Article
Biochemistry & Molecular Biology
Polat Ipek, Resit Yildiz, Mehmet Firat Baran, Abdulkerim Hatipoglu, Ayse Baran, Albert Sufianov, Ozal Beylerli
Summary: In recent decades, there has been an increasing research interest in metal nanoparticles as alternatives to cancer treatments and antibiotics. This article presents a comprehensive characterization of silver nanoparticles (AgNPs) produced from Papaver rhoeas leaf extract using various spectroscopic, microscopic, structural, and analytic techniques. The study reveals that PR-AgNPs are spherical with a maximum surface plasmon resonance of 464.03 nm, and have high thermal stability and antibacterial activity. The cytotoxic and proliferative effects of PR-AgNPs on various cancer cell lines are also evaluated. The findings highlight the potential of PR-AgNPs in nanomedicine and nanochemistry.
Article
Microbiology
Xin-Li An, Jian-Xin Xu, Mei-Rong Xu, Cai-Xia Zhao, Hu Li, Yong-Guan Zhu, Jian-Qiang Su
Summary: Shopping malls are unique ecosystems for the transmission of microorganisms of public health concern. Despite extensive investigation of natural environmental microbiomes, there is little knowledge about the microbial ecology in malls. Characterizing microbial distribution and potential pathogens will help establish a baseline for monitoring and preventing public health threats in malls.
Article
Engineering, Environmental
Lapo Mughini-Gras, Rozemarijn Q. J. van der Plaats, Paul W. J. J. van der Wielen, Patrick S. Bauerlein, Ana Maria de Roda Husman
Summary: This study highlights the presence of microplastic pollution in a major riverine environment, impacting microbial communities and potential pathogens. High concentrations of microplastics, primarily polyamide and polyvinylchloride, were found. Different microbial compositions were observed on microplastics of varying sizes, with seasonality and methodological effects also playing a role.
Article
Infectious Diseases
Jing Zhao, Yu Fu, Yong Wang, Mingjia Bao, Huiling Li, Hongbin Qiu
Summary: The study revealed that among the various pathogens causing infective diarrhea in East Heilongjiang, China, Salmonella displayed multiple drug resistance and polymorphic distribution in terms of strain homology.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Ecology
Ireri A. Carbajal-Valenzuela, Ariel H. Munoz-Sanchez, Juan Hernandez-Hernandez, Francisco Barona-Gomez, Camille Truong, Angelica Cibrian-Jaramillo
Summary: The study investigated the differences in endophytic microbiomes between symptomatic and asymptomatic vanilla plants, showing the presence of specific core microbiota in roots and stems. However, there were no significant differences in microbial community richness among feral, asymptomatic, and symptomatic cultivated vanilla. The findings lay the groundwork for a better understanding of the role of the microbiome in vanilla fungal diseases.
Review
Microbiology
Dana Nayduch, Saraswoti Neupane, Victoria Pickens, Tanya Purvis, Cassandra Olds
Summary: House flies are recognized as filth-associated organisms causing public nuisances. They bridge the gap between breeding environments and habitations, creating sanitation issues. Scientific surveys show that fly carriage of bacterial pathogens is more widespread and dangerous than thought, including antimicrobial resistance genes. Flies not only harbor but also transmit viable and infectious bacterial pathogens. The extent of fly dissemination of pathogens is extensive. The house fly's role as a reservoir, disseminator, and vector for pathogens has been greatly underestimated.
Review
Microbiology
Viola Halder, Brianna McDonnell, Deeva Uthayakumar, Jane Usher, Rebecca S. Shapiro
Summary: Genetic interaction (GI) analysis is a powerful genetic strategy used to dissect epistatic interactions between genes by analyzing the fitness and phenotypes of mutant cells. It has been applied in diverse microbial pathogens to study virulence, antimicrobial drug resistance, and host-pathogen interactions, providing important insights into complex genetic networks.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
E. Lawrence Bright, J. E. Darnbrough, D. T. Goddard, I. Griffiths, M. Cattelan, R. Springell
Summary: This study investigates the rate and mechanism of uranium mononitride oxidation, providing insights into fuel surface oxidation during manufacture and storage. The study reveals the formation of a UO2+xNy layer and a U2N3 interlayer on the surface of an epitaxial (001) UN thin film. This topotactic formation is predicted to play a critical role in passivation during long-term structural investigation.
