Article
Dermatology
Disha Chakraborty, Kamal Aggarwal
Summary: This study compared two different vitamin D analogues, calcipotriol and calcitriol, in combination with NBUVB phototherapy for the treatment of psoriasis. Both therapies showed significant reductions in symptoms, but the calcipotriol combination had better efficacy, lower relapse rate, and required fewer treatment sessions and doses of NBUVB.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anurag Kumar Gautam, Paruvathanahalli Siddalingam Rajinikanth
Summary: This study proposes the preparation of Nanostructured Lipid Carriers (NLCs) for the treatment of psoriasis and evaluates their effectiveness in vitro and in vivo. Results indicate that the TZT-CPT-NLC gel formulation exhibits good drug release and suitable chemical characteristics, suggesting that combination therapy may be a promising approach for the treatment of psoriasis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, Matthew D. Disney
Summary: This study utilized a DNA-encoded library to identify a compound that activates ribonuclease activity and incorporated it into the design of a next-generation ribonuclease targeting chimera. The developed chimera successfully alleviated the cellular phenotype of triple-negative breast cancer cells. This work demonstrates the potential of DNA-encoded libraries in identifying compounds with effector functions in heterobifunctional compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
James P. Falese, Anita Donlic, Amanda E. Hargrove
Summary: This article reviews recent advances in understanding RNA biology, including its crucial roles in various disease states and the challenges and methods for drug design targeting RNA. It focuses on discussing RNA structural hierarchy, functional classes, and dynamics, as well as methods for small molecule screening and RNA structure determination. Finally, it summarizes the unique challenges and emerging solutions for generating RNA-targeted ligands from both RNA and small molecule perspectives.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Agricultural Engineering
Yu Chen, Yuesen Wang, Lorenzo Pezzola, Roberto Mussi, Leslie Bromberg, John Heywood, Emmanuel Kasseris
Summary: This study investigates a simple, compact, and low-cost tar removal technology suitable for small-scale applications, which efficiently removes tar from gasification-to-power systems, helping to reduce air pollution and improve living quality.
BIOMASS & BIOENERGY
(2021)
Article
Multidisciplinary Sciences
Sangjin Seo, Dogyeong Ha, Taesung Kim
Summary: This study presents a method of controlling the transport of small molecules through evaporation in gas-permeable and low-aspect ratio nanoslits, affecting both diffusive and advective mass transports of solutes. Numerical simulations using the advection-diffusion equation characterize the effect of evaporation flux on mass transport, demonstrating the potential application of this evaporation-driven transport-control in micro/nanofluidic devices. Evaporation-driven advective flow offers a versatile manipulation scheme of fluid carrier in nanofluidic channels, providing a unique working principle for micro/nanofluidic applications such as molecule-valves, -concentrators, -pumps, and -filters.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Abhishek A. Kognole, Anthony Hazel, Alexander D. MacKerell
Summary: RNA molecules can be potential drug targets in various diseases due to their dysregulated expression or misfolding. Noncoding RNAs, which account for a large part of the human genome, have complex structures and can be targeted by small molecules. The SILCS computational approach, termed SILCS-RNA, was extended to target RNA in this study and evaluated against seven RNA targets. The method provides detailed functional group affinity patterns and facilitates the identification of new potential binding sites and ligand design.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2022)
Article
Chemistry, Inorganic & Nuclear
Palak Garg, Deepak Dange, Yixiao Jiang, Cameron Jones
Summary: This study investigates the reactions of a known 1,2-disilylene compound with various small molecule substrates, showcasing its potential as a powerful reducing reagent for transforming inert unsaturated molecules into valuable products.
DALTON TRANSACTIONS
(2022)
Article
Dermatology
David N. Adam, Marie Y. Jablonski Bernasconi, Henrik Thoning, Jashin J. Wu
Summary: Through a matching-adjusted indirect comparison, Cal/BD aerosol foam demonstrated significantly greater efficacy than HP/Taz lotion at 4 and 8 weeks, and had a more favorable safety profile up to 52 weeks. The proactive and reactive use of Cal/BD foam also had significant advantages over HP/Taz lotion in maintaining BSA and reducing adverse events.
DERMATOLOGY AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Helen L. Lightfoot, Graham F. Smith
Summary: RNA plays a vital role in cellular function and can contribute to various diseases. Small molecule-RNA targeting has emerged as a promising approach for drug discovery, with significant investments from pharmaceutical and biotechnology companies. However, the exploration of RNA as a secondary target in small molecule drug programs has been limited. This perspective discusses the safety aspects of smRNAs based on structure, target, and mechanism, and suggests evaluating these parameters to develop potentially safer drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xinyuan Liu, Shuting Pang, Liang Zeng, Wanyuan Deng, Mingqun Yang, Xiyue Yuan, Junyu Li, Chunhui Duan, Fei Huang, Yong Cao
Summary: BNTT2F, an electron acceptor with a low singlet-triplet gap of 0.20 eV and a B-N covalent bond, has been developed for organic solar cells. The optimized device based on BNTT2F achieved an efficiency of 8.3%, indicating the great potential of B-N covalent bond-containing pi-conjugated molecules in photovoltaics.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Chen-Ming Lin, Zhengyang Jiang, Zhe Gao, Maritess Arancillo, Kevin Burgess
Summary: The study explored the potential disruption of the NEDD8·NAE interaction using various chemotype designs through EKO evaluation. A compound was identified from a targeted library for its ability to bind NAE, inhibit NEDDylation, and induce cytotoxicity in leukemia cells. It represents a first-in-class inhibitor of NEDDylation and demonstrates the utility of EKO in evaluating chemotypes as potential PPI inhibitors.
Review
Biochemistry & Molecular Biology
Alexander C. Chacon, Alexa D. Melucci, Shuyang S. Qin, Peter A. Prieto
Summary: Metastatic melanoma, the deadliest form of skin cancer, can be treated with immune checkpoint inhibition (ICI) immunotherapy and newly developed small molecular (SM) inhibitors. Clinical combinations of ICI and SM therapies may provide synergistic effects in eradicating melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Dmitry O. Balakirev, Artur L. Mannanov, Nikita A. Emelianov, Polina K. Sukhorukova, Alexander K. Kalinichenko, Pavel A. Troshin, Dmitry Yu. Paraschuk, Sergey A. Ponomarenko, Yuriy N. Luponosov
Summary: The recent success in the development of non-fullerene acceptors (NFAs) for organic solar cells (OSCs) has led to a search for efficient and complementary donor materials. Understanding the structure-property correlations for new generations of acceptor and donor materials is crucial for advancing the field of OSCs. This study reports the synthesis and investigation of star-shaped small molecules based on benzotriindole (BTI) as potential donor materials for NF OSCs.
Article
Pharmacology & Pharmacy
Wai-Houng Chou, Alexander Gamboa, Javier O. Morales
Summary: Inkjet printing has emerged as a novel technology in the pharmaceutical industry for manufacturing personalized dosage forms and delivering drugs, including hydrophilic or poorly water-soluble small molecules, biological drugs, and nanoscale drug-loaded particles. However, challenges such as selecting the proper ink constituents and printer, ensuring dose accuracy, and stability studies of drugs within ink still need to be addressed for successful implementation in the field.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
