Article
Endocrinology & Metabolism
Shinjini C. Spaulding, Vivek Choudhary, Wendy B. Bollag
Summary: Aldosterone is considered as a link between hypertension and obesity, and obese individuals have elevated serum levels of VLDL. VLDL induces aldosterone production, mediated in part by PLD. Our study suggests that DAG, rather than PA, is the key lipid signal underlying PLD's mediation of aldosterone production. Manipulating lipin-1 levels/activity affects VLDL-stimulated steroidogenic gene expression and aldosterone production. Our findings highlight the potential of lipin-1 and its downstream pathways as novel therapeutic targets for obesity-associated hypertension.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Article
Endocrinology & Metabolism
Youichi Ohno, Mitsuhide Naruse, Felix Beuschlein, Florentine Schreiner, Mirko Parasiliti-Caprino, Jaap Deinum, William M. Drake, Francesco Fallo, Carmina T. Fuss, Marianne A. Grytaas, Takamasa Ichijo, Nobuya Inagaki, Miki Kakutani, Darko Kastelan, Ivana Kraljevic, Takuyuki Katabami, Tomaz Kocjan, Silvia Monticone, Paolo Mulatero, Sam O'Toole, Hiroki Kobayashi, Masakatsu Sone, Mika Tsuiki, Norio Wada, Tracy Ann Williams, Martin Reincke, Akiyo Tanabe
Summary: AVS is the standard lateralization technique in PA. International data showed lower rates of unilateral PA and adrenalectomy in Japanese centers compared to European centers. Reasons for not performing adrenalectomy in patients with unilateral PA were more likely to be physician-derived in Japan and patient-derived in Europe.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Olivia M. DeLozier, Sophie Dream, James W. Findling, William Rilling, Srividya Kidambi, Steven B. Magill, Douglas B. Evans, Tracy S. Wang
Summary: This study analyzed adrenal vein epinephrine and norepinephrine levels in nonpheochromocytoma patients to determine the normal range. The study found that there is a wide range of normal adrenal vein catecholamine levels in patients without pheochromocytoma, suggesting limited utility of adrenal venous sampling in determining the laterality of pheochromocytoma in patients with bilateral adrenal nodules.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hui Dong, Jiangnan Huang, Ying Zhang, Yifei Dong, Min Liu, Zhitao Yan, Jianling Li, Yang Chen, Yubao Zou, Jiguang Wang, Yuanyuan Kang, Zhiyuan Jiang, Wei Song, Yujie Zuo, Hongliang Xiong, Jianzhong Xu, Xiongjing Jiang
Summary: This study evaluated the success rate and safety of adrenal venous sampling (AVS) via the antecubital approach. The results showed that AVS via the antecubital approach is safe and feasible, with a high rate of successful sampling, and can be an alternative to femoral vein access.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Zhenglin Shen, Shaoyong Xu, Siyu Guan, Bo Chen, Qingan Li, Ming Yu, Zhao Gao
Summary: This study aimed to identify the appropriate signature veins for the right adrenal gland using a 3D model fused with adrenal venography images and to verify their accuracy through the selectivity index (SI) >2. The major venous morphology in the right anterior oblique at 30 degrees was found to be the trunk branch type, while irregular or hollow triangle types were infrequent. The central vein, brush vein, uvula vein, and capsular vein were identified as signature veins for the right adrenal venous sampling (AVS), and the accuracy of AVS was 100% in the other 53 patients, as verified by an SI >2.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kentaro Okamoto, Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Takamasa Ichijo, Takashi Yoneda, Mika Tsuiki, Norio Wada, Kenji Oki, Kouichi Tamura, Hiroki Kobayashi, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse
Summary: AVS may not be necessary for all PA patients without apparent ATs. Female normokalemic PA patients without apparent ATs and low ARRs may skip AVS, while male hypokalemic PA patients with high ARRs should consider AVS due to the high rates of unilateral subtype.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Seung Hun Lee, Jong Woo Kim, Hyun-Ki Yoon, Sang Wan Kim, Su Jin Kim, Kyu Eun Lee, Yu-Mi Lee, Tae-Yon Sung, Suck Joon Hong, Chan Soo Shin, Jung-Min Koh, Jung Hee Kim
Summary: The study analyzed the impact of AVS indices on postsurgical outcomes in PA patients. Results suggest that an LI value of >= 10 may be appropriate for achieving biochemical success, while CLR < 0.25 and ILR > 2 may be appropriate for achieving biochemical and clinical success.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Hongliang Xiong, Li Du, Jiao Yang, WeiTong Hu, JiaBing Huang, YunDe Li, Xi Chen, YiFei Dong
Summary: This study aimed to evaluate the guiding role of the left adrenal vein (LAV) for right adrenal venous sampling (AVS). The findings showed that the position of the right adrenal vein (RAV) orifice is closely related to the location of the LAV. Body mass index, sex, and the angle of the LAV were found to be associated with the position of the RAV orifice.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Agriculture, Dairy & Animal Science
Halima Abobaker, Nagmeldin A. Omer, Yun Hu, Abdulrahman A. Idriss, Ruqian Zhao
Summary: In this study, it was found that in ovo injection of betaine promotes adrenal glucocorticoid synthesis in chicken fetuses before hatching, which involves alterations in DNA methylation.