Article
Chemistry, Physical
Yujie Gao, Yuanhao Dong, Shuting Yang, Anchun Mo, Xin Zeng, Qianming Chen, Qiang Peng
Summary: The size of MXene nanosheets affects their antibacterial photothermal therapy efficacy, with smaller-sized nanosheets displaying higher antibacterial activity under near-infrared irradiation. This study provides guidance for the development of MXene-based therapeutics and highlights the importance of drug-free antibacterial therapy in treating antibiotic-resistant bacterial infections.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Muhammad Burhanuddin, Muhammad Khalid, M. G. B. Ashiq, Hafsa Najam, Mohammed S. Alqahtani, Thamraa Alshahrani, Arshi Anwar, Aneeqah Sabah, M. Asadullah Nadir
Summary: In this study, a series of LaxBi2_xSn2O7/SnO2(8-Bi2O3) nanostructures were synthesized using sol-gel technique. The presence of hybrid phase metal oxides was confirmed by XRD analysis and TEM results. The formation of heterojunction with multifunctional pyrochlore increased the dielectric constant and quantum efficiency of the material. Electrical parameters such as AC conductivity, impedance, dielectric constant, electric modulus, and tangent loss were studied using an impedance analyzer meter. The relaxation mechanisms at different polarization stages in the applied frequency range were discussed. The appearance of relaxation peaks at different frequencies indicates that the prepared hybrid nanocomposites are suitable for energy storage devices across a wide range of frequencies.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Microbiology
Sheng Ye, Shengkai Li, Chenjun Su, Zhuqing Shi, Heng Li, Jiawen Hong, Shengke Wang, Jingyan Zhao, Weiji Zheng, Shixuan Dong, Shuhan Ye, Yongliang Lou, Zhemin Zhou, Jimei Du
Summary: The study investigated the water quality index, microbial composition, and antimicrobial resistance genes in urban water habitats. It found that hospital waters had higher levels of nitrogen, phosphorus, and ammonia compared to wetlands. The hospital-related samples contained a large number of bacteria associated with the gut microbiome, while the wetland waters enriched bacteria associated with aquatic environments. The presence of antimicrobial resistance genes was observed in different water samples, with hospital-related samples carrying a larger number of ARGs associated with bacteria from Acinetobacter, Aeromonas, and Enterobacteriaceae.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Plant Sciences
Prachi Singh, Jyoti Singh, Shatrupa Ray, Anukool Vaishnav, Priyanka Jha, Rakesh Kumar Singh, Harikesh Bahadur Singh
Summary: Microbial volatile organic compounds (mVOCs) and their potential in plant growth and development remains understudied. In vitro experiments demonstrated that volatiles from Trichoderma asperellum BHU P1 and Ochrobactrum sp. BHU-PB1 inhibited the growth of Fusarium oxysporum f.sp lycopersici (FOL). Exposure to volatiles from Ochrobactrum sp. resulted in the highest seed germination and seedling growth. Compared to the control, plants treated with microbial volatile metabolites exhibited better growth parameters and lower disease incidence.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Engineering, Chemical
Shubhadeep Maity, Bijay Kumar Show, Supriya Bera
Summary: Ultrafine B2 NiAl and vacancy ordered phase (Al3Ni2 type) (Cu) form during consolidation of mechanically alloyed Al-Cu-Ni alloys with and without micro alloying addition of Zr and/or Ti, resulting in high hardness. The Al-Cu-(Ni15)-Zr alloy consolidated by spark plasma sintering exhibits a remarkable hardness value of 7.2 GPa. The wide range of hardness values indicates the significant influence of composition and synthesis route. The hardening mechanism is explained through point defect hardening and solute dislocation interaction.
