Article
Endocrinology & Metabolism
Pia Adam, Stefan Kircher, Iuliu Sbiera, Viktoria Florentine Koehler, Elke Berg, Thomas Knoesel, Benjamin Sandner, Wiebke Kristin Fenske, Hendrik Blaeker, Constantin Smaxwil, Andreas Zielke, Bence Sipos, Stephanie Allelein, Matthias Schott, Christine Dierks, Christine Spitzweg, Martin Fassnacht, Matthias Kroiss
Summary: High tumoral expression of PD-L1 in a large proportion of ATCs and a subgroup of PDTCs provides a rationale for immune checkpoint inhibition. FGFR expression is generally low in thyroid tumor cells. No impact of PD-L1 and FGFR 1-4 expression was observed on disease specific survival. The clinically observed synergism of PEM with LEN may be caused by immune modulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Su-Kang Kong, Byung Soo Kim, Hyangsoon Lim, Hyun Ji Kim, Young-Sik Kim
Summary: The authors analyzed the PD-L1 promoter and identified two ccRCC cell models with differential PD-L1 expression in response to IFN gamma and hypoxia. Mutant-VHL ccRCC cells showed higher PD-L1 expression due to increased HIF2 alpha levels and stronger response to IFN gamma stimulation compared to wild-type-VHL cells. This information suggests that Mutant-VHL ccRCC cells may respond better to immune checkpoint inhibitors, and the potential of using HIF2 alpha antagonists to reduce PD-L1 expression levels in combination therapy should be considered.
LABORATORY INVESTIGATION
(2022)
Article
Materials Science, Multidisciplinary
Yijun Mei, Lu Tang, Lidong Zhang, Jingyi Hu, Ziyao Zhang, Shun He, Jing Zang, Wei Wang
Summary: Combining immune checkpoint blockade therapy with other treatment modalities through nanotechnology can enhance immunity for effective cancer treatment. In this study, a three-in-one nanocomposite was fabricated, which could precisely target tumors and strengthen the antitumor efficacy through the interaction of different components. The combination therapy demonstrated a positive feedback-mediated multimodal antitumor effect and the potential for long-term tumor immune memory establishment.
Article
Chemistry, Multidisciplinary
Zikuan Gu, Shuxin Xu, Zhanchen Guo, Zhen Liu
Summary: This study presents a molecularly imprinted polymer-based PD-1 nano inhibitor, which effectively blocks the PD-1/PD-L1 signaling pathway with good specificity and high affinity. The inhibitor can reactivate T cells and reverse the chemoresistance of tumor cells, providing a promising option for cancer immunotherapy.
Article
Multidisciplinary Sciences
Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Summary: This study identifies elevated Notch signaling as a significant predictor of clinical benefit in immune checkpoint blockade (ICB) for relapsed small cell lung cancer (SCLC) patients. Activation of Notch signaling induces a low NE phenotype, leading to increased expression of antigen processing and presentation machinery (APM) genes and improved intrinsic tumor immunity.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Shuxian Cai, Ziyi Chen, Yingjie Wang, Min Wang, Junye Wu, Yuhong Tong, Lanlan Chen, Chunhua Lu, Huanghao Yang
Summary: A novel nanodrug MS NPs was developed by self-assembly of the immunoadjuvant metformin and the anticancer agent SN38, which reduced PD-L1 expression and enhanced antitumor effects. MS NPs showed enhanced chemo-immunotherapy effect, inhibited tumor metastasis, and had low toxicity in major organs, providing a new perspective on the development of novel immune checkpoint inhibitors.
Article
Oncology
Soledad Cameselle-Garcia, Samer Abdulkader-Sande, Maria Sanchez-Ares, Gemma Rodriguez-Carnero, Jesus Garcia-Gomez, Francisco Gude-Sampedro, Ihab Abdulkader-Nallib, Jose Manuel Cameselle-Teijeiro
Summary: In this study, frequent PD-L1 expression was observed in ATC while it was rare in PDTC. Along with PD-L1, ATC cases also exhibited increased levels of CD3(+) and CD8(+) T cells, CD68(+) and CD163(+) macrophages, and S100(+) dendritic cells compared to PDTC cases. Additionally, microsatellite instability may play a role in identifying immunotherapy candidates among patients with PDTC.
Article
Oncology
Loick Galland, Anne Laure Le Page, Julie Lecuelle, Frederic Bibeau, Youssef Oulkhouir, Valentin Derangere, Caroline Truntzer, Francois Ghiringhelli
Summary: The study aimed to identify biomarkers for the efficacy of ICI treatment in non-squamous NSCLC, finding that TTF1 expression and PD-L1 status can predict PFS and OS, improving prognosis prediction accuracy.
