Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 127, Issue 9, Pages 3287-3289Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI96497
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- Agencia Nacional de Promocion Cientifica y Tecnologica of Argentina
- UBA
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
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Chromatin modification influences gene expression by either repressing or activating genes, depending on the specific histone mark. Chromatin structure can also influence alternative splicing of transcripts; however, the mechanisms by which epigenetic marks influence splicing are poorly understood. A report in the current issue of the JCI highlights the biological importance of the coordinated control of alternative pre-mRNA splicing by chromatin structure and transcriptional elongation. Yuan et al. found that mutation of the histone methyl transferase SEDT2 affects alternative splicing fates of several key regulatory genes, including those involved in Wnt signaling. As a consequence, loss of SEDT2 in the intestine aggravated Wnt/beta-catenin signaling effects, thereby leading to colorectal cancer.
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