Article
Endocrinology & Metabolism
Tingting Geng, Jun-Xiang Chen, Yan-Feng Zhou, Qi Lu, Zhenzhen Wan, Liegang Liu, An Pan, Gang Liu
Summary: Based on data from the UK Biobank study, researchers found a significant association between proton pump inhibitor (PPI) use and increased risks of cardiovascular disease events and all-cause mortality in patients with type 2 diabetes. The study suggests that monitoring of adverse cardiovascular events and careful consideration of the benefits and risks of PPI use should be implemented in patients with type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Cardiac & Cardiovascular Systems
Wendy A. Davis, Timothy M. E. Davis
Summary: Recent reductions in chronic complications in Australians with type 2 diabetes and without diabetes have shown similar trends in both sexes over recent decades, suggesting improved overall CVD risk factor management for both male and female individuals.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
S. A. Paul Chubb, Kirsten E. Peters, David G. Bruce, Wendy A. Davis, Timothy M. E. Davis
Summary: This study aimed to determine whether undetected thyroid disease increases the risk of cardiovascular disease (CVD) events and death in people with type 2 diabetes. The results showed that subclinical hypothyroidism was not independently associated with CVD events or mortality in community-dwelling people with type 2 diabetes, despite its associations with CVD risk factors.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Emilie H. Zobel, Bernt Johan von Scholten, Tine W. Hansen, Frederik Persson, Soren Rasmussen, Benjamin Wolthers, Peter Rossing
Summary: This study aimed to investigate the impact of improvements in multiple risk markers on the risk of cardiovascular and kidney complications in individuals with type 2 diabetes. The results showed that participants with improvements in two or more risk markers had a reduced risk of disease complications compared to those with no or only one improved risk marker.
DIABETES OBESITY & METABOLISM
(2022)
Article
Medicine, General & Internal
Elizabeth T. Jensen, Joe Yi, Wesley Jackson, Rachana Singh, Robert M. Joseph, Karl C. K. Kuban, Michael E. Msall, Lisa Washburn, Rebecca Fry, Andrew M. South, T. Michael O'Shea
Summary: Early acid suppressant use in extremely preterm infants may be associated with poorer neurodevelopmental outcomes, including decreased IQ scores, autism spectrum disorder, and epilepsy.
Article
Endocrinology & Metabolism
HoJin Shin, Sebastian Schneeweiss, Robert J. Glynn, Elisabetta Patorno
Summary: Metformin was the most commonly initiated first-line antidiabetes treatment among adult patients with type 2 diabetes. While the use of SGLT-2i and GLP-1RA remained low from 2013 to 2019, it increased among patients with cardiovascular disease.
Article
Endocrinology & Metabolism
Wendy A. Davis, Emma Hamilton, Timothy M. E. Davis
Summary: This study aimed to investigate the temporal changes in the prevalence and incidence rates of distal symmetric polyneuropathy (DSPN) in community-based Australians with type 2 diabetes. The results showed that the prevalence and incidence rates of DSPN varied between different phases, and further research is needed to understand the specific trends and contributing factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ming-Hsun Lin, Wen-Tung Wu, Yong-Chen Chen, Tsung-Kun Lin, Yu-Ching Chou, Chien-An Sun
Summary: Lansoprazole is associated with a reduced risk of type 2 diabetes compared with other proton pump inhibitors.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Multidisciplinary Sciences
Hong-Mo Shih, Wen-Chen Tsai, Pei-Yu Wu, Li-Ting Chiu, Pei-Tseng Kung
Summary: Newly diagnosed diabetes patients with complications have an increased risk of dialysis within 5 years. The severity and number of complications are directly linked to the risk of dialysis.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Hsin-Ya Kuo, Chih-Sung Liang, Shih-Jen Tsai, Tzeng-Ji Chen, Che-Sheng Chu, Mu-Hong Chen
Summary: This study found that among patients with upper gastrointestinal disease (UGID), higher dosage of proton pump inhibitors (PPIs) was associated with an increased risk of type 2 diabetes mellitus (T2DM). Specifically, pantoprazole, lansoprazole, and omeprazole had the highest risk of T2DM development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Cardiac & Cardiovascular Systems
Melanie J. Davies, Heinz Drexel, Francois R. Jornayvaz, Zoltan Pataky, Petar M. Seferovic, Christoph Wanner
