Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume 45, Issue 2, Pages 265-276Publisher
WILEY
DOI: 10.1111/jcpe.12841
Keywords
autogenous bone block; bone morphogenetic protein-2 (MeSH terms); bone regeneration; dental implants; guided bone regeneration
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Funding
- Osteology Foundation
- Geistlich Pharma AG
- Dentsply Sirona Implants
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ObjectivesTo test whether or not the use of a xenogeneic block loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) results in different bone quantity and quality compared to an autogenous bone block. Materials and MethodsTwenty-four patients with insufficient bone volume for implant placement were randomly assigned to two treatment modalities: a xenogeneic bone block loaded with rhBMP-2 (test) and an autogenous bone block (control). The horizontal ridge width was evaluated prior to augmentation, after augmentation and at 4months. Patient-reported outcome measures (PROMs) were assessed at suture removal and at 4months. Biopsies were obtained at 4months and histologically evaluated. Intergroup comparisons were tested by a two-sided Wilcoxon-Mann-Whitney test, intra-group comparisons were performed with Wilcoxon-signed rank test, and all categorical variables were tested with Chi-squared tests. ResultsOne autogenous bone block failed. This patient was replaced, and in all subsequently treated 24 patients, implant placement was possible 4months later. The median ridge width increased from 4.0mm (Q1=2.0; Q3=4.0) (test) and 2.0mm (Q1=2.0; Q3=3.0) (control) to 7.0mm (Q1=6.0; Q3=8.0) (test) and 7.0mm (Q1=6.0; Q3=8.0) (control) at 4months (intergroup p>.05). A higher morbidity was reported at the augmented site in the control group during surgery. Sensitivity was more favourable in the test than that in the control group at 4months. The biopsies revealed more mineralized tissue in the control group (p<.0043). ConclusionsBoth treatment modalities were successful in regenerating bone to place dental implants. PROMs did not reveal any significant differences between the groups except for pain during surgery at the recipient site (in favour of the test group). Histologically, a higher amount of mineralized tissue was observed for the control group at 4months.
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