Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luscher
Summary: LOX-1, as a scavenger receptor, plays a crucial role in the development of atherosclerosis, with implications in various cell types, making it a promising diagnostic and therapeutic target for certain cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Nataliya Mushenkova, Evgeny E. Bezsonov, Varvara A. Orekhova, Tatyana Popkova, Antonina Starodubova, Alexander N. Orekhov
Summary: Atherosclerosis is a chronic disease with inflammatory components, now recognized as an active autoimmune process involving both innate and adaptive immune pathways. One of the key factors driving this process is the presence of modified LDL, which leads to the formation of oxidation-specific epitopes recognized by immune cells. Macrophage response to these epitopes is crucial for initiating and promoting inflammation in the arteries.
Article
Medicine, General & Internal
Julie Dang, Darosa Lim, Kevin Watters, Olivier Simard, Karine Doyon, Maxime Rheaume, Alexandra Mereniuk
Summary: This case describes an atypical presentation of cutaneous xanthomas caused by lipoprotein X dyslipidemia triggered by cholestatic fulminant hepatitis due to trimethoprim-sulfamethoxazole hypersensitivity. Significant improvement was seen in the patient's symptoms after treatment with cholestyramine and apheresis.
SAGE OPEN MEDICAL CASE REPORTS
(2021)
Review
Immunology
Yonghang He, Tingting Liu
Summary: Atherosclerosis is the pathological basis of acute cardiovascular and cerebrovascular diseases, with oxidized LDL being recognized as a major factor in its development. Numerous studies have shown that oxidized LDL can modulate the phenotypes of macrophages in atherosclerosis. This review summarizes the research progress on how oxidized LDL regulates macrophage polarization, which may provide new targets for the treatment of atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Concepcion Santiago-Fernandez, Flores Martin-Reyes, Monica Tome, Carolina Gutierrez-Repiso, Diego Fernandez-Garcia, Luis Ocana-Wilhelmi, Jose Rivas-Becerra, Franz Tatzber, Edith Pursch, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: Morbid obesity and hypoxia lead to increased levels of scavenger receptors (SRs) and inflammatory markers in visceral adipocytes. In a hypoxic state, ox-LDL enhances the proinflammatory response of visceral adipocytes to hypoxia.
Article
Nutrition & Dietetics
Jingya Lyu, Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Tomohiro Ibata, Takafumi Yoshimura, Hisakazu Iwama, Koji Murao
Summary: The study demonstrated that oxidized low-density lipoprotein (OxLDL) downregulates ABCA1 expression through the MEK/ERK/LXR pathway, leading to lipid accumulation in INS-1 cells, potentially resulting in impaired insulin synthesis and glucose-stimulated insulin secretion (GSIS).
Article
Biology
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Melanie Mahe, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Ines Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Summary: The study demonstrates that reducing phosphorylation at serine 196 of LXR alpha in hematopoietic cells can attenuate atherosclerosis and obesity induced by a high-fat diet in mice by reprogramming the transcriptional activity of LXR alpha in macrophages and T cells to promote an anti-inflammatory phenotype.
COMMUNICATIONS BIOLOGY
(2021)
Article
Environmental Sciences
Miki Kuroiwa, Shin-Ichiro Yamaguchi, Yoshinobu Kato, Arisa Hori, Saori Toyoura, Mai Nakahara, Nobuyuki Morimoto, Masafumi Nakayama
Summary: Our study demonstrates that the receptor Tim4 mediates the interaction between macrophages and microplastics through aromatic-aromatic interactions. It is involved in the engulfment of PS microplastics and MWCNTs, and disrupts the process of efferocytosis. These findings suggest that chronic exposure to large amounts of PS microplastics may lead to chronic inflammation and autoimmune diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: This study investigated the prevalence of sdLDL predominant phenotype in Korean adult patients and found that a significant proportion of patients had increased risk only due to sdLDL. This suggests that LDL particle size analysis has clinical significance in the Korean population.
Article
Biophysics
Kun Wang, Chaoye Gan, Huaying Wang, Meiying Ao, Youlong Fan, Yong Chen
Summary: Research shows that acidification causes changes in size and biomechanical properties of LDL/oxLDL particles, with significant decreases in hardness, potentially explaining their role in atherosclerosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Medicine, General & Internal
Jakub Ratajczak, Aldona Kubica, Piotr Michalski, Lukasz Pietrzykowski, Aleksandra Bialczyk, Agata Kosobucka-Ozdoba, Katarzyna Bergmann, Krzysztof Buczkowski, Magdalena Krintus, Piotr Jankowski, Jacek Kubica
Summary: In this cross-sectional study of 200 primary care patients without diagnosed cardiovascular disease, age, diabetes, material status, BMI, gender, and hypertension were found to be related to abnormal lipid parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yi Guo, Yong-Gen Zhang, Hong-Chun Li, Yin-Hai Xu
Summary: This study investigated lipid profiles in patients with ECCA and found that TC and sdLDL-C levels were significantly elevated while LDL-C levels were slightly lower in the ECCA group. After cholestasis relief, TC and sdLDL-C levels significantly decreased, and patients showed normal lipoprotein patterns.