Article
Oncology
LeAnne Young, Shanda Finnigan, Howard Streicher, Helen X. Chen, James Murray, H. Nida Sen, Elad Sharon
Summary: Ocular adverse events are rare complications of PD-1/PD-L1 inhibitor therapy, but can be severe enough to cause treatment discontinuation or delay. Proper evaluation by eye specialists is necessary in managing these adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Maxwell J. Kroloff, Josefin-Beate Holz, Omer Stern, Christopher J. Shepherd, Michelle Morrow, Louis Kayitalire, Deborah J. Wong
Summary: This article presents a case of a patient with BRAF V600E-mutated, PD-L1 positive anaplastic thyroid cancer refractory to standard therapies, but achieving 3 years of disease control and partial response through treatment with FS118. Further investigation is needed to understand the mechanism of dual PD-L1/LAG-3 blockade by FS118 in overcoming initial PD-1 pathway resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Endocrinology & Metabolism
Keith C. Bible, Electron Kebebew, James Brierley, Juan P. Brito, Maria E. Cabanillas, Thomas J. Clark, Antonio Di Cristofano, Robert Foote, Thomas Giordano, Jan Kasperbauer, Kate Newbold, Yuri E. Nikiforov, Gregory Randolph, M. Sara Rosenthal, Anna M. Sawka, Manisha Shah, Ashok Shaha, Robert Smallridge, Carol K. Wong-Clark
Summary: The guidelines for the management of anaplastic thyroid cancer (ATC) aim to provide evidence-based recommendations to inform clinical decision-making, encompassing diagnosis, treatment goals, locoregional and advanced disease approaches, palliative care, surveillance, and ethical considerations.
Article
Oncology
Xiaoming Wang, Yan Zhang, Jian Zheng, Cuixian Yao, Xiubo Lu
Summary: In anaplastic thyroid carcinoma, the lncRNA UCA1 attenuates the killing effect of cytotoxic CD8 + T cells on cancer cells through the miR-148a/PD-L1 pathway, providing insights into the potential mechanisms of immune evasion in this type of cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Arnaud Jannin, Alexandre Escande, Abir Al Ghuzlan, Pierre Blanchard, Dana Hartl, Benjamin Chevalier, Frederic Deschamps, Livia Lamartina, Ludovic Lacroix, Corinne Dupuy, Eric Baudin, Christine Do Cao, Julien Hadoux
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive form of thyroid cancer with a poor prognosis. Improving the management of this deadly disease involves the use of molecular tests for targeted therapies, fast-track dedicated care pathways, and prompt initiation of treatment. Adjuvant chemo-radiotherapy is recommended for localized disease after surgery, while chemotherapy or targeted therapy combined with decompressive cervical radiotherapy is recommended for locally advanced or metastatic disease.
Article
Oncology
Florian Eichhorn, Mark Kriegsmann, Laura V. Klotz, Katharina Kriegsmann, Thomas Muley, Christiane Zgorzelski, Petros Christopoulos, Hauke Winter, Martin E. Eichhorn
Summary: PD-L1 expression levels in lung cancer patients are associated with prognosis, with potential implications for patients undergoing surgical treatment. Further research is needed to fully understand the predictive value of PD-L1 in an adjuvant setting.