ADVANCED POWDER TECHNOLOGY
(2023)
Article
Energy & Fuels
Pengliang Ma, Yuegang Tang, Ruiqing Li, Qili Che, Peng Luo
Summary: Graphene with stable structure and good extensibility can be prepared using the improved Hummers redox method. Different coal-based graphenes have different crystal characteristics, and the structural order and graphitization degree are related to coal rank and coal macerals.
Article
Materials Science, Multidisciplinary
Chao Liu, Tielong Shen, Cunfeng Yao, Hailong Chang, Kongfang Wei, Lijuan Niu, Zhiwei Ma, Zhiguang Wang
Summary: The study found that a Si modified steel SIMP exhibited better oxidation resistance compared to T91 in 500 degrees C steam with a flow rate of 5 m/s, and the oxidation rate was significantly enhanced at relatively low dissolved oxygen levels. This suggested that not only alloy composition and dissolved oxygen, but also the flow rate, played important roles in the corrosion behavior of ferritic-martensitic steels.
Article
Biochemistry & Molecular Biology
Sekar Vijayakumar, Jingdi Chen, Zaira I. Gonzalez Sanchez, Kanchanlata Tungare, Mustansir Bhori, Esteban F. Duran-Lara, Periasamy Anbu
Summary: Nano-based drug delivery research is on the rise due to its potential applications in healthcare. However, traditional chemical synthesis methods have unwanted toxicity effects, making green synthesis-based and biocompatible methods necessary. This study presents the green synthesis of Moringa gum-capped MgO nanoparticles (Mgm-MgO NPs) and investigates their properties such as antioxidant activity, hemolysis potential, cytotoxicity, phytotoxicity, CAM assay, and embryotoxicity in zebrafish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Green & Sustainable Science & Technology
Punitha Nagarajan, Vijayakumar Subramaniyan, Vidhya Elavarasan, Nilavukkarasi Mohandoss, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: This study focuses on the synthesis of aluminium oxide nanoparticles (Al2O3 NPs) using Citrus aurantium peel extract as a green and efficient method. Various characterisation techniques were used to evaluate the morphology of Al2O3 NPs, as well as their antimicrobial and photocatalytic properties. The results showed that the biosynthesised Al2O3 NPs exhibited feasible antimicrobial, anti-proliferative, and photocatalytic activities, making them potential candidates for various applications.
Article
Pharmacology & Pharmacy
Alfredo Pereira, Elizabeth Valdes-Munoz, Adolfo Marican, Gustavo Cabrera-Barjas, Sekar Vijayakumar, Oscar Valdes, Diana Rafael, Fernanda Andrade, Paulina Abaca, Daniel Bustos, Esteban F. Duran-Lara
Summary: Due to the growing bacterial resistance to antibiotics, there is a need for new antimicrobial treatment options. This study focused on the rational design of hydrogels as potential delivery systems for cationic antimicrobial peptides (cAMPs). The researchers used docking and Molecular Dynamics simulations to select the best hydrogel candidates based on their interaction with two types of cAMPs. The results showed that MN4-CM5-CL1 hydrogel (HG2) was the most promising candidate for future in vitro or in vivo experiments.