Summary: Cardiovascular disease is the leading cause of mortality in patients with type 2 diabetes. Data from cardiovascular outcomes trials show that certain glucose-lowering medications, such as SGLT2 inhibitors and GLP-1 receptor agonists, have cardioprotective effects and can reduce cardiovascular events and mortality risk, as well as the risks of heart failure hospitalization, renal disease progression, and all-cause mortality. International guidelines now prioritize the use of these medications in the management of type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Janet B. B. McGill, Rajiv Agarwal, Stefan D. D. Anker, George L. L. Bakris, Gerasimos Filippatos, Bertram Pitt, Luis M. M. Ruilope, Andreas L. L. Birkenfeld, Maria L. L. Caramori, Meike Brinker, Amer Joseph, Andrea Lage, Robert Lawatscheck, Charlie Scott, Peter Rossing, FIDELIO-DKD Investigator, FIGARO-DKD Investigator
Summary: The aim of this study was to evaluate the effect of finerenone on cardiorenal outcomes and diabetes progression, and to assess its interaction with baseline HbA1c, HbA1c variability, diabetes duration and baseline insulin use. The results showed consistent risk reductions in cardiovascular and kidney outcomes with finerenone compared to placebo across subgroups. Higher HbA1c variability was associated with an increased risk of cardiorenal outcomes. The study concludes that finerenone is effective regardless of baseline characteristics. Overall, the study is rated 9 out of 10.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sohee Park, Han Eol Jeong, Sungho Bea, Oriana H. Y. Yu, Young Min Cho, Seng Chan You, Kenneth K. C. Man, Ju-Young Shin
Summary: This study assessed the risk of amputation associated with SGLT2is in patients with type 2 diabetes, based on baseline cardiovascular disease and diuretic use. The results showed that initiating SGLT2is did not increase the risk of amputation in vulnerable patient populations compared to DPP4is.
DIABETES OBESITY & METABOLISM
(2023)
Article
Transplantation
Rong M. Zhang, Frederik Persson, Janet B. McGill, Peter Rossing
Summary: Chronic kidney disease (CKD) associated with type 2 diabetes (T2D) is a serious complication with high morbidity and mortality. Current guidelines recommend annual screening for CKD, blood pressure and glucose control, as well as the use of renin-angiotensin system (RAS) inhibition. Recent additions to the guidelines include the use of SGLT2 inhibitors and finerenone, based on robust clinical trial data, to improve CKD outcomes in T2D patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Jocelyn J. Drinkwater, Wendy A. Davis, Angus W. Turner, Daniel McAullay, Timothy M. E. Davis
Summary: This study compares the prevalence of diabetic retinopathy (DR) and the incidence of new or worsening DR in Aboriginal Australians and Anglo-Celts with Type 2 diabetes. The findings reveal that Aboriginal participants have higher rates of DR and new or worsening DR, and their significantly higher odds of moderate non-proliferative DR or worse suggest there are ethnic-specific determinants of DR severity. This highlights the importance of providing equitable, culturally appropriate diabetes/ophthalmic care.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Sri Riyati Sugiarto, Balbir Singh, Madhu Page-Sharp, Wendy A. Davis, Sam Salman, King Ching Hii, Timothy M. E. Davis
Summary: The study aimed to assess the pharmacokinetic properties of artemether, lumefantrine, and their active metabolites in Plasmodium knowlesi malaria. The results showed that the disposition of these drugs in knowlesi malaria largely parallels that in other human malarias.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Dermatology
Laurens Manning, Ivana Bastos Ferreira, Paul Gittings, Jonathan Hiew, Erica Ryan, Mendel Baba, Edward Raby, Keryln Carville, Paul E. Norman, Wendy Angela Davis, Fiona Wood, Emma Jane Hamilton, Jens Carsten Ritter
Summary: Spray-on skin treatment showed high rates of complete healing at 6 months in patients with large diabetes-related foot wounds, but was not significantly better than standard care. Lower body mass index and non-plantar wounds were the only patient- or wound-related factors associated with complete healing at 6 months.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Critical Care Medicine
Kaspar F. Bachmann, Adrian Regli, Merli Maendul, Wendy Davis, Annika Reintam Blaser
Summary: This study suggests that the duration and higher grades of intraabdominal hypertension (IAH) are associated with kidney failure and may increase mortality.