ONCOTARGETS AND THERAPY
(2021)
Article
Medical Laboratory Technology
Yanhua Zhao, Siming Wang, Shanshan Liang, He Zhang, Yanxing Zhang, Rui Yu, Keyi Zhang, Hengjian Huang, Jun Dong, Wei Gan
Summary: In patients with obstructive jaundice, those with dyslipidemia show worsened liver function compared to those with simple obstructive jaundice. The decreased (HDL-c + LDL-c)/TC ratio is associated with poor liver function and disease progression in obstructive jaundice patients.
CLINICAL BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Young-Sun Im, Min-Hee Gwon, Jung-Mi Yun
Summary: PEITC, a naturally occurring isothiocyanate in cruciferous vegetables, has the potential to inhibit foam cell formation and may be a candidate for the treatment and prevention of vascular inflammation and atherosclerosis. It downregulates the expression of key genes related to lipid accumulation and inflammation, while upregulating genes associated with cholesterol efflux.
FOOD SCIENCE & NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Kotaro Kumagai, Seiichi Mawatari, Akihiro Moriuchi, Kohei Oda, Yasuhiro Takikawa, Naoya Kato, Shigeto Oda, Kazuaki Inoue, Shuji Terai, Takuya Genda, Masahito Shimizu, Isao Sakaida, Satoshi Mochida, Akio Ido
Summary: This multicenter retrospective observational study aimed to investigate whether early-phase prothrombin time-international normalized ratio (PT-INR) is an interventional prognostic indicator for patients with acute liver injury. The results showed that PT-INR on day 1 is the most accurate independent predictor for prognosis, and patients with PT-INR>=1.3 on day 1 have significantly lower transplant-free survival rates.
HEPATOLOGY RESEARCH
(2023)
Article
Immunology
Naoyuki Fukuda, Betty Balikagala, Tsuyoshi Ueno, Denis A. Anywar, Eisaku Kimura, Nirianne Marie Q. Palacpac, Emmanuel Odongo-Aginya, Martin Ogwang, Toshihiro Horii, Takashi Miida, Toshihiro Mita
Summary: The study found that mature Plasmodium falciparum parasites are rarely found in the peripheral blood because they are sequestered and attached to the endothelium. Intensive sequestration is associated with a delay in parasite clearance after artemisinin-based treatment. Sequestration plays an important role in the efficacy of artemisinin treatment for malaria.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Peripheral Vascular Disease
Takashi Miida
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Biochemistry & Molecular Biology
Mark Castleberry, Chase A. Raby, Anca Ifrim, Yasuhiro Shibata, Sachi Matsushita, Shinya Ugawa, Yutaka Miura, Atsushi Hori, Takashi Miida, MacRae F. Linton, Danielle L. Michell, Maki Tsujita, Kasey C. Vickers
Summary: HDL serves as dynamic transporters of various molecular cargo and plays important roles in lipid metabolism and inflammation. This study overcomes technical barriers and sheds light on the pathways involved in HDL-mediated bidirectional transport of sRNAs between immune cells. By utilizing a lipid-penetrating RNA-specific fluorescence dye, the absolute concentration of HDL-transported sRNAs is quantified, and HDL-mediated intercellular RNA transport between immune cells is characterized.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Multidisciplinary Sciences
Maika Takahashi, Kaori Saito, Tomohiko Ai, Shuko Nojiri, Abdullah Khasawneh, Faith Jessica Paran, Yuki Horiuchi, Satomi Takei, Takamasa Yamamoto, Mitsuru Wakita, Makoto Hiki, Takashi Miida, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe
Summary: Despite global COVID-19 vaccination campaigns, the pandemic remains a significant medical and social problem. The Ortho VITROS SARS-CoV-2 spike-specific quantitative IgG assay has been developed to assess neutralizing antibodies against SARS-CoV-2 spike antibodies. This study evaluated the clinical performance of VITROS S-IgG in Japan and found a good correlation with the surrogate virus neutralizing antibody test. The results suggest that VITROS S-IgG can be a useful diagnostic tool for assessing immune responses to vaccination and herd immunity, but careful analysis is necessary to interpret the results.
Article
Multidisciplinary Sciences
Junko Watanabe, Hiroaki Ihara, Satomi Takei, Ayako Nakamura, Yuichi Fujimoto, Tetsuya Handoh, Kana Kurokawa, Yuta Arai, Kohei Shibayama, Issei Sumiyoshi, Yusuke Ochi, Takahiro Okabe, Shigeki Misawa, Shinsaku Togo, Toshio Naito, Yoko Tabe, Takashi Miida, Kazuhisa Takahashi
Summary: A new combination treatment using sitafloxacin was presented in this study, targeting the rough morphotypes of aggressive MABS infections. The combination therapy showed synergistic effects against MABS strains, including highly resistant subspecies.