Article
Biochemistry & Molecular Biology
Jose Vinoth Raja Antony Samy, Rajeswari Ranga Anantha Sayanam, Chitra Balasubramanian, Natesan Vijayakumar, Sung-Jin Kim, Sekar Vijayakumar, Mansour K. Gatasheh, Mohammad Shamsul Ola, Omar Ahmed Basudan, Mohamed Saad Daoud, Moneera Saud Al-Bagmi, Badr Tayeb Hazazi
Summary: Hyperthyroidism is characterized by excess thyroid hormones in the blood. Prescription medications for its treatment have adverse effects and symptoms often recur after discontinuation. This study investigated the use of polyherbal extract from four medicinal plants for hyperthyroidism treatment. The extract showed high concentration of phytochemicals, antioxidant capacity, and the presence of 13 bioactive compounds. Treatment with the extract normalized thyroid function and improved thyroid follicles. These findings suggest that polyherbal formulations could be an effective and protective alternative to synthetic thyroid medications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Jamal M. Khaled, Naiyf S. Alharbi, Rayan M. Al-Huwaymil, Shine Kadaikunnan, Ahmed S. Alobaidi, Abdullah M. Alfalih
Summary: The stability of (1R, 2S)-(-)-Ephedrine hydrochloride in plasma and urine samples inoculated with C. albicans was examined using HPLC method. The results showed that C. albicans had an impact on the drug concentration in both plasma and urine samples, with the drug content remaining stable in plasma samples stored at -20 degrees C for three months but degrading in urine samples after one month.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Energy & Fuels
Venkatesan Karthick, Abdul Abduz Zahir, Muniappan Ayyanar, Singamoorthy Amalraj, Karunanithi Anbarasan, Abdul Abdul Rahuman, Shine Kadaikunnan, Chinnaperumal Kamaraj, Muthu Thiruvengadam, Peramaiyan Gangapriya, Purushothaman Tamizharasan
Summary: Nowadays, nanosized drugs continue to dominate the field of pharmacology due to their small molecular size, solubility, and penetrability. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized from Lablab purpureus leaf extract and their antioxidant, antidiabetic, and antimicrobial properties were evaluated. The synthesized ZnO NPs were characterized using various techniques and were found to have a typical particle size of 28 +/- 3.00 nm. The ZnO NPs exhibited inhibition of a-amylase and a-glucosidase, as well as excellent free radical scavenging activity. They also showed antimicrobial efficacy against gram-positive and gram-negative bacteria. The study suggests that ZnO NPs may have potential applications in reducing oxidative stress and maintaining healthy glucose levels.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Multidisciplinary Sciences
Govindan Rajivgandhi, Shine Kadaikunnan, Govindan Ramachandran, Gnansekaran Chackaravarthi, Chenthis Kanisha Chelliah, Muthuchamy Maruthupandy, Manoharan Natesan, Franck Quero, Wen-Jun Li
Summary: According to recent research, chitosan, a natural polysaccharide rich biopolymer, is an important carrier molecule for drug loading. Plant essential oils are also frequently used to treat infectious diseases. The study focused on encapsulating plant essential oils into chitosan nanoparticles to inhibit A549 human lung cancer cells. The results showed that chitosan had a unique and uniform size morphology, and the chitosan loaded essential oils at 1000 lg/mL concentration were more effective in damaging the cancer cells compared to chitosan or essential oils alone.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jamal M. Khaled, Naiyf S. Alharbi, Shine Kadaikunnan, Ahmed S. Alobaidi, Khaled Nauman, Abdul-Kareem M. Ghilan, Abeer O. Almazyed, Mohammed S. Aldosary, Saeed Al Rashedi, Abdullah M. Alfalih, Mohamed A. Farrag, Mohammed S. Alharbi
Summary: This study aimed to evaluate and monitor the prevalence of human pathogenic Candida strains and their resistance to antifungal drugs in Riyadh, Saudi Arabia. It also evaluated the synergy of antimicrobial agents against Candida species' resistance to antifungal drugs.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Agronomy
Khalid A. Al-Ghanim, Kaliyamoorthy Krishnappa, Jeganathan Pandiyan, Marcello Nicoletti, Baskar Gurunathan, Marimuthu Govindarajan
Summary: Agricultural and medical insect pests cause damage to crops and spread diseases, affecting both edible crops and non-target fauna and flora. The use of ecofriendly phytopesticides can mitigate the negative effects of synthetic chemicals.
