Article
Immunology
Sudhir Karthikeyan, Mikaela K. Dimick, Lisa Fiksenbaum, Hyunjin Jeong, Boris Birmaher, James L. Kennedy, Krista Lanctot, Anthony J. Levitt, Gregory E. Miller, Ayal Schaffer, L. Trevor Young, Eric A. Youngstrom, Ana C. Andreazza, Benjamin I. Goldstein
Summary: Elevated levels of pro-inflammatory marker CRP and lower levels of anti-inflammatory marker IL-10 were found in adolescents with BD during the most severe symptomatic interval, indicating a potential association with the course of BD symptoms. Future larger studies are needed to further investigate these findings.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Noreen Rahmani, Jessica Hatch, Mikaela Dimick, Melanie R. Naiberg, Lisa Fiksenbaum, Ana C. Andreazza, Christopher R. Bowie, Daniel P. Dickstein, Benjamin Goldstein
Summary: Inflammatory markers have an impact on neurocognitive function in adolescents with BD, with more balanced pro-to anti-inflammatory ratios associated with better neurocognitive flexibility. Prospective studies are needed to assess the direction of these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Burak Baykara, Dogukan Koc, Halil Resmi, Pinar Akan, Zeliha Tunca, Aysegul Ozerdem, Deniz Ceylan, Neslihan Gurz Yalcin, Nagihan Cevher Binici, Sevay Alsen Guney, Esther Mesman, Manon H. J. Hillegers, Neslihan Inal Emiroglu
Summary: This study compared peripheral BDNF levels between pediatric and adult BD patients and found that BDNF levels were significantly lower in pediatric BD patients than in adult BD patients, which could potentially serve as a marker to distinguish pediatric BD patients from healthy controls. Furthermore, higher BDNF levels in adult BD were associated with later disease onset, but this association was not observed in pediatric BD patients. Additionally, reduced BDNF levels were associated with illness duration in adult BD patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Neurosciences
Gianmarco De Felice, Mario Luciano, Alessia Boiano, Giulia Colangelo, Pierluigi Catapano, Bianca Della Rocca, Maria Vita Lapadula, Elena Piegari, Claudia Toni, Andrea Fiorillo
Summary: This review examines the role of brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD) and investigates its potential as a biomarker for BD. The results show a decrease in circulating levels of BDNF during acute phases of BD compared to healthy controls, which increase after effective therapy. The Val66Met polymorphism is associated with features typically linked to worse outcomes. While more research is needed, BDNF appears to be a promising biomarker for BD.
Article
Clinical Neurology
Luyu Ding, Yifan Wu, Lingtao Kong, Jiaze Sun, Fangru Qu, Kaiqi Xin, Anqi Yang, Xintong Yan, Yihui Lu, Xiaowei Jiang, Yanqing Tang, Feng Wu
Summary: This study investigates whether the glial cell line-derived neurotrophic factor (GDNF) levels differ in terms of gender in patients with bipolar disorder (BD). The results show that in the healthy control group, males have significantly higher GDNF levels compared to females, while in the BD group, males have significantly lower GDNF levels compared to males in the healthy control group.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Fangming Xu, Xiaobo Wang, Tianle Zhang, Tingting Xie, Xiao Xin, Yaxuan Zhao, Yumei Wang
Summary: This study analyzed the predictive ability of complete blood count and derived inflammatory indicators for BD patients with different states. Logistic regression analysis and ROC curve analysis were used to compute these indicators. The results showed that MON, hs-CRP, and NLR were independent risk factors for BD patients, while MON, hs-CRP, and NLR were predictors for BD-M patients. NLR and MHR were important indicators for BD-D, and MON was related to BD-mixed. The combined indicators MON+hs-CRP + NLR, MON+hs-CRP + NLR, and NLR + MHR had the highest diagnostic accuracy for predicting BD, BD-M, and BD-D patients, respectively.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Maya Kuperberg, Ole Kohler-Forsberg, Alec P. Shannon, Nevita George, Sophie Greenebaum, Charles L. Bowden, Joseph R. Calabrese, Michael Thase, Richard C. Shelton, Melvin McInnis, Thilo Deckersbach, Mauricio Tohen, James H. Kocsis, Terence A. Ketter, Edward S. Friedman, Dan Iosifescu, Michael J. Ostacher, Louisa G. Sylvia, Susan L. McElroy, Andrew A. Nierenberg
Summary: The study found that patients with bipolar disorder have an increased cardiometabolic risk associated with symptom severity, and treatment with quetiapine can worsen cardiometabolic markers. The results highlight the importance of monitoring cardiometabolic risks during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Xiuhua Wu, Zhongcheng Chen, Yingtao Liao, Zhihua Yang, Xiaolin Liang, Nianhong Guan, Zhaoyu Gan