JOURNAL OF CRITICAL CARE
(2022)
Article
Multidisciplinary Sciences
Sri Riyati Sugiarto, Diana Natalia, Dayang Shuaisah Awang Mohamad, Nawal Rosli, Wendy A. Davis, J. Kevin Baird, Balbir Singh, Iqbal Elyazar, Paul C. S. Divis, Timothy M. E. Davis
Summary: The predominant simian parasite known as Plasmodium knowlesi causing human malaria infection is found in Malaysian Borneo but there are few cases reported in Indonesian Borneo. To investigate the prevalence of P. knowlesi, a community-based malaria screening study was conducted in Kapuas Hulu District, West Kalimantan. The results suggest that P. knowlesi is rare in this area compared to geographically adjacent areas of Malaysian Borneo. Further studies are needed to determine the reasons for this disparity and to gather more data on monkey hosts and Anopheles mosquito vectors in Indonesian Borneo.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Jocelyn J. Drinkwater, Timothy M. E. Davis, Angus W. Turner, Wendy A. Davis
Summary: This study aimed to determine the prevalence and incidence of diabetic retinopathy (DR) in individuals with Type 2 diabetes and investigate whether distinct trajectories of the disease were associated. The results showed that a small percentage of patients developed at least moderate NPDR during the 6-year follow-up period. HbA(1c) was identified as the sole independent predictor of incident moderate NPDR or worse. Trajectory analysis identified two distinct groups - one with baseline/persistent DR and the other remaining DR free.
Article
Medicine, General & Internal
Wendy A. Davis, David G. Bruce, Sergio E. Starkstein, Timothy M. E. Davis
Summary: There is evidence to suggest that the coexistence of schizophrenia and type 2 diabetes leads to increased mortality. This study aimed to investigate whether the mortality gap had improved 15 years later. The results showed that the mortality rate was higher in patients with both type 2 diabetes and schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Wendy A. Davis, Timothy M. E. Davis
Summary: Recent reductions in chronic complications in Australians with type 2 diabetes and without diabetes have shown similar trends in both sexes over recent decades, suggesting improved overall CVD risk factor management for both male and female individuals.
CARDIOVASCULAR DIABETOLOGY
(2023)
Letter
Endocrinology & Metabolism
Timothy M. E. Davis, Sharon Maxwell, Cathy Chan, Helen I. Keen, Wendy A. Davis
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Timothy M. E. Davis, Wendy Davis
Summary: This study examines the relationship between glycaemia and treatment complexity in type 2 diabetes patients and finds that diabetes duration has an impact on glycemic and treatment characteristics, which is of great importance for managing the disease.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Timothy M. E. Davis, Stephen A. P. Chubb, Kirsten E. Peters, Wendy A. Davis
Summary: This study investigated the relationship between metformin therapy and vitamin B12 deficiency in 1492 patients with type 2 diabetes. The results showed that although metformin treatment increased the risk of vitamin B12 deficiency, there was no significant association between vitamin B12 status and neuropathy or anemia.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
David G. Bruce, Wendy A. Davis, Timothy M. E. Davis
Summary: The study investigated temporal changes in mobility in community-based individuals with type 2 diabetes. The results showed that almost one-quarter of the participants experienced clinically relevant mobility impairment that persisted or worsened over six years and was associated with late withdrawals and deaths. The Timed Up and Go (TUG) test may have important clinical utility in assessing mobility and its consequences in adults with type 2 diabetes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ruwani Rajapaksa, Wendy A. Davis, Timothy M. E. Davis
Summary: The aim of this study was to compare mortality rates in community-based Australians with type 1 diabetes (T1D), without diabetes, or with type 2 diabetes (T2D). The results showed that T1D substantially increases the risk of death, especially when diagnosed in late adolescence/young adulthood. The type of diabetes does not influence mortality rates after adjusting for key confounding variables.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
S. A. Paul Chubb, Wendy A. Davis, Timothy M. E. Davis
Summary: The study found that serum bicarbonate concentration below the laboratory reference interval is independently associated with all-cause mortality. Multiple logistic regression analysis was used to determine the independent factors of low baseline serum bicarbonate, and Cox regression model was used to evaluate the association between bicarbonate and mortality. The results showed that low serum bicarbonate is associated with increased mortality, and this association remained significant after adjusting for factors associated with mortality but not low serum bicarbonate.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
S. A. Paul Chubb, Kirsten E. Peters, David G. Bruce, Wendy A. Davis, Timothy M. E. Davis
Summary: This study aimed to determine whether undetected thyroid disease increases the risk of cardiovascular disease (CVD) events and death in people with type 2 diabetes. The results showed that subclinical hypothyroidism was not independently associated with CVD events or mortality in community-dwelling people with type 2 diabetes, despite its associations with CVD risk factors.
ACTA DIABETOLOGICA
(2022)