Review
Immunology
Vlad Dionisie, Gabriela Adriana Filip, Mihnea Costin Manea, Mirela Manea, Sorin Riga
Summary: Depression has a high recurrence rate and unclear pathogenic mechanisms, with the inflammatory mechanism gaining more support. SSRIs and SNRIs decrease neuroinflammation through various mechanisms, showing an association with antidepressant action.
INFLAMMOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bingjin Li, Wei Yang, Tongtong Ge, Yao Wang, Ranji Cui
Summary: This article discusses the candidate mechanisms by which stress can lead to dysregulated microglia, which in turn contribute to the pathogenesis of depressive disorders. It suggests that changes in microglial function can strongly influence neuronal network activity through dysregulated cytokine secretion and increased release of neurotoxic metabolites, thereby contributing to pathological outcomes in response to stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Ali Ameri, Masoomeh Frouz Asadi, Ava Ziaei, Majid Vatankhah, Omid Safa, Manoochehr Kamali, Mohammad Fathalipour, Masoumeh Mahmoodi, Soheil Hassanipour
Summary: The study evaluated the efficacy and safety of oral melatonin in patients with COVID-19-induced pneumonia. The results showed that melatonin significantly reduced mortality rate and requirement of IMV, as well as shortened hospitalization and time to clinical status improvement.
INFLAMMOPHARMACOLOGY
(2023)
Article
Psychiatry
Peiyi Wu, Aixia Zhang, Ning Sun, Lei Lei, Penghong Liu, Yikun Wang, Hejun Li, Chunxia Yang, Kerang Zhang
Summary: The study suggests that lower cortical thickness of the right supplementary motor area may serve as a neuroimaging biomarker for MDD diagnosis, and a greater extent of thinner cortical thickness in this region at baseline may predict improved SSRI treatment response.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Nicoleta Carmen Cosma, Berk Uesekes, Lisa Rebecca Otto, Susanna Gerike, Isabella Heuser, Francesca Regen, Julian Hellmann-Regen
Summary: Accumulating evidence suggests the specific involvement of inflammatory processes in major depressive disorder (MDD), particularly affecting innate immunity. Our study found that MDD patients exhibit differences in M1 and M2 polarization under specific cell culture conditions, with gender also playing a significant role in these polarization effects.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, Research & Experimental
Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim, Soo-Youn Lee
Summary: Proteomic analysis revealed changes in transthyretin and TBG levels in MDD patients, which also changed after antidepressant treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Salona Roy, Md Arif Ansari, Khushboo Choudhary, Sanjiv Singh
Summary: The article provides a comprehensive understanding of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases. The activation pathways of NLRP3 have emerged as the main target for therapeutic management of depression. The available drug inhibitors for NLRP3 in preclinical and clinical trials are discussed in detail.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Evgeny Shchetinin, Vladimir Baturin, Eduard Arushanyan, Albert Bolatchiev, Dmitriy Bobryshev
Summary: This review discusses the potential therapeutic use of melatonin in COVID-19 treatment. Based on fundamental studies and clinical observations, melatonin is believed to possess anti-inflammatory, antioxidant, and immunomodulatory properties, making it an effective addition to the methods of prevention and treatment of COVID-19.
Review
Cell Biology
Ryan T. McCallum, Melissa L. Perreault
Summary: This study discussed the widespread multi-system involvement of GSK-3 in contributing to the neuropathology of MDD, emphasizing the feed-forward mechanistic links between all major neuronal signaling pathways.