SCIENTIFIC REPORTS
(2023)
Review
Gastroenterology & Hepatology
Ryo Jimbo, Yoshihisa Arao, Atsunori Tsuchiya, Hanako Yamazaki, Masaki Mito, Yuichi Kojima, Yuji Kobayashi, Naruhiro Kimura, Kazunao Hayashi, Shuji Terai
Summary: This case report describes a 69-year-old male patient with multiple pancreatic parenchymal hemorrhages and acute liver failure. Literature review of similar cases identified through a systematic keyword search provides valuable information for physicians in diagnosing and treating this rare condition.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Hematology
Koji Tsuchiya, Konobu Kimura, Tomohiko Ai, Takamasa Yamamoto, Kaori Nagasaka, Hiroyuki Takemura, Yoko Edahiro, Kaori Saito, Yuki Horiuchi, Shigeki Misawa, Tomoiku Takaku, Jun Ando, Miki Ando, Takashi Miida, Kinya Uchihashi, Yoko Tabe
Summary: In this study, the feasibility of the Sysmex XN-3000 automated hematology analyzer for assessing TNC and BM cell density in routine BMA samples was evaluated. The results showed that XN-3000 provides a quantitative assessment of BM cellularity, supporting the qualitative assessment by myelogram and BM biopsy.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Takahito Kai, Satoshi Hirayama, Satoshi Soda, Fumiko Fuwa, Saori Nakagawa, Tsuyoshi Ueno, Atsushi Hori, Takashi Miida
Summary: This study investigated the levels of oxysterols, cholesterol oxidation derivatives, in treatment-naive patients with type 2 diabetes and their association with type 2 diabetes and atherosclerosis. The results demonstrated that the concentration of 25-hydroxycholesterol was significantly higher in type 2 diabetes patients and showed a significant association with type 2 diabetes.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kazuki Natsui, Atsunori Tsuchiya, Risa Imamiya, Mayuko Osada-Oka, Yui Ishii, Yohei Koseki, Nobutaka Takeda, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Riuko Ohashi, Yiwei Ling, Koji Ueda, Nobuko Moritoki, Kazuhiro Sato, Takahiro Nakajima, Yoshinori Hasegawa, Shujiro Okuda, Shinsuke Shibata, Shuji Terai
Summary: This study investigated the role of outer-membrane vesicles (OMVs) in the pathogenesis of cirrhosis. OMVs derived from Escherichia coli induced inflammation, fibrosis, and suppression of albumin production, exacerbating liver inflammation and fibrosis. These findings have important implications for the prevention and treatment of cirrhosis.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Shu Goto, Suguru Miida, Nobutaka Takeda, Yuichi Kojima, Yoshihisa Arao, Kazunao Hayashi, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai
Summary: Recent studies have shown that using machine learning to predict treatment response in patients with primary biliary cholangitis (PBC) may predict prognosis. This study used machine learning and pretreatment data to predict treatment response in PBC patients and evaluated it using the Paris II criteria. The results showed that machine learning models could improve treatment response prediction and enhance prognosis.
Article
Biochemistry & Molecular Biology
Yuto Tanaka, Kenya Kamimura, Osamu Shibata, Kohei Ogawa, Chiyumi Oda, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Toshifumi Wakai, Shuji Terai
Summary: A rat model of pancreatic cancer was developed by delivering human pancreatic cancer-related genes using pancreas-targeted hydrodynamic gene delivery. The molecular similarity between the rat model and human pancreatic cancer was determined.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konishi
Summary: Insulin resistance may lead to structural and functional abnormalities in the human brain, which may be mediated through resting-state functional connectivity between the hypothalamus and the cerebral cortex.
Article
Medicine, General & Internal
Sanae Kubota, Hiroshi Sasano, Mai Suzuki, Yukiko Fukui, Masayoshi Chonan, Takaaki Kawakami, Yoko Tabe, Takashi Miida, Toshimi Kimura, Toshio Naito
Summary: This study investigated the impact of the COVID-19 pandemic on the time between blood culture collection and administration of antibiotics in the outpatient Department of Emergency Medicine in a single university hospital in Japan. The findings showed a decrease in the implementation rate of antibiotic administration within 3 hours after blood culture collection during the COVID-19 pandemic, with an increase as the number of COVID-19-positive patients decreased. However, AST intervention improved the implementation rate and maintained it during subsequent COVID-19 waves.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Satoshi Oshiro, Fuminori Mizukoshi, Naeko Mizutani, Makoto Akiwa, Jun-Ichiro Sekiguchi, Tatsuya Tada, Yuki Yamamoto, Yoko Tabe, Takashi Miida, Teruo Kirikae
Summary: An immunochromatographic kit using antibodies against recombinant N protein was developed to detect SARS-CoV-2 omicron variants, including the variants BA.1.18, BA.1.1, BA.2, BA.2.12.1, BA.2.75, BA.4.1, BA.4.6, BE.1, BA.5.2.1, XE, BF.7, BF.7.4.1, XBB.1, XBB.1.5, BQ.1.1, as well as the Wuhan strain and a delta variant.
