Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Sanaz Askari, Saba Mokhtari, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: The effectiveness of memantine as an adjunct therapy to sertraline for patients with obsessive-compulsive disorder (OCD) was investigated. The results showed that memantine had a positive effect on executive function but did not support its efficacy as an adjunctive agent to sertraline for OCD symptoms.
Article
Psychiatry
Terence H. W. Ching, Rachael Grazioplene, Calvin Bohner, Stephen. A. A. Kichuk, Giuliana DePalmer, Elizabeth D'Amico, Jeffrey Eilbott, Anastasia Jankovsky, Michelle Burke, Jamila Hokanson, Brad Martins, Chelsea Witherow, Prerana Patel, Lucia Amoroso, Henry Schaer, Christopher Pittenger, Benjamin Kelmendi
Summary: This study aims to evaluate the feasibility, safety, and tolerability of psilocybin in the treatment of OCD and provide preliminary evidence on its effects on symptoms. It also aims to elucidate the neural mechanisms mediating these effects. The study design is a randomized, double-blind, placebo-controlled trial with 30 participants and a 12-week follow-up period.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Jon E. Grant, Roxanne Hook, Stephanie Valle, Eve Chesivoir, Samuel R. Chamberlain
Summary: Tolcapone, a COMT enzyme inhibitor, showed significant improvement in reducing OCD symptoms compared to placebo, indicating its potential as a new treatment option for OCD.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: This study aimed to evaluate the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD. The results showed that while agomelatine did not improve OCD symptoms, the combination treatment was safe and effective compared to placebo.
Article
Psychiatry
Ghazal Jahanbakhsh, Seyed Alireza Haji Seyed Javadi, Mahnaz Majidi, Marzieh Khademi, Ramin Karimi
Summary: This study evaluated the effectiveness of using low-frequency rTMS over the left dorsolateral prefrontal cortex as an adjunctive treatment for OCD patients refractory to treatment. The results showed that after 15 sessions, adjunctive low-frequency rTMS significantly reduced the Y-BOCS scores and the reduction was durable even after three to six months. Additionally, using antipsychotic agents along with serotonergic agents as adjuvant therapy may predict a better response to adjunctive rTMS.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Medicine, General & Internal
Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu, Ze-Zhi Li
Summary: This study aimed to investigate the efficacy of amisulpride augmentation therapy in treating patients with treatment-resistant schizophrenia. The results showed that amisulpride augmentation therapy improved psychiatric symptoms and cognitive function with tolerability and safety.
MILITARY MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, Marcela G. Ot'alora, Wael Garas, Casey Paleos, Ingmar Gorman, Christopher Nicholas, Michael Mithoefer, Shannon Carlin, Bruce Poulter, Ann Mithoefer, Sylvestre Quevedo, Gregory Wells, Sukhpreet S. Klaire, Bessel van der Kolk, Keren Tzarfaty, Revital Amiaz, Ray Worthy, Scott Shannon, Joshua D. Woolley, Cole Marta, Yevgeniy Gelfand, Emma Hapke, Simon Amar, Yair Wallach, Randall Brown, Scott Hamilton, Julie B. Wang, Allison Coker, Rebecca Matthews, Alberdina de Boer, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.
Article
Psychiatry
Richard A. Kanaan, Gina Oliver, Anita Dharan, Shahbaz Sendi, Alice Maier, Mohammadreza Mohebbi, Chee Ng, Sudie E. Back, Peter Kalivas, Michael Berk
Summary: This study investigated the efficacy of adjuvant N-acetylcysteine (NAC) treatment in patients with treatment-resistant PTSD. The results showed that there were no significant differences between NAC and placebo groups in CAPS-5 scores at 12 weeks, but significant differences were observed in craving duration and resistance at 64 weeks. Further research is needed to determine the efficacy of NAC for treatment-resistant PTSD.