Article
Psychiatry
Cheng-Teng Ip, Melanie Ganz, Vibeke H. Dam, Brice Ozenne, Annia Ruesch, Kristin Koehler-Forsberg, Martin B. Jorgensen, Vibe G. Frokjaer, Birgitte Sogaard, Soren R. Christensen, Gitte M. Knudsen, Sebastian Olbrich
Summary: This study replicated previous findings, showing higher EEG vigilance regulation stability in patients with major depressive disorder compared to healthy controls, with vigilance patterns normalizing towards healthy controls after treatment. These results support the diagnostic value of EEG-vigilance regulation as a biomarker for treatment choice in MDD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Ruidong Ding, Dingyuan Su, Qian Zhao, Yu Wang, Jia-Yi Wang, Shuangyu Lv, Xinying Ji
Summary: Major depressive disorder (MDD) is a growing global psychiatric disorder that severely impacts physical and mental health, leading to disability and suicide. The complex pathogenesis of depression has hindered the development of effective diagnostics and treatments. Recent research has focused on the role of microRNAs, short non-coding RNAs found at high levels in brain tissues, in depression. These microRNAs have been found to regulate the pathophysiology of depression, including the dysregulation of monoamines, neuroplasticity and neurogenesis abnormalities, hyperactivity of the HPA axis, and dysregulation of inflammatory responses. They may provide new insights for the diagnosis, treatment, and development of antidepressant drugs for MDD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhibing Ai, Yong Liu, Xueyu Shi, Wei Hu, Yueliang Zhang, Ran An, Gongwun Lei
Summary: This study investigates the antidepressant effects of apple pectin (AP) and citrus pectin (CP) in mice after induction of cerebral ischemia. The results demonstrate that oral administration of AP and CP can reduce depressive-like behaviors in mice and decrease inflammation levels in the brain hippocampus.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Developmental Biology
Cara Clementelli, Yuko Arita, Sarosh Ahmed, Debduth B. Pijush, Hyeon Jeong Park, Anait S. Levenson, Morgan R. Peltier
Summary: Fluoxetine prescribed during pregnancy can lead to sex-specific behavioral changes in offspring, similar to infections. The drug has significant sex- and infection-dependent effects on BDNF production in placenta explant cultures. Further studies are needed to investigate these effects in vivo and their impact on pregnancy and neurodevelopment outcomes.
Article
Neuroimaging
Vincent Beliveau, Ella Hedeboe, Patrick M. Fisher, Vibeke H. Dam, Martin B. Jorgensen, Vibe G. Frokjaer, Gitte M. Knudsen, Melanie Ganz
Summary: This study evaluated the performance of pretreatment structural brain magnetic resonance imaging measures in predicting the outcome of drug treatment for major depressive disorders. The results suggest that these measures can predict treatment response but not remission, and they do not generalize to an independent cohort.
NEUROIMAGE-CLINICAL
(2022)
Review
Pharmacology & Pharmacy
Jialei Zhu, Jing Jin, Jing Tang
Summary: This review summarized the inflammatory pathological mechanisms associated with postpartum depression (PPD) and introduced potential therapeutic alternatives. Due to limited research, there are still many directions for further investigation into the inflammatory mechanisms of PPD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Computer Science, Software Engineering
Keshav Gupta, Gurjit Singh Walia, Kapil Sharma
Summary: The study introduces a novel cancelable multimodal biometric system that combines multiple traits to generate revocable and noninvertible biometric features for protecting user data privacy and preventing theft. Experiments demonstrate high performance and tolerance against various security attacks.
Article
Medicine, General & Internal
Keshav Kumar Gupta, Ahmed Ismail, Edward Balai, Max Sallis Osborne, John Murphy
Summary: The study found that 52.5% of patients prefer outpatient letters to be written directly to them, while all surgeon letters were addressed to GPs. The research advocates for patient-directed letters to become the norm in order to improve patients' understanding of their own health and treatment decisions.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Otorhinolaryngology
Keshav Kumar Gupta, Shahram Anari
Summary: Medical treatment options for rhinitis during pregnancy should be carefully considered, taking into account the causes of rhinitis. Conservative treatment is important for pregnant women with pregnancy-induced rhinitis or pre-existing allergic or non-allergic rhinitis. Safe strategies such as exercise, positioning, saline nasal douching, and nasal valve dilators can provide relief for these patients. The use of common medical therapies for rhinitis may not be suitable for pregnant patients due to potential teratogenic effects, but topical corticosteroids such as budesonide are generally considered safe.
AURIS NASUS LARYNX
(2022)
Review
Otorhinolaryngology
Karan Jolly, Keshav Kumar Gupta, Jameel Muzaffar, Shahzada K. Ahmed
Summary: This study aimed to assess the efficacy and safety of intrathecal fluorescein (IF) used in the endoscopic management of anterior skull base cerebrospinal fluid (CSF) fistulae. The results showed that IF was effective in localizing CSF fistulae, with the most significant complications associated with higher doses (>50mg). Therefore, it is recommended to use low doses of IF (<50mg) in this field, with a frequent range of 10-30mg.
AURIS NASUS LARYNX
(2022)
Article
Business
Keshav Gupta, Yiran Su, Thilo Kunkel, Daniel Funk
Summary: This research analyzes the in-app behaviors of highly interactive consumers in a freemium gamified service and finds that consumers who heavily use the application or excel at in-app challenges are less likely to become super engagers. Among super engagers, some are socially competitive and make in-app purchases due to their inability to advance in the leaderboard, while others make purchases to collect extrinsic rewards. Additionally, highly interactive consumers who have more knowledge about the gamified service become super engagers in order to increase their chances of being socially competitive.