Summary: This study aimed to explore the relationship between serum levels of inflammatory markers and symptomatic severity of bipolar disorder (BD). The cross-sectional study found a significant association between inflammatory markers and severity of symptoms in BD patients. The dynamic change of serum inflammatory markers suggests that alterations in peripheral inflammatory markers in BD are state-dependent rather than trait-marked.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Mikhail S. Zinchuk, Alla B. Guekht, Tatiana A. Druzhkova, Natalia Gulyaeva, Alexander A. Shpak
Summary: This study aimed to evaluate the concentration of GDNF in tears and serum of patients with a current depressive episode. The results showed that GDNF concentration in the serum was significantly lower in women with MDD, and in BD patients, there was a significant correlation between GDNF concentration in tears and the use of anxiolytics or antidepressants. A significant correlation between GDNF concentrations in tears and serum was found in the control group. In conclusion, GDNF concentration in tears could be a biomarker of the current depressive episode.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Sukru Alperen Korkmaz, Sadice Kizgin, Esra Firat Oguz, Salim Neselioglu, Ozcan Erel
Summary: This study found significant differences in levels of thiol-disulphide parameters, ischemia-modified albumin (IMA), and C-reactive protein (CRP) between bipolar disorder (BD) patients in acute mania and early remission compared to healthy controls. Additionally, during the manic phase, markers such as neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), platelet-to-albumin ratio (PAR), and CRP levels were significantly higher. These findings highlight the importance of inflammation in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pediatrics
Robert P. P. Hoffman, Chack-Yung Yu
Summary: This study aimed to explore the relationships between hematologic inflammatory markers and body weight, biochemical inflammatory markers, and cardiometabolic risk factors. The results showed that inflammatory markers were positively correlated with body weight, but not with cardiometabolic risk factors.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Federica Klaus, Karoline Guetter, Rebecca Schlegel, Tobias R. Spiller, Erich Seifritz, Flurin Cathomas, Stefan Kaiser
Summary: The study investigated 75 peripheral inflammatory markers in patients with MDD, SZ and healthy controls, identifying CCL20 and TRAIL as inflammatory markers with significant group differences. TRAIL was elevated in both MDD and SZ, while CCL20 was specifically increased in SZ. No significant group differences were found in hsCRP.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
John de Back Jr, Erin P. Vaughan, Emily C. Kemp, Paul J. Frick, Emily L. Robertson, Toni M. Walker, Paige Picou
Summary: Due to the need for early identification of bipolar spectrum disorders, the newly developed Mood Disorder Assessment Schedule (MDAS) was tested in a sample of 396 inpatient adolescents. The MDAS showed stronger clinical utility than the standard diagnostic interview in identifying individuals at risk for bipolar spectrum disorders. This promising diagnostic tool may facilitate earlier diagnosis and prevent harmful effects of improper treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Bruno Perosa Carniel, Neusa Sica da Rocha
Summary: Based on the review of existing literature, Brain-Derived Neurotrophic Factor (BDNF) and inflammatory markers are considered important biomarkers related to depression, with potential applications in diagnosis, prognosis, and assessment of intervention responses. However, the role of cytokines in human brain activity is still insufficiently established despite their potential as markers of depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Ziwei Teng, Lu Wang, Sujuan Li, Yuxi Tan, Yan Qiu, Chujun Wu, Kun Jin, Jindong Chen, Jing Huang, Hui Tang, Hui Xiang, Bolun Wang, Hui Yuan, Haishan Wu
Summary: The study found significantly lower BDNF levels in patients with Bipolar Type II disorder (BD II) compared to patients with Major Depressive Disorder (MDD) and healthy controls. BD II and MDD patients showed similar cognitive deficits in attention, delayed memory, and RBANS total score. BDNF levels were positively associated with visuospatial/constructional and Stroop color-word in the BD II group, and with language in the MDD group.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Emmalin Buajitti, Laura C. Rosella, Ersi Zabzuni, L. Trevor Young, Ana C. Andreazza
Summary: This study used administrative data from Ontario, Canada to measure the prevalence, patient characteristics, and healthcare costs of mitochondrial disease, showing a prevalence rate of 1 in 3989. The findings highlight the high healthcare burden and costs incurred by patients with mitochondrial disease in the Ontario healthcare system.
