprotection was successful when the radiolabeled tetrazine was stirred in 6-M HCl(aq.) at 60 degrees C for 2.5 h. This is the first iodine-labeled H-tetrazine. In vivo investigations on its pretargeting ability are currently underway.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Lyngby Lassen, Mads Wissenberg, Christina Byrne, Andreas Kjaer, Philip Hasbak
Summary: This study found that 8 and 16 ECG gates can be used interchangeably for volumetric assessments in Rb-82 myocardial perfusion imaging. However, if filling and emptying rates are of interest, a minimum of 16 ECG gates should be used.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Otorhinolaryngology
Eva Lykke, Anders Christensen, Karina Juhl, Ulla Feldt-Rasmussen, Mette Friberg Hitz, Sannia Mia Svenningsen Sjostedt, Christoffer Holst Hahn, Ditte Maria Kraik Svensson, Karoline Kanstrup Springborg, Mads Georg Stage, Gitte Bjorn Hvilsom, Linda Maria Hilsted, Morten Dahl, Giedrius Lelkaitis, Andreas Kjaer, Preben Homoe, Christian von Buchwald
Summary: The purpose of this study was to investigate whether near-infrared autofluorescence image guidance can reduce the incidence of hypoparathyroidism in total thyroidectomy. The results showed that near-infrared autofluorescence imaging can improve the detection rate of parathyroid glands and reduce the rate of hypoparathyroidism, but the difference was not statistically significant. Further studies are needed to confirm the use of near-infrared autofluorescence imaging as an auxiliary tool for parathyroid gland identification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Anders Christensen, Irene Wessel, Birgitte Wittenborg Charabi, Karina Juhl, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Andreas Kjaer, Christian von Buchwald, Jesper Filtenborg Tvedskov
Summary: The aim of this study was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. A total of 50 cN0 OSCC patients scheduled for SNB were prospectively studied and injected with the tracer complex Tc99m:ICG:Nacocoll. Optical imaging appeared to be an effective tool for real-time SN identification unaffected by possible interference from the injection.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Cell Biology
Thorbjorn Soren Ronn Jensen, Tina Binderup, Markus Harboe Olsen, Andreas Kjaer, Kare Fugleholm
Summary: Anti-inflammatory treatment reduces the risk of recurrent chronic subdural hematoma (CSDH), but clinical implementation is improper due to side effects. This study aims to investigate the associations between cytokine levels and the risk of recurrence in CSDH patients and identify potential medical targets. The study found elevated levels of interleukin-1 receptor antagonist (IL-1ra) in recurrent CSDH patients, suggesting IL-1ra as a possible target for medical treatment.
Article
Biochemistry & Molecular Biology
Mads Lawaetz, Anders Christensen, Karina Juhl, Kirstine Karnov, Giedrius Lelkaitis, Anne-Marie Kanstrup Fiehn, Andreas Kjaer, Christian von Buchwald
Summary: There is currently no approved tumor-specific imaging agents for head and neck cancer. This study explored the expression of nine imaging targets in oral squamous cell carcinoma (OSCC) patients to identify potential molecular imaging targets. The urokinase-type plasminogen activator receptor (uPAR), integrin alpha v beta 6, and tissue factor showed high expression rates and are promising imaging targets for OSCC primary tumors, lymph node metastases, and recurrences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Marina Simon, Jesper Tranekjaer Jorgensen, Kamilla Norregaard, Jonas Rosager Henriksen, Gael Clergeaud, Thomas L. Andresen, Anders Elias Hansen, Andreas Kjaer
Summary: Traditional cancer treatments are often insufficient to achieve complete responses, so combination therapies are commonly used. Nanoparticle-based photothermal therapy (PTT) is a promising add-on treatment that uses localized hyperthermia to kill cancer cells. In this study, we evaluated the combination of gold nanoshell-based PTT and liposomal doxorubicin for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Constance E. Grandjean, Sune F. Pedersen, Camilla Christensen, Altea Dibenedetto, Thomas Eriksen, Tina Binderup, Andreas Kjaer
Summary: Atherosclerosis is a chronic inflammatory disease that can lead to cardiovascular events. This study evaluated and compared three different PET tracers and their uptake in the arterial vessel wall, as well as compared gene expression alterations.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Rosa Maja Mohring Gynthersen, Mette Frimodt Hansen, Lukas Frans Ocias, Andreas Kjaer, Randi Fons Petersen, Sisse Rye Ostrowski, Lene Harritshoj, Soren Jacobsen, Ulrik Overgaard, Karen Angeliki Krogfelt, Anne-Mette Lebech, Helene Mens
Summary: The presence of N. mikurensis DNA was detected in immunocompromised patients in Denmark, highlighting the potential underdiagnosis of this bacterium in Danish patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, Research & Experimental
Rasmus Munter, Esben Christensen, Thomas L. Andresen, Jannik B. Larsen
Summary: Nucleic acid therapies are considered a game changer in medicine, but concerns exist regarding adverse reactions against lipid nanoparticles used for mRNA delivery. This research shows that the administration route can regulate anti-particle immunity, with intramuscular injections generating lower levels of anti-nanoparticle antibodies compared to intravenous and subcutaneous injections.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)
Article
Biology
Milena Vujovic, Paolo Marcatili, Benny Chain, Joseph Kaplinsky, Thomas Lars Andresen
Summary: The TCRDivER algorithm integrates clone size and sequence similarity of T cell receptors (TCR) to reveal greater complexity in TCR repertoires and novel TCR repertoire traits. This tool is important for monitoring disease or therapy progression. Rating: 8 out of 10.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Xueyi Chen, Ferdia Gallagher, Mark A. Sellmyer, Alvaro A. Ordonez, Andreas Kjaer, Michael Ohliger, David M. Wilson, Sanjay K. Jain
Summary: Bacterial infections remain a major global threat even after the discovery of penicillin nearly a century ago. The overuse of antibiotics has led to the selection of multidrug-resistant super-bugs, highlighting the urgent need for new clinical tools. Next-generation molecular imaging offers unique opportunities to identify and monitor bacterial infections in a noninvasive manner, overcoming the limitations of current tools.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Danna Kamstrup Sell, Anders Wilgaard Sinkjaer, Babak Bakhshinejad, Andreas Kjaer
Summary: Mixing multiple peptide libraries with different displayed peptide characteristics can increase the throughput of selection. This study used next-generation sequencing to investigate the amplification capacity of three widely used commercial phage display peptide libraries and found that the length and cyclic conformation of displayed peptides can affect the propagation capacity of the libraries. Additionally, the Ph.D.(TM)-7 library showed higher propagation capacity. These findings provide evidence for considering peptide characteristics when pooling multiple combinatorial libraries for phage display selection.
Article
Biochemistry & Molecular Biology
Mikkel O. Norgard, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen
Summary: Extracellular vesicle (EV) secretion rate is increased by hypoxia-induced reactive oxygen species (ROS) production via the mitochondrial electron transport chain (ETC) and hypoxia-induced factor (HIF)-1 signaling. Stimulation of ETC by dichloroacetic acid (DCA) significantly increases EV secretion, which can be blocked by the antioxidant TEMPO and rotenone, an inhibitor of Complex I in the ETC. Inhibition of Complex III using antimycin A or blocking the mevalonate pathway and tyrosine metabolites with pitavastatin and 4-nitrobenzoate, respectively, enhances ROS-dependent EV secretion. These findings demonstrate that hypoxia-mimetics targeting the ETC can modify EV secretion, and ROS produced by the ETC acts as a potent stimulus for EV secretion.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)