Article
Pharmacology & Pharmacy
Adenike O. Adekeye, David Needham, Ruman Rahman
Summary: This study determined LDL receptor (LDLR) expression in high grade gliomas (HGGs) using immunohistochemistry and confirmed its potential as a therapeutic target. The study also analyzed LDLR expression levels in three cell line models, confirming their suitability for testing LDLR-targeted nanoparticle uptake, retention, and cytotoxicity.
Article
Cardiac & Cardiovascular Systems
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri-Sverdlov, David S. Leake
Summary: The study shows that cysteamine can induce regression of atherosclerotic lesions in LDL receptor-deficient mice, improve lesion stability, reduce oxidized phospholipids, decrease liver lipid levels and expression of specific proteins and cytokines, as well as enhance skeletal muscle function. No changes were observed in plasma lipid concentrations. This suggests that lysosomal oxidation inhibition with antioxidants targeted at lysosomes may be a promising therapy for atherosclerosis in patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Sophie Dream, Sandra Park, Tina W. Yen, William Rilling, Lisa Rein, Kara Doffek, James W. Findling, Steven B. Magill, Srividya Kidambi, Douglas B. Evans, Tracy S. Wang
Summary: This study investigates the utility of AV epinephrine levels in assessing successful AV cannulation for patients with primary aldosteronism. The results show that measuring epinephrine levels can help determine the success of AV catheter placement during AVS, thereby preventing unnecessary repeat AVS.
ENDOCRINE PRACTICE
(2022)
Article
Pediatrics
M. Rebecca Heiner-Fokkema, Ineke J. Riphagen, Nicole S. Wiersema, Jelmer J. van Zanden, Jenny E. Kootstra-Ros, Tineke H. Pinxterhuis, H. Louise Hooimeijer, Francjan J. van Spronsen, Anneke C. Muller Kobold, Wilhelmina H. A. de Jong
Summary: This study investigated plasma vitamin B12 markers in 170 children aged 0-18, deriving age-dependent reference intervals. Plasma methylmalonic acid was higher in young children, total cobalamin and holotranscobalamin peaked between 0.5-4 years and decreased by age 10. Plasma holotranscobalamin was correlated with total cobalamin, with their ratio independent of age. Early recognition and monitoring of children with suspected vitamin B12 deficiency may benefit from pediatric reference values for cobalamin markers.
PEDIATRIC RESEARCH
(2021)
Letter
Medical Laboratory Technology
Anneke C. Muller Kobold, Ido P. Kema, Janneke Dijck-Brouwer, Karin Koerts, Michiel Weening, Twan Storteboom, Jenny E. Kootstra-Ros, Martijn van Faassen, Ineke J. Riphagen
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Bernadette L. Dekker, Mirthe H. Links, Anneke C. Muller Kobold, Linda G. Swart-Busscher, Marleen Kars, Judith A. P. Bons, Adrienne H. Brouwers, Thera P. Links, Anouk N. A. Van der Horst-Schrivers
Summary: This study investigated whether a 4-day low-iodine diet (LID) is sufficient for adequate iodine depletion in differentiated thyroid cancer (DTC) patients preparing for I-131 therapy. The results showed no significant difference in the 24-hour urinary iodine excretion (UIE) between day 4 and day 7 of the LID. On day 4, 72.1% of DTC patients achieved adequate preparation, increasing to 82.0% on day 7. Compared to their regular diet, DTC patients had significantly lower nutrient intake during the LID.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Bruce H. R. Wolffenbuttel, Anneke C. Muller Kobold, Agata Sobczynska-Malefora, Dominic J. Harrington
Summary: Elevated serum B-12 concentration can be caused by supplementation or underlying disorders. Macro-B-12 can also lead to elevated levels, masking underlying B-12 deficiency.