Article
Biotechnology & Applied Microbiology
Kanagavalli Ramasubbu, Siddharth Padmanabhan, Khalid A. Al-Ghanim, Marcello Nicoletti, Marimuthu Govindarajan, Nadezhda Sachivkina, Vijayarangan Devi Rajeswari
Summary: Green methods of synthesizing nanoparticles, such as using plant leaves, are safe, eco-friendly, and cost-efficient. In this study, copper oxide nanoparticles (CuO NPs) fabricated with Sesbania grandiflora (Sg) leaves were tested for their effectiveness. The Sg-CuO NPs showed promising anti-diabetic, anti-oxidant, protein degradation-inhibiting, and anti-microbial properties, indicating their potential use in treating bacterial infections associated with hyperglycemia.
FERMENTATION-BASEL
(2023)
Article
Agricultural Engineering
Ramkumar Samynathan, Baskar Venkidasamy, Ashokraj Shanmugam, Jamal M. Khaled, Ill-Min Chung, Muthu Thiruvengadam
Summary: The impact of biotic and abiotic stress on tea includes reduced yield and changes in flavour, aroma, and phytochemical composition. The tea mosquito bug (TMB) is a major biotic stress that affects the growth, yield, and quality of tea. This study investigated the impact of TMB infestation on three Indian tea cultivars, revealing increased levels of antioxidant enzymes and phytochemicals, as well as differential production of secondary metabolites. Transcriptional analysis also showed induction of key flavonoid genes in infected plants.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
G. Vijayakumari, N. Iyandurai, A. Thamarai, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This study used spectral data analysis and density functional theory simulation to explore the impact of the compound on biology and medicine, and found that clemastine is the most effective anti-allergic drug for use in contemporary therapeutic targets.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
M. Vennila, S. Muthu, A. Senthil, T. Bharanidharan, M. Malar Wezhli, Jamal M. Khaled, Ghulam Abbas, Shine Kadaikunnan
Summary: In this study, theoretical investigations of the molecule 2-Acetyl Pyridine were conducted using DFT technique. The spectral properties, energy gap, and chemical nature were analyzed in gas and solvent phases. The study showed that the molecule exhibited highest nonlinear optical behavior in water solvent and highest transition energy in benzene solvent.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Thirupathi Balaji, Chethakkad Manikkan Manushankar, Khalid A. Al-Ghanim, Chinnaperumal Kamaraj, Durairaj Thirumurugan, Sundaram Thanigaivel, Marcello Nicoletti, Nadezhda Sachivkina, Marimuthu Govindarajan
Summary: The utilization of algae-derived nanoparticles has attracted attention for their environmentally sustainable characteristics and ability to interact with biologically active metabolites. In this study, copper oxide nanoparticles (CuONPs) were synthesized using P. boergesenii and their antibacterial and anticancer activities were evaluated. Various analytical techniques were used to characterize the CuONPs' stability and size distribution. The CuONPs showed significant antibacterial activity against Bacillus subtilis and Escherichia coli and exhibited cytotoxic effects on malignant melanoma cells.
Article
Chemistry, Physical
K. Parveen Begaum, T. Prabhu, M. Thirunavukkarasu, P. Sangeetha, Saleem Javed, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This study aims to investigate the global minimum energy structure of anti-blood cancer drug 4-(Bis (2-chloroethyl)amino)-L-phenylalanine (4B2CA-LPA) using functionalized density functional theory (DFT) calculations and examine the geometries and topological features of covalent and non-covalent interactions. The study also explores new non-covalent attraction forces in this molecule and analyzes electrostatic potential variation and global reactive descriptor energy variations in the solvation phases. Furthermore, the study evaluates the electronic excitations and optical properties of 4B2CA-LPA in liquids.
CHEMICAL PHYSICS IMPACT
(2023)