PSYCHIATRY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Irena Smaga, Malgorzata Frankowska, Malgorzata Filip
Summary: N-acetylcysteine (NAC) is a well-known mucolytic agent that has shown beneficial effects on different psychiatric disorders. It exerts its effects through regulating neurotransmitters, oxidative balance, and inflammatory mediators. While preclinical studies have shown positive results, further research is needed to establish the clinical efficacy of NAC for psychiatric disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychiatry
Eman M. Khedr, Khaled Elbeh, Mostafa Saber, Zeinab Abdelrady, Ahmed Abdelwarith
Summary: This study compared the effectiveness of low frequency repetitive transcranial magnetic stimulation over different brain regions for the treatment of obsessive-compulsive disorder (OCD). The results showed that both active treatment groups outperformed the sham group in improving OCD symptoms. Patients with shorter illness duration, lower baseline scores, and fewer comorbidities responded better to the treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Satish Suhas, Palash Kumar Malo, Vijay Kumar, Thomas Gregor Issac, Nellai K. Chithra, Binukumar Bhaskarapillai, Y. C. Janardhan Reddy, Naren P. Rao
Summary: This study conducted a network meta-analysis to compare the efficacy of various interventions in SRI-resistant OCD. The results suggest that deep TMS, ondansetron, CBT[TA], and aripiprazole may be considered as first-line interventions for adults with SRI-resistant OCD.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
Rituparna Maiti, Archana Mishra, Anand Srinivasan, Biswa Ranjan Mishra
Summary: This network meta-analysis evaluates and compares the effects of different pharmacological agents as augmentation agents for serotonin reuptake inhibitors (SRIs) in obsessive-compulsive disorder (OCD). The results show that memantine is the most effective augmentation agent for SRIs in OCD, followed by lamotrigine, ondansetron, and granisetron, with moderate certainty of evidence. Symptom reduction is greater in SRI-refractory OCD patients compared to non-refractory OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Neurosciences
Xiang-Zhen Kong, Premika S. W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gursel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Sarah E. Medland, Jose M. Menchon, Luciano Minuzzi, Pedro S. Moreira, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, Jose C. Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Oana Georgiana Rus-Oswald, Yuki Sakai, Joao R. Sato, Lianne Schmaal, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido A. van Wingen, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Vlasios Brakoulias, Vladan Starcevic, Umberto Albert, Shyam S. Arumugham, Brenda E. Bailey, Amparo Belloch, Tania Borda, Liliana Dell'Osso, Jason A. Elias, Martha J. Falkenstein, Ygor A. Ferrao, Leonardo F. Fontenelle, Lena Jelinek, Brian Kay, Christine Lochner, Giuseppe Maina, Donatella Marazziti, Hisato Matsunaga, Euripedes C. Miguel, Pedro Morgado, Massimo Pasquini, Ricardo Perez-Rivera, Sriramya Potluri, Janardhan Y. C. Reddy, Brad C. Riemann, Maria C. do Rosario, Roseli G. Shavitt, Dan J. Stein, Kirupamani Viswasam, Naomi A. Fineberg
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2020)
Article
Clinical Neurology
Emma M. Thompson, Albina R. Torres, Lucy Albertella, Ygor A. Ferrao, Jeggan Tiego, Roseli G. Shavitt, Maria Conceicao do Rosario, Euripedes C. Miguel, Leonardo F. Fontenelle
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Editorial Material
Neurosciences
Emily Behling, H. Michael Bloch
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Andre Zugman, Pedro Mario Pan, Ana Paula Arantes Bueno, Luciana Monteiro Moura, Ary Gadelha, Felipe Almeida Picon, Edson Amaro Jr, Giovanni Abrahao Salum, Euripedes Constantino Miguel, Luis Augusto Rohde, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski
Summary: The study found that the identification accuracy of the whole brain functional profile in children and adolescents is moderate at 38%, while the cortical volumetric profile has an accuracy of 95%. Among large-scale networks, the default-mode, frontoparietal, and dorsal-attention networks are the most discriminative. These results support the protracted development of specific individual structural and functional connectivity profiles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Psychiatry
Natalia Polga, Pedro Macul Ferreira de Barros, Luis C. Farhat, Karla Mathias de Almeida, Michael H. Bloch, Beny Lafer
Summary: Both advanced paternal and maternal age are associated with an increased risk of bipolar disorder (BD) in offspring. Further studies are needed to investigate the mechanisms behind this association.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Review
Psychology, Clinical
Samuel T. Wilkinson, Daniel Trujillo Diaz, Zachary W. Rupp, Anubhav Kidambi, Karina L. Ramirez, Jose M. Flores, Victor J. Avila-Quintero, T. Greg Rhee, Mark Olfson, Michael H. Bloch
Summary: This study found that lithium has a protective effect against suicide in bipolar disorder, as well as in mixed diagnostic samples. Clozapine was also shown to reduce the odds of suicide in psychotic disorders. However, other treatments such as electroconvulsive therapy and antipsychotics did not show significant associations with suicide risk.