Article
Otorhinolaryngology
Jeroen E. van Schaik, Anna C. Muller Kobold, Bernard F. A. M. van der Laan, Bert van der Vegt, Bettien M. van Hemel, Boudewijn E. C. Plaat
Summary: The diagnostic value of measuring SCC-Ag and CA15-3 concentrations in FNA samples for the detection of SCC metastases in cervical lymph nodes was evaluated. SCC-Ag measurement showed comparable sensitivity to FNAC and could be used as a cost-effective screening tool in samples with nondiagnostic or indeterminate FNAC results or when multiple lymph nodes are sampled. However, SCC-Ag in FNA samples had lower specificity compared to FNAC assessed by experienced pathologists in head and neck oncology. The addition of CA15-3 measurement did not enhance accuracy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Endocrinology & Metabolism
Antoinette D. Reichert, Marloes Nies, Wim J. E. Tissing, Anneke C. Muller Kobold, Marielle S. Klein Hesselink, Adrienne H. Brouwers, Bas Havekes, Marry M. van den Heuvel-eibrink, Helena J. H. van der Pal, John T. M. Plukker, Hanneke M. van Santen, Eleonora P. M. Corssmit, Romana T. Netea-Maier, Robin P. Peeters, Eveline W. C. M. van Dam, Johannes G. M. Burgerhof, Peter van der Meer, Gianni Bocca, Thera P. Links
Summary: In this follow-up study of relatively young survivors of pediatric DTC, there was a significant decrease in diastolic function over a 5-year period, potentially more pronounced than normal aging. Further follow-up is needed to assess the clinical consequences of this finding.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Sietske A. Berghuis, Arend F. Bos, Henk Groen, Wilhelmina H. A. de Jong, Anneke C. Muller Kobold, Lucie Wagenmakers-Huizinga, Pieter J. J. Sauer, Gianni Bocca
Summary: This study found that prenatal exposure to PCBs may impact pubertal development in 13-15 year old children, with boys showing higher hormone levels, earlier pubic hair development, and larger testicular volume, while girls showed advanced breast development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Bram M. ter Ellen, Jelmer Niewold, Antine Flikweert, Anneke C. Muller Kobold, Peter Heeringa, Matijs van Meurs, Jolanda M. Smit, Peter H. J. van der Voort, Izabela A. Rodenhuis-Zybert, Jill Moser
Summary: This study found that SARS-CoV-2 virus does not infect endothelial cells and adipokines cannot exacerbate microvascular dysfunction. Instead, endothelial activation associated with COVID-19 is likely a result of inflammatory responses initiated by other cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Antine W. Flikweert, Anneke C. Muller Kobold, Simone van der Sar-van der Brugge, Peter Heeringa, Izabela A. Rodenhuis-Zybert, Johan Bijzet, Adriana Tami, Bernardina T. F. van der Gun, Karin I. Wold, Anke Huckriede, Hildegard Franke, Judith M. A. Emmen, Marloes Emous, Marco J. J. H. Grootenboers, Matijs van Meurs, Peter H. J. van der Voort, Jill Moser
Summary: This study investigated the association between plasma adipokines and COVID-19 severity, systemic inflammation, clinical parameters, and outcome of COVID-19 patients. The results showed that circulating adipokine levels are associated with COVID-19 hospitalization, i.e., the need for oxygen support (general ward) or the need for mechanical ventilation and other organ support in the ICU.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medical Laboratory Technology
Mohammed F. F. Alkadhem, Lucie M. F. Wagenmakers-Huizenga, Marjan Wouthuyzen-Bakker, Anneke C. C. Muller Kobold
Summary: This study investigates the stability of synovial calprotectin and its susceptibility to potential interfering factors. It is found that factors such as time, storage temperature, EDTA, freeze-thaw cycles, viscosity, and blood and lipid contamination do not significantly affect the analysis of synovial calprotectin.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lisanne K. van Avezaath, Hessel P. Nijenhuis, Anneke C. Muller Kobold
Summary: This case report presents a 12-year-old child with MYH7 gene-associated hypertrophic cardiomyopathy, who had acute chest pain and unexpectedly high levels of cTnT and cTnI. Further investigation ruled out a cardiac cause and consulting a laboratory specialist revealed that the elevated levels were due to macrotroponin complexes, which have uncertain clinical significance. Awareness of macrotroponins could have prevented unnecessary diagnostics and prolonged hospital admission with psychological impact, especially in children.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Letter
Medical Laboratory Technology
Anneke C. Muller Kobold, Jacco J. de Haan, Reinoud P. H. Bokkers, Simeon J. S. Ruiter, Marius C. van den Heuvel, Eef G. W. M. Lentjes, Daan J. Touw, Koert P. de Jong
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mark R. Postma, Andre P. van Beek, Melanie M. van der Klauw, Eef G. W. M. Lentjes, Anneke C. Muller Kobold
Summary: Measurement of plasma IGF-1 plays a crucial role in the diagnosis and follow-up of acromegaly and growth hormone deficiency. However, this study found that the variability of IGF-1 results and non-adherence to clinical guidelines contribute to highly variable diagnostic and treatment outcomes.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Bernadette L. Dekker, Anouk N. A. van der Horst-schrivers, Adrienne H. Brouwers, Christopher M. Shuford, Ido P. Kema, Anneke C. Muller Kobold, Thera P. Links
Summary: Tg-IRMA is a reliable and useful tumor marker for thyroid carcinoma patients with lower titer TgAbs. However, Tg-IRMA values decrease due to interference from potentially interfering TgAbs.
EUROPEAN THYROID JOURNAL
(2022)
Article
Medical Laboratory Technology
Henrike M. Hamer, A. H. Leontine Mulder, Nanne K. de Boer, Femke Crouwel, Patrick F. van Rheenen, Marlies Spekle, Marloes Vermeer, Lucie Wagenmakers-Huizinga, Anneke C. Muller Kobold
Summary: This study evaluated the impact of different storage conditions on the reliability of calprotectin testing. The results showed that calprotectin concentration in stool samples declines over time, with a greater decline at higher temperatures. Extracted feces stored at 4 degrees C were found to be the most stable. However, the reliability of test results varied depending on the assay used.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)