Article
Multidisciplinary Sciences
Toshihiro Yokoi, Takaaki Oba, Ryutaro Kajihara, Scott Abrams, Fumito Ito
Summary: Despite the poor prognosis of metastatic triple-negative breast cancer (TNBC), a novel therapy involving in situ immunomodulation (ISIM) showed promising results in a mouse model. ISIM treatment led to increased effector T cells in circulation, infiltration of CD8(+) T cells into brain metastases, delayed progression of metastases, and improved survival rates. The combination of ISIM with anti-PD-L1 therapy overcame resistance and further improved survival outcomes, indicating the therapeutic potential of multimodal intralesional therapy for unresectable and metastatic TNBC patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xiaohong Zhou, Mirja Ramke, Ashish V. Chintakuntlawar, Jeong Yoon Lee, Jaya Rajaiya, James Chodosh
IMMUNOLOGY AND CELL BIOLOGY
(2017)
Article
Endocrinology & Metabolism
Naiyarat Prasongsook, Aditi Kumar, Ashish V. Chintakuntlawar, Robert L. Foote, Jan Kasperbauer, Julian Molina, Yolanda Garces, Daniel Ma, Michelle A. Neben Wittich, Joseph Rubin, Ronald Richardson, John Morris, Ian Hay, Vahab Fatourechi, Bryan McIver, Mabel Ryder, Geoffrey Thompson, Clive Grant, Melanie Richards, Thomas J. Sebo, Michael Rivera, Vera Suman, Sarah M. Jenkins, Robert C. Smallridge, Keith C. Bible
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Public, Environmental & Occupational Health
Ariela L. Marshall, Juliana Perez Botero, Aneel A. Ashrani, Rajiv K. Pruthi, John A. Heit, Ashish Chintakuntlawar, Jennifer C. Guenther, Mrinal M. Patnaik
JOURNAL OF WOMENS HEALTH
(2017)
Article
Oncology
Samer Alsidawi, Katharine A. Price, Ashish V. Chintakuntlawar, Gustavo F. Westin, Joaquin J. Garcia, Daniel J. Ma, Scott H. Okuno
Review
Otorhinolaryngology
John P. Marinelli, Jeffrey R. Janus, Jamie J. Van Gompel, Michael J. Link, Robert L. Foote, Christine M. Lohse, Katharine A. Price, Ashish V. Chintakuntlawar
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Otorhinolaryngology
Kevin C. Miller, John P. Marinelli, Jamie J. Van Gompel, Michael J. Link, Jeffrey R. Janus, Robert L. Foote, Katharine A. Price, Joaquin Garcia, Michael Rivera, Ashish V. Chintakuntlawar
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Endocrinology & Metabolism
Ashish Chintakuntlawar, Robert L. Foote, Jan L. Kasperbauer, Keith C. Bible
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
(2019)
Review
Oncology
Yucai Wang, Shouhao Zhou, Fang Yang, Xinyue Qi, Xin Wang, Xiaoxiang Guan, Chan Shen, Narjust Duma, Jesus Vera Aguilera, Ashish Chintakuntlawar, Katharine A. Price, Julian R. Molina, Lance C. Pagliaro, Thorvardur R. Halfdanarson, Axel Grothey, Svetomir N. Markovic, Grzegorz S. Nowakowski, Stephen M. Ansel, Michael L. Wang
Article
Oncology
Daniel J. Ma, Katharine A. Price, Eric J. Moore, Samir H. Patel, Michael L. Hinni, Joaquin J. Garcia, Darlene E. Graner, Nathan R. Foster, Brenda Ginos, Michelle Neben-Wittich, Yolanda I. Garces, Ashish V. Chintakuntlawar, Daniel L. Price, Kerry D. Olsen, Kathryn M. Van Abel, Jan L. Kasperbauer, Jeffrey R. Janus, Mark Waddle, Robert Miller, Satomi Shiraishi, Robert L. Foote
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Letter
Oncology
Daniel J. Ma, Katharine A. Price, Eric J. Moore, Samir H. Patel, Michael L. Hinni, Joaquin J. Garcia, Darlene E. Graner, Michelle Neben-Wittich, Yolanda I. Garces, Ashish V. Chintakuntlawar Mbbs, Daniel L. Price, Kathryn M. Van Abel, Jan L. Kasperbauer, Jeffrey R. Janus, Mark Waddle, Robert C. Miller, Satomi Shiraishi, Robert W. Mutter, Kimberly S. Corbin, Sean S. Park, Robert L. Foote
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Paul V. Viscuse, Katharine A. Price, Joaquin J. Garcia, David J. Schembri-Wismayer, Ashish Chintakuntlawar
FRONTIERS IN ONCOLOGY
(2019)
Article
Endocrinology & Metabolism
Ashish V. Chintakuntlawar, Jun Yin, Robert L. Foote, Jan L. Kasperbauer, Michael Rivera, Erik Asmus, Nina I. Garces, Jeffrey R. Janus, Minetta Liu, Daniel J. Ma, Eric J. Moore, John C. Morris, Michelle Neben-Wittich, Daniel L. Price, Katharine A. Price, Mabel Ryder, Kathryn M. Van Abel, Crystal Hilger, Eleyna Samb, Keith C. Bible
Article
Endocrinology & Metabolism
Nicole M. Iniguez-Ariza, Sina Jasim, Mabel M. Ryder, Ashish Chintakuntlawar, John C. Morris, Crystal R. Hilger, Michael E. Menefee, Robert C. Smallridge, Nina J. Karlin, Constanza Alcaino, Keith C. Bible
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Pathology
Kyriakos Chatzopoulos, Andrea R. Collins, Sotiris Sotiriou, Michael G. Keeney, Daniel W. Visscher, Michael Rivera, David J. Schembri-Wismayer, Jean E. Lewis, Patricia T. Greipp, William R. Sukov, Ashish Chintakuntlawar, Katharine A. Price, Joaquin J. Garcia
HEAD & NECK PATHOLOGY
(2020)