DEPRESSION AND ANXIETY
(2022)
Article
Biochemistry & Molecular Biology
Luis C. Farhat, Jose M. Flores, Emily Behling, Victor J. Avila-Quintero, Adam Lombroso, Samuele Cortese, Guilherme Polanczyk, Michael H. Bloch
Summary: We conducted a large-scale systematic review and meta-analysis to examine the effects of stimulant dose and dosing strategies on clinical outcomes in children/adolescents with ADHD. Our findings suggest that flexible titration of stimulant medications can improve efficacy and acceptability.
MOLECULAR PSYCHIATRY
(2022)
Review
Clinical Neurology
Emily Behling, Luis C. Farhat, Angeli Landeros-Weisenberger, Michael H. Bloch
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, acceptability, and tolerability of Vesicular monoamine transporter type 2 (VMAT2) inhibitors for chronic tic disorders (CTD), including Tourette syndrome (TS). The results showed that VMAT2 inhibitors did not have a significant effect on the short-term treatment of tic disorders and had no clinically meaningful impact on tic symptoms, but there were some adverse effects on tolerability and acceptability.
MOVEMENT DISORDERS
(2022)
Editorial Material
Psychology, Developmental
Michael H. Bloch, Krystal Finch
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Melanie V. Brady, Jessica Mariani, Yildiz Koca, Anna Szekely, Robert A. King, Michael H. Bloch, Angeli Landeros-Weisenberger, James F. Leckman, Flora M. Vaccarino
Summary: This study investigates the pathophysiology of early development in Tourette Syndrome (TS) using induced pluripotent stem cell (iPSC)-derived basal ganglia (BG) organoids. The findings suggest that TS individuals show impaired development of medial ganglionic eminence and reduced differentiation of cholinergic and GABAergic interneurons in the BG organoids. Transcriptome analyses reveal mispatterning in TS, with altered expression of GLI transcription factors and cilia disruption in the early stages of BG organoid differentiation.
MOLECULAR PSYCHIATRY
(2022)
Article
Pediatrics
Alice Lineham, Victor J. Avila-Quintero, Michael H. Bloch, Jennifer Dwyer
Summary: This study aims to investigate the association between acute dissociative symptoms and antidepressant response to ketamine in adolescents with treatment-resistant depression. The results indicate no significant relationship between dissociation symptoms and depression symptom improvement with ketamine treatment in this population. However, the interpretation of the findings may be limited due to the small sample size. Future research should include larger samples to more accurately measure the magnitude of association between acute dissociative symptoms and later antidepressant response to ketamine.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Matheus Ghossain Barbosa, Viviane Machado, Carolina Ziebold, Tais Moriyama, Rodrigo A. Bressan, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Lais Fonseca, Jim Van Os, Ary Gadelha
Summary: The Brazilian High-Risk Cohort study examined the measurement invariance of the CAPE-positive scale in children and adolescents over a three-year period. The results show that the scale is not invariant over time, indicating the need for further investigation into the factors influencing its results.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Thiago Blanco-Vieira, Joaquim Radua, Livia Marcelino, Michael Bloch, David Mataix-Cols, Maria Conceicao do Rosario
Summary: This study is the first systematic review and meta-analysis of obsessive-compulsive disorder (OCD) genetic epidemiology, aiming to update the current knowledge in the field. The findings include the high prevalence and familial nature of OCD, especially among the relatives of children and adolescent probands, with a phenotypic heritability of around 50%, and the higher correlations of OCD symptoms between monozygotic twins are mainly attributed to genetic and non-shared environmental factors.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
L. F. Fontenelle, A. R. Torres, M. C. do Rosario, R. G. Shavitt, Y. Ferrao, K. Petribu, A. V. Cordioli, E. C. Miguel
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2021)