Article
Hospitality, Leisure, Sport & Tourism
Nataliya Bredikhina, Keshav Gupta, Thilo Kunkel
Summary: This research investigates the effects of brand networking on athlete follower growth and finds that the size of pre-existing following and the establishment of brand networks with athletes and event brands are predictors of follower growth. The study also uncovers coopetitive relationships between athlete brands and shows how new brand networks, visible through social media, spur athlete brand growth.
EUROPEAN SPORT MANAGEMENT QUARTERLY
(2023)
Article
Medicine, General & Internal
Keshav Kumar Gupta, Georgios Garas, Matthew Idle, Susan Germain, Mriganka De
Summary: This study evaluated the utility of PuraBond (R) in Transoral Robotic Surgery (TORS) and found positive outcomes, supporting its safety and efficacy in postoperative hemostasis and regeneration. Larger studies are needed to further validate its benefits for patients.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Orthopedics
K. Jolly, K. K. Gupta, N. Bhamra, A. Aslanidou, R. Batra, S. Ahmed
Summary: This retrospective study analyzed CSF fistula repair surgeries conducted in a tertiary UK hospital between 2012 and 2019, with a total of 33 patients involved. The endoscopic endonasal approach to SCSFL repair showed excellent success rates, with most cases employing a multilayered reconstruction method. Postoperative complications were minimal.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Article
Medicine, General & Internal
Keshav Kumar Gupta, George Garas, Jonathan Wilkes, Mriganka De
Summary: Thyroid mucoepidermoid carcinoma is a rare but important thyroid malignancy with a good prognosis. This case contributes to the medical literature by providing new information and detailing the key histopathological features of thyroid carcinoma with synchronous different histological types.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Sabhav Gupta, Adarsh Pandey, Shivam Naruka, Keshav Gupta
Summary: An AI personal assistant is a software developed using Python that can accept verbal commands and perform various tasks, including opening applications, retrieving information, and forecasting weather. Its aim is to provide convenience to users and save their time.
MICRO-ELECTRONICS AND TELECOMMUNICATION ENGINEERING, ICMETE 2021
(2022)
Article
Engineering, Multidisciplinary
Eshita Sharma, Keshav Gupta, Lubaina Machinewala, Samaksh Dhingra, Shrey Tripathi, V. S. Shreyas, Sujit Kumar Chakrabarti
Summary: This paper explores key issues in the interview process and proposes an automated solution that has been demonstrated to be more effective, providing a valuable reference for future system development.
SADHANA-ACADEMY PROCEEDINGS IN ENGINEERING SCIENCES
(2022)
Article
Otorhinolaryngology
Keshav Kumar Gupta, Zahir Mughal, Ijaz Ahmad
Summary: This case report presents a rare anatomical variation of unilateral STC agenesis in a patient with stage III laryngeal squamous cell carcinoma. It highlights the diagnostic challenges and surgical implications of this condition.
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Education, Scientific Disciplines
Keshav Kumar Gupta, Navdeep Bhamra, Karan Jolly
Summary: This study aims to investigate the impact of a specific training program on the confidence and preparedness of newly qualified doctors. Results from pre- and post-course surveys show a statistically significant increase in confidence ratings across all questions. The study suggests that implementation of transition courses can have a positive effect on newly qualified doctors.
MEDICAL SCIENCE EDUCATOR
(2022)
Review
Surgery
Keshav Kumar Gupta, Edward Balai, Adnan Darr, Karan Jolly
Summary: This study evaluated the reconstructive techniques and post-operative CSF leak rates in patients with clival chordomas managed with an endoscopic endonasal approach (EEA). The majority of authors used a multi-layered reconstruction method. The use of a nasoseptal flap showed a lower CSF leak rate, but the difference was not statistically significant.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Keshav Kumar Gupta, Vinay Kumar Gupta, Ranjodh Singh Sanghera, Karan Jolly, Lisha McClleland
Summary: The study demonstrates a significant decrease in the number of patients seen in ENT emergency clinics from 2019 to 2020, aligning with global trends of reduced emergency department visits, trauma admissions, and admissions across various specialties.
CRANIOMAXILLOFACIAL TRAUMA & RECONSTRUCTION
(2022)