Article
Clinical Neurology
Manuel Gardea-Resendez, Stacey J. Winham, Francisco Romo-Nava, Alfredo Cuellar-Barboza, Matthew M. Clark, Ana Cristina Andreazza, Alejandra Cabello-Arreola, Marin Veldic, David J. Bond, Balwinder Singh, Miguel L. Prieto, Nicolas A. Nunez, Hannah Betcher, Katherine M. Moore, Thomas Blom, Colin Colby, Richard S. Pendegraft, Sydney S. Kelpin, Aysegul Ozerdem, Alessandro Miola, Eleanna De Filippis, Joanna M. Biernacka, Susan L. McElroy, Mark A. Frye
Summary: This study aims to assess diet quality in bipolar disorder patients and find associations between unhealthy diet quality and depression, obesity, and cardiometabolic abnormalities. These associations were found to be stronger in female participants.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Kritleen K. Bawa, Joycelyn Ba, Alex Kiss, RuoDing Wang, Vivian Feng, Walter Swardfager, Ana Andreazza, Damien Gallagher, Giovanni Marotta, Nathan Herrmann, Krista L. Lanctot
Summary: This study investigates the relationship between lipid peroxidation, apathy, and executive dysfunction in patients at risk for VCI. The results suggest that lipid peroxidation may play an important role in the co-occurrence of apathy and executive dysfunction in those at risk for VCI.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Vivian Feng, Shankar Tumati, Ruoding Wang, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Susan Marzolini, Paul Oh, Ana Andreazza, Krista L. Lanctot
Summary: This study found that markers of late-stage lipid peroxidation are elevated in coronary artery disease patients with poor sleep and are associated with daily disturbances. However, this association is not related to other factors or with sleep quality and its factors after exercise intervention.
Article
Cardiac & Cardiovascular Systems
Etienne Abdelnour-Berchtold, Aadil Ali, Cristina Baciu, Erika L. Beroncal, Aizhou Wang, Olivia Hough, Mitsuaki Kawashima, Manyin Chen, Yu Zhang, Mingyao Liu, Tom Waddell, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: Injured donor lungs stored at 10℃ demonstrated superior oxygenation and protective effects compared to the current clinical standard of 4℃ storage.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Medicine, Research & Experimental
Timofei Chernega, Jaehyoung Choi, Leonardo Salmena, Ana Cristina Andreazza
Summary: This article investigates the current treatment options for mitochondrial diseases and explores the potential of RNA-based therapeutic strategies, including the use of ASOs and RNAi drugs, allotopic therapies, and RNA-based antigenomic therapies. Furthermore, various mechanisms for delivering RNA therapeutic agents to the mitochondrial matrix are reviewed.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Medicine, General & Internal
Aadil Ali, Antti I. Nykanen, Erika Beroncal, Edson Brambate, Andrea Mariscal, Vinicius Michaelsen, Aizhou Wang, Mitsuaki Kawashima, Rafaela V. P. Ribeiro, Yu Zhang, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: This study demonstrates for the first time the feasibility of three-day lung preservation, leading to excellent early post-transplant outcomes. The combination of cold storage and intermittent ex vivo lung perfusion opens up new opportunities in organ transplantation.
