4.7 Editorial Material

New Era in Radiation Oncology for Lung Cancer: Recognizing the Importance of Cardiac Irradiation

Journal

JOURNAL OF CLINICAL ONCOLOGY
Volume 35, Issue 13, Pages 1381-+

Publisher

AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2016.71.5581

Keywords

-

Categories

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Oncology

Insurance Status is an Independent Predictor of Overall Survival in Patients With Stage III Non-small-cell Lung Cancer Treated With Curative Intent

Stephanie R. Rice, Melissa A. L. Vyfhuis, Katherine A. Scilla, Whitney M. Burrows, Neha Bhooshan, Mohan Suntharalingam, Martin J. Edelman, Josephine Feliciano, Shahed N. Badiyan, Charles B. Simone, Soren M. Bentzen, Steven J. Feigenberg, Pranshu Mohindra

CLINICAL LUNG CANCER (2020)

Article Oncology

Hypofractionated vs. conventional radiation therapy for stage III non-small cell lung cancer treated without chemotherapy

Michelle Iocolano, Aaron T. Wild, Margaret Hannum, Zhigang Zhang, Charles B. Simone, Daphna Gelblum, Abraham J. Wu, Andreas Rimner, Annemarie F. Shepherd

ACTA ONCOLOGICA (2020)

Review Health Care Sciences & Services

Proton Therapy for Partial Breast Irradiation: Rationale and Considerations

J. Isabelle Choi, Jana Fox, Richard Bakst, Shaakir Hasan, Robert H. Press, Arpit M. Chhabra, Brian Yeh, Charles B. Simone, Oren Cahlon

Summary: Partial breast irradiation (PBI) delivered with proton therapy offers a shorter treatment duration and reduced toxicities, targeting less non-target breast tissue and limiting unnecessary radiation dose to thoracic organs. Proton therapy is a precision radiotherapy technology that further limits normal tissue exposure to improve quality of life for early stage breast cancer patients.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Oncology

Quantitative Assessment of 3D Dose Rate for Proton Pencil Beam Scanning FLASH Radiotherapy and Its Application for Lung Hypofractionation Treatment Planning

Minglei Kang, Shouyi Wei, J. Isabelle Choi, Charles B. Simone, Haibo Lin

Summary: This study focuses on quantifying the dose rate of organs-at-risk and targets based on three proposed proton PBS dose rate metrics, showing significant impact of differences in dose rate metrics on the assessment of organ-at-risk dose rate, posing challenges to the clinical implementation of FLASH. Additional investigations are needed to explore the correlation between FLASH efficacy and the dose rate metrics in proton PBS therapy.

CANCERS (2021)

Article Oncology

A Novel Proton Pencil Beam Scanning FLASH RT Delivery Method Enables Optimal OAR Sparing and Ultra-High Dose Rate Delivery: A Comprehensive Dosimetry Study for Lung Tumors

Shouyi Wei, Haibo Lin, J. Isabelle Choi, Charles B. Simone, Minglei Kang

Summary: This study compares the performance of single-energy Bragg peak proton beams with transmission proton beams in lung tumor treatment planning, finding that Bragg peak plans achieve superior dosimetry performances in OARs while maintaining comparable dose rate performances. Beam angle optimization further improves OAR dosimetry parameters without compromising the 3D FLASH dose rate coverage.

CANCERS (2021)

Review Oncology

Proton Therapy in the Management of Pancreatic Cancer

Jana M. Kobeissi, Charles B. Simone, Haibo Lin, Lara Hilal, Carla Hajj

Summary: Radiation therapy plays a central role in the management of pancreatic cancer, and proton therapy is an emerging treatment modality. Proton irradiation remains a challenge in radiation therapy, but no significant differences in oncologic outcomes and toxicity rates have been shown compared to photon radiation treatment.

CANCERS (2022)

Review Oncology

Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum

Jana M. Kobeissi, Charles B. Simone, Lara Hilal, Abraham J. Wu, Haibo Lin, Christopher H. Crane, Carla Hajj

Summary: Radiation treatment is crucial in managing luminal gastrointestinal cancers, particularly esophageal and anorectal cancers. Proton therapy is gaining interest for its ability to decrease dose to nearby organs at risk. In esophageal cancer, protons have shown superior dosimetric characteristics in sparing organs at risk, but clinical significance is conflicting. However, evidence suggests that protons offer similar or improved oncologic outcomes with reduced toxicity compared to photons. In anorectal cancers, proton therapy has shown improved organ sparing, but clinical data is limited and toxicity benefits have not been clinically proven.

CANCERS (2022)

Review Oncology

Proton Therapy in the Management of Hepatocellular Carcinoma

Jana M. Kobeissi, Lara Hilal, Charles B. Simone, Haibo Lin, Christopher H. Crane, Carla Hajj

Summary: This review provides a concise and comprehensive summary on the use of proton therapy in the management of hepatocellular carcinoma (HCC). Proton radiation therapy plays a central role in the treatment of HCC, and evidence suggests it may be superior to photons in terms of survival and toxicity outcomes.

