Article
Biochemistry & Molecular Biology
Saif Rehman, Anchal Varma, Aakriti Gupta, Kenneth B. Storey
Summary: The regulation of m6A-related proteins in the liver of R. sylvatica during freezing and thawing conditions was analyzed. The study showed a decrease in the activity of demethylases and an increase in the total protein levels of m6A methyltransferase complex components during freezing. However, the demethylase fat mass and obesity showed a decreasing trend during recovery from frozen conditions. Levels of mRNA degraders also decreased under stress. Overall, the findings suggest the potential role of RNA methylation in freezing survival and its regulation in a hypometabolic state.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anchal Varma, Kenneth B. Storey
Summary: The regulation of citrate synthase (CS) in the liver of wood frogs during freezing was investigated. Results showed a significant decrease in the activity and catalytic efficiency of CS in the frozen frogs' liver, along with a decrease in phosphorylation levels. These results suggest that CS activity is suppressed and tricarboxylic acid (TCA) cycle flux is inhibited during freezing to support the frogs' survival in harsh winter conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Tighe Bloskie, Kenneth B. Storey
Summary: This study suggests that hypomethylation of H3K9 may play a key role in the metabolic recovery of wood frog brains during the thawing process, potentially affecting global gene transcription positively.
Article
Genetics & Heredity
Tighe Bloskie, Kenneth B. Storey
Summary: This study examines the role of DNA methylation in the response of wood frog brains to freezing. The results show DNA hypomethylation in wood frog brains during freeze-recovery through depressed DNMT expression and increased TET levels. Alleviating transcriptionally repressive 5-mC DNA methylation is a necessary component of the wood frog freeze-thaw cycle.
Article
Biochemistry & Molecular Biology
Tighe Bloskie, Kenneth B. Storey
Summary: A study found that the goldenrod gall fly protects its intracellular environment in prolonged winter subzero temperatures by producing cryoprotectants and suppressing gene transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jayden Sterling, Sharleen V. Menezes, Ramzi H. Abbassi, Lenka Munoz
Summary: Histone lysine demethylases (KDMs) are enzymes that remove methylation marks on lysines in nucleosomes' histone tails, regulating gene transcription and playing important roles in cancer development. KDMs can have activating or repressing effects on gene transcription, regulating the expression of oncogenes and tumor suppressors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Anchal Varma, Kenneth B. Storey
Summary: Wood frogs undergo physiological changes during winter, including suppressing the enzyme FBPase, which hinders gluconeogenesis, to adapt to freezing conditions.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Amanda M. S. Mattice, Anchal Varma, Kenneth B. Storey
Summary: The wood frog uses freeze tolerance to survive in cold environments. When exposed to freezing temperatures, the frog's body water can freeze, halting vital functions and causing damage. The study found that an enzyme called NADP-dependent isocitrate dehydrogenase (IDH) plays a role in antioxidant defense by maintaining the NADPH pool under stress conditions. The activity of IDH is regulated through reversible phosphorylation, with reduced phosphorylation observed in frozen and dehydrated frogs compared to controls.
Article
Biochemistry & Molecular Biology
Zihang Huang, Shuai Song, Xiaokai Zhang, Linqi Zeng, Aijun Sun, Junbo Ge
Summary: This review summarizes the impact of cardiac metabolism disorder on histone modifications and gene expression, as well as the dual role of metabolic substrates in regulating cardiac hypertrophy. The article suggests the therapeutic supplementation of metabolic substrates as a potential approach to restore histone modifications.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Nutrition & Dietetics
Omar Ramos-Lopez
Summary: This article reviews the evidence on the use of epigenetic signatures as potential biomarkers for predicting metabolic outcomes and discusses their potential application in the field of precision nutrition.
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Charalabos Antonatos, Katerina Grafanaki, Paschalia Asmenoudi, Panagiotis Xiropotamos, Paraskevi Nani, Georgios K. Georgakilas, Sophia Georgiou, Yiannis Vasilopoulos
Summary: This review provides an overview of the environmental factors, epigenetic modifications, and non-coding RNAs associated with the onset and progression of psoriasis. It also discusses therapeutic applications targeting the epigenome to suppress the inflammatory cutaneous cascade.
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Sudhir Verma, Aastha Singh, Akhil Varshney, R. Arun Chandru, Manisha Acharya, Jyoti Rajput, Virender Singh Sangwan, Amit K. Tiwari, Tuhin Bhowmick, Anil Tiwari
Summary: Epigenetic mechanisms play a crucial role in regulating gene expression and cellular responses, influencing various cell types during development. In the field of ophthalmology, epigenetic mechanisms may have significant impact on the pathogenesis of complex eye diseases, offering new insights for the development of novel treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Sanoji Wijenayake, Liam J. Hawkins, Kenneth B. Storey
Article
Biology
Andrew N. Rouble, Liam J. Hawkins, Kenneth B. Storey
JOURNAL OF THERMAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Liam J. Hawkins, Rasha Al-attar, Kenneth B. Storey
Article
Biochemistry & Molecular Biology
Jing Zhang, Liam J. Hawkins, Kenneth B. Storey
BIOCHEMISTRY AND CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Liam J. Hawkins, Minjing Wang, Baowen Zhang, Qi Xiao, Hui Wang, Kenneth B. Storey
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2019)
Article
Multidisciplinary Sciences
Michael A. S. Thorne, Nina Kocevar Britovsek, Liam Hawkins, Kathryn S. Lilley, Kenneth Storey
Article
Multidisciplinary Sciences
Liam J. Hawkins, Xiaoshuang Wang, Xiaomin Xue, Hui Wang, Kenneth B. Storey
Article
Cell Biology
Bryan E. Luu, Liam J. Hawkins, Kenneth B. Storey
Summary: Studies on dehydration tolerance have been mainly focused on plants and invertebrates, with vertebrate molecular mechanisms largely unexplored. This review highlights the physiological, cellular, and molecular responses of the African clawed frog to whole-body dehydration, showcasing adaptations such as water retention in vital organs, altered blood circulation, and activation of pro-survival pathways. The X. laevis genome research, in conjunction with ongoing studies, presents a promising avenue to delve deeper into the molecular adaptations for dehydration tolerance.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Aylin Erman, Liam J. Hawkins, Kenneth B. Storey
Summary: This study examines the role of miRNA in mediating biochemical changes that support African-clawed frog's endurance of dehydration. The results show an increase in miRNA biogenesis, muscle contractile proteins, and hypoxia stress tolerance, while muscle growth and differentiation decrease under dehydrating conditions.
Article
Zoology
Liam J. Hawkins, Hanane Hadj-Moussa, Vu C. Nguyen, Matthew E. Pamenter, Kenneth B. Storey
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2019)
Article
Genetics & Heredity
Liam J. Hawkins, Bryan E. Luu, Kenneth B. Storey
Article
Multidisciplinary Sciences
Liam J. Hawkins, Kenneth B. Storey