Review
Geriatrics & Gerontology
Krista L. Lanctot, Zahinoor Ismail, Kritleen K. Bawa, Jeffrey L. Cummings, Masud Husain, Moyra E. Mortby, Philippe Robert
Summary: This narrative review discusses the clinical features of apathy and depression in individuals with neurocognitive disorders, aiming to differentiate the two syndromes based on clinical presentation, diagnostic criteria, neuropathological features, and response to treatments.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Myuri Ruthirakuhan, Hugo Cogo-Moreira, Walter Swardfager, Nathan Herrmann, Krista L. Lanctot, Sandra E. Black
Summary: This study identified three groups of cardiovascular risk factors in cognitively normal elderly individuals, and only the vascular-dominant group was significantly associated with incidence of Alzheimer's disease. Selective mortality may contribute to the attenuated association between the vascular-metabolic group and incident AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Yi Zou, Anahit Grigorian, Kody G. G. Kennedy, Clement C. C. Zai, Suyi Shao, James L. L. Kennedy, Ana C. C. Andreazza, Stephanie H. H. Ameis, Chinthaka Heyn, Bradley J. J. Maclntosh, Benjamin I. I. Goldstein
Summary: Oxidative stress is associated with white matter diffusion metrics in adults with bipolar disorder (BD). This study examined the association of single-nucleotide polymorphisms in the oxidative stress system with fractional anisotropy (FA) and radial diffusivity (RD) in youth with BD. The results showed significant diagnosis-by-genotype interaction effects for FA and RD, suggesting that the SOD2 rs4880 GG genotype may attenuate the salutary antioxidant effects on white matter integrity in youth with BD. Future studies are needed to explore other genetic markers and oxidative stress biomarkers.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Krista L. Lanctot, Clara Chen, Ethan Mah, Alex Kiss, Abby Li, Dave Shade, Roberta W. Scherer, Danielle Vieira, Hamadou Coulibaly, Paul B. Rosenberg, Alan J. Lerner, Prasad R. Padala, Olga Brawman-Mintzer, Christopher H. van Dyck, Anton P. Porsteinsson, Suzanne Craft, Allan Levey, William J. Burke, Jacobo Mintzer, Nathan Herrmann
Summary: This study conducted a cost consequence analysis using data from the Apathy in Dementia Methylphenidate Trial 2 to investigate the economic attractiveness of treating apathy with methylphenidate. The results showed that methylphenidate treatment improved health utility over the 6-month follow-up period, while there was no significant difference in resource utilization costs between the treatment and placebo groups. These findings can help decision-making to improve the quality of life for patients with Alzheimer's disease while considering the burden on the healthcare system.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Natasha Z. Anita, Felicia Kwan, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Shiropa Noor, Krista L. Lanctot, Nathan Herrmann, Paul I. Oh, Baiju R. Shah, Jeremy Gilbert, Angela Assal, Ilana J. Halperin, Ameer Y. Taha, Walter Swardfager
Summary: Type 2 diabetes mellitus (T2DM) increases the risk of cognitive decline and dementia. Disruptions in the cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) pathway have been reported in T2DM, obesity, and cognitive impairment. This study analyzes linoleic acid (LA)-derived CYP450-sEH oxylipins and their relationship with cognition in T2DM, considering potential differences between obese and nonobese individuals.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Cell & Tissue Engineering
David F. Bodenstein, Pavel Powlowski, Kassandra A. Zachos, Dana El Soufi El Sabbagh, Hyunjin Jeong, Liliana Attisano, Landon Edgar, Douglas C. Wallace, Ana Cristina Andreazza
Summary: Mitochondrial dysfunction is related to various diseases, and autologous mitochondrial transplantation is a potential approach for treating mitochondrial dysfunction. The use of a 5-μm filter B provides high-quality and pure mitochondria for isolation.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Neurosciences
Angela Duong, Hyunjin Jeong, Dana El Soufi El Sabbagh, Ana C. Andreazza
Summary: On March 11, 2020, the World Health Organization declared the outbreak of SARS-CoV-2 as a global pandemic. In patients with SARS-CoV-2, inflammatory markers such as interleukin 6 and C-reactive protein are consistently elevated. This study investigates whether psychiatric patients with preexisting elevated interleukin 6 and C-reactive protein are more susceptible to severe COVID-19 complications.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)