CANCERS (2022)

Article Oncology

An International Consensus on the Design of Prospective Clinical-Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer

Beatriz E. Amendola, Anand Mahadevan, Jesus Manuel Blanco Suarez, Robert J. Griffin, Xiaodong Wu, Naipy C. Perez, Daniel S. Hippe, Charles B. Simone Ii, Majid Mohiuddin, Mohammed Mohiuddin, James W. Snider, Hualin Zhang, Quynh-Thu Le, Nina A. Mayr

Summary: SFRT shows promising potential as a new treatment modality for challenging tumors. However, the development of clinical trials is hindered by the variability in SFRT methods and the unfamiliarity with heterogeneous dosing, requiring a broad consensus.

CANCERS (2022)

Article Medicine, General & Internal

Application of Spectral Algorithm Applied to Spatially Registered Bi-Parametric MRI to Predict Prostate Tumor Aggressiveness: A Pilot Study

Rulon Mayer, Baris Turkbey, Peter L. Choyke, Charles B. Simone

Summary: This study predicts the risk of clinically significant prostate cancer (CsPCa) and correlates it with the ISUP grade using processed SCR derived from SRBP-MRI. The results show a high correlation between SCR values and ISUP grade and CsPCa/CiPCa, indicating the potential of SRBP-MRI in non-invasive management of prostate cancer.

DIAGNOSTICS (2023)

Article Oncology

Proton Bragg Peak FLASH Enables Organ Sparing and Ultra-High Dose-Rate Delivery: Proof of Principle in Recurrent Head and Neck Cancer

Michael Pennock, Shouyi Wei, Chingyun Cheng, Haibo Lin, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Richard L. Bakst, Rafi Kabarriti, Charles B. Simone II, Nancy Y. Y. Lee, Minglei Kang, Robert H. Press

Summary: Bragg peak proton FLASH is a novel radiotherapy technique that combines ultra-high dose rates and conformal organ sparing for cancer treatment. By modifying the planning software and treatment delivery, Bragg peak FLASH can improve organ sparing and target coverage compared to conventional proton therapy. This study demonstrates the potential benefits of Bragg peak proton FLASH in head and neck reirradiation.

CANCERS (2023)

Article Oncology

Pencil Beam Scanning Bragg Peak FLASH Technique for Ultra-High Dose Rate Intensity-Modulated Proton Therapy in Early-Stage Breast Cancer Treatment

Grant Lattery, Tyler Kaulfers, Chingyun Cheng, Xingyi Zhao, Balaji Selvaraj, Haibo Lin, Charles B. Simone II, J. Isabelle Choi, Jenghwa Chang, Minglei Kang

Summary: This study focused on developing ultra-high dose rate intensity-modulated proton therapy (IMPT) for hypofractionated treatment of early-stage breast cancer. The results showed that the Bragg peak FLASH-RT technique achieved comparable plan quality to conventional IMPT, demonstrating the feasibility of early-stage breast cancer clinical applications.

CANCERS (2023)

Article Oncology

The Applications and Pitfalls of Cone-Beam Computed Tomography-Based Synthetic Computed Tomography for Adaptive Evaluation in Pencil-Beam Scanning Proton Therapy

Pingfang Tsai, Yu-Lun Tseng, Brian Shen, Christopher Ackerman, Huifang A. Zhai, Francis Yu, Charles B. Simone II, J. Isabelle Choi, Nancy Y. Lee, Rafi Kabarriti, Stanislav Lazarev, Casey L. Johnson, Jiayi Liu, Chin-Cheng Chen, Haibo Lin

Summary: This study evaluates the potential of cone-beam computed tomography (CBCT)-based synthetic CT (sCT) as an alternative to verification CT (vCT) in proton therapy for enhanced treatment monitoring and early adaptation. The study found that sCT agreed with vCT in regions of homogeneous tissues, but discrepancies were observed in the thorax and abdomen. The study also observed outliers in sCT plans when there was an anatomy change or in low-density regions. The target coverage variance in most sCT cases compared to vCT was less than 5%. The study concludes that the use of sCT allows for precise treatment and prompt early adaptation in proton therapy, but quality assurance of sCT is crucial in the early stages of clinical implementation.

CANCERS (2023)

Article Medicine, General & Internal

Relationship between Eccentricity and Volume Determined by Spectral Algorithms Applied to Spatially Registered Bi-Parametric MRI and Prostate Tumor Aggressiveness: A Pilot Study

Rulon Mayer, Baris Turkbey, Peter L. Choyke, Charles B. Simone

Summary: This study aims to assess tumor aggressiveness through analysis of bi-parametric MRI images using methods like signal to clutter ratio. The results show that the processed tumor eccentricity and volume computations from spatially registered BP-MRIs have a significant correlation with the ISUP grade.

DIAGNOSTICS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

The Role of Positron Emission Tomography Imaging in Radiotherapy Target Delineation

Hari Menon, Chunxiao Guo, Vivek Verma, Charles B. Simone

PET CLINICS (2020)

No Data Available